Brief Information of the Cell Line and Protein
Cell Line ID: CL000041 , LTK-
Category Transformed cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_3392
Protein ID: PT00854 , Metabotropic glutamate receptor 5
Gene Name GRM5
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P41594
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000041  Protein ID: PT00854
 
Compound ID Compound Name Compound Formula
CP0180064
3-Chloro-5-(3-pyridin-2-ylethynyl-cyclohex-2-enyloxy)-pyridine
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C18H15ClN2O
 1
1
IC50 = 0.9 nM
   TI
   LI
   LO
   TS
CP0191235
2-Methyl-6-(phenylethynyl)pyridine
   Show/Hide
C14H11N
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0245158
2-{[3-(pyridin-3-yloxy)cyclohex-1-en-1-yl]ethynyl}pyridine
   Show/Hide
C18H16N2O
 1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0308281
2-[1-(4-Bromo-benzenesulfonyl)-1,2,3,6-tetrahydro-pyridin-4-ylethynyl]-pyridine
   Show/Hide
C18H15BrN2O2S
 1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
CP0344714
2-Cyclohex-1-enylethynyl-pyridine
   Show/Hide
C13H13N
 1
1
IC50 = 2.4 nM
   TI
   LI
   LO
   TS
CP0180066
4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
   Show/Hide
C17H20N2O2
 1
1
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0334583
2-Cyclopent-1-enylethynyl-pyridine
   Show/Hide
C12H11N
 1
1
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0098719
2-methyl-4-(pyridin-3-ylethynyl)thiazole
   Show/Hide
C11H8N2S
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0446569
3-Amino-6-chloro-pyrazine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C11H10ClN5O
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0375397
2-Methyl-4-phenylethynyl-thiazole
   Show/Hide
C12H9NS
 1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0394845
3-Hydroxy-6-methyl-pyridine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C13H13N3O2
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0324324
2-[1-(Toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-4-ylethynyl]-pyridine
   Show/Hide
C19H18N2O2S
 1
1
IC50 = 7.9 nM
   TI
   LI
   LO
   TS
CP0505098
3-Amino-6-methyl-pyrazine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C12H13N5O
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0324322
2-[1-(Toluene-3-sulfonyl)-1,2,3,6-tetrahydro-pyridin-4-ylethynyl]-pyridine
   Show/Hide
C19H18N2O2S
 1
1
IC50 = 8.2 nM
   TI
   LI
   LO
   TS
CP0210657
N-[3-(2-pyridin-2-ylethynyl)cyclohex-2-en-1-yl]pyridin-3-amine
   Show/Hide
C18H17N3
 1
1
IC50 = 8.6 nM
   TI
   LI
   LO
   TS
CP0495077
6-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C18H17N5O
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0523126
3-Amino-6-chloro-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C10H8ClN5O
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0245160
4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
   Show/Hide
C20H18N2O2
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0446386
(5-Ethoxy-[3,3']bipyridinyl-6-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C18H18N4O
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0441909
3-Amino-6-bromo-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C10H8BrN5O
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0297150
N-[4-(2-pyridin-2-ylethynyl)cyclohex-3-en-1-yl]pyridin-3-amine
   Show/Hide
C18H17N3
 1
1
IC50 = 12.6 nM
   TI
   LI
   LO
   TS
CP0534820
4-Methyl-2-phenylethynyl-thiazole
   Show/Hide
C12H9NS
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0275061
2-{[3-(pyridin-4-yloxy)cyclohex-1-en-1-yl]ethynyl}pyridine
   Show/Hide
C18H16N2O
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0461598
(5-Chloro-3-ethoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C13H14ClN3O
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0541551
3-ethoxy-N-(6-methylpyridin-2-yl)-5-pyridin-3-yloxypyridin-2-amine
   Show/Hide
C18H18N4O2
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0394846
6-Bromo-pyridine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C12H10BrN3O
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0215813
2-{[3-(pyridin-4-ylthio)cyclohex-1-en-1-yl]ethynyl}pyridine
   Show/Hide
C18H16N2S
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0394198
3-Amino-6-methyl-pyridine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C13H14N4O
 1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CP0464655
3-Amino-6-chloro-5-isopropylamino-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C13H15ClN6O
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0319652
2-[3-(2-pyridin-2-ylethynyl)cyclohex-2-en-1-yl]isoindole-1,3-dione
   Show/Hide
C21H16N2O2
 1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
CP0433538
3-Amino-6-methyl-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C11H11N5O
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0501657
6-Methyl-pyridine-2-carboxylic acid (6-methyl-pyridin-2-yl)-amide
   Show/Hide
C13H13N3O
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0044825
4-Pyridin-2-ylethynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid phenyl ester
   Show/Hide
C19H16N2O2
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0505660
(3-Ethoxy-5-pyrimidin-5-yl-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C17H17N5O
 1
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
CP0496575
2-[5-Ethoxy-6-(6-methyl-pyridin-2-ylamino)-pyridin-3-yl]-benzonitrile
   Show/Hide
C20H18N4O
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0523196
(3-Ethoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C13H15N3O
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0515859
(5-Ethoxy-4'-methyl-[3,3']bipyridinyl-6-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C19H20N4O
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0559322
5-Ethoxy-6-(6-methyl-pyridin-2-ylamino)-nicotinonitrile
   Show/Hide
C14H14N4O
 1
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
CP0510857
(5-Bromo-3-ethoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C13H14BrN3O
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0551301
2-(2-Methyl-thiazol-4-ylethynyl)-pyridine
   Show/Hide
C11H8N2S
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0184518
2-(1-Phenylmethanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-ylethynyl)-pyridine
   Show/Hide
C19H18N2O2S
 1
1
IC50 = 58 nM
   TI
   LI
   LO
   TS
CP0378233
5'-Ethoxy-6'-(6-methyl-pyridin-2-ylamino)-[3,3']bipyridinyl-2-carbonitrile
   Show/Hide
C19H17N5O
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0402486
2-Phenylethynyl-thiazole
   Show/Hide
C11H7NS
 1
1
IC50 = 81 nM
   TI
   LI
   LO
   TS
CP0460297
4-Phenylethynyl-thiazole
   Show/Hide
C11H7NS
 1
1
IC50 = 97 nM
   TI
   LI
   LO
   TS
CP0430196
3-Amino-6-chloro-5-piperidin-1-yl-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C15H17ClN6O
 1
1
IC50 = 103 nM
   TI
   LI
   LO
   TS
CP0390955
2-Hydroxy-5-methyl-N-(6-methyl-pyridin-2-yl)-benzamide
   Show/Hide
C14H14N2O2
 1
1
IC50 = 105 nM
   TI
   LI
   LO
   TS
CP0184513
2-Cyclohexylethynyl-pyridine
   Show/Hide
C13H15N
 1
1
IC50 = 106 nM
   TI
   LI
   LO
   TS
CP0562106
(3-Ethoxy-5-methyl-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C14H17N3O
 1
1
IC50 = 119 nM
   TI
   LI
   LO
   TS
CP0508853
4-(2-Methyl-thiazol-4-ylethynyl)-pyridine
   Show/Hide
C11H8N2S
 1
1
IC50 = 122 nM
   TI
   LI
   LO
   TS
CP0496576
3-ethoxy-5-(3-fluorophenyl)-N-(6-methylpyridin-2-yl)pyridin-2-amine
   Show/Hide
C19H18FN3O
 1
1
IC50 = 126 nM
   TI
   LI
   LO
   TS
CP0464669
3-Amino-6-chloro-5-dimethylamino-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C12H13ClN6O
 1
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
CP0390525
(3-Ethoxy-pyridin-2-yl)-pyridin-2-yl-amine
   Show/Hide
C12H13N3O
 1
1
IC50 = 138 nM
   TI
   LI
   LO
   TS
CP0485590
6-Chloro-3-methylamino-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C11H10ClN5O
 1
1
IC50 = 145 nM
   TI
   LI
   LO
   TS
CP0522484
6-Chloro-5-dimethylamino-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C12H12ClN5O
 1
1
IC50 = 158 nM
   TI
   LI
   LO
   TS
CP0512343
4-[3-(2-pyridin-2-ylethynyl)cyclohex-2-en-1-yl]morpholine
   Show/Hide
C17H20N2O
 1
1
IC50 = 164 nM
   TI
   LI
   LO
   TS
CP0464656
6-Methyl-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C11H10N4O
 1
1
IC50 = 165 nM
   TI
   LI
   LO
   TS
CP0403381
(5'-Ethoxy-[2,3']bipyridinyl-6'-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C18H18N4O
 1
1
IC50 = 193 nM
   TI
   LI
   LO
   TS
CP0078222
2-[3-(Naphthalen-2-ylsulfanyl)-cyclohex-1-enylethynyl]-pyridine
   Show/Hide
C23H19NS
 1
1
IC50 = 213 nM
   TI
   LI
   LO
   TS
CP0495182
(3-Ethoxy-5-isothiazol-3-yl-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C16H16N4OS
 1
1
IC50 = 243 nM
   TI
   LI
   LO
   TS
CP0497988
6-Chloro-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C10H7ClN4O
 1
1
IC50 = 254 nM
   TI
   LI
   LO
   TS
CP0562107
(3-Ethoxy-5-phenyl-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C19H19N3O
 1
1
IC50 = 267 nM
   TI
   LI
   LO
   TS
CP0059390
N-[4-(2-pyridin-2-ylethynyl)cyclohex-3-en-1-yl]naphthalen-2-amine
   Show/Hide
C23H20N2
 1
1
IC50 = 306 nM
   TI
   LI
   LO
   TS
CP0559321
(6-Methyl-pyridin-2-yl)-(3-propyl-pyridin-2-yl)-amine
   Show/Hide
C14H17N3
 1
1
IC50 = 394 nM
   TI
   LI
   LO
   TS
CP0496733
(3-Methoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C12H13N3O
 1
1
IC50 = 458 nM
   TI
   LI
   LO
   TS
CP0515599
(3-Ethoxy-pyrazin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C12H14N4O
 1
1
IC50 = 497 nM
   TI
   LI
   LO
   TS
CP0496013
(3-Ethoxy-5-p-tolyl-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C20H21N3O
 1
1
IC50 = 513 nM
   TI
   LI
   LO
   TS
CP0542916
(3-Ethoxy-pyridin-2-yl)-(6-methoxy-pyridin-2-yl)-amine
   Show/Hide
C13H15N3O2
 1
1
IC50 = 556 nM
   TI
   LI
   LO
   TS
CP0264787
2-(1,2,3,6-Tetrahydro-pyridin-4-ylethynyl)-pyridine
   Show/Hide
C12H12N2
 1
1
IC50 = 580 nM
   TI
   LI
   LO
   TS
CP0515598
(6-Methyl-pyridin-2-yl)-(3-methylsulfanyl-pyridin-2-yl)-amine
   Show/Hide
C12H13N3S
 1
1
IC50 = 790 nM
   TI
   LI
   LO
   TS
CP0485789
(3-Benzyloxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C18H17N3O
 1
1
IC50 = 870 nM
   TI
   LI
   LO
   TS
CP0275062
N-cyclopentyl-4-(2-pyridin-2-ylethynyl)cyclohex-3-en-1-amine
   Show/Hide
C18H22N2
 1
1
IC50 = 987 nM
   TI
   LI
   LO
   TS
CP0515597
(3-Isopropoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C14H17N3O
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0461597
(6-Methyl-pyridin-2-yl)-(3-propoxy-pyridin-2-yl)-amine
   Show/Hide
C14H17N3O
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0562427
(3-Ethoxy-pyridin-2-yl)-(6-trifluoromethyl-pyridin-2-yl)-amine
   Show/Hide
C13H12F3N3O
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0496808
(3-Ethoxy-4-methyl-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
   Show/Hide
C14H17N3O
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0498509
3-N-ethyl-2-N-(6-methylpyridin-2-yl)pyridine-2,3-diamine
   Show/Hide
C13H16N4
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0446568
3-Amino-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C10H9N5O
 1
1
IC50 = 3536 nM
   TI
   LI
   LO
   TS
CP0430197
3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C10H9ClN6O
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0383355
3-Amino-5-dimethylamino-pyrazine-2-carboxylic acid pyridin-2-ylamide
   Show/Hide
C12H14N6O
 1
1
IC50 = 5084 nM
   TI
   LI
   LO
   TS
CP0562428
6-(3-Ethoxy-pyridin-2-ylamino)-pyridine-2-carboxylic acid methyl ester
   Show/Hide
C14H15N3O3
 1
1
IC50 = 6200 nM
   TI
   LI
   LO
   TS