Brief Information of the Cell Line and Protein
Cell Line ID: CL000043 , U2OS
Synonyms
U-2 OS
U-2OS
U-2-OS
U2-OS
U20-S
U20S
2T
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0042
Protein ID: PT02429 , Neurotensin receptor type 1
Gene Name NTSR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P30989
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000043  Protein ID: PT02429
 
Compound ID Compound Name Compound Formula
CP0076458
(2S)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)-4-methylpentanoic acid
   Show/Hide
C27H27ClN4O5
 1
1
EC50 = 750 nM
   TI
   LI
   LO
   TS
CP0385363
(2R)-2-[[1-(7-chloroquinolin-4-yl)-5-(2-methoxyphenyl)pyrazole-3-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C26H25ClN4O4
 1
1
EC50 = 970 nM
   TI
   LI
   LO
   TS
CP0073850
2-cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C24H28N4O3
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0244251
(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C27H27ClN4O5
 1
1
EC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0391446
(2S)-2-[[2-(2,6-dimethoxyphenyl)-1-naphthalen-1-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C28H29N3O5
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0403584
(2S)-2-[[2-(2,6-dimethoxyphenyl)-1-quinolin-4-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C27H28N4O5
 1
1
EC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0414336
2-cyclopropyl-6-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C23H26N4O2
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0431889
(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dichlorophenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C25H21Cl3N4O3
 1
1
EC50 = 5200 nM
   TI
   LI
   LO
   TS
CP0426797
2-cyclopentyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C26H32N4O3
 1
1
EC50 = 5800 nM
   TI
   LI
   LO
   TS
CP0299409
2-cyclobutyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]quinazoline
   Show/Hide
C25H30N4O3
 1
1
EC50 = 5900 nM
   TI
   LI
   LO
   TS
CP0389970
2-cyclopropyl-4-[4-(2-ethoxyphenyl)piperazin-1-yl]-6,7-dimethoxyquinazoline
   Show/Hide
C25H30N4O3
 1
1
EC50 = 6100 nM
   TI
   LI
   LO
   TS
CP0397189
2-ethenyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C23H26N4O3
 1
1
EC50 = 7000 nM
   TI
   LI
   LO
   TS
CP0404473
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-propan-2-ylquinazoline
   Show/Hide
C24H30N4O3
 1
1
EC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0442333
(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethylphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C27H27ClN4O3
 1
1
EC50 = 9200 nM
   TI
   LI
   LO
   TS
CP0403582
(2R)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C27H27ClN4O5
 1
1
EC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0389971
2-cyclobutyl-6-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C24H28N4O2
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0718178
2-[(5-(2,6-Dimethoxy-phenyl)-1-{4-[(3-dimethylamino-propyl)-methyl-carbamoyl]-2-isopropyl-phenyl}-1H-pyrazole-3-carbonyl)-amino]-adamantane-2-carboxylic acid hydrochloride
   Show/Hide
C39H52ClN5O6
 3
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 80000 nM
   TI
   LI
   LO
   TS
3
IC50 = 50.1 nM
   TI
   LI
   LO
   TS
CP0404494
4-[4-(2-chlorophenyl)piperazin-1-yl]-2-cyclobutyl-6,7-dimethoxyquinazoline
   Show/Hide
C24H27ClN4O2
 1
1
EC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0449764
2-cyclobutyl-6,7-dimethoxy-4-(4-phenylpiperazin-1-yl)quinazoline
   Show/Hide
C24H28N4O2
 1
1
EC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0404474
2-benzyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C28H30N4O3
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0414330
2-(cyclopropylmethyl)-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C25H30N4O3
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0389972
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-(2-methylpropyl)quinazoline
   Show/Hide
C25H32N4O3
 1
1
EC50 = 15000 nM
   TI
   LI
   LO
   TS
CP0446958
2-cyclobutyl-6,7-dimethoxy-4-[4-(2-methylphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C25H30N4O2
 1
1
EC50 = 15000 nM
   TI
   LI
   LO
   TS
CP0410521
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-propylquinazoline
   Show/Hide
C24H30N4O3
 1
1
EC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0482873
6-ethoxy-7-methoxy-4-[4-(3-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
   Show/Hide
C28H30N4O3
 1
1
EC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0385643
2-cyclobutyl-4-[4-(2-fluorophenyl)piperazin-1-yl]-6,7-dimethoxyquinazoline
   Show/Hide
C24H27FN4O2
 1
1
EC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0389968
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
   Show/Hide
C27H28N4O3
 1
1
EC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0404486
4-[4-(2-chlorophenyl)piperazin-1-yl]-2-cyclopropyl-6,7-dimethoxyquinazoline
   Show/Hide
C23H25ClN4O2
 1
1
EC50 = 20000 nM
   TI
   LI
   LO
   TS
CP0389973
4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]-6-ethoxy-7-methoxy-2-phenylquinazoline
   Show/Hide
C29H32N4O4
 1
1
EC50 = 23000 nM
   TI
   LI
   LO
   TS
CP0462288
2-cyclobutyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C23H26N4O
 1
1
EC50 = 23000 nM
   TI
   LI
   LO
   TS
CP0389969
2-cyclopropyl-6,7-dimethoxy-4-[4-[(4-methylphenyl)methyl]piperazin-1-yl]quinazoline
   Show/Hide
C25H30N4O2
 1
1
EC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0397190
2-cyclobutyl-6,7-dimethoxy-4-(4-pyridin-2-ylpiperazin-1-yl)quinazoline
   Show/Hide
C23H27N5O2
 1
1
EC50 = 26000 nM
   TI
   LI
   LO
   TS
CP0404493
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]quinazoline
   Show/Hide
C34H42N6O4
 1
1
EC50 = 26000 nM
   TI
   LI
   LO
   TS
CP0404492
2-cyclobutyl-7-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C24H28N4O2
 1
1
EC50 = 30000 nM
   TI
   LI
   LO
   TS
CP0137804
2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid
   Show/Hide
C32H31ClN4O5
 1
1
EC50 = 31000 nM
   TI
   LI
   LO
   TS
CP0404490
6-cyclobutyl-8-[4-(2-methoxyphenyl)piperazin-1-yl]-[1,3]dioxolo[4,5-g]quinazoline
   Show/Hide
C24H26N4O3
 1
1
EC50 = 34000 nM
   TI
   LI
   LO
   TS
CP0484628
2-cyclopropyl-6,7-dimethoxy-4-[4-[(2-methoxyphenyl)methyl]piperazin-1-yl]quinazoline
   Show/Hide
C25H30N4O3
 1
1
EC50 = 35000 nM
   TI
   LI
   LO
   TS
CP0414333
2-ethyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C23H28N4O3
 1
1
EC50 = 43000 nM
   TI
   LI
   LO
   TS
CP0404491
[4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]-phenylmethanone
   Show/Hide
C24H26N4O3
 1
1
EC50 = 45000 nM
   TI
   LI
   LO
   TS
CP0389974
6-ethoxy-7-methoxy-4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
   Show/Hide
C28H30N4O3
 1
1
EC50 = 46000 nM
   TI
   LI
   LO
   TS
CP0403583
2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]adamantane-2-carboxylic acid
   Show/Hide
C32H31ClN4O5
 1
1
EC50 = 46000 nM
   TI
   LI
   LO
   TS
CP0467725
(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2-methoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C26H25ClN4O4
 1
1
EC50 = 56000 nM
   TI
   LI
   LO
   TS
CP0482871
4-[4-(2,6-dimethylphenyl)piperazin-1-yl]-6-ethoxy-7-methoxy-2-phenylquinazoline
   Show/Hide
C29H32N4O2
 1
1
EC50 = 61000 nM
   TI
   LI
   LO
   TS
CP0391447
(2S)-2-[[2-(2,6-dimethoxyphenyl)-1-pyridin-4-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C23H26N4O5
 1
1
EC50 = 66000 nM
   TI
   LI
   LO
   TS
CP0426767
[4-(2-cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]-(2-methoxyphenyl)methanone
   Show/Hide
C25H28N4O4
 1
1
EC50 = 68000 nM
   TI
   LI
   LO
   TS
CP0432870
(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-phenylimidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C25H23ClN4O3
 1
1
EC50 = 72000 nM
   TI
   LI
   LO
   TS
CP0397442
6-ethoxy-7-methoxy-4-[4-(2-nitrophenyl)piperazin-1-yl]-2-phenylquinazoline
   Show/Hide
C27H27N5O4
 1
1
EC50 = 75000 nM
   TI
   LI
   LO
   TS
CP0379932
2-[6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazolin-2-yl]-N,N-dimethylethanamine
   Show/Hide
C25H33N5O3
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0379934
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methylquinazoline
   Show/Hide
C22H26N4O3
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0379936
6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline
   Show/Hide
C21H24N4O3
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0385644
4-[4-(4-fluorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline
   Show/Hide
C26H25FN4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0385645
4-[4-(2-fluorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline
   Show/Hide
C26H25FN4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0389975
6-ethoxy-7-methoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
   Show/Hide
C27H28N4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0397191
2-cyclopropyl-6,7-dimethoxy-4-piperazin-1-ylquinazoline
   Show/Hide
C17H22N4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0414335
4-[4-(benzenesulfonyl)piperazin-1-yl]-2-cyclopropyl-6,7-dimethoxyquinazoline
   Show/Hide
C23H26N4O4S
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0447083
4-[4-(2-chlorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline
   Show/Hide
C26H25ClN4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0456791
6-ethoxy-7-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline
   Show/Hide
C28H30N4O3
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0456792
6,7-dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
   Show/Hide
C26H26N4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0539005
6-ethoxy-4-[4-(2-fluorophenyl)piperazin-1-yl]-7-methoxy-2-phenylquinazoline
   Show/Hide
C27H27FN4O2
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0387784
(2S)-2-[[2-(2-methoxyphenyl)-1-quinolin-4-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C26H26N4O4
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0432871
(2S)-4-methyl-2-[(2-phenyl-1-pyridin-4-ylimidazole-4-carbonyl)amino]pentanoic acid
   Show/Hide
C21H22N4O3
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0458854
(2S)-2-[[2-(2-methoxyphenyl)-1-pyridin-4-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C22H24N4O4
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0479765
(2S)-2-[[2-(2,6-dimethoxyphenyl)-1-(4-methylphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C25H29N3O5
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0482514
(2S)-4-methyl-2-[(2-phenyl-1-quinolin-4-ylimidazole-4-carbonyl)amino]pentanoic acid
   Show/Hide
C25H24N4O3
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0523406
(2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,4-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid
   Show/Hide
C27H27ClN4O5
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS