General Information of the Compound
Compound ID
CP0495212
Compound Name
methyl (E)-2-[(1S,6S,7S,8aS)-1'-benzyl-6-ethyl-4'-methoxy-3'-oxospiro[3,5,6,7,8,8a-hexahydro-2H-indolizine-1,2'-indole]-7-yl]-3-methoxyprop-2-enoate
    Show/Hide
Structure
Formula
C30H36N2O5
Molecular Weight
504.627
Canonical SMILES
CC[C@@H]1CN2CC[C@@]3([C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC)N(Cc1ccccc1)c1cccc(OC)c1C3=O
    Show/Hide
InChI
InChI=1S/C30H36N2O5/c1-5-21-18-31-15-14-30(26(31)16-22(21)23(19-35-2)29(34)37-4)28(33)27-24(12-9-13-25(27)36-3)32(30)17-20-10-7-6-8-11-20/h6-13,19,21-22,26H,5,14-18H2,1-4H3/b23-19+/t21-,22+,26+,30+/m1/s1
    Show/Hide
InChIKey
OATYCYBMQGFTJB-PAKGBSETSA-N
Physicochemical Property
logP
4.4606
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
68.31
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155538541
ChEMBL ID
CHEMBL4476666
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01791, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 258 nM
   TI
   LI
   LO
   TS
Protein ID: PT02264, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 136 nM
   TI
   LI
   LO
   TS
Protein ID: PT02699, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 249 nM
   TI
   LI
   LO
   TS