| Compound ID |
Compound Name |
Compound Formula |
|
CP0502792
|
1-(4-((S)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C24H31N5O4
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 1.9 nM
|
|
|
|
CP0470062
|
1-Ethyl-3-(4-((S)-7-(2-hydroxyethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C23H31N5O4
|
2
|
| 1 |
IC50 = 1.6 nM
|
|
|
| 2 |
IC50 = 1.7 nM
|
|
|
|
CP0470063
|
(S)-1-ethyl-3-(4-(7-(2-hydroxyethyl)-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C22H29N5O4
|
2
|
| 1 |
IC50 = 2.2 nM
|
|
|
| 2 |
IC50 = 2.6 nM
|
|
|
|
CP0473302
|
1-(4-((R)-7-(cyclopropylmethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C25H33N5O3
|
2
|
| 1 |
IC50 = 2.8 nM
|
|
|
| 2 |
IC50 = 5 nM
|
|
|
|
CP0512787
|
(S)-1-(4-(7,7-Dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)urea
Show/Hide
|
C22H29N5O4
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 4.8 nM
|
|
|
|
CP0294749
|
1-ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1,3-dimethylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea
Show/Hide
|
C22H29N7O2
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 8 nM
|
|
|
|
CP0465338
|
(S)-1-(4-(7,7-Dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-(1-methyl-1H-pyrazol-4-yl)urea
Show/Hide
|
C24H29N7O3
|
2
|
| 1 |
IC50 = 4.3 nM
|
|
|
| 2 |
IC50 = 6 nM
|
|
|
|
CP0465340
|
1-Ethyl-3-(4-((S)-7-(2-hydroxy-2-methylpropyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C25H35N5O4
|
2
|
| 1 |
IC50 = 4.4 nM
|
|
|
| 2 |
IC50 = 6.3 nM
|
|
|
|
CP0505884
|
(S)-1-(4-(7,7-Dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C22H29N5O3
|
2
|
| 1 |
IC50 = 4.6 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0373185
|
1-(4-((S)-7-(cyclopropylmethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C25H33N5O3
|
2
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0505876
|
(S)-1-ethyl-3-(4-(7-(2-hydroxy-2-methylpropyl)-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C24H33N5O4
|
2
|
| 1 |
IC50 = 7.2 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
|
CP0488381
|
(S)-1-(4-(7,7-Dimethyl-4-(3-methylmorpholino)-5-oxo-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethyl urea
Show/Hide
|
C22H27N5O4
|
2
|
| 1 |
IC50 = 7.6 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0101395
|
1-ethyl-3-[4-[1-methyl-7-[(3S)-3-methylmorpholin-4-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea
Show/Hide
|
C20H25N7O2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 47 nM
|
|
|
|
CP0215951
|
1-ethyl-3-[4-[7-[(3S)-3-ethylmorpholin-4-yl]-1-methylpyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea
Show/Hide
|
C21H27N7O2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0512777
|
1-methyl-4-(4-((R)-7-(2-cyanoethyl)-7-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C24H30N6O3
|
2
|
| 1 |
IC50 = 8.3 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0378139
|
(S)-6-(4-(7,7-Dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenylamino)pyridin-2(1H)-one
Show/Hide
|
C24H27N5O3
|
2
|
| 1 |
IC50 = 9.3 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0000815
|
Rapamycin C-7, analog 4
Show/Hide
|
C51H79NO13
|
2
|
| 1 |
IC50 < 10 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0373174
|
1-(4-((S)-7-(2-cyanoethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C24H30N6O3
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0473307
|
1-ethyl-3-(4-((R)-7-(hydroxymethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C22H29N5O4
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
|
CP0233146
|
1-ethyl-3-[4-[4-[(3S)-3-ethylmorpholin-4-yl]-5-methylpyrrolo[3,2-d]pyrimidin-2-yl]phenyl]urea
Show/Hide
|
C22H28N6O2
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0390704
|
1-Ethyl-3-(4-((S)-7-(2-methoxyethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C24H33N5O4
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 15 nM
|
|
|
|
CP0373177
|
1-(4-(7,7-Dimethyl-4-morpholino-5-oxo-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C21H25N5O4
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0378133
|
1-Ethyl-3-(4-((R)-7-(2-hydroxy-2-methylpropyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C25H35N5O4
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
|
CP0466373
|
1-Ethyl-3-(4-((R)-7-(2-hydroxyethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C23H31N5O4
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0466378
|
(R)-1-ethyl-3-(4-(7-(2-hydroxyethyl)-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C22H29N5O4
|
2
|
| 1 |
IC50 = 23 nM
|
|
|
| 2 |
IC50 = 47 nM
|
|
|
|
CP0373159
|
(S)-1-(2-Cyanoethyl)-3-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C23H28N6O3
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0466379
|
1-(4-((R)-4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-(2-hydroxyethyl)-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C24H31N5O4
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0465337
|
(S)-1-(4-(7,7-Dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-(oxetan-3-yl)urea
Show/Hide
|
C23H29N5O4
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0505052
|
(R)-1-ethyl-3-(4-(7-(hydroxymethyl)-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C21H27N5O4
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0505879
|
1-((R)-2,3-Dihydroxypropyl)-3-(4-(7,7-dimethyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C23H31N5O5
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 47 nM
|
|
|
|
CP0378134
|
(R)-1-ethyl-3-(4-(7-(2-hydroxy-2-methylpropyl)-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C24H33N5O4
|
2
|
| 1 |
IC50 = 41 nM
|
|
|
| 2 |
IC50 = 43 nM
|
|
|
|
CP0465339
|
1-Ethyl-3-(4-((R)-7-(2-methoxyethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C24H33N5O4
|
2
|
| 1 |
IC50 = 41 nM
|
|
|
| 2 |
IC50 = 69 nM
|
|
|
|
CP0378359
|
1-(4-((S)-7-(2-(Dimethylamino)ethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
Show/Hide
|
C25H36N6O3
|
2
|
| 1 |
IC50 = 42 nM
|
|
|
| 2 |
IC50 = 51 nM
|
|
|
|
CP0378351
|
1-ethyl-3-(4-((S)-7-(hydroxymethyl)-7-methyl-4-((S)-3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C22H29N5O4
|
2
|
| 1 |
IC50 = 48 nM
|
|
|
| 2 |
IC50 = 77 nM
|
|
|
|
CP0275536
|
5-(1H-indol-5-yl)-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C19H19N5O2
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 231 nM
|
|
|
|
CP0275534
|
5-[4-(1H-imidazol-2-yl)phenyl]-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C20H20N6O2
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 273 nM
|
|
|
|
CP0101392
|
1-ethyl-3-[4-[6-[(3S)-3-ethylmorpholin-4-yl]-7-methylpurin-2-yl]phenyl]urea
Show/Hide
|
C21H27N7O2
|
2
|
| 1 |
IC50 = 69 nM
|
|
|
| 2 |
IC50 = 153 nM
|
|
|
|
CP0473310
|
1-ethyl-3-[4-[5-methyl-4-[(3S)-3-methylmorpholin-4-yl]pyrrolo[3,2-d]pyrimidin-2-yl]phenyl]urea
Show/Hide
|
C21H26N6O2
|
2
|
| 1 |
IC50 = 77 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0079284
|
5-(2-amino-3H-benzimidazol-5-yl)-3-(cyclohexylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C19H21N7O
|
2
|
| 1 |
IC50 = 92 nM
|
|
|
| 2 |
IC50 = 201 nM
|
|
|
|
CP0076228
|
5-(3H-benzimidazol-5-yl)-3-(cyclohexylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C19H20N6O
|
2
|
| 1 |
IC50 = 137 nM
|
|
|
| 2 |
IC50 = 427 nM
|
|
|
|
CP0376020
|
(S)-1-ethyl-3-(4-(7-(hydroxymethyl)-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)urea
Show/Hide
|
C21H27N5O4
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 234 nM
|
|
|
|
CP0079286
|
3-(oxan-4-ylmethyl)-5-[4-(1H-1,2,4-triazol-5-yl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C19H19N7O2
|
2
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
IC50 = 273 nM
|
|
|
|
CP0222482
|
1-ethyl-3-[4-[1-methyl-7-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[4,3-d]pyrimidin-5-yl]phenyl]urea
Show/Hide
|
C20H23N7O2
|
2
|
| 1 |
IC50 = 270 nM
|
|
|
| 2 |
IC50 = 340 nM
|
|
|
|
CP0087145
|
3-(cyclohexylmethyl)-5-[4-(2-hydroxypropan-2-yl)phenyl]-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C21H26N4O2
|
2
|
| 1 |
IC50 = 322 nM
|
|
|
| 2 |
IC50 = 1350 nM
|
|
|
|
CP0101393
|
1-ethyl-3-[4-[7-methyl-6-[(3S)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]urea
Show/Hide
|
C20H25N7O2
|
2
|
| 1 |
IC50 = 630 nM
|
|
|
| 2 |
IC50 = 2200 nM
|
|
|
|
CP0205211
|
3-(cyclohexylmethyl)-5-(1H-indazol-5-yl)-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C19H20N6O
|
1
|
| 1 |
IC50 = 633 nM
|
|
|
|
CP0215952
|
1-ethyl-3-[4-[7-methyl-6-[(3R)-3-methylmorpholin-4-yl]purin-2-yl]phenyl]urea
Show/Hide
|
C20H25N7O2
|
2
|
| 1 |
IC50 = 650 nM
|
|
|
| 2 |
IC50 = 730 nM
|
|
|
|
CP0176096
|
1-ethyl-3-[4-[7-methyl-6-(1,4-oxazepan-4-yl)purin-2-yl]phenyl]urea
Show/Hide
|
C20H25N7O2
|
2
|
| 1 |
IC50 = 7200 nM
|
|
|
| 2 |
IC50 = 8900 nM
|
|
|
|
CP0152241
|
5-[2-(methylamino)-3H-benzimidazol-5-yl]-3-(oxan-4-ylmethyl)-1H-imidazo[4,5-b]pyrazin-2-one
Show/Hide
|
C19H21N7O2
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0267910
|
4-[5-(4-hydroxyphenyl)-2-oxo-1H-imidazo[4,5-b]pyrazin-3-yl]cyclohexane-1-carboxamide
Show/Hide
|
C18H19N5O3
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0305075
|
4-[5-(4-hydroxyphenyl)-2-oxo-1H-imidazo[4,5-b]pyrazin-3-yl]cyclohexane-1-carboxamide
Show/Hide
|
C18H19N5O3
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
