Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT06102 , Probable G-protein coupled receptor 142
Gene Name GPR142
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q7Z601
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT06102
 
Compound ID Compound Name Compound Formula
CP0943716
3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
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C20H15F3N6O
 1
1
EC50 = 0.05 nM
   TI
   LI
   LO
   TS
CP0525627
2-[5-[[[5-butyl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carbonyl]amino]methyl]imidazol-1-yl]acetic acid
   Show/Hide
C23H25N7O3S
 1
1
EC50 = 0.2 nM
   TI
   LI
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   TS
CP0887620
N-(3-chlorophenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C19H15ClN6O
 1
1
EC50 = 0.21 nM
   TI
   LI
   LO
   TS
CP0965988
4-methyl-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(trifluoromethoxy)phenyl)benzamide
   Show/Hide
C21H17F3N6O2
 1
1
EC50 = 0.21 nM
   TI
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CP0887621
3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-m-tolylbenzamide
   Show/Hide
C20H18N6O
 1
1
EC50 = 0.37 nM
   TI
   LI
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   TS
CP0903216
N-(3-chlorophenyl)-4-methyl-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H17ClN6O
 1
1
EC50 = 0.37 nM
   TI
   LI
   LO
   TS
CP0903297
N-(3-fluoro-5-(trifluoromethyl)phenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H14F4N6O
 1
1
EC50 < 0.38 nM
   TI
   LI
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   TS
CP0943718
3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-nitrophenyl)benzamide
   Show/Hide
C19H15N7O3
 1
1
EC50 < 0.38 nM
   TI
   LI
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   TS
CP0958685
N-(3-(difluoromethoxy)phenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H16F2N6O2
 1
1
EC50 < 0.38 nM
   TI
   LI
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   TS
CP0969091
N-(3-bromo-5-methylphenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H17BrN6O
 1
1
EC50 < 0.38 nM
   TI
   LI
   LO
   TS
CP0969090
4-methyl-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
   Show/Hide
C21H17F3N6O
 1
1
EC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0943717
N-(2-fluoro-3-(trifluoromethyl)phenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H14F4N6O
 1
1
EC50 = 0.45 nM
   TI
   LI
   LO
   TS
CP0965900
3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(trifluoromethoxy)phenyl)benzamide
   Show/Hide
C20H15F3N6O2
 1
1
EC50 = 0.47 nM
   TI
   LI
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   TS
CP0965901
3-(4-(1,4-dimethyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
   Show/Hide
C21H17F3N6O
 1
1
EC50 = 0.63 nM
   TI
   LI
   LO
   TS
CP0887622
3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)benzamide
   Show/Hide
C21H16F4N6O2
 1
1
EC50 = 0.64 nM
   TI
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   TS
CP0956051
3-(4-(1,4-dimethyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-N-(3-(trifluoromethoxy)phenyl)benzamide
   Show/Hide
C21H17F3N6O2
 1
1
EC50 = 0.64 nM
   TI
   LI
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CP0965989
methyl 3-(3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamido)benzoate
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C21H18N6O3
 1
1
EC50 = 0.73 nM
   TI
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   TS
CP0903299
N-(3-cyanophenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H15N7O
 1
1
EC50 = 0.74 nM
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CP0903301
N-(3-(dimethylamino)phenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C21H21N7O
 1
1
EC50 = 0.85 nM
   TI
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   TS
CP0962197
N-(3-methoxyphenyl)-3-(4-(1-methyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H18N6O2
 1
1
EC50 = 0.86 nM
   TI
   LI
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   TS
CP0965902
N-(3-chlorophenyl)-3-(4-(1,4-dimethyl-1H-imidazol-5-yl)-1H-1,2,3-triazol-1-yl)benzamide
   Show/Hide
C20H17ClN6O
 1
1
EC50 = 0.95 nM
   TI
   LI
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   TS
CP0489368
5-butyl-N-[(3,5-dimethylimidazol-4-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C23H27N7OS
 1
1
EC50 = 1 nM
   TI
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   TS
CP0489369
5-butyl-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C22H25N7OS
 1
1
EC50 = 1 nM
   TI
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   TS
CP0554561
5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C21H23N7O2S
 1
1
EC50 = 1.3 nM
   TI
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   TS
CP0404590
1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-propyl-N-(2-pyridin-4-ylpropan-2-yl)pyrazole-4-carboxamide
   Show/Hide
C24H26N6OS
 1
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
CP0525625
5-butyl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C23H24N6OS
 1
1
EC50 = 7 nM
   TI
   LI
   LO
   TS
CP0859662
N-((1R,3S)-3-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C22H25F3N6O
 2
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
2
EC50 < 120 nM
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   LI
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   TS
CP0449774
5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-pyrrolidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C21H28N8O2
 1
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0701745
3-chloro-N-((1R,3S)-3-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methylbenzamide
   Show/Hide
C21H25ClN6O
 2
1
EC50 = 14 nM
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2
EC50 = 14.4 nM
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CP0943180
N-((2S,4R)-2-(5-(1-(cyclopropylmethyl)-4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C24H27F3N6O2
 1
1
EC50 = 14 nM
   TI
   LI
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   TS
CP0914179
N-((2S,4R)-2-(5-(1-cyclobutyl-4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C24H27F3N6O2
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0339388
5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C22H30N8O2
 1
1
EC50 = 22 nM
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CP0525624
1-[4-(cyclobutylamino)-5-methylpyrimidin-2-yl]-5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]pyrazole-4-carboxamide
   Show/Hide
C21H28N8O2
 1
1
EC50 = 25 nM
   TI
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   TS
CP0374931
(2S)-3-(4-fluorophenyl)-N-[2-methyl-5-[2-(methylamino)pyridin-4-yl]pyrazol-3-yl]-2-(2H-triazol-4-ylmethylamino)propanamide
   Show/Hide
C22H24FN9O
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0939972
3-chloro-N-((2S,4R)-2-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methylbenzamide
   Show/Hide
C20H23ClN6O2
 1
1
EC50 = 27 nM
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CP0489367
1-[4-(azetidin-1-yl)-5-methylpyrimidin-2-yl]-5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]pyrazole-4-carboxamide
   Show/Hide
C20H26N8O2
 1
1
EC50 = 28 nM
   TI
   LI
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   TS
CP0387774
5-(ethoxymethyl)-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C22H22N6O2S
 1
1
EC50 = 30 nM
   TI
   LI
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   TS
CP0487839
5-butyl-N-[(2,3-dimethylimidazol-4-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C23H27N7OS
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0121654
N-[(1R,3S)-3-[(3,5-dimethylimidazol-4-yl)carbamoyl]cyclohexyl]-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C21H25F3N4O2
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0961053
N-((2S,4R)-2-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethoxy)benzamide
   Show/Hide
C21H23F3N6O3
 1
1
EC50 = 30 nM
   TI
   LI
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   TS
CP0859663
N-((1R,3S)-3-(5-(6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-3-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C23H25F3N6O2
 2
1
EC50 = 32 nM
   TI
   LI
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2
EC50 < 120 nM
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CP0939973
3-chloro-N-((2S,4R)-2-(5-(imidazo[1,2-a]pyridin-3-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methylbenzamide
   Show/Hide
C22H21ClN6O2
 1
1
EC50 = 35 nM
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CP0480716
(2S)-N-[5-[2-(methylamino)pyridin-4-yl]-1,3,4-thiadiazol-2-yl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C21H21N7OS2
 1
1
EC50 = 36 nM
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CP0249490
(2S)-N-[2-methyl-5-[2-(methylamino)pyridin-4-yl]pyrazol-3-yl]-3-phenyl-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C23H25N7OS
 1
1
EC50 = 37 nM
   TI
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CP0369079
(2S)-N-(2-methyl-5-pyridin-4-ylpyrazol-3-yl)-3-phenyl-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C22H22N6OS
 1
1
EC50 = 37 nM
   TI
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CP0870287
N-((1R,3S)-3-(5-(1-(2,2-difluoroethyl)-4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C23H25F5N6O
 2
1
EC50 = 41 nM
   TI
   LI
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2
EC50 < 120 nM
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CP0526730
2-[[(2S)-3-(4-fluorophenyl)-1-[[2-methyl-5-[2-(methylamino)pyridin-4-yl]pyrazol-3-yl]amino]-1-oxopropan-2-yl]amino]acetic acid
   Show/Hide
C21H23FN6O3
 1
1
EC50 = 42 nM
   TI
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   TS
CP0678057
N-((2S,4R)-2-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C21H23F3N6O2
 1
1
EC50 = 43 nM
   TI
   LI
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   TS
CP0924820
N-((1R,3S)-3-(5-(1,2-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C22H25F3N6O
 2
1
EC50 = 46 nM
   TI
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2
EC50 < 120 nM
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CP0369078
(2S)-3-(4-fluorophenyl)-N-[2-methyl-5-[2-(methylamino)pyridin-4-yl]pyrazol-3-yl]-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C23H24FN7OS
 1
1
EC50 = 49 nM
   TI
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CP0569457
N-methyl-N-[(1R,3S)-3-[[5-methyl-3-(2-morpholin-4-ylethyl)imidazol-4-yl]carbamoyl]cyclohexyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C26H34F3N5O3
 1
1
EC50 = 51 nM
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CP0047893
(2S)-N-[3-(2-methylpyridin-4-yl)phenyl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C25H24N4OS
 1
1
EC50 = 52 nM
   TI
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CP0042063
2-[[(2S)-1-[(2-methyl-5-pyridin-4-ylpyrazol-3-yl)amino]-1-oxo-3-phenylpropan-2-yl]amino]acetic acid
   Show/Hide
C20H21N5O3
 1
1
EC50 = 52 nM
   TI
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CP0402163
N-[(1R,3S)-3-[[3-(cyclopropylmethyl)-5-methylimidazol-4-yl]carbamoyl]cyclohexyl]-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C24H29F3N4O2
 1
1
EC50 = 52 nM
   TI
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CP0526853
(2S)-N-(3-methoxy-5-pyridin-4-ylphenyl)-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C25H24N4O2S
 2
1
EC50 = 53 nM
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2
EC50 = 810 nM
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CP0939971
N-((2S,4R)-2-(5-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C22H23F3N6O2
 1
1
EC50 = 53 nM
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CP0513075
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-[(1-pyridin-2-ylcyclopropyl)amino]propanamide
   Show/Hide
C27H25N5O2
 1
1
EC50 = 54 nM
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CP0402164
N-[(1R,3S)-3-[[3-(2,2-difluoroethyl)-5-methylimidazol-4-yl]carbamoyl]cyclohexyl]-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C22H25F5N4O2
 1
1
EC50 = 63 nM
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CP0247821
(2S)-N-[5-(2-methylpyridin-4-yl)-2-oxo-1H-pyridin-3-yl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C24H23N5O2S
 2
1
EC50 = 67 nM
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2
EC50 = 290 nM
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CP0301279
(2S)-3-phenyl-N-(3-pyridin-4-ylphenyl)-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C24H22N4OS
 2
1
EC50 = 67 nM
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2
EC50 = 970 nM
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CP0341788
(2S)-3-phenyl-N-[3-(1H-pyrazol-5-yl)phenyl]-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C22H21N5OS
 1
1
EC50 = 67 nM
   TI
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CP0395512
(2S)-3-(4-fluorophenyl)-N-[2-methyl-5-[2-(methylamino)pyridin-4-yl]pyrazol-3-yl]-2-(2H-tetrazol-5-ylmethylamino)propanamide
   Show/Hide
C21H23FN10O
 1
1
EC50 = 71 nM
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CP0402166
N-[(1R,3S)-3-[(3,5-dimethylimidazol-4-yl)carbamoyl]cyclohexyl]-N-methyl-3-(trifluoromethoxy)benzamide
   Show/Hide
C21H25F3N4O3
 1
1
EC50 = 71 nM
   TI
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CP0869212
N-methyl-N-((1R,3S)-3-(5-(4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-3-(trifluoromethyl)benzamide
   Show/Hide
C21H23F3N6O
 2
1
EC50 = 76 nM
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2
EC50 < 120 nM
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CP0406758
(2S)-2-[(2-amino-2-oxoethyl)amino]-3-(4-fluorophenyl)-N-[2-methyl-5-[2-(methylamino)pyridin-4-yl]pyrazol-3-yl]propanamide
   Show/Hide
C21H24FN7O2
 1
1
EC50 = 78 nM
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   TS
CP0564644
N-methyl-N-[(1R,3S)-3-[[5-methyl-3-(2,2,2-trifluoroethyl)imidazol-4-yl]carbamoyl]cyclohexyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C22H24F6N4O2
 1
1
EC50 = 81 nM
   TI
   LI
   LO
   TS
CP0452217
(2S)-3-phenyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C20H18N6OS2
 1
1
EC50 = 86 nM
   TI
   LI
   LO
   TS
CP0481725
(2S)-N-(2-methoxy-5-pyridin-4-ylphenyl)-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C25H24N4O2S
 2
1
EC50 = 89 nM
   TI
   LI
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   TS
2
EC50 = 1000 nM
   TI
   LI
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   TS
CP0470413
5-butyl-N-[(2-methylpyrazol-3-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C22H25N7OS
 1
1
EC50 = 90 nM
   TI
   LI
   LO
   TS
CP0374930
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C23H21N5O2S
 2
1
EC50 = 90 nM
   TI
   LI
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   TS
2
EC50 = 502 nM
   TI
   LI
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   TS
CP0395510
(2S)-3-phenyl-N-(2-pyridin-4-yl-1,3-thiazol-5-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C21H19N5OS2
 2
1
EC50 = 90 nM
   TI
   LI
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   TS
2
EC50 = 161 nM
   TI
   LI
   LO
   TS
CP0360743
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C23H21N5O2S
 3
1
EC50 = 93 nM
   TI
   LI
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   TS
2
EC50 = 500 nM
   TI
   LI
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   TS
3
EC50 = 930 nM
   TI
   LI
   LO
   TS
CP0423881
N-[(1R,3S)-3-[[3-(cyanomethyl)-5-methylimidazol-4-yl]carbamoyl]cyclohexyl]-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C22H24F3N5O2
 1
1
EC50 = 93 nM
   TI
   LI
   LO
   TS
CP0488631
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide
   Show/Hide
C25H23N5O2
 1
1
EC50 = 95 nM
   TI
   LI
   LO
   TS
CP0403868
(2S)-3-phenyl-N-(5-pyridin-4-yl-1H-pyrazol-3-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C21H20N6OS
 2
1
EC50 = 95 nM
   TI
   LI
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   TS
2
EC50 = 164 nM
   TI
   LI
   LO
   TS
CP0526729
ethyl 2-[[(2S)-1-[(2-methyl-5-pyridin-4-ylpyrazol-3-yl)amino]-1-oxo-3-phenylpropan-2-yl]amino]acetate
   Show/Hide
C22H25N5O3
 1
1
EC50 = 95 nM
   TI
   LI
   LO
   TS
CP0376015
5-(ethoxymethyl)-1-(4-ethoxy-5-methylpyrimidin-2-yl)-N-[(3-methylimidazol-4-yl)methyl]pyrazole-4-carboxamide
   Show/Hide
C19H25N7O3
 1
1
EC50 = 96 nM
   TI
   LI
   LO
   TS
CP0413885
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-[(1-pyrimidin-2-ylcyclopropyl)amino]propanamide
   Show/Hide
C26H24N6O2
 1
1
EC50 = 99 nM
   TI
   LI
   LO
   TS
CP0554560
5-butyl-N-(3-methyl-4,5,6,7-tetrahydrobenzimidazol-4-yl)-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C25H29N7OS
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0965062
N-((2S,4R)-2-(5-(6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-3-yl)-4H-1,2,4-triazol-3-yl)tetrahydro-2H-pyran-4-yl)-N-methyl-3-(trifluoromethyl)benzamide
   Show/Hide
C22H23F3N6O3
 1
1
EC50 = 102 nM
   TI
   LI
   LO
   TS
CP0423883
3-chloro-N-[(1R,3S)-3-[[3-(2,2-difluoroethyl)-5-methylimidazol-4-yl]carbamoyl]cyclohexyl]-N-methylbenzamide
   Show/Hide
C21H25ClF2N4O2
 1
1
EC50 = 104 nM
   TI
   LI
   LO
   TS
CP0349499
3-[[(2S)-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanoyl]amino]-5-pyridin-4-ylbenzoic acid
   Show/Hide
C25H22N4O3S
 2
1
EC50 = 110 nM
   TI
   LI
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   TS
2
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0486940
(2S)-2-(1H-imidazol-5-ylmethylamino)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C23H22N6O2
 1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
CP0548909
N-methyl-N-[(1R,3S)-3-[[5-methyl-3-(2,2,2-trifluoroethyl)imidazol-4-yl]carbamoyl]cyclohexyl]-3-(trifluoromethoxy)benzamide
   Show/Hide
C22H24F6N4O3
 1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
CP0374933
2-[[(2S)-3-phenyl-2-(1,3-thiazol-5-ylmethylamino)propanoyl]amino]-5-pyridin-4-ylthiophene-3-carboxylic acid
   Show/Hide
C23H20N4O3S2
 2
1
EC50 = 121 nM
   TI
   LI
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   TS
2
EC50 = 1250 nM
   TI
   LI
   LO
   TS
CP0525573
N-methyl-N-[(1R,3S)-3-[(5-methyl-3-propan-2-ylimidazol-4-yl)carbamoyl]cyclohexyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C23H29F3N4O2
 1
1
EC50 = 131 nM
   TI
   LI
   LO
   TS
CP0423882
N-methyl-N-[(1R,3S)-3-[[5-methyl-3-[(1-methylazetidin-3-yl)methyl]imidazol-4-yl]carbamoyl]cyclohexyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C25H32F3N5O2
 1
1
EC50 = 147 nM
   TI
   LI
   LO
   TS
CP0047894
(2S)-N-[3-(1-methylpyrazol-4-yl)phenyl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C23H23N5OS
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0093721
(2S)-3-phenyl-N-[3-(1H-pyrazol-4-yl)phenyl]-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C22H21N5OS
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0413922
(2S)-N-[5-(3-methylimidazol-4-yl)-1,3,4-thiadiazol-2-yl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C19H19N7OS2
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0566813
(2S)-3-phenyl-N-[5-pyridin-4-yl-2-(2,2,2-trifluoroethyl)pyrazol-3-yl]-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C23H21F3N6OS
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0349498
(2S)-N-[2-oxo-5-(1H-pyrazol-5-yl)-1H-pyridin-3-yl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C21H20N6O2S
 1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
CP0476872
(2S)-2-[[1-(2-methyl-1,3-thiazol-4-yl)cyclopropyl]amino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C26H25N5O2S
 1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
CP0387773
5-butyl-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
   Show/Hide
C23H26N6OS2
 1
1
EC50 = 200 nM
   TI
   LI
   LO
   TS
CP0331814
(2S)-N-[3-(2-aminopyridin-4-yl)phenyl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C24H23N5OS
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0413886
(2S)-2-[(1-methylpyrazol-3-yl)methylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C24H24N6O2
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0452215
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-[[(1S)-1-pyridin-2-ylethyl]amino]propanamide
   Show/Hide
C26H25N5O2
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0114936
(2S)-N-[5-(1-methylpyrazol-4-yl)-2-oxo-1H-pyridin-3-yl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C22H22N6O2S
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0410728
(2S)-N-(4-methoxy-3-pyridin-4-ylphenyl)-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C25H24N4O2S
 2
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
2
EC50 = 980 nM
   TI
   LI
   LO
   TS
CP0489735
1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-propyl-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C22H22N6OS
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0452218
2-[2-oxo-3-[[(2S)-3-phenyl-2-[(1-pyridin-2-ylcyclopropyl)amino]propanoyl]amino]-5-pyridin-4-ylpyridin-1-yl]acetic acid
   Show/Hide
C29H27N5O4
 1
1
EC50 = 260 nM
   TI
   LI
   LO
   TS
CP0406428
(2S)-3-phenyl-N-(3-pyridin-4-yl-1,2-oxazol-5-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C21H19N5O2S
 2
1
EC50 = 263 nM
   TI
   LI
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   TS
2
EC50 = 306 nM
   TI
   LI
   LO
   TS
CP0413884
(2S)-N-[1-[2-(dimethylamino)ethyl]-2-oxo-5-pyridin-4-ylpyridin-3-yl]-3-phenyl-2-[(1-pyridin-2-ylcyclopropyl)amino]propanamide
   Show/Hide
C31H34N6O2
 1
1
EC50 = 280 nM
   TI
   LI
   LO
   TS
CP0397601
(2S)-3-phenyl-N-(2-pyridin-4-yl-1,3-thiazol-4-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C21H19N5OS2
 2
1
EC50 = 287 nM
   TI
   LI
   LO
   TS
2
EC50 = 452 nM
   TI
   LI
   LO
   TS
CP0507370
(2S)-3-phenyl-N-(4-pyridin-4-ylpyrimidin-2-yl)-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C22H20N6OS
 2
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
2
EC50 = 360 nM
   TI
   LI
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   TS
CP0480717
(2S)-N-(2-methoxy-5-pyridin-4-ylpyridin-3-yl)-3-phenyl-2-[(1-pyridin-2-ylcyclopropyl)amino]propanamide
   Show/Hide
C28H27N5O2
 1
1
EC50 = 350 nM
   TI
   LI
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   TS
CP0452208
(2S)-2-[[(2R)-oxolan-2-yl]methylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C24H26N4O3
 1
1
EC50 = 390 nM
   TI
   LI
   LO
   TS
CP0513072
(2S)-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)-N-[5-(1,3-thiazol-5-yl)-1,3,4-thiadiazol-2-yl]propanamide
   Show/Hide
C18H16N6OS3
 1
1
EC50 = 390 nM
   TI
   LI
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   TS
CP0513073
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(pyrimidin-2-ylmethylamino)propanamide
   Show/Hide
C24H22N6O2
 1
1
EC50 = 440 nM
   TI
   LI
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   TS
CP0482488
2-[5-[[(2S)-3-phenyl-2-(1,3-thiazol-5-ylmethylamino)propanoyl]amino]-3-pyridin-4-ylpyrazol-1-yl]acetic acid
   Show/Hide
C23H22N6O3S
 1
1
EC50 = 516 nM
   TI
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   TS
CP0341789
(2S)-3-phenyl-N-(3-phenylphenyl)-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C25H23N3OS
 1
1
EC50 = 640 nM
   TI
   LI
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   TS
CP0481701
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(1-pyridin-2-ylpropylamino)propanamide
   Show/Hide
C27H27N5O2
 1
1
EC50 = 730 nM
   TI
   LI
   LO
   TS
CP0397599
(2S)-3-phenyl-N-(5-pyridin-4-yl-1,3-thiazol-2-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C21H19N5OS2
 2
1
EC50 = 734 nM
   TI
   LI
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   TS
2
EC50 = 1040 nM
   TI
   LI
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   TS
CP0481726
(2S)-2-(cyclopropylmethylamino)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C23H24N4O2
 1
1
EC50 = 760 nM
   TI
   LI
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   TS
CP0377336
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(2-phenylethylamino)propanamide
   Show/Hide
C27H26N4O2
 1
1
EC50 = 780 nM
   TI
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   TS
CP0497660
(2S)-2-(benzylamino)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C26H24N4O2
 1
1
EC50 = 830 nM
   TI
   LI
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   TS
CP0489734
5-ethyl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C21H20N6OS
 1
1
EC50 = 1000 nM
   TI
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   TS
CP0525623
1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-pentyl-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C24H26N6OS
 1
1
EC50 = 1000 nM
   TI
   LI
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   TS
CP0476873
(2S)-2-[2-(oxan-4-yl)ethylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C26H30N4O3
 1
1
EC50 = 1060 nM
   TI
   LI
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   TS
CP0414754
(2S)-3-phenyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C21H19N5OS2
 2
1
EC50 = 1081 nM
   TI
   LI
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   TS
2
EC50 = 1110 nM
   TI
   LI
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   TS
CP0500981
5-butan-2-yl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C23H24N6OS
 1
1
EC50 = 1200 nM
   TI
   LI
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   TS
CP0476874
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(2-pyridin-2-ylethylamino)propanamide
   Show/Hide
C26H25N5O2
 1
1
EC50 = 1320 nM
   TI
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   TS
CP0253142
5-(methoxymethyl)-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C21H20N6O2S
 1
1
EC50 = 1500 nM
   TI
   LI
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   TS
CP0114935
(2S)-N-[3-(1-methylpyrazol-3-yl)phenyl]-3-phenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C23H23N5OS
 1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0520368
(2S)-3-phenyl-N-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
   Show/Hide
C20H19N7OS
 1
1
EC50 = 2170 nM
   TI
   LI
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   TS
CP0452209
(2S)-2-[(5-methyl-1,2-oxazol-3-yl)methylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
   Show/Hide
C24H23N5O3
 1
1
EC50 = 2200 nM
   TI
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   TS
CP0452219
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-2-[[(2R)-5-oxopyrrolidin-2-yl]methylamino]-3-phenylpropanamide
   Show/Hide
C24H25N5O3
 1
1
EC50 = 2230 nM
   TI
   LI
   LO
   TS
CP0542235
(2S)-3-phenyl-1-(6-pyridin-4-yl-2,3-dihydroimidazo[1,2-b]pyrazol-1-yl)-2-(1,3-thiazol-5-ylmethylamino)propan-1-one
   Show/Hide
C23H22N6OS
 1
1
EC50 = 2780 nM
   TI
   LI
   LO
   TS
CP0407848
N-ethyl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-propyl-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
   Show/Hide
C24H26N6OS
 1
1
EC50 = 3000 nM
   TI
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   TS
CP0125163
(2S)-N,3-diphenyl-2-(1,3-thiazol-4-ylmethylamino)propanamide
   Show/Hide
C19H19N3OS
 1
1
EC50 = 3300 nM
   TI
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   TS
CP0400660
(2S)-2-amino-3-(4-chlorophenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
   Show/Hide
C19H17ClN4O2
 1
1
EC50 = 3800 nM
   TI
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   TS
CP0526855
(2S)-2-amino-3-(4-fluorophenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
   Show/Hide
C19H17FN4O2
 1
1
EC50 = 4200 nM
   TI
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   TS
CP0526856
(2S)-2-amino-3-(4-cyanophenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
   Show/Hide
C20H17N5O2
 1
1
EC50 = 4600 nM
   TI
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   TS
CP0383672
(2S)-2-amino-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
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C19H18N4O2
 1
1
EC50 = 4800 nM
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CP0486941
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-[[(1R)-1-pyridin-2-ylethyl]amino]propanamide
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C26H25N5O2
 1
1
EC50 = 6000 nM
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CP0536577
(2S)-2-amino-3-(4-methylphenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
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C20H20N4O2
 1
1
EC50 = 6600 nM
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CP0452214
(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(2-pyridin-2-ylpropan-2-ylamino)propanamide
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C27H27N5O2
 1
1
EC50 = 9450 nM
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CP0526854
(2R)-2-amino-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
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C19H18N4O2
 1
1
EC50 = 13000 nM
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CP0491804
N-[(1-methylimidazol-4-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-propylpyrazole-4-carboxamide
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C21H23N7OS
 1
1
EC50 = 15000 nM
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CP0452216
(2S)-2-[(1,1-dioxothian-4-yl)methylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
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C25H28N4O4S
 1
1
EC50 = 20000 nM
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CP0407844
5-butyl-N-(1H-indol-3-ylmethyl)-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carboxamide
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C26H26N6OS
 1
1
EC50 > 20000 nM
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CP0407845
N-[(3-methyl-1,2-oxazol-5-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-propylpyrazole-4-carboxamide
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C21H22N6O2S
 1
1
EC50 > 20000 nM
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CP0383694
(2S)-2-amino-3-(4-methoxyphenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
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C20H20N4O3
 1
1
EC50 = 25000 nM
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CP0400658
2-amino-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)acetamide
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C12H12N4O2
 1
1
EC50 > 33000 nM
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CP0416289
(2S)-2-amino-3-(2-chlorophenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
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C19H17ClN4O2
 1
1
EC50 > 33000 nM
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CP0416290
(2S)-2-amino-3-(3-chlorophenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
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C19H17ClN4O2
 1
1
EC50 > 33000 nM
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CP0481724
(2S)-2-amino-3-cyclohexyl-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
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C19H24N4O2
 1
1
EC50 > 33000 nM
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CP0497659
(2S)-2-amino-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-2-phenylacetamide
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C18H16N4O2
 1
1
EC50 > 33000 nM
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CP0536578
(2S)-2-acetamido-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
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C21H20N4O3
 1
1
EC50 > 33000 nM
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CP0544660
N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide
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C19H17N3O2
 1
1
EC50 > 33000 nM
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CP0374929
(2S)-3-phenyl-N-(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)-2-(1,3-thiazol-5-ylmethylamino)propanamide
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C20H18N6O2S
 1
1
EC50 > 33000 nM
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CP0942968
Cis-3-chloro-N-((1R,3S)-3-(5-(1,2-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methylbenzamide
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C21H25ClN6O
 1
1
EC50 < 120 nM
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CP0956139
Cis-3-chloro-N-((1R,3S)-3-(5-(1-(2-methoxyethyl)-4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methylbenzamide
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C23H29ClN6O2
 1
1
EC50 < 120 nM
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CP0958176
Cis-rac-3-chloro-N-((1S,3R)-3-(5-(1,4-dimethyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-N-methylbenzamide
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C21H25ClN6O
 1
1
EC50 < 120 nM
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CP0961952
Cis-3-chloro-N-methyl-N-((1R,3S)-3-(5-(4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)benzamide
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C20H23ClN6O
 1
1
EC50 < 120 nM
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CP0962744
Cis-N-methyl-N-((1R,3S)-3-(5-(2-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-3-(trifluoromethyl)benzamide
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C21H23F3N6O
 1
1
EC50 < 120 nM
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CP0965850
N-methyl-N-((1R,3S)-3-(5-(4-methyl-1H-imidazol-5-yl)-4H-1,2,4-triazol-3-yl)cyclohexyl)-3-(trifluoromethoxy)benzamide
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C21H23F3N6O2
 1
1
EC50 < 120 nM
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