General Information of the Compound
Compound ID
CP0432867
Compound Name
3-N,3-N-diethyl-2-N-(thiophene-2-)-4H,5H,7H-thieno[2,3-c]pyran-2,3-diamido
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Structure
Formula
C17H20N2O3S2
Molecular Weight
364.492
Canonical SMILES
CCN(CC)C(=O)c1c(NC(=O)c2cccs2)sc2COCCc12
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InChI
InChI=1S/C17H20N2O3S2/c1-3-19(4-2)17(21)14-11-7-8-22-10-13(11)24-16(14)18-15(20)12-6-5-9-23-12/h5-6,9H,3-4,7-8,10H2,1-2H3,(H,18,20)
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InChIKey
GPNICEMFQIXARR-UHFFFAOYSA-N
Physicochemical Property
logP
3.6166
Rotatable Bonds
5
Heavy Atom Count
24
Polar Areas
58.64
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24901576
ChEMBL ID
CHEMBL228382
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01160, Kinesin-like protein KIF11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
EC50 = 17000 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS