General Information of the Compound
Compound ID
CP0523152
Compound Name
3-amino-1-[5-(2,5-difluorophenyl)spiro[1,3,4-thiadiazole-2,4'-2,3-dihydrochromene]-3-yl]propan-1-one
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Structure
Formula
C19H17F2N3O2S
Molecular Weight
389.427
Canonical SMILES
NCCC(=O)N1N=C(SC11CCOc2ccccc12)c1cc(F)ccc1F
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InChI
InChI=1S/C19H17F2N3O2S/c20-12-5-6-15(21)13(11-12)18-23-24(17(25)7-9-22)19(27-18)8-10-26-16-4-2-1-3-14(16)19/h1-6,11H,7-10,22H2
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InChIKey
JEEPQMREUASVEU-UHFFFAOYSA-N
Physicochemical Property
logP
3.1861
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
67.92
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 42634877
SID: 81073919
ChEMBL ID
CHEMBL3402349
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01160, Kinesin-like protein KIF11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
EC50 > 500 nM
   TI
   LI
   LO
   TS