| Compound ID |
Compound Name |
Compound Formula |
|
CP0037325
|
2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl}phenyl)cyclohexyl]acetic acid
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|
C22H26N4O3
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0085747
|
2-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetic acid
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|
C21H24N4O4
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
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CP0443966
|
2-[4-[4-[(8R)-4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl]phenyl]cyclohexyl]acetic acid
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|
C22H26N4O4
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0397266
|
2-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]-N-cyclopentylacetamide
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|
C26H33N5O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0075126
|
4-amino-6-[4-[4-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C23H26N6O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0444005
|
2-[4-[4-(4-amino-8,8-dimethyl-5-oxo-7H-pyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetic acid
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|
C23H28N4O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0169155
|
2-[4-[4-[(6S)-4-amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetic acid
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|
C20H23N3O4
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0478905
|
2-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetamide
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|
C21H25N5O3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0456207
|
2-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetonitrile
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|
C21H23N5O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0390735
|
4-amino-6-(4-tert-butylphenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C17H20N4O2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0466199
|
2-[4-[4-(4-amino-2-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetic acid
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|
C22H26N4O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0390736
|
4-amino-6-[4-[4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C23H30N4O3
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0466198
|
4-amino-6-[4-[4-[2-[(3R)-3-hydroxypyrrolidin-1-yl]-2-oxoethyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C25H31N5O4
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0487515
|
4-amino-6-[4-[4-(2-morpholin-4-yl-2-oxoethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C25H31N5O4
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0375926
|
4-amino-6-[4-[4-[2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C27H35N5O4
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0456206
|
2-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]-N-[(2R)-1-hydroxy-3-methylbutan-2-yl]acetamide
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|
C26H35N5O4
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0397267
|
4-amino-6-[4-[4-[2-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C24H28N6O3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0444007
|
4-amino-6-[4-[4-(2-amino-2-methylpropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C23H31N5O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0235742
|
CHEMBL1833980
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|
C20H23N3O4
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0375925
|
4-amino-6-[4-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C24H29N5O4
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0390734
|
2-[4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4-yl)phenyl]cyclohexyl]acetic acid
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|
C22H25N3O4
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0444006
|
4-amino-6-[4-[4-(2-oxo-2-pyrrolidin-1-ylethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C25H31N5O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0197867
|
3-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]propanoic acid
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|
C22H26N4O4
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0295979
|
2-[4-[4-[(6S)-4-amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetonitrile
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|
C20H22N4O2
|
1
|
| 1 |
IC50 = 175 nM
|
|
|
|
CP0487514
|
4-amino-6-[4-[4-[2-(4-methyl-3-oxopiperazin-1-yl)-2-oxoethyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C26H32N6O4
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0456205
|
4-amino-6-[4-[4-[(5-methyl-1H-1,2,4-triazol-3-yl)methyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C23H27N7O2
|
1
|
| 1 |
IC50 = 253 nM
|
|
|
|
CP0397265
|
4-amino-6-[4-(1-benzoylpiperidin-4-yl)phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C25H25N5O3
|
1
|
| 1 |
IC50 = 276 nM
|
|
|
|
CP0390733
|
4-amino-6-[4-[1-(2-ethoxyacetyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C22H27N5O4
|
1
|
| 1 |
IC50 = 393 nM
|
|
|
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CP0375927
|
2-[[2-[4-[4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetyl]-methylamino]acetic acid
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|
C24H29N5O5
|
1
|
| 1 |
IC50 = 421 nM
|
|
|
|
CP0397259
|
4-amino-6-[4-[1-(oxane-4-carbonyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C24H29N5O4
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0390732
|
4-amino-6-[4-[1-(cyclohexanecarbonyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
Show/Hide
|
C25H31N5O3
|
1
|
| 1 |
IC50 = 514 nM
|
|
|
|
CP0478903
|
4-amino-6-[4-[1-(4-hydroxycyclohexanecarbonyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C25H31N5O4
|
1
|
| 1 |
IC50 = 574 nM
|
|
|
|
CP0397263
|
4-amino-6-[4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C22H27N5O3
|
1
|
| 1 |
IC50 = 601 nM
|
|
|
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CP0397261
|
6-[4-(1-acetylpiperidin-4-yl)phenyl]-4-amino-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C20H23N5O3
|
1
|
| 1 |
IC50 = 609 nM
|
|
|
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CP0375921
|
4-amino-6-(4-methylphenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C14H14N4O2
|
1
|
| 1 |
IC50 = 681 nM
|
|
|
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CP0281746
|
2-[4-[4-(4-amino-6-methyl-7H-[1,4]dioxino[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid
Show/Hide
|
C21H25N3O4
|
1
|
| 1 |
IC50 = 735 nM
|
|
|
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CP0456204
|
4-amino-6-[4-[4-(2H-tetrazol-5-ylmethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
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|
C21H24N8O2
|
1
|
| 1 |
IC50 = 774 nM
|
|
|
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CP0397262
|
4-amino-6-[4-[1-(1,2-oxazole-3-carbonyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
Show/Hide
|
C22H22N6O4
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
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CP0390730
|
4-amino-6-[4-[1-(1,2-oxazole-5-carbonyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
Show/Hide
|
C22H22N6O4
|
1
|
| 1 |
IC50 = 1310 nM
|
|
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CP0375920
|
2-[4-[4-(4-amino-7,8-dihydro-5H-pyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]ethanol
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|
C21H28N4O2
|
1
|
| 1 |
IC50 = 1380 nM
|
|
|
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CP0397270
|
4-amino-6-[4-[1-(1,2,5-oxadiazole-3-carbonyl)piperidin-4-yl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one
Show/Hide
|
C21H21N7O4
|
1
|
| 1 |
IC50 = 6750 nM
|
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