General Information of the Protein
Protein ID
PT01160
Protein Name
Kinesin-like protein KIF11
Secondarily
Protein Name
Kinesin-like protein 1
Kinesin-like spindle protein HKSP
Kinesin-related motor protein Eg5
Thyroid receptor-interacting protein 5
Gene Name
KIF11
Secondarily
Gene Name
EG5
KNSL1
TRIP5
Sequence
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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Organism
Homo sapiens, Human
Protein Classification
Other cytosolic protein
Function
Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
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Uniprot ID
Primary ID:
P52732

Secondarily ID:
A0AV49
B2RMV3
Q15716
Q5VWX0
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Ensembl ID
ENSG00000138160
HGNC ID
HGNC:6388
Subcellular Location
Cytoplasm
Cytoplasm
Cytoskeleton
Spindle pole
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000068 , A-549
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0427180
 Compound Info 
3-N,3-N-diethyl-5-methyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C19H24N2O2S2
  1
1
EC50 = 100 nM
 Bioactivity Info 
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CP0442403
 Compound Info 
3-N,3-N-diethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C18H22N2O2S2
  1
1
EC50 = 480 nM
 Bioactivity Info 
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CP0440383
 Compound Info 
N-[3-(piperidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]thiophene-2-carboxamide
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C19H22N2O2S2
  1
1
EC50 = 540 nM
 Bioactivity Info 
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CP0440384
 Compound Info 
N-[3-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]thiophene-2-carboxamide
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C18H20N2O2S2
  1
1
EC50 = 1100 nM
 Bioactivity Info 
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CP0522578
 Compound Info 
N-[3-(diethylcarbamoyl)-5-methyl-4H,5H,6H-cyclopenta[b]thiophen-2-yl]thiophene-2-carboxamide
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C18H22N2O2S2
  1
1
EC50 = 1500 nM
 Bioactivity Info 
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CP0268586
 Compound Info 
3-N,3-N-diethyl-5,5-dimethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C20H26N2O2S2
  1
1
EC50 = 1700 nM
 Bioactivity Info 
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CP0528612
 Compound Info 
N-[3-(morpholin-4-ylcarbonyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]thiophene-2-carboxamide
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C18H20N2O3S2
  1
1
EC50 = 1800 nM
 Bioactivity Info 
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CP0528611
 Compound Info 
3-N,3-N,5-triethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C20H26N2O2S2
  1
1
EC50 = 1900 nM
 Bioactivity Info 
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CP0535460
 Compound Info 
N-[3-(diethylcarbamoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-yl]thiophene-2-carboxamide
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C17H20N2O2S2
  1
1
EC50 = 2200 nM
 Bioactivity Info 
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CP0525776
 Compound Info 
3-N,3-N-diethyl-6-methyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C19H24N2O2S2
  1
1
EC50 = 2600 nM
 Bioactivity Info 
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CP0437384
 Compound Info 
3-N,3-N-dimethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C16H18N2O2S2
  1
1
EC50 = 3600 nM
 Bioactivity Info 
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CP0437097
 Compound Info 
3-N,3-N-diethyl-2-N-(thiophene-3-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C18H22N2O2S2
  1
1
EC50 = 4300 nM
 Bioactivity Info 
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CP0501506
 Compound Info 
3-N,3-N-diethyl-4-methyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C19H24N2O2S2
  1
1
EC50 = 4700 nM
 Bioactivity Info 
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CP0437383
 Compound Info 
N-[3-(diethylcarbamoyl)-4-methyl-4H,5H,6H-cyclopenta[b]thiophen-2-yl]thiophene-2-carboxamide
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C18H22N2O2S2
  1
1
EC50 = 5400 nM
 Bioactivity Info 
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CP0444406
 Compound Info 
N-[3-(diethylcarbamoyl)-4H,5H,6H,7H,8H-cyclohepta[b]thiophen-2-yl]thiophene-2-carboxamide
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C19H24N2O2S2
  1
1
EC50 = 5800 nM
 Bioactivity Info 
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CP0444405
 Compound Info 
3-N-[2-(dimethylamino)ethyl]-3-N-methyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C19H25N3O2S2
  1
1
EC50 = 7600 nM
 Bioactivity Info 
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CP0442401
 Compound Info 
N-[3-(diethylcarbamoyl)-4H,5H,7H-thieno[2,3-c]thiopyran-2-yl]thiophene-2-carboxamide
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C17H20N2O2S3
  1
1
EC50 = 9600 nM
 Bioactivity Info 
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CP0435879
 Compound Info 
3-N,3-N-diethyl-6,6-dimethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C20H26N2O2S2
  1
1
EC50 = 14000 nM
 Bioactivity Info 
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CP0432867
 Compound Info 
3-N,3-N-diethyl-2-N-(thiophene-2-)-4H,5H,7H-thieno[2,3-c]pyran-2,3-diamido
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C17H20N2O3S2
  1
1
EC50 = 17000 nM
 Bioactivity Info 
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CP0528613
 Compound Info 
N-[3-(diethylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]furan-2-carboxamide
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C18H22N2O3S
  1
1
EC50 = 20000 nM
 Bioactivity Info 
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CP0541768
 Compound Info 
3-N,3-N-diethyl-4,5-dimethyl-2-N-(thiophene-2-)thiophene-2,3-diamido
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C16H20N2O2S2
  1
1
EC50 = 29000 nM
 Bioactivity Info 
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CP0501510
 Compound Info 
N-[3-(diethylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,3-thiazole-5-carboxamide
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C18H23N3O2S2
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0503101
 Compound Info 
N-[3-(diethylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3-thiazole-5-carboxamide
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C17H21N3O2S2
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0525775
 Compound Info 
3-N,3-N,6-triethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C20H26N2O2S2
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0949891
 Compound Info 
N,N-diethyl-2-(thiophen-2-ylmethylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
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C18H24N2OS2
  1
1
EC50 > 30000 nM
 Bioactivity Info 
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CP0541766
 Compound Info 
2-N-benzene-3-N,3-N-diethyl-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C20H24N2O2S
  1
1
EC50 = 34000 nM
 Bioactivity Info 
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CP0501507
 Compound Info 
3-N-[2-(dimethylamino)ethyl]-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C18H23N3O2S2
  1
1
EC50 = 37000 nM
 Bioactivity Info 
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CP0047482
 Compound Info 
2-(thiophene-2-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
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C14H13NO3S2
  1
1
EC50 < 30000 nM
 Bioactivity Info 
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CP0233491
 Compound Info 
ethyl 2-(thiophene-2-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
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C16H17NO3S2
  1
1
EC50 < 30000 nM
 Bioactivity Info 
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CP0433960
 Compound Info 
3-N,3-N-diethyl-2-N-(thiophene-2-)thiophene-2,3-diamido
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C14H16N2O2S2
  1
1
EC50 < 30000 nM
 Bioactivity Info 
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CP0501509
 Compound Info 
2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C14H14N2O2S2
  1
1
EC50 < 30000 nM
 Bioactivity Info 
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CP0525774
 Compound Info 
3-N,3-N-diethyl-2-N-(thiophene-2-)-4H,5H,6H,7H-thieno[2,3-c]pyridine-2,3-diamido
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C17H21N3O2S2
  1
1
EC50 < 30000 nM
 Bioactivity Info 
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CP0539692
 Compound Info 
3-N,3-N-diethyl-2-N-(thiophene-2-)-1-benzothiophene-2,3-diamido
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C18H18N2O2S2
  1
1
EC50 < 30000 nM
 Bioactivity Info 
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Cell Line ID: CL000067 , HCT 116
 Cell Line Info 
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0252482
 Compound Info 
(S)-2-(3-aminopropyl)-4-(2,5-difluorophenyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide
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C22H25F2N3O
  1
1 IC50 = 2.2 nM
CP0157181
 Compound Info 
(S)-2-((S)-3-amino-4,4-difluorobutyl)-4-(2,5-difluorophenyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide
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C23H25F4N3O
  1
1 IC50 = 5.2 nM
CP0224339
 Compound Info 
ARRY-520
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C20H22F2N4O2S
  2
1 IC50 = 6 nM
2 IC50 = 18 nM
CP0039077
 Compound Info 
(2R)-2-amino-3-{[(4-methoxyphenyl)diphenylmethyl]sulfanyl}propanoic acid
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C23H23NO3S
  5
1 IC50 = 28.5 nM
2 IC50 = 166 nM
3 IC50 = 270 nM
4 Ki < 50 nM
5 Ki = 200 nM
CP0063755
 Compound Info 
6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-quinolinone
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C16H12F3NO
  2
1 IC50 = 46 nM
2 Ki = 1.8 nM
CP0148456
 Compound Info 
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
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C23H25NO2S
  1
1 IC50 = 127 nM
CP0219859
 Compound Info 
(2S)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
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C23H25NO2S
  1
1 IC50 = 130 nM
CP0086475
 Compound Info 
2-[(4-methoxyphenyl)-diphenylmethyl]sulfanylethanamine
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C22H23NOS
  1
1 IC50 = 136 nM
CP0082019
 Compound Info 
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
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C22H21NO2S
  9
1 IC50 = 140 nM
2 IC50 = 185.9 nM
3 IC50 = 284.9 nM
4 IC50 = 620 nM
5 IC50 = 1000 nM
6 IC50 = 1900 nM
7 Ki = 26 nM
8 Ki = 50 nM
9 Ki = 71.9 nM
CP0086558
 Compound Info 
(2S)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropanoic acid
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C23H23NO3S
  1
1 IC50 = 230 nM
CP0086460
 Compound Info 
(2R)-2-amino-3-tritylsulfanylpropan-1-ol
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C22H23NOS
  1
1 IC50 = 310 nM
CP0068771
 Compound Info 
N-(4-acetyl-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
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C13H15N3O2S
  2
1 IC50 = 800 nM
2 IC50 = 1300 nM
CP0268586
 Compound Info 
3-N,3-N-diethyl-5,5-dimethyl-2-N-(thiophene-2-)-4,5,6,7-tetrahydro-1-benzothiophene-2,3-diamido
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C20H26N2O2S2
  1
1 IC50 = 3100 nM
CP0002988
 Compound Info 
Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (11)
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C14H16N2O3S
  3
1 IC50 = 14000 nM
2 IC50 = 20000 nM
3 IC50 = 30000 nM
Clinical Information about the Protein
Target 1 ( Kinesin-like protein KIF11 (KIF11) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Solid tumour/cancer [ICD-11: 2A00-2F9Z]
2 Acute myeloid leukaemia [ICD-11: 2A60]
Clinical Trial Drug(s) 5 Clinical Trial Drugs  5
1 ARRY-520
 Drug Info 
Phase 2
Solid tumour/cancer
2 AZD-4877
 Drug Info 
Phase 2
Acute myeloid leukaemia
3 Ispinesib
 Drug Info 
Phase 2
Solid tumour/cancer
4 LY2523355
 Drug Info 
Phase 2
Acute myeloid leukaemia
5 MK-0731
 Drug Info 
Phase 1
Solid tumour/cancer
Target 2 ( Kinesin spindle messenger RNA (KIF11 mRNA) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Haematological malignancy [ICD-11: 2B33.Y]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 EMD-534085
 Drug Info 
Phase 1
Haematological malignancy