Brief Information of the Cell Line and Protein
Cell Line ID: CL000031 , MDCK
 Cell Line Info 
Synonyms
MDCK (NBL-2)
MDCK(NBL-2)
NBL-2
Madin-Darby Canine Kidney
Madin Darby Canine Kidney
Category Spontaneously immortalized cell line
Organism
Canis lupus familiaris (Dog)
Cellosaurus ID
CVCL_0422
Protein ID: PT01982 , Endothelin-converting enzyme 1
 Protein Info 
Gene Name ECE1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P42892
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000031
 Cell Line Info 
 Protein ID: PT01982
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0057474
 Compound Info 
(2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-1-carboxylic acid 2-methoxycarbonyl-phenyl ester
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C13H13NO3
  1
1
IC50 = 67 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0051845
 Compound Info 
(3R,5S)-5-{[(2,5-difluorobenzyl)amino]methyl}-1-(5-propylpyrimidin-2-yl)pyrrolidine-3-thiol
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C19H24F2N4S
  1
1
IC50 = 72.9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0102761
 Compound Info 
(2S,4R)-4-Acetylsulfanyl-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-1-carboxylic acid 2,3-dihydro-benzo[1,4]dioxin-5-yl ester
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C23H22F3NO6S
  1
1
IC50 = 76.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0102762
 Compound Info 
(2S,4R)-4-Benzoylsulfanyl-2-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-1-carboxylic acid 2,3-dihydro-benzo[1,4]dioxin-5-yl ester
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C28H24F3NO6S
  1
1
IC50 = 480.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0102763
 Compound Info 
propan-2-yl (4R)-2-[[(2,5-difluorophenyl)methylamino]methyl]-4-sulfanylpyrrolidine-1-carboxylate
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C16H22F2N2O2S
  1
1
IC50 = 1090 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0146486
 Compound Info 
(4R)-N'-methyl-N'-[(4-methylbenzene)sulfonyl]-1-(naphthalene-2-sulfonyl)-4-sulfanylpyrrolidine-2-carbohydrazide
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C23H25N3O5S3
  1
1
IC50 = 2530 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0057472
 Compound Info 
methyl 2-[[2-[methyl-[(4R)-1-naphthalen-2-ylsulfonyl-4-sulfanylpyrrolidine-2-carbonyl]amino]acetyl]amino]benzoate
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C26H27N3O6S2
  1
1
IC50 = 10890 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS