| Compound ID |
Compound Name |
Compound Formula |
|
CP0567086
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 0.206 nM
|
|
|
|
CP0380936
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H34ClN3O3
|
1
|
| 1 |
Ki = 0.514 nM
|
|
|
|
CP0473459
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 0.68 nM
|
|
|
|
CP0442878
|
US8722896, (-)-(3R)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl-1-[(2- methoxypyridin-3- ylmethyl)pyrrolidine-3- carboxamide
Show/Hide
|
C26H34ClN3O4
|
1
|
| 1 |
Ki = 0.71 nM
|
|
|
|
CP0429202
|
US8722896, (+/-)-2-Methyl-3-((3- acetoxy)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H35ClN2O5
|
1
|
| 1 |
Ki = 0.89 nM
|
|
|
|
CP0406923
|
US8722896, (-)-(3R)-1-(3-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 1.03 nM
|
|
|
|
CP0411933
|
US8722896, (-)-(3R)-1-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 1.24 nM
|
|
|
|
CP0527454
|
US8722896, (-)-(2R)-2-Methyl-3-(indol-7- ylmethylamino)-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H34N4O3
|
1
|
| 1 |
Ki = 1.39 nM
|
|
|
|
CP0382564
|
US8722896, (+/-)-(3R)-2-Methyl-3-(indolin-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 1.53 nM
|
|
|
|
CP0389377
|
US8722896, (-)-(2R)-2-Methyl-3-((4- fluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32ClFN2O3
|
1
|
| 1 |
Ki = 1.62 nM
|
|
|
|
CP0381728
|
US8722896, (+/-)-2-Methyl-3-((2- methoxybenzyl)methylamino)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O4
|
1
|
| 1 |
Ki = 1.76 nM
|
|
|
|
CP0543358
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O2
|
1
|
| 1 |
Ki = 1.86 nM
|
|
|
|
CP0434740
|
US8722896, (-)-(3R)-1-(2,3- Dimethylbenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 1.89 nM
|
|
|
|
CP0385679
|
US8722896, (+/-)-(3R)-4-(Indol-7-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-2- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 1.94 nM
|
|
|
|
CP0395052
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 2.22 nM
|
|
|
|
CP0385771
|
US8722896, (+/-)-(3R)-4-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylmorphoine- 2-carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0539313
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H34ClN3O3
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0407648
|
US8722896, (+/-)-4-(Indol-4-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H34ClN3O4
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0411934
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 2.62 nM
|
|
|
|
CP0425068
|
US8722896, (+/-)-4-(Indolin-4-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H36ClN3O4
|
1
|
| 1 |
Ki = 2.64 nM
|
|
|
|
CP0414708
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 2.87 nM
|
|
|
|
CP0409766
|
US8722896, (-)-(3R)-1-(1-Methyl-indol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 2.92 nM
|
|
|
|
CP0536418
|
US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide
Show/Hide
|
C31H40ClN3O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0409888
|
US8722896, (-)-(3R)-1-(3-Hydroxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 3.02 nM
|
|
|
|
CP0411918
|
US8722896, (+/-)-4-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H35ClN2O5
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0438209
|
US8722896, (+/-)-4-(Indol-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H34ClN3O4
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0565930
|
US8722896, (-)-(3R)-N-(3,4-Dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutyl-1-[(2-methoxypyridin- 3-ylmethyl)pyrrolidine-3- carboxamide
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
Ki = 3.53 nM
|
|
|
|
CP0441441
|
US8722896, (-)-(3R)-1-(3-Amino-4- fluorobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33ClFN3O3
|
1
|
| 1 |
Ki = 3.57 nM
|
|
|
|
CP0414711
|
US8722896, (-)-(3R)-1-(3-Amino-4- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H36ClN3O4
|
1
|
| 1 |
Ki = 3.68 nM
|
|
|
|
CP0429156
|
US8722896, (-)-(3R)-1-(1-Methyl-indol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 3.68 nM
|
|
|
|
CP0440530
|
US8722896, (-)-(3R)-1-(3-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 3.68 nM
|
|
|
|
CP0538202
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H35ClN2O4
|
1
|
| 1 |
Ki = 3.72 nM
|
|
|
|
CP0407056
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 3.76 nM
|
|
|
|
CP0414108
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O2
|
1
|
| 1 |
Ki = 3.94 nM
|
|
|
|
CP0456488
|
US8722896, (+/-)-2-Methyl-3-(N-methyl-indol- 4-ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 3.96 nM
|
|
|
|
CP0550799
|
US8722896, (-)-(3R)-1-(2-Ethoxybenzyl)-N- (9-fluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37FN2O4
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0413772
|
US8722896, (+/-)-(3R)-4-(Indol-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 4.26 nM
|
|
|
|
CP0415779
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 4.36 nM
|
|
|
|
CP0550615
|
US8722896, (-)-(3R)-1-(4-Fluorobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClFN2O3
|
1
|
| 1 |
Ki = 4.46 nM
|
|
|
|
CP0538643
|
US8722896, (+/-)-4-(Indolin-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H36ClN3O4
|
1
|
| 1 |
Ki = 4.77 nM
|
|
|
|
CP0525107
|
US8722896, (+/-)-2-Methyl-3-(1,3- (benzodioxol-4-ylmethylamino)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H33ClN2O5
|
1
|
| 1 |
Ki = 4.8 nM
|
|
|
|
CP0560297
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H33ClN2O5
|
1
|
| 1 |
Ki = 5.16 nM
|
|
|
|
CP0547645
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O2
|
1
|
| 1 |
Ki = 5.34 nM
|
|
|
|
CP0406213
|
US8722896, (+/-)-4-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H36ClN3O4
|
1
|
| 1 |
Ki = 5.42 nM
|
|
|
|
CP0509246
|
US8722896, (+/-)-2-Methyl-3-(Indol-7- ylmethylamino)-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O2
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0470369
|
US8722896, (+/-)-(3R)-4-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylmorphoine- 2-carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 6.16 nM
|
|
|
|
CP0512549
|
US8722896, (+/-)-2-Methyl-3-(2,3-dihydro- 1,4-benzodioxin-5- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H35ClN2O5
|
1
|
| 1 |
Ki = 6.16 nM
|
|
|
|
CP0407661
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 6.19 nM
|
|
|
|
CP0415902
|
US8722896, (+/-)-2-Methyl-3-(N-methyl-indol- 7-ylmethylamino)-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C29H38ClN3O2
|
1
|
| 1 |
Ki = 6.2 nM
|
|
|
|
CP0481505
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 6.54 nM
|
|
|
|
CP0401494
|
US8722896, (+/-)-2-Methyl-3-((3- amino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H34ClN3O3
|
1
|
| 1 |
Ki = 6.64 nM
|
|
|
|
CP0512557
|
US8722896, (-)-(3R)-1-(3-Nitro-4- fluorobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H31ClFN3O5
|
1
|
| 1 |
Ki = 6.83 nM
|
|
|
|
CP0422502
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0473452
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H41ClN2O2
|
1
|
| 1 |
Ki = 7.22 nM
|
|
|
|
CP0474714
|
US8722896, (-)-(3R)-1-(N-Methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 7.24 nM
|
|
|
|
CP0516674
|
US8722896, (+/-)-2-Methyl-3-(2,3- dimethylbenzylmethylamino)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C28H39ClN2O2
|
1
|
| 1 |
Ki = 7.24 nM
|
|
|
|
CP0402861
|
US8722896, (-)-(3R)-1-(2,5- Dimethoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O5
|
1
|
| 1 |
Ki = 7.32 nM
|
|
|
|
CP0385774
|
US8722896, (+/-)-2-Methyl-3-(N-methyl-indol- 4-ylmethylamino)-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C29H38ClN3O2
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
|
CP0414576
|
US8722896, (+/-)-4-(2-Methoxybenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylthiomorpholine-2- carboxamide
Show/Hide
|
C27H35ClN2O4S
|
1
|
| 1 |
Ki = 8.13 nM
|
|
|
|
CP0409929
|
US8722896, (+/-)-2-Methyl-3-((2,3- dimethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 8.14 nM
|
|
|
|
CP0470124
|
US8722896, (-)-(3R)-1-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 8.22 nM
|
|
|
|
CP0401174
|
US8722896, (+/-)-4-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H36ClN3O4
|
1
|
| 1 |
Ki = 8.24 nM
|
|
|
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CP0395039
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O2
|
1
|
| 1 |
Ki = 8.6 nM
|
|
|
|
CP0525150
|
US8722896, (-)-(3R)-1-(2-Ethoxybenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 8.77 nM
|
|
|
|
CP0414002
|
US8722896, (-)-(3R)-1-(2,3-Dimethylbenzyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O2
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0527445
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0414726
|
US8722896, (-)-(3R)-1-(2-Methoxy-5- methylbenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H39ClN2O4
|
1
|
| 1 |
Ki = 8.94 nM
|
|
|
|
CP0543356
|
US8722896, (-)-(2R)-2-Methyl-3-((2,4,6- trifluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H30ClF3N2O3
|
1
|
| 1 |
Ki = 9.02 nM
|
|
|
|
CP0459954
|
US8722896, (+/-)-2-Methyl-3-((3- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O3
|
1
|
| 1 |
Ki = 9.16 nM
|
|
|
|
CP0440553
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H38N2O4
|
1
|
| 1 |
Ki = 9.31 nM
|
|
|
|
CP0409780
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O3
|
1
|
| 1 |
Ki = 9.36 nM
|
|
|
|
CP0413931
|
US8722896, (-)-(3R)-1-(2-Methylbenzyl)- N-(9-fluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35FN2O3
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0411377
|
US8722896, (-)-(3R)-1-(3-aminobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H34ClN3O3
|
1
|
| 1 |
Ki = 9.83 nM
|
|
|
|
CP0538191
|
US8722896, (+/-)-2-Methyl-3-(indan-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 9.86 nM
|
|
|
|
CP0546621
|
US8722896, (+/-)-2-Methyl-3-(N-methyl-indol- 7-ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 10.6 nM
|
|
|
|
CP0527419
|
US8722896, (+/-)-2-Methyl-3-((2,5- dimethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 10.7 nM
|
|
|
|
CP0407815
|
US8722896, (+/-)-2-Methyl-3-(7-Azaindol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H33ClN4O3
|
1
|
| 1 |
Ki = 10.8 nM
|
|
|
|
CP0411921
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-5- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O4
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0468217
|
US8722896, (+/-)-4-Benzyl-N-(9-fluoro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C26H33FN2O4
|
1
|
| 1 |
Ki = 11.1 nM
|
|
|
|
CP0462741
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O2
|
1
|
| 1 |
Ki = 11.2 nM
|
|
|
|
CP0460112
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C30H40ClN3O2
|
1
|
| 1 |
Ki = 11.3 nM
|
|
|
|
CP0539444
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(9-fluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33FN2O3
|
1
|
| 1 |
Ki = 11.4 nM
|
|
|
|
CP0527426
|
US8722896, (-)-(3R)-1-(3-Methylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0470350
|
US8722896, (-)-(3R)-1-(2-Methylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O3
|
1
|
| 1 |
Ki = 11.9 nM
|
|
|
|
CP0403001
|
US8722896, (-)-(3R)-1-(2-Flurobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClFN2O3
|
1
|
| 1 |
Ki = 12.2 nM
|
|
|
|
CP0441458
|
US8722896, (-)-(2R)-2-Methyl-3-((2,4,5- trifluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H30ClF3N2O3
|
1
|
| 1 |
Ki = 13.3 nM
|
|
|
|
CP0413971
|
US8722896, (-)-(3R)-N-(9-Chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl-1- (pyridin-4-ylmethyl)pyrrolidine- 3-carboxamide
Show/Hide
|
C25H32ClN3O3
|
1
|
| 1 |
Ki = 13.5 nM
|
|
|
|
CP0441446
|
US8722896, (+/-)-4-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylthiomorpholine-2- carboxamide
Show/Hide
|
C26H33ClN2O3S
|
1
|
| 1 |
Ki = 13.5 nM
|
|
|
|
CP0546626
|
US8722896, (-)-(3R)-1-(2-Ethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 13.7 nM
|
|
|
|
CP0435220
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1,4- benzodioxin-5-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H37ClN2O5
|
1
|
| 1 |
Ki = 13.9 nM
|
|
|
|
CP0469307
|
US8722896, (+/-)-4-(N-methyl-indolin-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H38ClN3O4
|
1
|
| 1 |
Ki = 14.2 nM
|
|
|
|
CP0545288
|
US8722896, (-)-(3R)-1-(3-Aminobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 14.7 nM
|
|
|
|
CP0429710
|
US8722896, (+/-)-4-(N-methyl-indolin-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H38ClN3O4
|
1
|
| 1 |
Ki = 14.8 nM
|
|
|
|
CP0414706
|
US8722896, (-)-(3R)-1-(3-Methylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0547140
|
US8722896, (+/-)-2-Methyl-3-((3- hydroxy)benzylamino)-N- (9-chloro-3,3-difluoro-3,4- dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H31ClF2N2O4
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0417474
|
US8722896, (+/-)-2-Methyl-3-((2- amino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H34ClN3O3
|
1
|
| 1 |
Ki = 15.7 nM
|
|
|
|
CP0541404
|
US8722896, (+/-)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- propylpanamide
Show/Hide
|
C26H32ClN3O3
|
1
|
| 1 |
Ki = 15.8 nM
|
|
|
|
CP0438210
|
US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0488978
|
US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0438258
|
US8722896, (-)-(2R)-2-Ethyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 16.7 nM
|
|
|
|
CP0425071
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O2
|
1
|
| 1 |
Ki = 16.9 nM
|
|
|
|
CP0417246
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(9-bromo-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33BrN2O3
|
1
|
| 1 |
Ki = 17.4 nM
|
|
|
|
CP0406691
|
US8722896, (-)-(2R)-2-Ethyl-3-(2- methoxybenzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O4
|
1
|
| 1 |
Ki = 17.8 nM
|
|
|
|
CP0491030
|
US8722896, (-)-(3R)-1-(3-fluorobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClFN2O3
|
1
|
| 1 |
Ki = 17.9 nM
|
|
|
|
CP0534594
|
US8722896, (-)-(3R)-1-(2-Ethoxybenzyl)-N- (3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H38N2O4
|
1
|
| 1 |
Ki = 18.7 nM
|
|
|
|
CP0406434
|
US8722896, (+/-)-2-Methyl-3-((2,6- dimethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 18.9 nM
|
|
|
|
CP0435016
|
US8722896, (-)-(3R)-1-(3-chlorobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32Cl2N2O3
|
1
|
| 1 |
Ki = 19.5 nM
|
|
|
|
CP0486583
|
US8722896, (-)-(3R)-1-(1-Methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0497787
|
US8722896, (-)-(3R)-1-(2,3-Dimethylbenzyl- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H41ClN2O2
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0420461
|
US8722896, (-)-(3R)-1-(Indan-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H37ClN2O3
|
1
|
| 1 |
Ki = 20.4 nM
|
|
|
|
CP0532713
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H37ClN2O4
|
1
|
| 1 |
Ki = 21.4 nM
|
|
|
|
CP0472435
|
US8722896, (+/-)-2-Methyl-3-(Indol-4- ylmethylamino)-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O2
|
1
|
| 1 |
Ki = 21.6 nM
|
|
|
|
CP0468100
|
US8722896, (+/-)-1-Benzyl-N-(9-bromo-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33BrN2O3
|
1
|
| 1 |
Ki = 21.9 nM
|
|
|
|
CP0460110
|
US8722896, (+/-)-2-Methyl-3-((4- amino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H34ClN3O3
|
1
|
| 1 |
Ki = 22.2 nM
|
|
|
|
CP0460192
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-3- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O4
|
1
|
| 1 |
Ki = 23.8 nM
|
|
|
|
CP0429177
|
US8722896, (-)-(2R)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-fluoro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H34FN3O3
|
1
|
| 1 |
Ki = 24.2 nM
|
|
|
|
CP0541395
|
US8722896, (+/-)-2-Methyl-3-((2- chloro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32Cl2N2O3
|
1
|
| 1 |
Ki = 24.2 nM
|
|
|
|
CP0427996
|
US8722896, (+/-)-2-Methyl-3-((1-methyl-1H- pyrrol-2-yl)methylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C24H34ClN3O3
|
1
|
| 1 |
Ki = 24.3 nM
|
|
|
|
CP0429303
|
US8722896, (-)-(3R)-1-(2-Isopropylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 24.4 nM
|
|
|
|
CP0550771
|
US8722896, (+/-)-2-Methyl-3-(indolin-7- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5-benzo dioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 26.1 nM
|
|
|
|
CP0407084
|
US8722896, (+/-)-4-Benzyl-N-(9-Bromo-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C26H33BrN2O4
|
1
|
| 1 |
Ki = 26.9 nM
|
|
|
|
CP0523306
|
US8722896, (+/-)-4-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperazine-2- carboxamide
Show/Hide
|
C26H34ClN3O3
|
1
|
| 1 |
Ki = 27.2 nM
|
|
|
|
CP0573579
|
US8722896, (-)-(3R)-1-((1-Methyl-1H-pyrrol- 2-yl)methyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C25H34ClN3O3
|
1
|
| 1 |
Ki = 27.3 nM
|
|
|
|
CP0527404
|
US8722896, (+/-)-4-(3-Aminobenzyl)-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
Ki = 27.5 nM
|
|
|
|
CP0573792
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-3- nitro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H34ClN3O6
|
1
|
| 1 |
Ki = 28.1 nM
|
|
|
|
CP0546072
|
US8722896, (+/-)-2-Methyl-3-((3- fluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32ClFN2O3
|
1
|
| 1 |
Ki = 28.8 nM
|
|
|
|
CP0403480
|
US8722896, (-)-(3R)-1-(3-Ethylbenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 30.2 nM
|
|
|
|
CP0416403
|
US8722896, (-)-(3R)-1-(2-Methoxy-3-methyl- benzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 30.8 nM
|
|
|
|
CP0397799
|
US8722896, (+/-)-2-Methyl-3-(pyridin-3- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C24H32ClN3O3
|
1
|
| 1 |
Ki = 31.2 nM
|
|
|
|
CP0497754
|
US8722896, (-)-(3R)-1-(2-Methoxy-5-methyl- benzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 32.4 nM
|
|
|
|
CP0518417
|
US8722896, (+/-)-2-Methyl-3-(pyridin-2- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C24H32ClN3O3
|
1
|
| 1 |
Ki = 32.6 nM
|
|
|
|
CP0472598
|
US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H35ClN2O3
|
1
|
| 1 |
Ki = 33.9 nM
|
|
|
|
CP0441514
|
US8722896, (+/-)-2-Methyl-3-((2- trifluoromethyl)benzylamino)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H32ClF3N2O3
|
1
|
| 1 |
Ki = 34.6 nM
|
|
|
|
CP0441414
|
US8722896, (+/-)-2-Methyl-3-((3- dimethylamino)benzylamino)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H38ClN3O3
|
1
|
| 1 |
Ki = 34.8 nM
|
|
|
|
CP0533721
|
US8722896, (-)-(3R)-1-(2-Methoxy-3- aminobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H36ClN3O4
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0385151
|
US8722896, (+/-)-1-Benzyl-N-(8-chloro-2,3- dihydro-1,4-benzodioxin-6- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C25H31ClN2O3
|
1
|
| 1 |
Ki = 37.6 nM
|
|
|
|
CP0407173
|
US8722896, (-)-(3R)-1-((3- Dimethylamino)benzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H38ClN3O3
|
1
|
| 1 |
Ki = 38.4 nM
|
|
|
|
CP0523881
|
US8722896, (-)-(3R)-1-Benzyl-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O2
|
1
|
| 1 |
Ki = 38.6 nM
|
|
|
|
CP0486574
|
US8722896, (-)-(3R)-1-(2-Chlorobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32Cl2N2O3
|
1
|
| 1 |
Ki = 38.9 nM
|
|
|
|
CP0409773
|
US8722896, (+/-)-2-Methyl-3-((3- chloro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32Cl2N2O3
|
1
|
| 1 |
Ki = 39.8 nM
|
|
|
|
CP0515366
|
US8722896, (+/-)-4-(2-Methylbenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 40.3 nM
|
|
|
|
CP0417807
|
US8722896, (-)-(3R)-1-(2- Trifluoromethoxybenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H32ClF3N2O4
|
1
|
| 1 |
Ki = 40.4 nM
|
|
|
|
CP0548900
|
US8722896, (+/-)-2-Methyl-3-((2-ethyl-3- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H39ClN2O3
|
1
|
| 1 |
Ki = 40.8 nM
|
|
|
|
CP0414723
|
US8722896, (-)-(3R)-1-(7-Azaindol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H33ClN4O3
|
1
|
| 1 |
Ki = 41.4 nM
|
|
|
|
CP0565000
|
US8722896, (-)-(3R)-1-(2,3- Dimethoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O5
|
1
|
| 1 |
Ki = 43.4 nM
|
|
|
|
CP0422404
|
US8722896, (+/-)-4-(2,5-Dimethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 43.8 nM
|
|
|
|
CP0541452
|
US8722896, (-)-(3R)-1-(2-Ethyl-3- methylbenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0409826
|
US8722896, (+/-)-4-(2,3-Dimethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0531135
|
US8722896, (-)-(3R)-1-(Furan-2-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C24H31ClN2O4
|
1
|
| 1 |
Ki = 45.5 nM
|
|
|
|
CP0406951
|
US8722896, (+/-)-2-Methyl-3-((3-ethyl- benzylamino)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0550807
|
US8722896, (-)-(2R)-2-Ethyl-3- (benzylamino)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O3
|
1
|
| 1 |
Ki = 48.8 nM
|
|
|
|
CP0411914
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 49.6 nM
|
|
|
|
CP0547941
|
US8722896, (-)-(3R)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl-1- (pyridin-3-ylmethyl)pyrrolidine- 3-carboxamide
Show/Hide
|
C25H32ClN3O3
|
1
|
| 1 |
Ki = 49.6 nM
|
|
|
|
CP0539627
|
US8722896, (+/-)-2-Methyl-3-((3- hydroxy)benzylamino)-N-(9- fluoro-3,3-difluoro-3,4- dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33FN2O4
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0420228
|
US8722896, (-)-(3R)-1-(2- Trifluoromethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H32ClF3N2O3
|
1
|
| 1 |
Ki = 51.8 nM
|
|
|
|
CP0422530
|
US8722896, (-)-(3R)-1-(4-aminobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H34ClN3O3
|
1
|
| 1 |
Ki = 52.8 nM
|
|
|
|
CP0527395
|
US8722896, (+/-)-2-Methyl-3-((2- nitro)benzylamino-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32ClN3O5
|
1
|
| 1 |
Ki = 54.2 nM
|
|
|
|
CP0484551
|
US8722896, (-)-(3R)-1-Benzyl-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H34N2O3
|
1
|
| 1 |
Ki = 55.6 nM
|
|
|
|
CP0470050
|
US8722896, (-)-(3R)-1-(3-Nitro-4- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H34ClN3O6
|
1
|
| 1 |
Ki = 57.3 nM
|
|
|
|
CP0548004
|
US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-propyl pyrrolidine-3-carboxamide
Show/Hide
|
C25H31ClN2O3
|
1
|
| 1 |
Ki = 58.2 nM
|
|
|
|
CP0475553
|
US8722896, (-)-(3R)-1-(2-Hydroxybenzyl)-N- (3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H34N2O4
|
1
|
| 1 |
Ki = 60.5 nM
|
|
|
|
CP0390286
|
US8722896, (+/-)-2-Methyl-3-(indazol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H33ClN4O3
|
1
|
| 1 |
Ki = 61.6 nM
|
|
|
|
CP0473450
|
US8722896, (+/-)-2-Methyl-3-((3-amino-5- methoxy)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H36ClN3O4
|
1
|
| 1 |
Ki = 62.2 nM
|
|
|
|
CP0527409
|
US8722896, (-)-(3R)-1-(2-Aminobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 65.1 nM
|
|
|
|
CP0458995
|
US8722896, (-)-(3R)-1-Benzyl-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O2
|
1
|
| 1 |
Ki = 65.2 nM
|
|
|
|
CP0519403
|
US8722896, (+/-)-1-Benzyl-N-(3,4-dihydro- 2H-1,5-benzodioxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C26H34N2O3
|
1
|
| 1 |
Ki = 65.8 nM
|
|
|
|
CP0407211
|
US8722896, (-)-(3R)-1-(2-Methoxy-3- nitrobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H34ClN3O6
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0542105
|
US8722896, (-)-(3R)-1-(4-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 70.7 nM
|
|
|
|
CP0527418
|
US8722896, (+/-)-2-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- benzylpyrrolidine-3- carboxamide
Show/Hide
|
C29H31ClN2O3
|
1
|
| 1 |
Ki = 73 nM
|
|
|
|
CP0547963
|
US8722896, (+/-)-2-Methyl-3- (benzylmethylamino)-N-(9- chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O2
|
1
|
| 1 |
Ki = 73.4 nM
|
|
|
|
CP0549335
|
US8722896, (+/-)-2-Methyl-3-(6-chloro-1,3- benzodioxole-5-methylamino)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H32Cl2N2O5
|
1
|
| 1 |
Ki = 74.5 nM
|
|
|
|
CP0573511
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (6-chloro-2,3,4,5-tetrahydro-1- benzoxepin-8-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O2
|
1
|
| 1 |
Ki = 82 nM
|
|
|
|
CP0407725
|
US8722896, (-)-(3R)-1-(2-Nitrobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClN3O5
|
1
|
| 1 |
Ki = 85.7 nM
|
|
|
|
CP0533724
|
US8722896, (+/-)-1-Benzyl-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
Ki = 88.2 nM
|
|
|
|
CP0407172
|
US8722896, (-)-(3R)-1-(2-Ethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 92.4 nM
|
|
|
|
CP0525102
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-3- amino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H36ClN3O4
|
1
|
| 1 |
Ki = 92.4 nM
|
|
|
|
CP0549367
|
US8722896, (+/-)-4-Benzyl-N-(9-fluoro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperazine-2- carboxamide
Show/Hide
|
C26H34FN3O3
|
1
|
| 1 |
Ki = 94.5 nM
|
|
|
|
CP0548054
|
US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-(2,2- dimethylpropyl) pyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O3
|
1
|
| 1 |
Ki = 107 nM
|
|
|
|
CP0407112
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O2
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0462686
|
US8722896, (+/-)-4-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylthiomorpholine-2- carboxamide
Show/Hide
|
C26H34N2O3S
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0422503
|
US8722896, (-)-(3R)-1-(2-Methoxy-5- aminobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H36ClN3O4
|
1
|
| 1 |
Ki = 112 nM
|
|
|
|
CP0542616
|
US8722896, (+/-)-4-Benzyl-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C25H33N3O4
|
1
|
| 1 |
Ki = 113 nM
|
|
|
|
CP0407672
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-benzylpropanamide
Show/Hide
|
C28H31ClN2O3
|
1
|
| 1 |
Ki = 121 nM
|
|
|
|
CP0406919
|
US8722896, (+/-)-2-Methyl-3-(furan-2- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C23H31ClN2O4
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0548886
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H34N2O3
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0525106
|
US8722896, (+/-)-4-(4-Aminobenzyl)-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
Ki = 138 nM
|
|
|
|
CP0550840
|
US8722896, (+/-)-2-Methyl-3-(furan-3- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C23H31ClN2O4
|
1
|
| 1 |
Ki = 145 nM
|
|
|
|
CP0403040
|
US8722896, (+/-)-2-Methyl-3-((3- amino-4-fluoro)benzylamino)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33ClFN3O3
|
1
|
| 1 |
Ki = 155 nM
|
|
|
|
CP0380931
|
US8722896, (+/-)-1-Benzyl-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
Ki = 168 nM
|
|
|
|
CP0497756
|
US8722896, (+/-)-2-Methyl-3-((3- isopropyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H39ClN2O3
|
1
|
| 1 |
Ki = 177 nM
|
|
|
|
CP0385782
|
US8722896, (-)-(3R)-1-(Indazol-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H33ClN4O3
|
1
|
| 1 |
Ki = 179 nM
|
|
|
|
CP0468181
|
US8722896, (+/-)-2-Methyl-3-(Indol-7- ylmethylamino)-N-(6-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 8-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O2
|
1
|
| 1 |
Ki = 183 nM
|
|
|
|
CP0573681
|
US8722896, N-[(2S)-2-Aminopropanoyl]- (2S)-valylamide
Show/Hide
|
C8H17N3O2
|
1
|
| 1 |
Ki = 183 nM
|
|
|
|
CP0429630
|
US8722896, (+/-)-2-Methyl-3-((2- isopropyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H39ClN2O3
|
1
|
| 1 |
Ki = 197 nM
|
|
|
|
CP0544770
|
US8722896, (+/-)-2-Methyl-3-((3-nitro-5- methoxy)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H34ClN3O6
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0546629
|
US8722896, (+/-)-2-Methyl-3-(indol-7- ylmethylamino)-N-(9-fluoro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C27H34FN3O3
|
1
|
| 1 |
Ki = 206 nM
|
|
|
|
CP0429654
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-yl- isopropylpropyl)propanamide
Show/Hide
|
C26H36N2O3
|
1
|
| 1 |
Ki = 227 nM
|
|
|
|
CP0538185
|
US8722896, (-)-(R)-3-(1-Benzylpyrrolidin-2- yl)-N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 232 nM
|
|
|
|
CP0574169
|
US8722896, N-[(+/-)-2-Methyl-3-(indol- 4ylmethyl)aminopropanoyl]- (+/-)-valyl-(3,4-dihydro-2H-1,5- benzodioxepin-7- ylmethyl)amide
Show/Hide
|
C28H36N4O4
|
1
|
| 1 |
Ki = 248 nM
|
|
|
|
CP0400902
|
US8722896, (-)-(3R)-1-(2-Nitrobenzyl)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H35N3O5
|
1
|
| 1 |
Ki = 251 nM
|
|
|
|
CP0536438
|
US8722896, (-)-(3R)-1-(2-Nitrobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H34ClN3O5
|
1
|
| 1 |
Ki = 251 nM
|
|
|
|
CP0572997
|
US8722896, (+/-)-2-Methyl-3-((4- nitro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32ClN3O5
|
1
|
| 1 |
Ki = 252 nM
|
|
|
|
CP0560269
|
US8722896, (+/-)-2-Methyl-3-((3,5- dinitro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H31ClN4O7
|
1
|
| 1 |
Ki = 254 nM
|
|
|
|
CP0566906
|
US8722896, 1-Benzyl-N-(9-bromo-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl azetidine-3-carboxamide
Show/Hide
|
C25H31BrN2O3
|
1
|
| 1 |
Ki = 258 nM
|
|
|
|
CP0550861
|
US8722896, (-)-(3R)-1-(Furan-3-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C24H31ClN2O4
|
1
|
| 1 |
Ki = 264 nM
|
|
|
|
CP0575839
|
US8722896, (-)-(3R)-1-(3-Nitrobenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H34ClN3O5
|
1
|
| 1 |
Ki = 267 nM
|
|
|
|
CP0538203
|
US8722896, 3-(Benzyl(methyl)amino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H33ClN2O3
|
1
|
| 1 |
Ki = 272 nM
|
|
|
|
CP0409757
|
US8722896, (+/-)-1-Benzyl-N-(3-chloro-4,5- dimethoxy-benzyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C25H33ClN2O3
|
1
|
| 1 |
Ki = 277 nM
|
|
|
|
CP0411941
|
US8722896, (+/-)-N-(3,4-Dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutyl-3- (phenylamino)cyclopentane- carboxamide
Show/Hide
|
C26H34N2O3
|
1
|
| 1 |
Ki = 285 nM
|
|
|
|
CP0460241
|
US8722896, (-)-(3R)-1-(2-Methoxy-5- nitrobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H34ClN3O6
|
1
|
| 1 |
Ki = 292 nM
|
|
|
|
CP0563752
|
US8722896, (-)-(3R)-1-(2-Nitrobenzyl)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33N3O5
|
1
|
| 1 |
Ki = 297 nM
|
|
|
|
CP0409756
|
US8722896, (-)-(3R)-1-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide
Show/Hide
|
C31H40ClN3O2
|
1
|
| 1 |
Ki = 303 nM
|
|
|
|
CP0443851
|
US8722896, (+/-)-2-Methyl-3-(Indol-4- ylmethylamino)-N-(6-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 8-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O2
|
1
|
| 1 |
Ki = 308 nM
|
|
|
|
CP0380194
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(6-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33ClN2O3
|
1
|
| 1 |
Ki = 330 nM
|
|
|
|
CP0549363
|
US8722896, 3-(Benzylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C24H31ClN2O3
|
1
|
| 1 |
Ki = 344 nM
|
|
|
|
CP0429166
|
US8722896, (+/-)-2-Methyl-3-((3,5- diamino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H35ClN4O3
|
1
|
| 1 |
Ki = 356 nM
|
|
|
|
CP0385691
|
US8722896, (-)-(3R)-1-(3-Isopropylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 426 nM
|
|
|
|
CP0967470
|
US8722896, (+/-)-2-Methyl-3-((3- nitro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32ClN3O5
|
1
|
| 1 |
Ki = 474 nM
|
|
|
|
CP0486538
|
US8722896, 3-(Benzylamino)-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C24H32N2O3
|
1
|
| 1 |
Ki = 518 nM
|
|
|
|
CP0402982
|
US8722896, (-)-(3R)-1-(3-nitrobenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClN3O5
|
1
|
| 1 |
Ki = 650 nM
|
|
|
|
CP0429692
|
US8722896, (-)-(3R)-1-(3,5-Diaminobenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H35ClN4O3
|
1
|
| 1 |
Ki = 670 nM
|
|
|
|
CP0431792
|
US8722896, (-)-(3R)-N-(3,4-Dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutyl-1-(pyridin-2- ylmethyl)pyrrolidine-3- carboxamide
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
Ki = 674 nM
|
|
|
|
CP0413792
|
US8722896, (+/-)-3-Methyl-3-((2- methoxy)benzylamino)-N- (3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H36N2O4
|
1
|
| 1 |
Ki = 734 nM
|
|
|
|
CP0546671
|
US8722896, (+/-)-2-Methyl-3- (benzyl(methyl)amino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O3
|
1
|
| 1 |
Ki = 795 nM
|
|
|
|
CP0459990
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(8-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33ClN2O3
|
1
|
| 1 |
Ki = 796 nM
|
|
|
|
CP0515331
|
US8722896, (+/-)-N-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-(1,2-dimethyl) propylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O3
|
1
|
| 1 |
Ki = 964 nM
|
|
|
|
CP0417809
|
US8722896, (+/-)-2-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylisoxazolidin-5- carboxamide
Show/Hide
|
C25H31ClN2O4
|
1
|
| 1 |
Ki = 976 nM
|
|
|
|
CP0402814
|
US8722896, (+/-)-2-Methyl-3-(pyridin-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C24H32ClN3O3
|
1
|
| 1 |
Ki = 1058 nM
|
|
|
|
CP0543249
|
US8722896, (-)-(3R)-1-(4-Nitrobenzyl)-N- (3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H35N3O5
|
1
|
| 1 |
Ki = 1070 nM
|
|
|
|
CP0411026
|
US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isopropyl pyrrolidine-3-carboxamide
Show/Hide
|
C25H31ClN2O3
|
1
|
| 1 |
Ki = 1190 nM
|
|
|
|
CP0444243
|
US8722896, 1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl azetidine-3-carboxamide
Show/Hide
|
C25H31ClN2O3
|
1
|
| 1 |
Ki = 1190 nM
|
|
|
|
CP0472599
|
US8722896, (-)-(3R)-1-(4-nitrobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClN3O5
|
1
|
| 1 |
Ki = 1284 nM
|
|
|
|
CP0574144
|
US8722896, N-[(+/-)-2-Methyl-3- benzylaminopropanoyl]-(+/-)- valyl-(3,4-dihydro-2H-1,5- benzodioxepin-7- ylmethyl)amide
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
Ki = 1422 nM
|
|
|
|
CP0409890
|
US8722896, (-)-(3R)-1-(3,5-Dinitrobenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H31ClN4O7
|
1
|
| 1 |
Ki = 1508 nM
|
|
|
|
CP0472509
|
US8722896, (+)-(3S)-1-Benzyl-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H34N2O3
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0474498
|
US8722896, (+/-)-1-Benzyl-N-(8-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33ClN2O3
|
1
|
| 1 |
Ki = 1630 nM
|
|
|
|
CP0441456
|
US8722896, (+/-)-1-Benzyl-N-(6-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33ClN2O3
|
1
|
| 1 |
Ki = 1880 nM
|
|
|
|
CP0550863
|
US8722896, (+/-)-1-Benzyl-N-(3,4-dihydro- 2H-1,5-benzodioxepin-7-yl- isopropyl-propyl)-pyrrolidine- 3-carboxamide
Show/Hide
|
C27H36N2O3
|
1
|
| 1 |
Ki = 2100 nM
|
|
|
|
CP0558188
|
US8722896, (+/-)-3-Methyl-3-(benzylamino)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H34N2O3
|
1
|
| 1 |
Ki = 2680 nM
|
|
|
|
CP0574006
|
US8722896, (+/-)-1-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isopropyl piperidine-3-carboxamide
Show/Hide
|
C26H33ClN2O3
|
1
|
| 1 |
Ki = 4430 nM
|
|
|
|
CP0573699
|
US8722896, (+)-(2S)-2-Amino-N- isobutylpropanamide
Show/Hide
|
C7H16N2O
|
1
|
| 1 |
Ki = 9840 nM
|
|
|
|
CP0375672
|
US8722896, N-(9-Chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutyl-3-(pyrrolidin-2- yl)propanamide
Show/Hide
|
C21H31ClN2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0407535
|
US8722896, (+/-)-2-Methyl-3- (benzyl(methyl)amino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H36N2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0408157
|
US8722896, (-)-(2R)-2-Amino-N- isobutylpropanamide
Show/Hide
|
C7H16N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0408203
|
US8722896, (+/-)-2-Methyl-3-amino-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C18H27ClN2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0413968
|
US8722896, (+/-)-2-Methyl-3-amino-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C18H28N2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0417829
|
US8722896, (+)-(2S)-2-Benzylamino-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C24H32N2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0425006
|
US8722896, N-[(2S)-2-Aminopropanoyl]- (2R)-valylamide
Show/Hide
|
C8H17N3O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0425034
|
US8722896, (+/-)-3-Methyl-3-amino-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C18H28N2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0440505
|
US8722896, (-)-(2R)-2-Benzylamino-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C24H31ClN2O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0459989
|
US8722896, (+/-)-N-(9-Chloro-3,4-dihydro- 2H-1,5-benzodioxepin-7- ylmethyl)-N-isobutyl-3- phenoxycyclopentanecarbox- amide
Show/Hide
|
C26H32ClNO4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0460195
|
US8722896, (+/-)-2-Methyl-3-(pyrimidine-3- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C23H31ClN4O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0462747
|
US8722896, (-)-(3R)-N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutyl-1-(pyridin-3-ylmethyl) piperidine-3-carboxamide
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0470068
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(6-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-8-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0472053
|
US8722896, 3-Amino-N-(3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
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C17H26N2O3
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1
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| 1 |
Ki > 10000 nM
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CP0472415
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US8722896, (+/-)-N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutyl-3-amino-4- phenylbutanamide
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C24H32N2O3
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1
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| 1 |
Ki > 10000 nM
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CP0509250
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US8722896, (+)-(2S)-2-Benzylamino-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
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C24H31ClN2O3
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1
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| 1 |
Ki > 10000 nM
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CP0519855
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US8722896, 3-Amino-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
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C17H25ClN2O3
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1
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| 1 |
Ki > 10000 nM
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CP0524583
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US8722896, (-)-(3R)-1-(3-Nitrobenzyl)-N- (3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
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C27H35N3O5
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1
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| 1 |
Ki > 10000 nM
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CP0538929
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US8722896, N-(9-Chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutyl-5-phenylpentanamide
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C25H32ClNO3
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1
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| 1 |
Ki > 10000 nM
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CP0546078
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US8722896, (-)-(2R)-N-(9-Chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl-2- (phenethylamino)propanamide
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C25H33ClN2O3
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1
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| 1 |
Ki > 10000 nM
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CP0546859
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US8722896, (-)-(2R)-2-Benzylamino-N-(3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
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C24H32N2O3
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1
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| 1 |
Ki > 10000 nM
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