Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01982 , Endothelin-converting enzyme 1
Gene Name ECE1
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P42892
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01982
 
Compound ID Compound Name Compound Formula
CP0190261
2-{2-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoylamino}-propionic acid
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C21H28F2N3O7P
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0133532
(S)-3-Biphenyl-4-yl-2-[(S)-5-(2-fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-propionic acid
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C27H26FN2O6P
 1
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
CP0182802
(S)-3-Cyclohexyl-2-[(S)-5-(2,4-difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-propionic acid
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C21H27F2N2O6P
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0101004
CGS-31,447
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C28H28N5O3P
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0448711
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-naphthalen-2-yl-propionic acid
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C25H24FN2O6P
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0107342
[[(2S)-5-(2,4-difluorophenyl)-1-oxo-1-[2-(4-phenylphenyl)ethylamino]pent-4-yn-2-yl]amino]methylphosphonic acid
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C26H25F2N2O4P
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0336734
(S)-5-(2-Fluoro-phenyl)-2-[(S)-5-(2-fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-pent-4-ynoic acid
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C23H21F2N2O6P
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0362349
[[(2S)-5-(2-fluorophenyl)-1-oxo-1-[2-(4-phenylphenyl)ethylamino]pent-4-yn-2-yl]amino]methylphosphonic acid
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C26H26FN2O4P
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0286476
[[(2S)-5-(2,4-difluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C24H23F2N2O4P
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0357578
[[(2S)-1-[2-(4-bromophenyl)ethylamino]-5-(2,4-difluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C20H20BrF2N2O4P
 1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0037872
(S)-2-[(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acid
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C18H23F2N2O6P
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0217898
[[(2S)-5-(2,4-difluorophenyl)-1-(2-naphthalen-2-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C24H23F2N2O4P
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0167269
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-phenyl-propionic acid
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C21H22FN2O6P
 1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
CP0309874
[[(2S)-1-[[3-(2-aminoethyl)-1H-indol-2-yl]amino]-5-(2-fluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C22H24FN4O4P
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0357542
2-[(3S)-3-[[(2S)-5-(2,4-difluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
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C24H24F2N3O7P
 1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CP0183199
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-3-methyl-butyric acid
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C17H22FN2O6P
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0183200
[[(2S)-1-[2-(4-bromophenyl)ethylamino]-5-(2-fluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C20H21BrFN2O4P
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0184322
[[(2S)-5-(2,4-difluorophenyl)-1-oxo-1-(2-phenylethylamino)pent-4-yn-2-yl]amino]methylphosphonic acid
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C20H21F2N2O4P
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0285033
[[(2S)-1-[[3-(2-aminoethyl)-1H-indol-2-yl]amino]-5-(2,4-difluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C22H23F2N4O4P
 1
1
IC50 = 111 nM
   TI
   LI
   LO
   TS
CP0037870
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acid
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C18H24FN2O6P
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0048197
[[(2S)-5-(2-fluorophenyl)-1-(2-naphthalen-1-ylethylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C24H24FN2O4P
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0167270
[[(2S)-5-(2,4-difluorophenyl)-1-(3-methylbutylamino)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C17H23F2N2O4P
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0284970
[[(2S)-5-(2,4-difluorophenyl)-1-oxo-1-(3-phenylpropylamino)pent-4-yn-2-yl]amino]methylphosphonic acid
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C21H23F2N2O4P
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0301536
[[(1S)-4-(2-fluorophenyl)-1-(2H-tetrazol-5-yl)but-3-ynyl]amino]methylphosphonic acid
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C12H13FN5O3P
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0175778
({(S)-4-(2,4-Difluoro-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethylcarbamoyl]-but-3-ynylamino}-methyl)-phosphonic acid
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C22H25F2N2O6P
 1
1
IC50 = 160 nM
   TI
   LI
   LO
   TS
CP0133531
(S)-5-(2,4-Difluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoic acid
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C12H12F2NO5P
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0208567
[[(2S)-5-(2-fluorophenyl)-1-oxo-1-(2-phenylethylamino)pent-4-yn-2-yl]amino]methylphosphonic acid
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C20H22FN2O4P
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0349167
(S)-2-[(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methylsulfanyl-butyric acid
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C17H22FN2O6PS
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0255899
(S)-5-(2-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoic acid
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C12H13FNO5P
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0228833
[[(2S)-1-(benzylamino)-5-(2-fluorophenyl)-1-oxopent-4-yn-2-yl]amino]methylphosphonic acid
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C19H20FN2O4P
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0286276
[[(2S)-5-(2,4-difluorophenyl)-1-oxo-1-(2-pyridin-2-ylethylamino)pent-4-yn-2-yl]amino]methylphosphonic acid
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C19H20F2N3O4P
 1
1
IC50 = 310 nM
   TI
   LI
   LO
   TS
CP0037918
(S)-2-[(S)-5-(3-Fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acid
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C18H24FN2O6P
 1
1
IC50 = 400 nM
   TI
   LI
   LO
   TS
CP0087775
CGS-26303
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C16H18N5O3P
 1
1
IC50 = 410 nM
   TI
   LI
   LO
   TS
CP0358558
(S)-4-Methyl-2-[(S)-5-phenyl-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-pentanoic acid
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C18H25N2O6P
 1
1
IC50 = 510 nM
   TI
   LI
   LO
   TS
CP0062600
[[(1S)-4-phenyl-1-(2H-tetrazol-5-yl)but-3-ynyl]amino]methylphosphonic acid
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C12H14N5O3P
 1
1
IC50 = 590 nM
   TI
   LI
   LO
   TS
CP0044595
(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-2H-pyran-2-yl hydrogen (S)-1-((S)-1-(1H-indol-3-yl)-3-oxobutan-2-ylamino)-4-methyl-1-oxopentan-2-ylphosphoramidate
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C23H34N3O10P
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0189925
(S)-2-[(S)-5-(2-Chloro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-4-methyl-pentanoic acid
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C18H24ClN2O6P
 1
1
IC50 = 4300 nM
   TI
   LI
   LO
   TS