General Information of the Compound
Compound ID
CP0336734
Compound Name
(S)-5-(2-Fluoro-phenyl)-2-[(S)-5-(2-fluoro-phenyl)-2-(phosphonomethyl-amino)-pent-4-ynoylamino]-pent-4-ynoic acid
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Structure
Formula
C23H21F2N2O6P
Molecular Weight
490.399
Canonical SMILES
OC(=O)[C@H](CC#Cc1ccccc1F)NC(=O)[C@H](CC#Cc1ccccc1F)NCP(O)(O)=O
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InChI
InChI=1S/C23H21F2N2O6P/c24-18-11-3-1-7-16(18)9-5-13-20(26-15-34(31,32)33)22(28)27-21(23(29)30)14-6-10-17-8-2-4-12-19(17)25/h1-4,7-8,11-12,20-21,26H,13-15H2,(H,27,28)(H,29,30)(H2,31,32,33)/t20-,21-/m0/s1
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InChIKey
LEUUZEFIWDNUGB-SFTDATJTSA-N
Physicochemical Property
logP
1.811
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
135.96
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10648756
SID: 15680360
ChEMBL ID
CHEMBL39777
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01982, Endothelin-converting enzyme 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 28 nM
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