| Compound ID |
Compound Name |
Compound Formula |
|
CP0422093
|
(2S)-1-[2-(1,5-dimethylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H27N5O2S
|
1
|
| 1 |
Activity = 11 nM
|
|
|
|
CP0059177
|
(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C27H26N4O2S
|
1
|
| 1 |
Activity = 17 nM
|
|
|
|
CP0391199
|
(2S)-1-[2-[(6-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C25H25N5O2S
|
1
|
| 1 |
Activity = 20 nM
|
|
|
|
CP0436316
|
(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C25H25N5O2S
|
1
|
| 1 |
Activity = 22 nM
|
|
|
|
CP0515983
|
(2S)-1-[2-(1,6-dimethylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H27N5O2S
|
1
|
| 1 |
Activity = 28 nM
|
|
|
|
CP0382195
|
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-[2-(2-fluorophenyl)phenyl]pyrrolidine-2-carboxamide
Show/Hide
|
C27H25FN4O2
|
1
|
| 1 |
Activity = 68 nM
|
|
|
|
CP0382196
|
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H24N4O2S
|
1
|
| 1 |
Activity = 68 nM
|
|
|
|
CP0394570
|
(2S)-1-[3-(1-methylbenzimidazol-2-yl)propanoyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C28H28N4O2
|
1
|
| 1 |
Activity = 98 nM
|
|
|
|
CP0394568
|
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-[2-(2-methoxyphenyl)phenyl]pyrrolidine-2-carboxamide
Show/Hide
|
C28H28N4O3
|
1
|
| 1 |
Activity = 210 nM
|
|
|
|
CP0382190
|
(2S)-1-[3-(1H-benzimidazol-2-yl)propanoyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C27H26N4O2
|
1
|
| 1 |
Activity = 240 nM
|
|
|
|
CP0433114
|
(S)-1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)-N-(2-(1H-pyrrol-1-yl)phenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C24H23N5O2S
|
1
|
| 1 |
Activity = 240 nM
|
|
|
|
CP0382194
|
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(2-phenoxyphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H24N4O3S
|
1
|
| 1 |
Activity = 450 nM
|
|
|
|
CP0405058
|
(2S)-1-[3-(1-methylbenzimidazol-2-yl)propanoyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H27N5O2
|
1
|
| 1 |
Activity = 480 nM
|
|
|
|
CP0433116
|
(2S)-1-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C24H22N4O2S2
|
1
|
| 1 |
Activity = 545 nM
|
|
|
|
CP0433115
|
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(4-phenylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H24N4O2S
|
1
|
| 1 |
Activity = 1700 nM
|
|
|
|
CP0382191
|
(2S)-1-[2-(1,3-benzoxazol-2-ylsulfanyl)acetyl]-N-(2-pyrrol-1-ylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C24H22N4O3S
|
1
|
| 1 |
Activity = 1750 nM
|
|
|
|
CP0462533
|
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-phenylpyrrolidine-2-carboxamide
Show/Hide
|
C20H20N4O2S
|
1
|
| 1 |
Activity = 20000 nM
|
|
|
|
CP0501979
|
(2S)-1-[2-(1H-benzimidazol-2-ylsulfanyl)acetyl]-N-(3-phenylphenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C26H24N4O2S
|
1
|
| 1 |
Activity = 20000 nM
|
|
|
|
CP0969650
|
Orexin A
Show/Hide
|
C152H246N46O45S4
|
1
|
| 1 |
EC50 = 0.068 nM
|
|
|
|
CP0380127
|
N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide
Show/Hide
|
C32H34N4O5S
|
1
|
| 1 |
EC50 = 1616 nM
|
|
|
|
CP0385734
|
2-(dimethylamino)-N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]benzamide
Show/Hide
|
C33H37N5O5S
|
1
|
| 1 |
EC50 = 2750 nM
|
|
|
|
CP0380343
|
N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-2-methoxybenzamide
Show/Hide
|
C32H34N4O6S
|
1
|
| 1 |
EC50 = 5227 nM
|
|
|
|
CP0380341
|
3-[3-[[3-[2-[(3-chlorobenzoyl)amino]ethylamino]phenyl]sulfamoyl]-4-methoxyphenyl]-N,N-dimethylbenzamide
Show/Hide
|
C31H31ClN4O5S
|
1
|
| 1 |
EC50 = 5720 nM
|
|
|
|
CP0385733
|
2-chloro-N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]benzamide
Show/Hide
|
C31H31ClN4O5S
|
1
|
| 1 |
EC50 = 6134 nM
|
|
|
|
CP0385732
|
3-[4-methoxy-3-[[3-[2-[(3-methoxybenzoyl)amino]ethylamino]phenyl]sulfamoyl]phenyl]-N,N-dimethylbenzamide
Show/Hide
|
C32H34N4O6S
|
1
|
| 1 |
EC50 = 9248 nM
|
|
|
|
CP0544123
|
(2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxamide
Show/Hide
|
C22H35N3O4S
|
1
|
| 1 |
EC50 > 14000 nM
|
|
|
|
CP0528724
|
N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)ethanesulfonamide
Show/Hide
|
C19H36N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0528725
|
N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)-1- propionylpiperidin-3- yl)methanesulfonamide
Show/Hide
|
C22H34N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0528726
|
US10287305, Example 303
Show/Hide
|
C22H34N2O5S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0528727
|
N-((2R,3S)-1-acetyl-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
Show/Hide
|
C21H32N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0528728
|
N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
Show/Hide
|
C19H30N2O3S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0528729
|
N-[1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]ethanesulfonamide
Show/Hide
|
C19H36N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0542690
|
N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)propane-2-sulfonamide
Show/Hide
|
C20H38N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0542691
|
N-[(2R,3S)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]-N-methylmethanesulfonamide
Show/Hide
|
C19H36N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0544498
|
US10287305, Example 5
Show/Hide
|
C21H32N2O5S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0568990
|
N-[(2R,3S)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]ethanesulfonamide
Show/Hide
|
C19H36N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0573347
|
N-(cis-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)propane-1-sulfonamide
Show/Hide
|
C20H38N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0573592
|
N-[(2R,3R)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]ethanesulfonamide
Show/Hide
|
C19H36N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0577855
|
N-((2R,3S)-1-acetyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
Show/Hide
|
C18H34N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0578033
|
CHEMBL5073349
Show/Hide
|
C19H36N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0578323
|
[(2R,3S)-1-acetyl-2-[(4-propan-2-ylcyclohexyl)oxymethyl]piperidin-3-yl]carbamic acid
Show/Hide
|
C18H32N2O4
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0579679
|
N-(cis-1-acetyl-2-(((cis-4- methylcyclohexyl)oxy)methyl)- piperidin-3-yl)methanesulfonamide
Show/Hide
|
C16H30N2O4S
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0567781
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 1.05 nM
|
|
|
|
CP0240486
|
[(2S)-2-[[4-(4-fluorophenyl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C24H23FN6O2
|
1
|
| 1 |
IC50 = 2.21 nM
|
|
|
|
CP0329822
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]piperidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C24H24FN7O
|
1
|
| 1 |
IC50 = 2.27 nM
|
|
|
|
CP0479636
|
[(2S)-2-[[4-(5-fluoropyridin-2-yl)triazol-2-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H21FN8O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0403779
|
N-ethyl-N-[2-[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]ethyl]-5-methyl-2-(triazol-2-yl)benzamide
Show/Hide
|
C22H22FN7O
|
1
|
| 1 |
IC50 = 3.22 nM
|
|
|
|
CP0479637
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone
Show/Hide
|
C24H20F2N6O2
|
1
|
| 1 |
IC50 = 3.22 nM
|
|
|
|
CP0322682
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-(5-methyl-2-pyrimidin-2-ylphenyl)methanone
Show/Hide
|
C25H23FN6O2
|
1
|
| 1 |
IC50 = 3.29 nM
|
|
|
|
CP0322680
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0225046
|
[(4S)-4-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 3.36 nM
|
|
|
|
CP0240487
|
[(3R)-3-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]morpholin-4-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0437404
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7O2
|
1
|
| 1 |
IC50 = 3.76 nM
|
|
|
|
CP0240488
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-fluoro-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H19F2N7O2
|
1
|
| 1 |
IC50 = 3.95 nM
|
|
|
|
CP0520900
|
[(2S)-2-[[1-(5-fluoropyridin-2-yl)pyrazol-4-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 3.98 nM
|
|
|
|
CP0162718
|
[(2S)-2-[[5-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-3-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7O3
|
1
|
| 1 |
IC50 = 4.54 nM
|
|
|
|
CP0520899
|
[(4R)-4-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-thiazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7OS
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0520897
|
[(2S)-2-[[4-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 5.39 nM
|
|
|
|
CP0560368
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7O2
|
1
|
| 1 |
IC50 = 8.08 nM
|
|
|
|
CP0338972
|
[(2S)-2-[[4-(5-fluoropyridin-2-yl)triazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H21FN8O2
|
1
|
| 1 |
IC50 = 12.1 nM
|
|
|
|
CP0133670
|
N-ethyl-N-[2-[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]ethyl]-2-(triazol-2-yl)benzamide
Show/Hide
|
C21H20FN7O
|
1
|
| 1 |
IC50 = 20.6 nM
|
|
|
|
CP0520898
|
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]piperidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C24H24FN7O
|
1
|
| 1 |
IC50 = 20.8 nM
|
|
|
|
CP0417073
|
methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]sulfanylpyridine-3-carboxylate
Show/Hide
|
C22H23N5O3S
|
2
|
| 1 |
IC50 = 48 nM
|
|
|
| 2 |
Ki = 6.3 nM
|
|
|
|
CP0162716
|
[(2S)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-thiazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7OS
|
1
|
| 1 |
IC50 = 61.1 nM
|
|
|
|
CP0441196
|
methyl 2-[[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]amino]pyridine-3-carboxylate
Show/Hide
|
C22H24N6O3
|
2
|
| 1 |
IC50 = 69 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0397830
|
N-[4-[(2R,5R)-5-(4-cyano-3-methylpyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]-5-phenylpyridin-2-yl]acetamide
Show/Hide
|
C27H27N5O3
|
2
|
| 1 |
IC50 = 71 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0391755
|
N-[6-[(2R,5R)-5-(4-cyano-3-methylpyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]-5-phenylpyridin-2-yl]acetamide
Show/Hide
|
C27H27N5O3
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0477767
|
4-(5-fluoropyridin-2-yl)-2-[[(2S)-3-[5-methyl-2-(triazol-2-yl)benzoyl]-1,3-oxazinan-2-yl]methyl]-1,2,4-triazol-3-one
Show/Hide
|
C22H21FN8O3
|
1
|
| 1 |
IC50 = 85.5 nM
|
|
|
|
CP0398066
|
[(2R,5R)-2-methyl-5-(4-methylsulfanylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H23N5O2S
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
Ki = 39 nM
|
|
|
|
CP0441643
|
[(2R,5R)-2-methyl-5-(5-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H23N5O2
|
2
|
| 1 |
IC50 = 142 nM
|
|
|
| 2 |
Ki = 37 nM
|
|
|
|
CP0322681
|
[(4R)-4-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7O2
|
1
|
| 1 |
IC50 = 149 nM
|
|
|
|
CP0415396
|
[(2R,5R)-5-(4-ethynylpyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H21N5O2
|
2
|
| 1 |
IC50 = 240 nM
|
|
|
| 2 |
Ki = 49 nM
|
|
|
|
CP0454454
|
methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-3-carboxylate
Show/Hide
|
C22H23N5O4
|
2
|
| 1 |
IC50 = 309 nM
|
|
|
| 2 |
Ki = 66 nM
|
|
|
|
CP0486988
|
[(2R,5R)-5-(4-ethylpyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H25N5O2
|
2
|
| 1 |
IC50 = 310 nM
|
|
|
| 2 |
Ki = 57 nM
|
|
|
|
CP0244025
|
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O2
|
1
|
| 1 |
IC50 = 344 nM
|
|
|
|
CP0338971
|
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C23H22FN7O
|
1
|
| 1 |
IC50 = 363 nM
|
|
|
|
CP0445513
|
[(2R,5R)-2-methyl-5-[4-(trifluoromethyl)pyridin-2-yl]oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H20F3N5O2
|
2
|
| 1 |
IC50 = 370 nM
|
|
|
| 2 |
Ki = 64 nM
|
|
|
|
CP0415395
|
[(2R,5R)-5-(4-bromopyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C20H20BrN5O2
|
2
|
| 1 |
IC50 = 380 nM
|
|
|
| 2 |
Ki = 130 nM
|
|
|
|
CP0398072
|
[(2R,5R)-5-(4-iodopyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C20H20IN5O2
|
2
|
| 1 |
IC50 = 410 nM
|
|
|
| 2 |
Ki = 59 nM
|
|
|
|
CP0441636
|
[(2R,5R)-2-methyl-5-(4-methylsulfonylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H23N5O4S
|
2
|
| 1 |
IC50 = 510 nM
|
|
|
| 2 |
Ki = 350 nM
|
|
|
|
CP0414622
|
[(2R,5R)-5-(4-chloropyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C20H20ClN5O2
|
2
|
| 1 |
IC50 = 550 nM
|
|
|
| 2 |
Ki = 120 nM
|
|
|
|
CP0448293
|
[(2R,5R)-5-(4-methoxypyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H23N5O3
|
2
|
| 1 |
IC50 = 620 nM
|
|
|
| 2 |
Ki = 140 nM
|
|
|
|
CP0398070
|
[(2R,5R)-2-methyl-5-(6-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H23N5O2
|
2
|
| 1 |
IC50 = 745 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0417070
|
US9586950, 1
Show/Hide
|
C23H22N6O4
|
2
|
| 1 |
IC50 = 749 nM
|
|
|
| 2 |
Ki = 56 nM
|
|
|
|
CP0441642
|
[(2R,5R)-2-methyl-5-(4-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C21H23N5O2
|
2
|
| 1 |
IC50 = 788 nM
|
|
|
| 2 |
Ki = 166 nM
|
|
|
|
CP0441197
|
US9546152, example 1
Show/Hide
|
C22H22N6O2
|
2
|
| 1 |
IC50 = 996 nM
|
|
|
| 2 |
Ki = 114 nM
|
|
|
|
CP0441215
|
2-{[(3R,6R)-6-methyl-1-{[2-(2H- 1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3- yl]sulfanyl}pyridine-4-carbonitrile
Show/Hide
|
C21H20N6OS
|
2
|
| 1 |
IC50 = 1411 nM
|
|
|
| 2 |
Ki = 324 nM
|
|
|
|
CP0448330
|
[(2R,5R)-5-[4-(dimethylamino)pyridin-2-yl]oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H26N6O2
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
Ki = 1400 nM
|
|
|
|
CP0535977
|
2-({(3r,6r)-1-[(2- cyclopropylphenyl)carbonyl]- 6-methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
Show/Hide
|
C23H25N3O2
|
2
|
| 1 |
IC50 = 1741 nM
|
|
|
| 2 |
Ki = 519 nM
|
|
|
|
CP0410159
|
2-(((3R,6R)-1-(2-(2H-1,2,3-Triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile
Show/Hide
|
C21H21N7O
|
2
|
| 1 |
IC50 = 1742 nM
|
|
|
| 2 |
Ki = 287 nM
|
|
|
|
CP0398071
|
methyl 2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxylate
Show/Hide
|
C22H23N5O4
|
4
|
| 1 |
IC50 = 1800 nM
|
|
|
| 2 |
IC50 = 1809 nM
|
|
|
| 3 |
Ki = 310 nM
|
|
|
| 4 |
Ki = 311 nM
|
|
|
|
CP0489021
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C30H30N2O6S
|
1
|
| 1 |
IC50 = 1910 nM
|
|
|
|
CP0391757
|
3-methyl-2-{[(3r,6r)-6- methyl-1-{[2- (trifluoromethoxy)phenyl] carbonyl}piperidin-3- yl]oxy}pyridine-4-carbonitrile
Show/Hide
|
C21H20F3N3O3
|
2
|
| 1 |
IC50 = 1967 nM
|
|
|
| 2 |
Ki = 757 nM
|
|
|
|
CP0279489
|
2-({(3r,6r)-1-[(2- ethoxyphenyl)carbonyl]-6- methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
Show/Hide
|
C22H25N3O3
|
2
|
| 1 |
IC50 = 2102 nM
|
|
|
| 2 |
Ki = 594 nM
|
|
|
|
CP0441640
|
[(2R,5R)-5-(4-fluoropyridin-2-yl)oxy-2-methylpiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C20H20FN5O2
|
2
|
| 1 |
IC50 = 2300 nM
|
|
|
| 2 |
Ki = 430 nM
|
|
|
|
CP0530447
|
[(2R,5R)-2-methyl-5-(4-phenylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C26H25N5O2
|
2
|
| 1 |
IC50 = 2400 nM
|
|
|
| 2 |
Ki = 360 nM
|
|
|
|
CP0484907
|
[(2R)-2-[[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]methyl]-1,3-oxazolidin-3-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone
Show/Hide
|
C22H20FN7O2
|
1
|
| 1 |
IC50 = 2690 nM
|
|
|
|
CP0397863
|
3-methyl-2-({(3r,6r)-6- methyl-1-[(2-pyrrolidin-1- ylphenyl)carbonyl]piperidin-3- yl}oxy)pyridine-4-carbonitrile
Show/Hide
|
C24H28N4O2
|
2
|
| 1 |
IC50 = 3102 nM
|
|
|
| 2 |
Ki = 790 nM
|
|
|
|
CP0064820
|
Orexin receptor antagonist 1
Show/Hide
|
C21H20N6O2
|
4
|
| 1 |
IC50 = 3200 nM
|
|
|
| 2 |
IC50 = 3800 nM
|
|
|
| 3 |
Ki = 829 nM
|
|
|
| 4 |
Ki = 830 nM
|
|
|
|
CP0441635
|
propan-2-yl 2-[(2R,5R)-5-(4-cyanopyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]benzoate
Show/Hide
|
C23H25N3O4
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0441195
|
3-methyl-2-({(3r,6r)-6- methyl-1-[(3-phenylpyridin-4- yl)carbonyl]piperidin-3- yl}oxy)pyridine-4-carbonitrile
Show/Hide
|
C25H24N4O2
|
2
|
| 1 |
IC50 = 4446 nM
|
|
|
| 2 |
Ki = 1611 nM
|
|
|
|
CP0410158
|
3-methyl-2-{[(3r,6r)-6- methyl-1-{[2-(2h-tetrazol-2- yl)phenyl]carbonyl}piperidin- 3-yl]oxy}pyridine-4- carbonitrile
Show/Hide
|
C21H21N7O2
|
2
|
| 1 |
IC50 = 4588 nM
|
|
|
| 2 |
Ki = 572 nM
|
|
|
|
CP0447277
|
3-methyl-2-({(3r,6r)-6- methyl-1-[(2-phenylpyridin-3- yl)carbonyl]piperidin-3- yl}oxy)pyridine-4-carbonitrile
Show/Hide
|
C25H24N4O2
|
2
|
| 1 |
IC50 = 4673 nM
|
|
|
| 2 |
Ki = 1128 nM
|
|
|
|
CP0074339
|
Orexin receptor antagonist 2
Show/Hide
|
C23H21N5O2
|
2
|
| 1 |
IC50 = 4900 nM
|
|
|
| 2 |
Ki = 569 nM
|
|
|
|
CP0410157
|
3-methyl-2-{[(3r,6r)-6- methyl-1-{[2- (trifluoromethyl)phenyl]carbonyl} piperidin-3- yl]oxy}pyridine-4-carbonitrile
Show/Hide
|
C21H20F3N3O2
|
2
|
| 1 |
IC50 = 4956 nM
|
|
|
| 2 |
Ki = 1155 nM
|
|
|
|
CP0283227
|
US9546152, example 2
Show/Hide
|
C22H23N7O3
|
2
|
| 1 |
IC50 = 5928 nM
|
|
|
| 2 |
Ki = 3568 nM
|
|
|
|
CP0088519
|
2-{[(3r,6r)-1-{[4-methoxy-2- (2h-1,2,3-triazol-2- yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]oxy}-3- methylpyridine-4-carbonitrile
Show/Hide
|
C23H24N6O3
|
2
|
| 1 |
IC50 = 6123 nM
|
|
|
| 2 |
Ki = 1170 nM
|
|
|
|
CP0459404
|
ethyl 2-[(2R,5R)-5-(4-cyanopyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]benzoate
Show/Hide
|
C22H23N3O4
|
1
|
| 1 |
IC50 = 7100 nM
|
|
|
|
CP0447275
|
US9556190, Example 1
Show/Hide
|
C24H25N5O4
|
2
|
| 1 |
IC50 = 8287 nM
|
|
|
| 2 |
Ki = 834 nM
|
|
|
|
CP0086965
|
Orexin receptor antagonist 3
Show/Hide
|
C22H21N5O3
|
1
|
| 1 |
IC50 = 8400 nM
|
|
|
|
CP0441641
|
N,N-dimethyl-2-[(3R,6R)-6-methyl-1-[2-(triazol-2-yl)benzoyl]piperidin-3-yl]oxypyridine-4-carboxamide
Show/Hide
|
C23H26N6O3
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 470 nM
|
|
|
|
CP0448331
|
2-[(3R,6R)-1-[2-(difluoromethoxy)benzoyl]-6-methylpiperidin-3-yl]oxypyridine-4-carbonitrile
Show/Hide
|
C20H19F2N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0459405
|
methyl 2-[(2R,5R)-5-(4-cyanopyridin-2-yl)oxy-2-methylpiperidine-1-carbonyl]benzoate
Show/Hide
|
C21H21N3O4
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0555072
|
2-[(3R,6R)-6-methyl-1-[2-(2,2,2-trifluoroethyl)benzoyl]piperidin-3-yl]oxypyridine-4-carbonitrile
Show/Hide
|
C21H20F3N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0391725
|
US9546152, example 89
Show/Hide
|
C21H20BrN7O2
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 1662 nM
|
|
|
|
CP0397828
|
2-({(3r,6r)-1-[(2-cyclopropyl- 6-methoxypyridin-3- yl)carbonyl]-6- methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
Show/Hide
|
C23H26N4O3
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 1887 nM
|
|
|
|
CP0417071
|
2-({(3r,6r)-1-[(6-methoxy- 2,4'-bipyridin-3-yl)carbonyl]- 6-methylpiperidin-3-yl}oxy)-3- methylpyridine-4-carbonitrile
Show/Hide
|
C25H25N5O3
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 5765 nM
|
|
|
|
CP0436506
|
US9546152, example 84
Show/Hide
|
C21H24N4O3S
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 2517 nM
|
|
|
|
CP0544810
|
N-[3-[(1S,3S,4S,7S,9S)-3,9-dimethyl-9-[3-(pyridine-4-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-4-carboxamide
Show/Hide
|
C32H29N5O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0550046
|
3-[(1S,3S,4S,7S,9S)-9-[3-(dimethylamino)phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]-N,N-dimethylaniline
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0551691
|
4-(dimethylamino)-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[[4-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
|
C38H41N5O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0575201
|
3-(dimethylamino)-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[[3-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
|
C38H41N5O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0576136
|
N-[4-[(1S,3R,4S,7S,9S)-9-[3-(benzenesulfonamido)phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzenesulfonamide
Show/Hide
|
C32H31N3O7S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0576137
|
2-(dimethylamino)-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[[2-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
|
C38H41N5O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0482664
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-[2-(dimethylamino)phenyl]sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-pyridin-2-ylprop-2-enamide
Show/Hide
|
C34H38N4O6S
|
1
|
| 1 |
Ki = 1.36 nM
|
|
|
|
CP0458264
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(2-methylphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C32H34N2O7S
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0533961
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(2-nitrophenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C31H31N3O9S
|
1
|
| 1 |
Ki = 1.81 nM
|
|
|
|
CP0550047
|
4-methoxy-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
|
C36H35N3O7
|
1
|
| 1 |
Ki = 1.87 nM
|
|
|
|
CP0548986
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-[2-(dimethylamino)phenyl]sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide;hydrochloride
Show/Hide
|
C33H38ClN3O7S
|
1
|
| 1 |
Ki = 1.92 nM
|
|
|
|
CP0478354
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(2-chlorophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C31H31ClN2O7S
|
1
|
| 1 |
Ki = 1.93 nM
|
|
|
|
CP0533960
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(2-cyanophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C32H31N3O7S
|
1
|
| 1 |
Ki = 1.96 nM
|
|
|
|
CP0469646
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C31H32N2O6S
|
1
|
| 1 |
Ki = 1.97 nM
|
|
|
|
CP0381092
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-[2-(trifluoromethyl)phenyl]sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C32H31F3N2O7S
|
1
|
| 1 |
Ki = 2.05 nM
|
|
|
|
CP0532155
|
(E)-N-[(4R,7R,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,6,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
|
C31H30N2O6S
|
1
|
| 1 |
Ki = 2.06 nM
|
|
|
|
CP0458262
|
(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(2-fluorophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H31FN2O7S
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1
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| 1 |
Ki = 2.07 nM
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CP0413656
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(2-bromophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H31BrN2O7S
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1
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| 1 |
Ki = 2.1 nM
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CP0542988
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4-methoxy-N-[3-[(1R,3S,4R,7R,9S)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C36H35N3O7
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2
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| 1 |
Ki = 2.17 nM
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| 2 |
Ki = 5.23 nM
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CP0569609
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4-methoxy-N-[3-[(1S,3S,4S,7S,9S)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C36H35N3O7
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2
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| 1 |
Ki = 2.17 nM
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| 2 |
Ki = 3.99 nM
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CP0406970
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(3-bromophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H31BrN2O7S
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1
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| 1 |
Ki = 2.27 nM
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CP0535224
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(3-methoxyphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C32H34N2O8S
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1
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| 1 |
Ki = 2.44 nM
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CP0570847
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3-methoxy-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[(3-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C36H35N3O7
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1
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| 1 |
Ki = 2.86 nM
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CP0458265
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(3-methylphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C32H34N2O7S
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1
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| 1 |
Ki = 2.98 nM
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CP0381085
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(3-chlorophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H31ClN2O7S
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1
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| 1 |
Ki = 3.47 nM
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CP0568637
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4-(dimethylamino)-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[[4-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C38H41N5O5
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1
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| 1 |
Ki = 3.88 nM
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CP0406969
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(4-fluorophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H31FN2O7S
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1
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| 1 |
Ki = 4.05 nM
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CP0406973
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tert-butyl (4R,4aS,7R,7aR,12bS)-7-[[(E)-3-(furan-3-yl)prop-2-enoyl]-methylamino]-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-3-carboxylate
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C30H36N2O7
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1
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| 1 |
Ki = 4.15 nM
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CP0402787
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(2,4,6-trimethylphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C34H38N2O7S
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1
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| 1 |
Ki = 4.16 nM
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CP0468868
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(E)-N-[(1S,9R,10R,13S)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H34N2O5S
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1
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| 1 |
Ki = 4.34 nM
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CP0535222
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(3-nitrophenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C31H31N3O9S
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1
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| 1 |
Ki = 5.05 nM
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CP0381090
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(4-chlorophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H31ClN2O7S
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1
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| 1 |
Ki = 5.13 nM
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CP0526039
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(E)-N-[(1S,9R,10R,13R)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H34N2O5S
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1
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| 1 |
Ki = 5.51 nM
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CP0517863
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(4-methylphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H34N2O7S
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1
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| 1 |
Ki = 5.85 nM
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CP0474021
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(E)-N-[(1R,9R,13R)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraen-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H32N2O5S
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1
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| 1 |
Ki = 5.89 nM
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CP0560544
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-butylsulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C29H36N2O7S
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1
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| 1 |
Ki = 5.94 nM
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CP0513255
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-[3-(trifluoromethyl)phenyl]sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H31F3N2O7S
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1
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| 1 |
Ki = 6.19 nM
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CP0548985
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(4-bromophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C31H31BrN2O7S
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1
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| 1 |
Ki = 6.21 nM
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CP0411352
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(2-methoxyphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H34N2O8S
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1
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| 1 |
Ki = 6.37 nM
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CP0568424
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-[3-(dimethylamino)phenyl]sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide;hydrochloride
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C33H38ClN3O7S
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1
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| 1 |
Ki = 7.25 nM
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CP0478355
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(3-cyanophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H31N3O7S
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1
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| 1 |
Ki = 7.3 nM
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CP0526040
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(E)-N-[(1R,9R,10S,13S)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadec-2(7)-en-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C30H36N2O5S
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1
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| 1 |
Ki = 7.45 nM
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CP0406968
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(3-fluorophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C31H31FN2O7S
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1
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| 1 |
Ki = 7.6 nM
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CP0575202
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N-[3-[(1S,3S,4S,7S,9S)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]-3-methoxybenzamide
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C35H33N3O6
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1
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| 1 |
Ki = 7.66 nM
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CP0551698
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3-(dimethylamino)-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[[3-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
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C38H41N5O5
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1
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| 1 |
Ki = 7.85 nM
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CP0381084
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C31H32N2O7S
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1
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| 1 |
Ki = 8.14 nM
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CP0517862
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(4-methoxyphenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H34N2O8S
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1
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| 1 |
Ki = 8.99 nM
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CP0474022
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(E)-N-[(1R,9R,10S,13S)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C30H32N2O5S
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1
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| 1 |
Ki = 9.35 nM
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CP0474023
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(E)-N-[(1R,9R,10S,13S)-17-(benzenesulfonyl)-10-hydroxy-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H34N2O6S
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1
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| 1 |
Ki = 11.2 nM
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CP0411353
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropanecarbonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C29H32N2O6
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1
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| 1 |
Ki = 12 nM
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CP0458261
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-cyclopropylsulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C28H32N2O7S
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1
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| 1 |
Ki = 12.1 nM
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CP0406971
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(4-nitrophenyl)sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C31H31N3O9S
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1
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| 1 |
Ki = 12.5 nM
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CP0458263
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-[4-(trifluoromethyl)phenyl]sulfonyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H31F3N2O7S
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1
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| 1 |
Ki = 12.6 nM
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CP0411354
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-[4-(dimethylamino)phenyl]sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide;hydrochloride
Show/Hide
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C33H38ClN3O7S
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1
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| 1 |
Ki = 12.9 nM
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CP0381086
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(4-cyanophenyl)sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C32H31N3O7S
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1
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| 1 |
Ki = 13.9 nM
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CP0406974
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-[(E)-3-phenylprop-2-enoyl]-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C34H34N2O6
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1
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| 1 |
Ki = 14 nM
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CP0539028
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(E)-N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-(4-methylbenzoyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C33H34N2O6
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1
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| 1 |
Ki = 14 nM
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CP0570848
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N-[3-[(1S,3S,4S,7S,9S)-3,9-dimethyl-9-[3-(pyridine-2-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-2-carboxamide
Show/Hide
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C32H29N5O5
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1
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| 1 |
Ki = 14.9 nM
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CP0530719
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(E)-N-[(4R,7S,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,6,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C31H30N2O6S
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1
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| 1 |
Ki = 17.8 nM
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CP0551697
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N-[3-[(1S,3S,4S,7S,9S)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]-2-methoxybenzamide
Show/Hide
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C35H33N3O6
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1
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| 1 |
Ki = 18 nM
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CP0569988
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N-[3-[(1S,3R,4S,7S,9R)-3,9-dimethyl-9-[3-(pyridine-2-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-2-carboxamide
Show/Hide
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C32H29N5O5
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1
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| 1 |
Ki = 18.3 nM
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CP0863976
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1-(6,8-Difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea Dihydrochloride
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C19H20Cl2F2N4O
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1
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| 1 |
Ki = 18.9 nM
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CP0413999
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(E)-N-[(1R,2R,5R,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C33H36N2O6S
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1
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| 1 |
Ki = 20.9 nM
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CP0410356
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
Show/Hide
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C29H34N2O5
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1
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| 1 |
Ki = 22.5 nM
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CP0571097
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N-[3-[(1S,3S,4S,7S,9S)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
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C34H31N3O5
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1
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| 1 |
Ki = 23.4 nM
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CP0568638
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N-[3-[(1S,3R,4S,7S,9R)-9-(3-benzamidophenyl)-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
Show/Hide
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C34H31N3O5
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1
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| 1 |
Ki = 25.4 nM
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CP0521759
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(E)-N-[(1R,9R,10S,13R)-17-(benzenesulfonyl)-10-hydroxy-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H34N2O6S
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1
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| 1 |
Ki = 31.6 nM
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CP0551690
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2-methoxy-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[(3-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C36H35N3O7
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1
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| 1 |
Ki = 32.8 nM
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CP0572986
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tert-butyl N-[3-[(1S,3S,4S,6S,7S)-3,6-dimethyl-6-[3-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]carbamate
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C30H39N3O7
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1
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| 1 |
Ki = 34.2 nM
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CP0570447
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-[2-(dimethylamino)phenyl]sulfonyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methyl-3-pyridin-3-ylprop-2-enamide
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C34H38N4O6S
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1
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| 1 |
Ki = 42.3 nM
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CP0579158
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N-[3-[(1S,3R,4S,7S,9R)-3,9-dimethyl-9-[3-(pyridine-3-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-3-carboxamide
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C32H29N5O5
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1
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| 1 |
Ki = 52 nM
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CP0554291
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(E)-N-[(1R,2R,5S,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-5-hydroxy-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H36N2O7S
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1
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| 1 |
Ki = 101 nM
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CP0551696
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N-[3-[(1S,3R,4S,7S,9R)-3,9-dimethyl-9-[3-(pyridine-4-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-4-carboxamide
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C32H29N5O5
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1
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| 1 |
Ki = 104 nM
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CP0580119
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4-methoxy-N-[3-[(1R,3R,4R,7R,9R)-9-[3-[(4-methoxybenzoyl)amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C36H35N3O7
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1
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| 1 |
Ki = 110 nM
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CP0557356
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(E)-N-[(4R,4aR,7S,7aR,12bS)-3-(benzenesulfonyl)-9-methoxy-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H32N2O6S
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1
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| 1 |
Ki = 187 nM
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CP0676321
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Nalfurafine hydrochloride
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C28H33ClN2O5
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1
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| 1 |
Ki = 250 nM
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CP0406972
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-[4-(dimethylamino)phenyl]sulfonyl-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C32H35N3O7S
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1
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| 1 |
Ki = 320 nM
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CP0863977
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N-[(4R,4aS,7R,7aR,12bS)-3-(Cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-N-methylcinnamamide Hydrochloride
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C30H35ClN2O4
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1
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| 1 |
Ki = 389 nM
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CP0416649
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(E)-N-[(1R,9R,10S,13R)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C30H32N2O5S
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1
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| 1 |
Ki = 461 nM
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CP0416647
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(E)-N-[(1R,9R,13S)-17-(benzenesulfonyl)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10-tetraen-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H32N2O5S
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1
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| 1 |
Ki = 502 nM
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CP0533959
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(E)-N-[(4R,4aS,7R,7aR,12bS)-3-acetyl-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C27H30N2O6
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1
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| 1 |
Ki = 541 nM
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CP0551695
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2-(dimethylamino)-N-[3-[(1S,3R,4S,7S,9R)-9-[3-[[2-(dimethylamino)benzoyl]amino]phenyl]-3,9-dimethyl-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]benzamide
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C38H41N5O5
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1
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| 1 |
Ki = 634 nM
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CP0562830
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N-[3-[(1S,3S,4S,7S,9S)-3,9-dimethyl-9-[3-(pyridine-3-carbonylamino)phenyl]-2,5,8-trioxa-10-azatricyclo[5.2.1.04,10]decan-3-yl]phenyl]pyridine-3-carboxamide
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C32H29N5O5
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1
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| 1 |
Ki = 691 nM
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CP0157028
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(2E)-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18)-trien-14-yl]-3-(furan-2-yl)-N-methylprop-2-enamide
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C28H32N2O5
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1
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| 1 |
Ki = 751 nM
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CP0530090
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(E)-N-[(3R,4aR,10R,10aS)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-10a-hydroxy-6-methoxy-2,3,4,4a,9,10-hexahydro-1H-phenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H38N2O6S
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1
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| 1 |
Ki = 842 nM
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CP0429699
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(E)-N-[(4R,4aS,7S,7aR,12bS)-3-(benzenesulfonyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C31H32N2O7S
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1
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| 1 |
Ki = 849 nM
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CP0061099
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(2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-14-hydroxymorphinan-6-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C28H32N2O4
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1
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| 1 |
Ki = 1245 nM
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CP0064578
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1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea
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C19H20Br2N2O3
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1
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| 1 |
Ki = 3162.28 nM
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CP0415397
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[(2R,5R)-2-methyl-5-(3-methylpyridin-2-yl)oxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
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C21H23N5O2
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1
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| 1 |
Ki = 4756 nM
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CP0416648
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(E)-N-[(1R,9R,10S,13R)-17-(benzenesulfonyl)-10-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadec-2(7)-en-13-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C30H36N2O5S
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1
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| 1 |
Ki > 10000 nM
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CP0414351
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[(2R,5R)-2-methyl-5-pyridin-2-yloxypiperidin-1-yl]-[2-(triazol-2-yl)phenyl]methanone
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C20H21N5O2
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1
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| 1 |
Ki = 14000 nM
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CP0384267
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(E)-N-[(1R,2S,5S,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-5-hydroxy-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H36N2O7S
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1
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| 1 |
Ki > 10 nM
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CP0416552
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(E)-N-[(3S,4aR,10R,10aS)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-10a-hydroxy-6-methoxy-2,3,4,4a,9,10-hexahydro-1H-phenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H38N2O6S
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1
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| 1 |
Ki > 10 nM
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CP0520808
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(E)-N-[(3R,4aS,10R,10aR)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-6-methoxy-1,2,3,4,4a,9,10,10a-octahydrophenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H38N2O5S
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1
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| 1 |
Ki > 10 nM
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CP0530089
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(E)-N-[(3S,4aS,10R,10aR)-10-[benzenesulfonyl(cyclopropylmethyl)amino]-6-methoxy-1,2,3,4,4a,9,10,10a-octahydrophenanthren-3-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H38N2O5S
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1
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| 1 |
Ki > 10 nM
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CP0535214
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(E)-N-[(1R,2S,5R,6R,14S)-6-[benzenesulfonyl(cyclopropylmethyl)amino]-11-methoxy-15-oxatetracyclo[10.2.1.05,14.08,13]pentadeca-8(13),9,11-trien-2-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
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C33H36N2O6S
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1
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| 1 |
Ki > 10 nM
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