| Compound ID |
Compound Name |
Compound Formula |
|
CP0539166
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(2-methyl-1,3-thiazol-5-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0554850
|
2-[5-(cyclopropylmethyl)-3-[3-(3,3-dimethylbut-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0362415
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H24F2N4O5S2
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0362412
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxetan-3-yl)but-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H28F2N4O5S2
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0538516
|
2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiazol-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0258271
|
2-[3-[3-(2-cyclopentylethynyl)phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H29FN4O4S2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0317515
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(4- methylpent-1-yn-1- yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0362435
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(2-thiophen-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H22F2N4O4S3
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0514743
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(oxolan-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O5S2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0537718
|
2-[5-(cyclopropylmethyl)-3-[3-(3-cyclopropylprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O4S2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0484667
|
2-(5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C31H26FN5O4S3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0487438
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0253018
|
2-[3-[3-(3-cyclopentyl-3-fluoroprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H29F3N4O4S2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0362419
|
2-(5-(2-cyclopropylethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylfuran-2- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C32H27FN4O5S2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0514745
|
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((5-methylthiophen-3- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0539180
|
2-[3-[3-(2-cyclopropylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H24F2N4O4S2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0557973
|
2-(5-(cyclopropylmethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-4- yl)ethynyl)phenyl)-1H-pyrazol-1- yl)thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O4S3
|
1
|
| 1 |
IC50 = 101 nM
|
|
|
|
CP0253022
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H24F2N4O4S3
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0258268
|
2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3-(pent-1- yn-1-yl)phenyl)-4-(3- fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0556265
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-hex-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H28F2N4O4S2
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0258249
|
2-[3-[3-[(E)-2-cyclopentylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H30F2N4O4S2
|
1
|
| 1 |
IC50 = 108 nM
|
|
|
|
CP0362527
|
2-[3-[3-(2-cyclopentylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H28F2N4O4S2
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0514956
|
2-[3-(3-but-1-ynyl-4-fluorophenyl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H24F2N4O4S2
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0539167
|
2-[5-(cyclopropylmethyl)-3-[3-[(E)-3,3-dimethylbut-1-enyl]-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H30F2N4O4S2
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0258272
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-[5-(trifluoromethyl)thiophen-2-yl]ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H22F4N4O4S3
|
1
|
| 1 |
IC50 = 113 nM
|
|
|
|
CP0547640
|
2-[3-[3-[2-(5-chlorothiophen-2-yl)ethynyl]phenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H22ClFN4O4S3
|
1
|
| 1 |
IC50 = 113 nM
|
|
|
|
CP0258267
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-prop-1-ynylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H22F2N4O4S2
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0265966
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0354427
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(3-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O4S3
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0362434
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H24F2N4O5S2
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0539857
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methyl-1,3-oxazol-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24FN5O5S2
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0362413
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H25F3N4O5S2
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0538515
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[(E)-prop-1-enyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H24F2N4O4S2
|
1
|
| 1 |
IC50 = 126 nM
|
|
|
|
CP0317516
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-fluorobut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C28H23F3N4O4S2
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0366919
|
2-[3-[3-(2-cyclobutylethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H26F2N4O4S2
|
1
|
| 1 |
IC50 = 133 nM
|
|
|
|
CP0362416
|
2-[5-(cyclopropylmethyl)-3-[3-[2-[5-(difluoromethyl)thiophen-2-yl]ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H23F3N4O4S3
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0362417
|
2-[3-[3-[(E)-2-cyclopropylethenyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C29H26F2N4O4S2
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0258248
|
2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24F2N4O4S2
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
|
CP0537720
|
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-3-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H26F2N4O4S3
|
1
|
| 1 |
IC50 = 142 nM
|
|
|
|
CP0253019
|
2-[3-[3-(3-cyclopentyl-3-hydroxyprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H30F2N4O5S2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0253023
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-prop-1-ynylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H23FN4O4S2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0317514
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-(3-phenylphenyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H25FN4O4S2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0484666
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 152 nM
|
|
|
|
CP0354428
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[(E)-2-(5-methylthiophen-2-yl)ethenyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H27FN4O4S3
|
1
|
| 1 |
IC50 = 158 nM
|
|
|
|
CP0365470
|
2-[5-(cyclopropylmethyl)-3-[3-(3,3-difluoroprop-1-ynyl)-4-fluorophenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C27H20F4N4O4S2
|
1
|
| 1 |
IC50 = 163 nM
|
|
|
|
CP0364193
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-methylfuran-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H25FN4O5S2
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
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CP0514744
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-1,3-thiazol-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H23F2N5O4S3
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
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CP0538517
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(2-spiro[2.2]pentan-2-ylethynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H29FN4O4S2
|
1
|
| 1 |
IC50 = 175 nM
|
|
|
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CP0258266
|
2-[3-[3-(3-cyclopentylprop-1-ynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H30F2N4O4S2
|
1
|
| 1 |
IC50 = 178 nM
|
|
|
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CP0552591
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-(oxolan-2-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H28F2N4O5S2
|
1
|
| 1 |
IC50 = 178 nM
|
|
|
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CP0537723
|
2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[2-(5-propan-2-ylthiophen-2-yl)ethynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H29FN4O4S3
|
1
|
| 1 |
IC50 = 179 nM
|
|
|
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CP0364192
|
2-[5-(cyclopropylmethyl)-3-[3-[2-(5-cyclopropylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C33H27FN4O4S3
|
1
|
| 1 |
IC50 = 183 nM
|
|
|
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CP0362531
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(1-methylpyrazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C30H24F2N6O4S2
|
1
|
| 1 |
IC50 = 189 nM
|
|
|
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CP0547641
|
2-(5-(2-cyclopropylethyl)- 3-(3-((5-cyclopropylthiophen- 2-yl)ethynyl)phenyl)-4-(3- fluoro-4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole- 4-carboxylic acid
Show/Hide
|
C34H29FN4O4S3
|
1
|
| 1 |
IC50 = 189 nM
|
|
|
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CP0364209
|
2-[5-(2-cyclopropylethyl)-3-[4-fluoro-3-[2-(5-methylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H26F2N4O4S3
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
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CP0253020
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-fluoro-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H27F3N4O5S2
|
1
|
| 1 |
IC50 = 201 nM
|
|
|
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CP0538514
|
2-[5-(cyclopropylmethyl)-3-[3-[2-(3,5-dimethylthiophen-2-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H27FN4O4S3
|
1
|
| 1 |
IC50 = 201 nM
|
|
|
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CP0539178
|
2-[5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-[3-(1-methylcyclopropyl)prop-1-ynyl]phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C32H31FN4O4S2
|
1
|
| 1 |
IC50 = 251 nM
|
|
|
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CP0549707
|
2-[5-(cyclopropylmethyl)-3-(3-ethynyl-4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C26H20F2N4O4S2
|
1
|
| 1 |
IC50 = 253 nM
|
|
|
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CP0253021
|
2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-pyrrolidin-1-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Show/Hide
|
C31H29F2N5O4S2
|
1
|
| 1 |
IC50 = 267 nM
|
|
|
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CP0484664
|
2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(cyclopropylmethyl)-4- (3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
Show/Hide
|
C34H29FN4O4S3
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
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CP0317517
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(3-methylimidazol-4-yl)ethynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H24F2N6O4S2
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1
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| 1 |
IC50 = 299 nM
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CP0317925
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2-(3-(3-((5-cyclobutylthiophen- 2-yl)ethynyl)phenyl)- 5-(2-cyclopropylethyl)- 4-(3-fluoro-4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid
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C35H31FN4O4S3
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1
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| 1 |
IC50 = 299 nM
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CP0365471
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2-(5-(2-cyclopropylethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid
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C33H29FN4O4S3
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1
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| 1 |
IC50 = 299 nM
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CP0484665
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2-(5-(cyclopropylmethyl)-3- (3-((2,5-dimethylthiophen-3- yl)ethynyl)phenyl)-4-(3-fluoro- 4-sulfamoylbenzyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
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C32H27FN4O4S3
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1
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| 1 |
IC50 = 299 nM
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CP0364189
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2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-[1-(trifluoromethyl)cyclopropyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H23F3N4O4S2
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1
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| 1 |
IC50 = 303 nM
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CP0364208
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[3-(3,3,3-trifluoroprop-1-en-2-yl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H22F4N4O4S2
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1
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| 1 |
IC50 = 398 nM
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CP0362528
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2-[5-(cyclopropylmethyl)-3-(4-fluoro-3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H25FN4O4S2
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1
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| 1 |
IC50 = 401 nM
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CP0553356
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2-[3-[3-(2-cyanoethynyl)-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F2N5O4S2
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1
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| 1 |
IC50 = 474 nM
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CP0258245
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2-(3-([1,1'-biphenyl]- 3-yl)-5-((2,2- difluorocyclopropyl) methyl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C30H24F2N4O4S2
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1
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| 1 |
IC50 = 501 nM
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CP0558851
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(4-hydroxybut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H24F2N4O5S2
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1
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| 1 |
IC50 = 577 nM
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CP0354426
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2-[3-[3-(3-cyclopropylbut-1-ynyl)phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C32H31FN4O4S2
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1
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| 1 |
IC50 = 708 nM
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CP0514955
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2-(3-([1,1''-biphenyl]- 3-yl)-5-(2- cyclopropylethyl)-4- (4-sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid (M + H)+ = 585
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C31H28N4O4S2
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1
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| 1 |
IC50 = 727 nM
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CP0539856
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxolan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H28F2N4O6S2
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1
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| 1 |
IC50 = 815 nM
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CP0543634
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2-[3-[3-[2-(2-cyclopropylcyclopropyl)ethynyl]phenyl]-5-(2-cyclopropylethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H31FN4O4S2
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1
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| 1 |
IC50 = 1027 nM
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CP0362529
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-[3-hydroxy-3-(oxetan-3-yl)prop-1-ynyl]phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C30H26F2N4O6S2
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1
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| 1 |
IC50 = 1499 nM
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CP0258269
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C29H26F2N4O4S2
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1
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| 1 |
IC50 = 2053 nM
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CP0258246
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2-(3-([1,1'-biphenyl]- difluorocyclopropyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid
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C29H22F2N4O4S2
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1
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| 1 |
IC50 = 2529 nM
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CP0258270
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(2-piperidin-4-ylethynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O4S2
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1
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| 1 |
IC50 = 2579 nM
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CP0258273
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2-[5-(2-cyclopropylethyl)-3-[3-(3,3-dicyclopropylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H33FN4O4S2
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1
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| 1 |
IC50 = 3183 nM
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CP0144066
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2-[5-(cyclopropylmethyl)-3-[4-fluoro-3-(3-morpholin-4-ylprop-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C31H29F2N5O5S2
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1
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| 1 |
IC50 = 5045 nM
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CP0543608
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2-[3-[3-[2-(5-tert-butylthiophen-2-yl)ethynyl]-4-fluorophenyl]-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C34H30F2N4O4S3
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1
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| 1 |
IC50 = 10602 nM
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CP0487439
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2-[5-(2-cyclopropylethyl)-3-[3-(3-cyclopropyl-3-methylbut-1-ynyl)phenyl]-4-[(3-fluoro-4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C33H33FN4O4S2
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1
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| 1 |
IC50 = 10751 nM
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CP0362414
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2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-[4-fluoro-3-(3,3,3-trifluoroprop-1-ynyl)phenyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C27H19F5N4O4S2
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1
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| 1 |
IC50 = 14005 nM
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CP0144065
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2-[3-(3-phenylphenyl)-4-[(4-sulfamoylphenyl)methyl]-5-(2,2,2-trifluoroethyl)pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
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C28H21F3N4O4S2
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1
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| 1 |
IC50 = 15849 nM
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CP0538518
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2-(5-(2-cyclopropylethyl)-4-(3- fluoro-4-sulfamoylbenzyl)- 3-(3-((2-methylthiazol-5- yl)ethynyl)phenyl)-1H-pyrazol- 1-yl)thiazole-4-carboxylic acid
Show/Hide
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C31H26FN5O4S3
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1
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| 1 |
IC50 = 17756 nM
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