General Information of the Compound
Compound ID
CP0301536
Compound Name
[[(1S)-4-(2-fluorophenyl)-1-(2H-tetrazol-5-yl)but-3-ynyl]amino]methylphosphonic acid
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Structure
Formula
C12H13FN5O3P
Molecular Weight
325.24
Canonical SMILES
OP(O)(=O)CN[C@@H](CC#Cc1ccccc1F)c1nnn[nH]1
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InChI
InChI=1S/C12H13FN5O3P/c13-10-6-2-1-4-9(10)5-3-7-11(12-15-17-18-16-12)14-8-22(19,20)21/h1-2,4,6,11,14H,7-8H2,(H2,19,20,21)(H,15,16,17,18)/t11-/m0/s1
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InChIKey
ZVYGKCUEVQFXLW-NSHDSACASA-N
Physicochemical Property
logP
0.5465
Rotatable Bonds
5
Heavy Atom Count
22
Polar Areas
124.02
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10426451
SID: 15445645
ChEMBL ID
CHEMBL40028
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01982, Endothelin-converting enzyme 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 150 nM