Brief Information of the Cell Line and Protein
Cell Line ID: CL000009 , LLC-PK1
Synonyms
LLC-PK(1)
LLC-PK-1
LLC PK-1
LLc-PK1
LLC PK1
LLCPK1
Lilly Laboratories Culture-Porcine Kidney 1
Category Spontaneously immortalized cell line
Organism
Sus scrofa (Pig)
Cellosaurus ID
CVCL_0391
Protein ID: PT06079 , ATP-dependent translocase ABCB1
Gene Name ABCB1B
Organism Mus musculus, Mouse
Protein Classification Transporter
Uniprot ID P06795
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000009  Protein ID: PT06079
 
Compound ID Compound Name Compound Formula
CP0667196
Ivermectin
   Show/Hide
C95H146O28
 1
1
IC50 = 500 nM
   TI
   LI
   LO
   TS
CP0036222
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
   Show/Hide
C62H111N11O12
 2
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
2
Ki = 3500 nM
   TI
   LI
   LO
   TS
CP0041632
ITRAZOLE
   Show/Hide
C35H38Cl2N8O4
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0040184
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine
   Show/Hide
C28H31FN4O
 1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CP0033565
(+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
   Show/Hide
C32H41NO2
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0036382
CAS_52-53-9
   Show/Hide
C27H38N2O4
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0063077
1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
   Show/Hide
C18H14Cl4N2O
 2
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
2
Ki = 98400 nM
   TI
   LI
   LO
   TS
CP0030899
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
   Show/Hide
C22H17ClN2
 2
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
2
Ki = 25100 nM
   TI
   LI
   LO
   TS
CP0005212
US8987315, Ketoconazole
   Show/Hide
C26H28Cl2N4O4
 2
1
IC50 = 6700 nM
   TI
   LI
   LO
   TS
2
Ki = 6930 nM
   TI
   LI
   LO
   TS
CP0055461
CHEBI:7550
   Show/Hide
C26H29N3O6
 1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0075209
(2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
   Show/Hide
C46H58N4O9
 1
1
IC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0013607
2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride
   Show/Hide
C29H38FN3O3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0034615
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
   Show/Hide
C20H24N2O2
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0078108
12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
   Show/Hide
C18H13ClFN3
 1
1
IC50 = 33000 nM
   TI
   LI
   LO
   TS
CP0055087
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
   Show/Hide
C37H67NO13
 1
1
IC50 > 35000 nM
   TI
   LI
   LO
   TS
CP0000305
(-)-(etorphine)
   Show/Hide
C17H19NO3
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0008077
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
   Show/Hide
C22H29FO5
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0027419
1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
   Show/Hide
C28H29F2N3O
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0035927
(Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine,cyanide
   Show/Hide
C10H16N6S
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0036175
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
   Show/Hide
C37H48N6O5S2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0036823
(-)-etoposide
   Show/Hide
C29H32O13
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0037274
(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
   Show/Hide
C22H25NO6
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0038098
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
   Show/Hide
C21H30O5
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0038418
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triaza-cyclotetradecane-4-carboxylic acid
   Show/Hide
C30H39N5O7S2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0048327
(2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide
   Show/Hide
C38H50N6O5
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0054979
DIGOXIN
   Show/Hide
C41H64O14
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0663086
Ranitidine
   Show/Hide
C13H22N4O3S
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0084033
BROMOCRIPTINE
   Show/Hide
C32H40BrN5O5
 1
1
Ki = 6390 nM
   TI
   LI
   LO
   TS
CP0068493
(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine
   Show/Hide
C25H29I2NO3
 1
1
Ki = 12700 nM
   TI
   LI
   LO
   TS
CP0194869
ERGOCRISTINE
   Show/Hide
C35H39N5O5
 1
1
Ki = 15300 nM
   TI
   LI
   LO
   TS
CP0035720
(-)-reserpine
   Show/Hide
C33H40N2O9
 1
1
Ki = 17900 nM
   TI
   LI
   LO
   TS
CP0045584
(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione
   Show/Hide
C33H35N5O5
 1
1
Ki = 18000 nM
   TI
   LI
   LO
   TS
CP0076396
ERGOCORNINE
   Show/Hide
C31H39N5O5
 1
1
Ki = 19100 nM
   TI
   LI
   LO
   TS
CP0047240
(6aR,9R)-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
   Show/Hide
C32H41N5O5
 1
1
Ki = 26900 nM
   TI
   LI
   LO
   TS