Brief Information of the Cell Line and Protein
Cell Line ID: CL000017 , HeLa
Synonyms
HELA
Hela
He La
He-La
HeLa-CCL2
Henrietta Lacks cells
Helacyton gartleri
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0030
Protein ID: PT00889 , Estrogen receptor beta
Gene Name ESR2
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID Q92731
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000017  Protein ID: PT00889
 
Compound ID Compound Name Compound Formula
CP0042711
4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol
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C18H20O2
 1
1
EC50 = 0.02 nM
   TI
   LI
   LO
   TS
CP0006292
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
   Show/Hide
C18H24O2
 5
1
EC50 = 0.07 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.37 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.59 nM
   TI
   LI
   LO
   TS
4
EC50 = 0.84 nM
   TI
   LI
   LO
   TS
5
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0044042
(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one
   Show/Hide
C18H22O2
 3
1
EC50 = 2.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 26 nM
   TI
   LI
   LO
   TS
3
EC50 = 166 nM
   TI
   LI
   LO
   TS
CP0012708
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
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C15H10O5
 3
1
EC50 = 4.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 73 nM
   TI
   LI
   LO
   TS
3
EC50 = 956 nM
   TI
   LI
   LO
   TS
CP0063761
(1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
   Show/Hide
C18H24O2
 1
1
EC50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0342151
3-arylquinazolinethione, 1ba
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C14H10N2O3S
 2
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
2
EC50 = 2793 nM
   TI
   LI
   LO
   TS
CP0053327
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromene-4-thione
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C15H10O4S
 2
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
2
EC50 = 1125 nM
   TI
   LI
   LO
   TS
CP0214394
2-(4-hydroxy-2-methylphenyl)-1-benzothiophen-6-ol
   Show/Hide
C15H12O2S
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0141053
2-(4-hydroxyphenyl)-1-benzothiophen-6-ol
   Show/Hide
C14H10O2S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0074985
3-(3-fluoro-4-hydroxyphenyl)-5,7-dihydroxy-3,4-dihydroquinazoline-4-thione
   Show/Hide
C14H9FN2O3S
 2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
EC50 = 776 nM
   TI
   LI
   LO
   TS
CP0334570
2-(3-fluoro-4-hydroxyphenyl)-1-benzothiophen-6-ol
   Show/Hide
C14H9FO2S
 1
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
CP0154961
3-arylquinazolinethione, 1be
   Show/Hide
C16H14N2O2S
 2
1
EC50 = 53 nM
   TI
   LI
   LO
   TS
2
EC50 = 1462 nM
   TI
   LI
   LO
   TS
CP0274861
3-arylquinazolinone, 1aan
   Show/Hide
C16H14N2O3
 2
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
2
EC50 = 4521 nM
   TI
   LI
   LO
   TS
CP0095067
3-arylquinazolinone, 1aa
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C14H10N2O4
 2
1
EC50 = 76 nM
   TI
   LI
   LO
   TS
2
EC50 = 2918 nM
   TI
   LI
   LO
   TS
CP0162129
3-arylquinazolinone, 1ac
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C15H12N2O4
 2
1
EC50 = 111 nM
   TI
   LI
   LO
   TS
2
EC50 = 5305 nM
   TI
   LI
   LO
   TS
CP0167082
3-(3-fluoro-4-hydroxyphenyl)-5,7-dihydroxy-3,4-dihydroquinazolin-4-one
   Show/Hide
C14H9FN2O4
 2
1
EC50 = 117 nM
   TI
   LI
   LO
   TS
2
EC50 = 3112 nM
   TI
   LI
   LO
   TS
CP0222463
3-arylquinazolinone, 1aaj
   Show/Hide
C15H12N2O3
 2
1
EC50 = 136 nM
   TI
   LI
   LO
   TS
2
EC50 = 2392 nM
   TI
   LI
   LO
   TS
CP0109776
3-arylquinazolinethione, 1bc
   Show/Hide
C15H12N2O3S
 2
1
EC50 = 160 nM
   TI
   LI
   LO
   TS
2
EC50 = 2406 nM
   TI
   LI
   LO
   TS
CP0228049
2-phenyl-1-benzothiophen-6-ol
   Show/Hide
C14H10OS
 1
1
EC50 = 166 nM
   TI
   LI
   LO
   TS
CP0276781
3-arylquinazolinethione, 1bf
   Show/Hide
C13H9N3O3S
 2
1
EC50 = 173 nM
   TI
   LI
   LO
   TS
2
EC50 = 4859 nM
   TI
   LI
   LO
   TS
CP0185029
2-(4-methylphenyl)-1-benzothiophen-6-ol
   Show/Hide
C15H12OS
 1
1
EC50 = 174 nM
   TI
   LI
   LO
   TS
CP0148181
2-(4-hydroxy-3-propylphenyl)-1-benzothiophen-6-ol
   Show/Hide
C17H16O2S
 1
1
EC50 = 186 nM
   TI
   LI
   LO
   TS
CP0133181
3-(2-fluoro-4-hydroxyphenyl)-5,7-dihydroxy-3,4-dihydroquinazolin-4-one
   Show/Hide
C14H9FN2O4
 2
1
EC50 = 190 nM
   TI
   LI
   LO
   TS
2
EC50 = 1143 nM
   TI
   LI
   LO
   TS
CP0109775
3-arylquinazolinethione, 1bd
   Show/Hide
C15H12N2O2S
 2
1
EC50 = 222 nM
   TI
   LI
   LO
   TS
2
EC50 = 1669 nM
   TI
   LI
   LO
   TS
CP0040010
2-(3-hydroxyphenyl)-1-benzothiophen-6-ol
   Show/Hide
C14H10O2S
 1
1
EC50 = 245 nM
   TI
   LI
   LO
   TS
CP0205233
3-(2-chloro-4-hydroxyphenyl)-5,7-dihydroxy-3,4-dihydroquinazolin-4-one
   Show/Hide
C14H9ClN2O4
 2
1
EC50 = 251 nM
   TI
   LI
   LO
   TS
2
EC50 = 1427 nM
   TI
   LI
   LO
   TS
CP0210429
2-(3-ethyl-4-hydroxyphenyl)-1-benzothiophen-6-ol
   Show/Hide
C16H14O2S
 1
1
EC50 = 257 nM
   TI
   LI
   LO
   TS
CP0203623
2-(4-hydroxy-3-methylphenyl)-1-benzothiophen-6-ol
   Show/Hide
C15H12O2S
 1
1
EC50 = 302 nM
   TI
   LI
   LO
   TS
CP0205232
3-arylquinazolinone, 1ak
   Show/Hide
C13H9N3O4
 2
1
EC50 = 358 nM
   TI
   LI
   LO
   TS
2
EC50 = 3143 nM
   TI
   LI
   LO
   TS
CP0203601
4-(6-hydroxy-1-benzothiophen-2-yl)benzene-1,2-diol
   Show/Hide
C14H10O3S
 1
1
EC50 = 525 nM
   TI
   LI
   LO
   TS
CP0146459
3-arylquinazolinone, 1am
   Show/Hide
C14H9IN2O4
 2
1
EC50 = 593 nM
   TI
   LI
   LO
   TS
2
EC50 = 8317 nM
   TI
   LI
   LO
   TS
CP0167085
3-arylquinazolinone, 1aas
   Show/Hide
C17H14N2O3
 2
1
EC50 = 729 nM
   TI
   LI
   LO
   TS
2
EC50 = 4261 nM
   TI
   LI
   LO
   TS
CP0283226
3-arylquinazolinone, 1aao
   Show/Hide
C16H12N2O3
 2
1
EC50 = 750 nM
   TI
   LI
   LO
   TS
2
EC50 = 4624 nM
   TI
   LI
   LO
   TS
CP0070388
Bisphenol A (BPA)
   Show/Hide
C15H16O2
 1
1
EC50 = 757 nM
   TI
   LI
   LO
   TS
CP0222461
3-arylquinazolinone, 1at
   Show/Hide
C14H10N2O4
 2
1
EC50 = 904 nM
   TI
   LI
   LO
   TS
2
EC50 = 10082 nM
   TI
   LI
   LO
   TS
CP0141380
3-arylquinazolinone, 1as
   Show/Hide
C14H10N2O3
 1
1
EC50 = 961 nM
   TI
   LI
   LO
   TS
CP0179273
3-arylquinazolinone, 1aac
   Show/Hide
C14H10N2O4S
 2
1
EC50 = 983 nM
   TI
   LI
   LO
   TS
2
EC50 = 1985 nM
   TI
   LI
   LO
   TS
CP0045464
3-(3-chloro-4-hydroxyphenyl)-5,7-dihydroxy-3,4-dihydroquinazolin-4-one
   Show/Hide
C14H9ClN2O4
 2
1
EC50 = 1181 nM
   TI
   LI
   LO
   TS
2
EC50 = 5137 nM
   TI
   LI
   LO
   TS
CP0316541
3-arylquinazolinone, 1ai
   Show/Hide
C15H12N2O4
 2
1
EC50 = 1254 nM
   TI
   LI
   LO
   TS
2
EC50 = 4576 nM
   TI
   LI
   LO
   TS
CP0167098
2-ethyl-5,7-dihydroxy-3-(4-hydroxyphenyl)-3,4-dihydroquinazolin-4-one
   Show/Hide
C16H14N2O4
 2
1
EC50 = 1261 nM
   TI
   LI
   LO
   TS
2
EC50 = 9317 nM
   TI
   LI
   LO
   TS
CP0141377
2,5,7-trihydroxy-3-(4-hydroxyphenyl)-3,4-dihydroquinazolin-4-one
   Show/Hide
C14H10N2O5
 2
1
EC50 = 1313 nM
   TI
   LI
   LO
   TS
2
EC50 = 9268 nM
   TI
   LI
   LO
   TS
CP0420367
CHEBI:34029
   Show/Hide
C14H14O2
 1
1
EC50 = 1395 nM
   TI
   LI
   LO
   TS
CP0288405
3-arylquinazolinone, 1av
   Show/Hide
C15H12N2O4
 1
1
EC50 = 1583 nM
   TI
   LI
   LO
   TS
CP0320563
3-arylquinazolinone, 1ap
   Show/Hide
C14H9IN2O4
 1
1
EC50 = 1638 nM
   TI
   LI
   LO
   TS
CP0283224
3-arylquinazolinone, 1au
   Show/Hide
C14H10N2O3
 1
1
EC50 = 1721 nM
   TI
   LI
   LO
   TS
CP0109772
3-arylquinazolinone, 1an
   Show/Hide
C14H8I2N2O4
 1
1
EC50 = 1966 nM
   TI
   LI
   LO
   TS
CP0179292
3-arylquinazolinone, 1aai
   Show/Hide
C14H11N3O3
 1
1
EC50 = 2064 nM
   TI
   LI
   LO
   TS
CP0274862
3-arylquinazolinone, 1aam
   Show/Hide
C15H9F3N2O6S
 1
1
EC50 = 3804 nM
   TI
   LI
   LO
   TS
CP0140876
3-arylquinazolinone, 1aab
   Show/Hide
C15H12N2O4S
 1
1
EC50 = 3843 nM
   TI
   LI
   LO
   TS
CP0167086
3-arylquinazolinone, 1aar
   Show/Hide
C15H12N2O4
 1
1
EC50 = 4457 nM
   TI
   LI
   LO
   TS
CP0236221
3-arylquinazolinone, 1aal
   Show/Hide
C15H9N3O3
 1
1
EC50 = 7579 nM
   TI
   LI
   LO
   TS
CP0161944
3-arylquinazolinone, 1ab
   Show/Hide
C15H12N2O4
 1
1
EC50 = 8506 nM
   TI
   LI
   LO
   TS
CP0334411
3-arylquinazolinone, 1aak
   Show/Hide
C15H12N2O4
 1
1
EC50 = 8506 nM
   TI
   LI
   LO
   TS
CP0044826
2-chloro-5,7-dihydroxy-3-(4-hydroxyphenyl)-3,4-dihydroquinazolin-4-one
   Show/Hide
C14H9ClN2O4
 1
1
EC50 = 8776 nM
   TI
   LI
   LO
   TS
CP0205163
3-arylquinazolinone, 1ao
   Show/Hide
C15H12N2O4
 2
1
EC50 = 8870 nM
   TI
   LI
   LO
   TS
2
EC50 = 9344 nM
   TI
   LI
   LO
   TS
CP0276123
3-arylquinazolinone, 1aap
   Show/Hide
C16H12N2O5
 1
1
EC50 = 9406 nM
   TI
   LI
   LO
   TS
CP0045448
3-arylquinazolinone, 1al
   Show/Hide
C13H9N3O4
 1
1
EC50 = 9763 nM
   TI
   LI
   LO
   TS
CP0807075
methyl 7-acetoxy-3-(4-acetoxyphenyl)-4-thioxo-3,4-dihydroquinazoline-5-carboxylate
   Show/Hide
C20H16N2O6S
 1
1
EC50 = 11342 nM
   TI
   LI
   LO
   TS
CP0211271
3-arylquinazolinone, 1aaq
   Show/Hide
C20H14N2O3
 1
1
EC50 = 11685 nM
   TI
   LI
   LO
   TS
CP0178147
1-[2-hydroxy-5-(6-hydroxy-1-benzothiophen-2-yl)phenyl]ethan-1-one
   Show/Hide
C16H12O3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0214393
2-(3-fluoro-4-hydroxyphenyl)-1-benzothiophene-4,6-diol
   Show/Hide
C14H9FO3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0257596
2-(4-hydroxy-3-methylphenyl)-1-benzothiophene-4,6-diol
   Show/Hide
C15H12O3S
 1
1
EC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0040732
(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
   Show/Hide
C28H31NO2
 2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0409283
4-[2,2,2-tribromo-1-(4-hydroxyphenyl)ethyl]phenol
   Show/Hide
C14H11Br3O2
 2
1
IC50 = 40.2 nM
   TI
   LI
   LO
   TS
2
Kd = 4.677 nM
   TI
   LI
   LO
   TS
CP0059607
CHEBI:72754
   Show/Hide
C15H10F6O2
 2
1
IC50 = 69.8 nM
   TI
   LI
   LO
   TS
2
Kd = 10.72 nM
   TI
   LI
   LO
   TS
CP0414384
4-[2,2,2-trichloro-1-(4-hydroxyphenyl)ethyl]phenol
   Show/Hide
C14H11Cl3O2
 2
1
IC50 = 85.4 nM
   TI
   LI
   LO
   TS
2
Kd = 11.22 nM
   TI
   LI
   LO
   TS
CP0486016
1-(4-{octahydro-1H-pyrido[1,2-a]piperazin-2-yl}phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C29H33N3O
 2
1
IC50 = 98 nM
   TI
   LI
   LO
   TS
2
IC50 = 252 nM
   TI
   LI
   LO
   TS
CP0428331
1-[4-(3,4-dimethylpiperazin-1-yl)phenyl]-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C27H31N3O
 2
1
IC50 = 106 nM
   TI
   LI
   LO
   TS
2
IC50 = 330 nM
   TI
   LI
   LO
   TS
CP0503858
2-(4-fluorophenyl)-1-[4-(1-methylpiperidin-4-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C27H29FN2O
 2
1
IC50 = 162 nM
   TI
   LI
   LO
   TS
2
IC50 = 239 nM
   TI
   LI
   LO
   TS
CP0391567
1-[4-(4-ethyl-3-methylpiperazin-1-yl)phenyl]-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C28H33N3O
 2
1
IC50 = 173 nM
   TI
   LI
   LO
   TS
2
IC50 = 399 nM
   TI
   LI
   LO
   TS
CP0441762
1-[4-(4-methylpiperazin-1-yl)phenyl]-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C26H29N3O
 2
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
2
IC50 = 428 nM
   TI
   LI
   LO
   TS
CP0041761
2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
   Show/Hide
C28H27NO4S
 2
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
2
IC50 = 341 nM
   TI
   LI
   LO
   TS
CP0428333
1-[4-(1-methylpiperidin-4-yl)phenyl]-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C27H30N2O
 2
1
IC50 = 266 nM
   TI
   LI
   LO
   TS
2
IC50 = 464 nM
   TI
   LI
   LO
   TS
CP0378036
1-[4-(4-cyclopentylpiperazin-1-yl)phenyl]-2-(3-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C30H35N3O2
 2
1
IC50 = 268 nM
   TI
   LI
   LO
   TS
2
IC50 = 1110 nM
   TI
   LI
   LO
   TS
CP0421247
1-[4-(4-cyclohexylpiperazin-1-yl)phenyl]-2-(3-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C31H37N3O2
 2
1
IC50 = 276 nM
   TI
   LI
   LO
   TS
2
IC50 = 1285 nM
   TI
   LI
   LO
   TS
CP0496081
2-(3-hydroxyphenyl)-1-{4-[4-(propan-2-yl)piperazin-1-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol
   Show/Hide
C28H33N3O2
 2
1
IC50 = 286 nM
   TI
   LI
   LO
   TS
2
IC50 = 943 nM
   TI
   LI
   LO
   TS
CP0428338
2-(3-hydroxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol
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C26H29N3O2
 2
1
IC50 = 287 nM
   TI
   LI
   LO
   TS
2
IC50 = 1677 nM
   TI
   LI
   LO
   TS
CP0050678
2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol
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C28H32N2O2
 2
1
IC50 = 289 nM
   TI
   LI
   LO
   TS
2
IC50 = 346 nM
   TI
   LI
   LO
   TS
CP0420366
4-[2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl]phenol
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C14H11F3O2
 2
1
IC50 = 331 nM
   TI
   LI
   LO
   TS
2
Kd = 42.66 nM
   TI
   LI
   LO
   TS
CP0144749
1-(4-fluorophenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
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C21H18FNO
 1
1
IC50 = 421 nM
   TI
   LI
   LO
   TS
CP0421365
2-(3-hydroxyphenyl)-1-{4-[4-(2-methylpropyl)piperazin-1-yl]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol
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C29H35N3O2
 2
1
IC50 = 491 nM
   TI
   LI
   LO
   TS
2
IC50 = 1945 nM
   TI
   LI
   LO
   TS
CP0391060
2-(3-hydroxyphenyl)-1-[4-(1-methylpiperidin-4-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol
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C27H30N2O2
 2
1
IC50 = 496 nM
   TI
   LI
   LO
   TS
2
IC50 = 1730 nM
   TI
   LI
   LO
   TS
CP0503859
2-(3-fluorophenyl)-1-[4-(1-methylpiperidin-4-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-6-ol
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C27H29FN2O
 2
1
IC50 = 879 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0498205
1-[4-(3-ethyl-4-methylpiperazin-1-yl)phenyl]-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol
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C28H33N3O
 2
1
IC50 = 1155 nM
   TI
   LI
   LO
   TS
2
IC50 = 4454 nM
   TI
   LI
   LO
   TS
CP0404806
1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]phenyl}-2-(3-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolin-6-ol
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C29H33N3O2
 1
1
IC50 = 1370 nM
   TI
   LI
   LO
   TS
CP0003923
(2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
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C26H29NO
 2
1
IC50 = 1530 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS