Brief Information of the Compound and Protein
Compound Name
(3R,5S)-5-{[(2,5-difluorobenzyl)amino]methyl}-1-(5-propylpyrimidin-2-yl)pyrrolidine-3-thiol
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PubChem ID
CID: 44401169
Canonical SMILES
CCCc1cnc(nc1)N1C[C@H](S)CC1CNCc1cc(F)ccc1F
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Compound Formula C19H24F2N4S
Compound Structure
Protein Name
Endothelin-converting enzyme 1
Protein Classification
Enzyme
>
Protease
>
Metallo protease
>
Metallo protease MAE clan
>
Metallo protease M13 family
Uniprot ID
P42892
Gene Name
ECE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000031 MDCK Canis lupus familiaris (Dog)  1
1
IC50 = 72.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10.4 nM