| Compound ID |
Compound Name |
Compound Formula |
|
CP0000305
|
(-)-(etorphine)
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|
C17H19NO3
|
3
|
| 1 |
Activity = 1 nM
|
|
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| 2 |
EC50 = 120 nM
|
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| 3 |
Ki = 4.6 nM
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CP0048724
|
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
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C20H23NO4
|
6
|
| 1 |
EC50 = 0.16 nM
|
|
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| 2 |
IC50 = 6.62 nM
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|
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| 3 |
Ki = 0.33 nM
|
|
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| 4 |
Ki = 0.39 nM
|
|
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| 5 |
Ki = 0.4 nM
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| 6 |
Ki = 0.7 nM
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CP0482815
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-5-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 0.19 nM
|
|
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| 2 |
Ki = 0.14 nM
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CP0468679
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-6-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 0.21 nM
|
|
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| 2 |
Ki = 0.15 nM
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CP0536914
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-2-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 0.24 nM
|
|
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| 2 |
Ki = 0.14 nM
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CP0486035
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-4-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 0.32 nM
|
|
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| 2 |
Ki = 0.16 nM
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CP0468659
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-3-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 0.37 nM
|
|
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| 2 |
Ki = 0.14 nM
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CP0466683
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-2-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 0.39 nM
|
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| 2 |
Ki = 0.16 nM
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CP0468660
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-5-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 0.41 nM
|
|
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| 2 |
Ki = 0.15 nM
|
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|
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CP0429251
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-3-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 0.47 nM
|
|
|
| 2 |
Ki = 0.13 nM
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|
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CP0401959
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-nitropyridine-4-carboxamide
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|
C26H28N4O6
|
2
|
| 1 |
EC50 = 0.53 nM
|
|
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| 2 |
Ki = 0.17 nM
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CP0438126
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-6-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 0.59 nM
|
|
|
| 2 |
Ki = 0.18 nM
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|
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CP0533780
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-4-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 0.59 nM
|
|
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| 2 |
Ki = 0.17 nM
|
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|
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CP0540668
|
methyl (E)-2-[(2S,6'S,7'S,8'aS)-4-cyano-6'-ethyl-3-oxospiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
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|
C23H27N3O4
|
2
|
| 1 |
EC50 = 0.7 nM
|
|
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| 2 |
Ki = 0.5 nM
|
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|
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CP0429253
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-4-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
4
|
| 1 |
EC50 = 0.77 nM
|
|
|
| 2 |
EC50 = 80 nM
|
|
|
| 3 |
IC50 = 50.7 nM
|
|
|
| 4 |
Ki = 0.26 nM
|
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|
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CP0482816
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-7-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
4
|
| 1 |
EC50 = 0.95 nM
|
|
|
| 2 |
EC50 = 37 nM
|
|
|
| 3 |
IC50 = 15.59 nM
|
|
|
| 4 |
Ki = 0.18 nM
|
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|
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CP0482817
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-7-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 0.97 nM
|
|
|
| 2 |
Ki = 0.28 nM
|
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|
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CP0479012
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-4-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 1.05 nM
|
|
|
| 2 |
Ki = 0.26 nM
|
|
|
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CP0376007
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-4-hydroxyisoquinoline-3-carboxamide
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|
C30H31N3O5
|
2
|
| 1 |
EC50 = 1.06 nM
|
|
|
| 2 |
Ki = 0.45 nM
|
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|
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CP0379323
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-isoquinolin-3-ylpropanamide
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|
C32H35N3O4
|
2
|
| 1 |
EC50 = 1.14 nM
|
|
|
| 2 |
Ki = 0.68 nM
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|
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CP0477362
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-fluoropyridine-4-carboxamide
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|
C26H28FN3O4
|
2
|
| 1 |
EC50 = 1.2 nM
|
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| 2 |
Ki = 0.36 nM
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CP0451842
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-chloro-4-hydroxyisoquinoline-3-carboxamide
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|
C30H30ClN3O5
|
2
|
| 1 |
EC50 = 1.23 nM
|
|
|
| 2 |
Ki = 0.73 nM
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|
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CP0401954
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-cyanopyridine-4-carboxamide
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|
C27H28N4O4
|
2
|
| 1 |
EC50 = 1.28 nM
|
|
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| 2 |
Ki = 0.87 nM
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CP0379613
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-phenylprop-2-enamide
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|
C26H26N2O3
|
2
|
| 1 |
EC50 = 1.38 nM
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| 2 |
Ki = 0.1 nM
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CP0401956
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(trifluoromethyl)pyridine-4-carboxamide
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|
C27H28F3N3O4
|
2
|
| 1 |
EC50 = 1.38 nM
|
|
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| 2 |
Ki = 0.43 nM
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CP0190770
|
methyl (E)-2-[(2S,6'S,7'S,8'aS)-6'-ethyl-3-oxo-4-phenylspiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
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|
C28H32N2O4
|
2
|
| 1 |
EC50 = 1.4 nM
|
|
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| 2 |
Ki = 0.91 nM
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CP0430356
|
methyl (E)-2-[(2S,6'S,7'S,8'aS)-6'-ethyl-3-oxospiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
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|
C22H28N2O4
|
2
|
| 1 |
EC50 = 1.4 nM
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| 2 |
Ki = 0.46 nM
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CP0468970
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-phenylpyridine-4-carboxamide
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|
C32H33N3O4
|
2
|
| 1 |
EC50 = 1.46 nM
|
|
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| 2 |
Ki = 0.63 nM
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CP0430349
|
methyl (E)-2-[(2S,6'S,7'S,8'aS)-6'-ethyl-4-(furan-3-yl)-3-oxospiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
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|
C26H30N2O5
|
2
|
| 1 |
EC50 = 1.5 nM
|
|
|
| 2 |
Ki = 0.94 nM
|
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|
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CP0438127
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-3-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 1.57 nM
|
|
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| 2 |
Ki = 0.27 nM
|
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CP0086185
|
methyl (E)-2-[(2S,6'S,7'S,8'aS)-6'-ethyl-4-methoxy-3-oxospiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
Show/Hide
|
C23H30N2O5
|
2
|
| 1 |
EC50 = 1.7 nM
|
|
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| 2 |
Ki = 0.75 nM
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CP0386575
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-chloro-4-methoxyisoquinoline-3-carboxamide
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|
C31H32ClN3O5
|
2
|
| 1 |
EC50 = 1.74 nM
|
|
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| 2 |
Ki = 0.55 nM
|
|
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CP0401955
|
4-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]carbamoyl]pyridine-3-carboxylic acid
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|
C27H29N3O6
|
2
|
| 1 |
EC50 = 1.83 nM
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| 2 |
Ki = 0.76 nM
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CP0485961
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-3-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 1.85 nM
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| 2 |
Ki = 0.2 nM
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CP0477127
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-cyclopentylpyridine-4-carboxamide
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|
C31H37N3O4
|
2
|
| 1 |
EC50 = 1.85 nM
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| 2 |
Ki = 0.6 nM
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CP0451265
|
methyl (E)-2-[(2S,6'S,7'S,8'aS)-6'-ethyl-4-hydroxy-3-oxospiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
Show/Hide
|
C22H28N2O5
|
2
|
| 1 |
EC50 = 2 nM
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| 2 |
Ki = 1.4 nM
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CP0438130
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-6-carboxamide;hydrochloride
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|
C29H31ClN2O5
|
2
|
| 1 |
EC50 = 2.23 nM
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| 2 |
Ki = 0.29 nM
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CP0468971
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-ethylpyridine-4-carboxamide
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|
C28H33N3O4
|
2
|
| 1 |
EC50 = 2.29 nM
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| 2 |
Ki = 0.32 nM
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CP0517634
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-cyclohexylpyridine-4-carboxamide
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|
C32H39N3O4
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2
|
| 1 |
EC50 = 2.46 nM
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| 2 |
Ki = 0.78 nM
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CP0438129
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-5-carboxamide;hydrochloride
Show/Hide
|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 2.47 nM
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| 2 |
Ki = 0.39 nM
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CP0397511
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-chloroisoquinoline-3-carboxamide
Show/Hide
|
C30H30ClN3O4
|
2
|
| 1 |
EC50 = 2.62 nM
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| 2 |
Ki = 1.26 nM
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CP0923260
|
N-(6-dezoxymorphine-6beta-yl)nicotinamide
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|
C23H23N3O3
|
2
|
| 1 |
EC50 = 2.83 nM
|
|
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| 2 |
Ki = 1.25 nM
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CP0429249
|
N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-7-carboxamide;hydrochloride
Show/Hide
|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 2.97 nM
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| 2 |
Ki = 0.19 nM
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CP0438131
|
N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-6-carboxamide;hydrochloride
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|
C29H31ClN2O4S
|
2
|
| 1 |
EC50 = 3.01 nM
|
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| 2 |
Ki = 0.28 nM
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CP0370812
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy-6alpha-[(3'-isoquinolyl)acetamido]morphinan
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|
C30H31N3O4
|
2
|
| 1 |
EC50 = 3.3 nM
|
|
|
| 2 |
Ki = 1.11 nM
|
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CP0386572
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-cyanoisoquinoline-3-carboxamide
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C31H30N4O4
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2
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| 1 |
EC50 = 3.32 nM
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| 2 |
Ki = 0.99 nM
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CP0072627
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BUPRENORPHINE
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C29H41NO4
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1
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| 1 |
EC50 = 3.6 nM
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CP0429250
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-5-carboxamide;hydrochloride
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C29H31ClN2O5
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2
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| 1 |
EC50 = 3.72 nM
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| 2 |
Ki = 0.35 nM
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CP0438132
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1H-indole-7-carboxamide;hydrochloride
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C29H32ClN3O4
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2
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| 1 |
EC50 = 3.85 nM
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| 2 |
Ki = 0.23 nM
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CP0430355
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methyl (E)-2-[(2S,6'S,7'S,8'aS)-4-acetyloxy-6'-ethyl-3-oxospiro[1H-indole-2,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
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C24H30N2O6
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2
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| 1 |
EC50 = 3.9 nM
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| 2 |
Ki = 2.5 nM
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CP0429252
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-2-carboxamide;hydrochloride
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C29H31ClN2O4S
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2
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| 1 |
EC50 = 4.02 nM
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| 2 |
Ki = 0.27 nM
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CP0375589
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-2-isoquinolin-3-ylacetamide
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C31H33N3O4
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2
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| 1 |
EC50 = 4.6 nM
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| 2 |
Ki = 1.2 nM
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CP0849956
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N-(6-dezoxymorphine-6beta-yl)isonicotinamide
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C23H23N3O3
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2
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| 1 |
EC50 = 4.62 nM
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| 2 |
Ki = 2 nM
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CP0379249
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-7-(dimethylamino)isoquinoline-3-carboxamide
Show/Hide
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C32H36N4O4
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2
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| 1 |
EC50 = 4.7 nM
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| 2 |
Ki = 4.4 nM
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CP0401958
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N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-cycloheptylpyridine-4-carboxamide
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C33H41N3O4
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2
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| 1 |
EC50 = 5.11 nM
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| 2 |
Ki = 0.93 nM
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CP0468680
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzofuran-2-carboxamide;hydrochloride
Show/Hide
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C29H31ClN2O5
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2
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| 1 |
EC50 = 5.52 nM
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| 2 |
Ki = 0.44 nM
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CP0043301
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(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide
Show/Hide
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C26H35N5O6
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2
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| 1 |
EC50 = 5.6 nM
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| 2 |
EC50 = 19 nM
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CP0375588
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]quinazoline-2-carboxamide
Show/Hide
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C29H30N4O4
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2
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| 1 |
EC50 = 6 nM
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| 2 |
Ki = 1.11 nM
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CP0471110
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-benzothiophene-7-carboxamide;hydrochloride
Show/Hide
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C29H31ClN2O4S
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3
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| 1 |
EC50 = 6.21 nM
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| 2 |
IC50 = 566.14 nM
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| 3 |
Ki = 0.31 nM
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CP0375587
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-1-methylisoquinoline-3-carboxamide
Show/Hide
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C31H33N3O4
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2
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| 1 |
EC50 = 7.2 nM
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| 2 |
Ki = 2.1 nM
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CP0865241
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N-(6-dezoxy-7,8-dihydromorphine-6beta-yl)nicotinamide
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C23H25N3O3
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2
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| 1 |
EC50 = 7.98 nM
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| 2 |
Ki = 3.29 nM
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CP0849955
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N-(6-dezoxy-7,8-dihydromorphine-6beta-yl)isonicotinamide
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C23H25N3O3
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2
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| 1 |
EC50 = 8.16 nM
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| 2 |
Ki = 3.73 nM
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CP0379250
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-7-(dimethylamino)-2-methyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
Show/Hide
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C33H42N4O4
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2
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| 1 |
EC50 = 11.4 nM
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| 2 |
Ki = 1.79 nM
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CP0401960
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methyl 4-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]carbamoyl]pyridine-3-carboxylate
Show/Hide
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C28H31N3O6
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2
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| 1 |
EC50 = 13.4 nM
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| 2 |
Ki = 4.31 nM
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CP0376008
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N-[2-[[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethyl]isoquinoline-3-carboxamide
Show/Hide
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C32H34N4O5
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2
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| 1 |
EC50 = 14.1 nM
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| 2 |
Ki = 2.7 nM
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CP0379324
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(3S)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-2-methyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
Show/Hide
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C31H37N3O4
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2
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| 1 |
EC50 = 19.4 nM
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| 2 |
Ki = 2.9 nM
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CP0401957
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N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(2-methylpropyl)pyridine-4-carboxamide
Show/Hide
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C30H37N3O4
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2
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| 1 |
EC50 = 19.7 nM
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| 2 |
Ki = 7.2 nM
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CP0926696
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N-(6-dezoxy-14alpha-hydroxy-7,8-dihydromorphine-6beta-yl)nicotinamide
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C23H25N3O4
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2
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| 1 |
EC50 = 25.7 nM
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| 2 |
Ki = 6.91 nM
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CP0926695
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N-(6-dezoxy-14alpha-hydroxy-7,8-dihydromorphine-6beta-yl)isonicotinamide
Show/Hide
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C23H25N3O4
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2
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| 1 |
EC50 = 26.42 nM
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| 2 |
Ki = 7.02 nM
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CP0379351
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-6-nitroisoquinoline-3-carboxamide
Show/Hide
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C30H30N4O6
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2
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| 1 |
EC50 = 31.5 nM
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| 2 |
Ki = 5.7 nM
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CP0542667
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N-[(1S)-3-[(1S,5R)-3-[3-[2-[[2-[2-[7-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]heptylamino]-2-oxoethoxy]acetyl]amino]ethyl]-5-propan-2-yl-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-4,4-difluorocyclohexane-1-carboxamide
Show/Hide
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C65H92F2N10O10
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3
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| 1 |
EC50 = 36.3 nM
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| 2 |
IC50 = 50 nM
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| 3 |
Ki = 6.05 nM
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CP0388839
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-7-nitroisoquinoline-3-carboxamide
Show/Hide
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C30H30N4O6
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2
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| 1 |
EC50 = 42.7 nM
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| 2 |
Ki = 3.6 nM
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CP0055167
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methyl (E)-2-[(2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
Show/Hide
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C23H30N2O5
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2
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| 1 |
EC50 = 53 nM
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| 2 |
Ki = 37 nM
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CP0398303
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N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-6,7-dimethoxyisoquinoline-3-carboxamide
Show/Hide
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C32H35N3O6
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2
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| 1 |
EC50 = 85.2 nM
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| 2 |
Ki = 13.4 nM
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CP0135923
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CHEBI:6956
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C23H30N2O4
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2
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| 1 |
EC50 = 203 nM
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| 2 |
Ki = 230 nM
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CP0038839
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(4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
Show/Hide
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C19H21NO4
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1
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| 1 |
IC50 = 15.37 nM
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CP0576676
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N-[(1S)-1-[4-[[2-[2-[7-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]heptylamino]-2-oxoethoxy]acetyl]amino]phenyl]-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]propyl]-4,4-difluorocyclohexane-1-carboxamide
Show/Hide
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C64H90F2N10O10
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2
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| 1 |
IC50 = 40 nM
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| 2 |
Ki = 51.8 nM
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CP0444193
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(6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N'-[4-[[[2-[2-[6-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]hexylamino]-2-oxoethoxy]acetyl]amino]methyl]cyclohexyl]-N-cyclohexylcarbamimidothioate
Show/Hide
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C56H83N9O9S2
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2
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| 1 |
IC50 = 61.9 nM
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| 2 |
Ki = 25.4 nM
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CP0546089
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N-[(1S)-3-[(1S,5R)-3-[3-[2-[[2-[2-[9-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]nonylamino]-2-oxoethoxy]acetyl]amino]ethyl]-5-propan-2-yl-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-4,4-difluorocyclohexane-1-carboxamide
Show/Hide
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C67H96F2N10O10
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2
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| 1 |
IC50 = 74.4 nM
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| 2 |
Ki = 11.2 nM
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CP0571863
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2-[2-[6-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]hexylamino]-2-oxoethoxy]-N-methylacetamide
Show/Hide
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C35H51N5O9
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2
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| 1 |
IC50 = 133.1 nM
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| 2 |
Ki = 2 nM
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CP0546088
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N-[(1S)-3-[(1S,5R)-3-[3-[2-[[2-[2-[5-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]pentylamino]-2-oxoethoxy]acetyl]amino]ethyl]-5-propan-2-yl-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-4,4-difluorocyclohexane-1-carboxamide
Show/Hide
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C63H88F2N10O10
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2
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| 1 |
IC50 = 1103 nM
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| 2 |
Ki = 4.23 nM
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CP0381721
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N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-iodobenzamide
Show/Hide
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C27H29IN2O4
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1
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| 1 |
Ki = 0.11 nM
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CP0525477
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N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-4-iodobenzamide
Show/Hide
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C26H27IN2O4
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1
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| 1 |
Ki = 0.11 nM
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CP0462179
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(E)-N-[(4R,4aR,7R,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
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C26H25N3O5
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1
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| 1 |
Ki = 0.12 nM
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CP0411622
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(E)-N-[(4R,4aR,7R,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(4-chlorophenyl)prop-2-enamide
Show/Hide
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C26H25ClN2O3
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1
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| 1 |
Ki = 0.15 nM
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CP0968453
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(4'-(pyrazolylacetamido)morphinan
Show/Hide
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C25H30N4O4
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1
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| 1 |
Ki = 0.17 nM
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CP0376739
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N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-methoxybenzamide
Show/Hide
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C27H30N2O5
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1
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| 1 |
Ki = 0.18 nM
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CP0411620
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(E)-N-[(4R,4aR,7R,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
Show/Hide
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C27H25F3N2O3
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1
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| 1 |
Ki = 0.19 nM
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CP0945186
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-[(3'-(imidazolyl-5''-yl)propanamido]morphinan
Show/Hide
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C26H32N4O4
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1
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| 1 |
Ki = 0.2 nM
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CP0966714
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(3'-(pyrazolylacetamido)morphinan
Show/Hide
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C25H30N4O4
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1
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| 1 |
Ki = 0.2 nM
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CP0770774
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(3'-(pyrazolyl-3''-yl)propanamido]morphinan
Show/Hide
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C26H32N4O4
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1
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| 1 |
Ki = 0.21 nM
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CP0448209
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N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-iodobenzamide
Show/Hide
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C26H27IN2O4
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1
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| 1 |
Ki = 0.22 nM
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CP0514011
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N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-hydroxybenzamide
Show/Hide
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C26H28N2O5
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1
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| 1 |
Ki = 0.23 nM
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CP0770773
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17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(3'-(pyrazolylcarbaxamido)morphinan
Show/Hide
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C24H28N4O4
|
1
|
| 1 |
Ki = 0.28 nM
|
|
|
|
CP0488751
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-methylbenzamide
Show/Hide
|
C27H30N2O4
|
1
|
| 1 |
Ki = 0.29 nM
|
|
|
|
CP0966484
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(3'-(pyrazolyl-4''-yl)propanamido]morphinan
Show/Hide
|
C26H32N4O4
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0376797
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-aminobenzamide
Show/Hide
|
C26H29N3O4
|
1
|
| 1 |
Ki = 0.43 nM
|
|
|
|
CP0966713
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(2'-(imidazolylcarboxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 0.44 nM
|
|
|
|
CP0488787
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-fluorobenzamide
Show/Hide
|
C26H27FN2O4
|
1
|
| 1 |
Ki = 0.47 nM
|
|
|
|
CP0913138
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-[(2'-(imidazolylcarboxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 0.47 nM
|
|
|
|
CP0913106
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(2'-(imidazolylacetamido)morphinan
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
Ki = 0.48 nM
|
|
|
|
CP0951061
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-[(3'-pyrazolyl-3''-yl)propanamido]morphinan
Show/Hide
|
C26H32N4O4
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0951062
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(3'-(imidazolyl-2''-yl)propanamido]morphinan
Show/Hide
|
C26H32N4O4
|
1
|
| 1 |
Ki = 0.57 nM
|
|
|
|
CP0951072
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(5'-imidazolylcarboxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 0.58 nM
|
|
|
|
CP0952603
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(4'-pyrazolylcarboxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 0.59 nM
|
|
|
|
CP0952667
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(3'-(imidazolyl-5''-yl)propanamido]morphinan
Show/Hide
|
C26H32N4O4
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0488783
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]tridecanamide
Show/Hide
|
C32H48N2O4
|
1
|
| 1 |
Ki = 0.61 nM
|
|
|
|
CP0952666
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(3'-pyrazolylcarboxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 0.61 nM
|
|
|
|
CP0969554
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(4'-(pyrazolylcarboxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 0.65 nM
|
|
|
|
CP0488795
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-4-(trifluoromethoxy)benzamide
Show/Hide
|
C27H27F3N2O5
|
1
|
| 1 |
Ki = 0.66 nM
|
|
|
|
CP0943883
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-[(3'-(imidazolyl-2''-yl)propanamido]morphinan
Show/Hide
|
C26H32N4O4
|
1
|
| 1 |
Ki = 0.69 nM
|
|
|
|
CP0381718
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]naphthalene-2-carboxamide
Show/Hide
|
C30H30N2O4
|
1
|
| 1 |
Ki = 0.74 nM
|
|
|
|
CP0508806
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(4-methoxyphenyl)prop-2-enamide
Show/Hide
|
C27H28N2O4
|
1
|
| 1 |
Ki = 0.74 nM
|
|
|
|
CP0969555
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-(5'-imidazolylacetamido)morphinan
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
Ki = 0.82 nM
|
|
|
|
CP0967728
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(2'-(imidazolylacetamido)morphinan
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
Ki = 0.83 nM
|
|
|
|
CP0376790
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(trifluoromethyl)benzamide
Show/Hide
|
C27H27F3N2O4
|
1
|
| 1 |
Ki = 0.85 nM
|
|
|
|
CP0943884
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(4'-pyrazolylacetamido)morphinan
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
Ki = 0.88 nM
|
|
|
|
CP0448208
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-4-phenylbenzamide
Show/Hide
|
C32H32N2O4
|
1
|
| 1 |
Ki = 0.95 nM
|
|
|
|
CP0451932
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-iodobenzamide
Show/Hide
|
C24H25IN2O4
|
1
|
| 1 |
Ki = 0.97 nM
|
|
|
|
CP0966715
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(3'-pyrazolylacetamido)morphinan
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
Ki = 1.05 nM
|
|
|
|
CP0952665
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-[(3'-(pyrazolyl-4''-yl)propanamido]morphinan
Show/Hide
|
C26H32N4O4
|
1
|
| 1 |
Ki = 1.09 nM
|
|
|
|
CP0967025
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(5'-imidazolylcarbaxamido)morphinan
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
Ki = 1.11 nM
|
|
|
|
CP0376795
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-chlorobenzamide
Show/Hide
|
C26H27ClN2O4
|
1
|
| 1 |
Ki = 1.15 nM
|
|
|
|
CP0966485
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6alpha-(5'-imidazolylacetamido)morphinan
Show/Hide
|
C25H30N4O4
|
1
|
| 1 |
Ki = 1.34 nM
|
|
|
|
CP0477031
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-nitrobenzamide
Show/Hide
|
C26H27N3O6
|
1
|
| 1 |
Ki = 1.41 nM
|
|
|
|
CP0376738
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-2-iodobenzamide
Show/Hide
|
C26H27IN2O4
|
1
|
| 1 |
Ki = 1.56 nM
|
|
|
|
CP0558536
|
(6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N'-[4-[[[2-[2-[8-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]octylamino]-2-oxoethoxy]acetyl]amino]methyl]cyclohexyl]-N-cyclohexylcarbamimidothioate
Show/Hide
|
C58H87N9O9S2
|
1
|
| 1 |
Ki = 2.92 nM
|
|
|
|
CP0511993
|
2-[2-[4-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]butylamino]-2-oxoethoxy]-N-methylacetamide
Show/Hide
|
C33H47N5O9
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0487351
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(3-nitrophenyl)prop-2-enamide
Show/Hide
|
C27H27N3O5
|
1
|
| 1 |
Ki = 3.74 nM
|
|
|
|
CP0511994
|
(6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N'-[4-[[[2-[2-[4-[[2-[2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]amino]-2-oxoethoxy]acetyl]amino]butylamino]-2-oxoethoxy]acetyl]amino]methyl]cyclohexyl]carbamimidothioate
Show/Hide
|
C48H69N9O9S2
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0379614
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(4-chlorophenyl)prop-2-enamide
Show/Hide
|
C27H27ClN2O3
|
1
|
| 1 |
Ki = 3.81 nM
|
|
|
|
CP0488797
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-bromobenzamide
Show/Hide
|
C26H27BrN2O4
|
1
|
| 1 |
Ki = 3.85 nM
|
|
|
|
CP0455711
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]benzamide
Show/Hide
|
C26H28N2O4
|
1
|
| 1 |
Ki = 4.03 nM
|
|
|
|
CP0432957
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-phenylprop-2-enamide
Show/Hide
|
C27H28N2O3
|
1
|
| 1 |
Ki = 4.73 nM
|
|
|
|
CP0488780
|
N-[(4R,4aS,7S,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-iodobenzamide
Show/Hide
|
C26H27IN2O4
|
1
|
| 1 |
Ki = 5.07 nM
|
|
|
|
CP0517446
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
Show/Hide
|
C28H27F3N2O3
|
1
|
| 1 |
Ki = 5.44 nM
|
|
|
|
CP0488752
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(dimethylamino)benzamide
Show/Hide
|
C28H33N3O4
|
1
|
| 1 |
Ki = 6.4 nM
|
|
|
|
CP0376791
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]adamantane-2-carboxamide
Show/Hide
|
C30H38N2O4
|
1
|
| 1 |
Ki = 6.5 nM
|
|
|
|
CP0376737
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]heptanamide
Show/Hide
|
C26H36N2O4
|
1
|
| 1 |
Ki = 9.5 nM
|
|
|
|
CP0477030
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]cyclohexanecarboxamide
Show/Hide
|
C26H34N2O4
|
1
|
| 1 |
Ki = 11.54 nM
|
|
|
|
CP0488753
|
N-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]acetamide
Show/Hide
|
C21H26N2O4
|
1
|
| 1 |
Ki = 20.46 nM
|
|
|
|
CP0411621
|
(E)-N-[(4R,4aR,7R,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(4-methoxyphenyl)prop-2-enamide
Show/Hide
|
C28H30N2O4
|
1
|
| 1 |
Ki = 25.16 nM
|
|
|
|
CP0923261
|
N-(6-dezoxy-3-methyl-morphine-6beta-yl)isonicotinamide
Show/Hide
|
C24H25N3O3
|
1
|
| 1 |
Ki = 40.59 nM
|
|
|
|
CP0495212
|
methyl (E)-2-[(1S,6S,7S,8aS)-1'-benzyl-6-ethyl-4'-methoxy-3'-oxospiro[3,5,6,7,8,8a-hexahydro-2H-indolizine-1,2'-indole]-7-yl]-3-methoxyprop-2-enoate
Show/Hide
|
C30H36N2O5
|
1
|
| 1 |
Ki = 249 nM
|
|
|
|
CP0468881
|
methyl (E)-2-[(1S,6S,7S,8aS)-6-ethyl-4'-methoxy-1'-methyl-3'-oxospiro[3,5,6,7,8,8a-hexahydro-2H-indolizine-1,2'-indole]-7-yl]-3-methoxyprop-2-enoate
Show/Hide
|
C24H32N2O5
|
1
|
| 1 |
Ki = 375 nM
|
|
|
|
CP0477029
|
N-[(4R,4aS,7R,7aR,12bS)-4a-hydroxy-9-methoxy-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-iodobenzamide
Show/Hide
|
C27H29IN2O4
|
1
|
| 1 |
Ki > 100 nM
|
|
|
