Protein Information

General Information of the Protein

Protein ID	PT06102
Protein Name	Probable G-protein coupled receptor 142
Secondarily Protein Name	G-protein coupled receptor PGR2
Gene Name	GPR142
Secondarily Gene Name	PGR2
Sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor
Function	Orphan receptor. Show/Hide
Uniprot ID	Primary ID: Q7Z601 Secondarily ID: A4CYJ8 Q86SL3 Show/Hide
Ensembl ID	ENSG00000257008
HGNC ID	HGNC:20088
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0155420 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[4-(2-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C20H16Cl2N6O	2
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
2	EC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0432996 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C20H16Cl2N6O	2
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
2	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0475865 Compound Info	N-(2,3-dichlorophenyl)-2-[4-(4-imidazol-1-ylphenyl)triazol-1-yl]acetamide Show/Hide	C19H14Cl2N6O	2
1	EC50 = 16 nM Bioactivity Info	TI LI LO TS
2	EC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0155419 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[6-(2-methylimidazol-1-yl)pyridin-3-yl]triazol-1-yl]acetamide Show/Hide	C19H15Cl2N7O	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0094466 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C20H15Cl2FN6O	2
1	EC50 = 32 nM Bioactivity Info	TI LI LO TS
2	EC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0419292 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C21H18Cl2N6O2	2
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
2	EC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0433029 Compound Info	N-(2,3-dimethylphenyl)-2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C23H24N6O2	2
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
2	EC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0419296 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[2-fluoro-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C20H15Cl2FN6O	2
1	EC50 = 77 nM Bioactivity Info	TI LI LO TS
2	EC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0008174 Compound Info	2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-N-naphthalen-1-ylacetamide Show/Hide	C25H22N6O2	2
1	EC50 = 115 nM Bioactivity Info	TI LI LO TS
2	EC50 = 252 nM Bioactivity Info	TI LI LO TS
CP0432995 Compound Info	N-(2,3-dichlorophenyl)-2-[4-[4-[(2-methylimidazol-1-yl)methyl]phenyl]triazol-1-yl]acetamide Show/Hide	C21H18Cl2N6O	2
1	EC50 = 589 nM Bioactivity Info	TI LI LO TS
2	EC50 = 716 nM Bioactivity Info	TI LI LO TS
CP0432994 Compound Info	N-(2,3-difluorophenyl)-2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C21H18F2N6O2	2
1	EC50 = 634 nM Bioactivity Info	TI LI LO TS
2	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0432997 Compound Info	N-(2,3-dichlorophenyl)-N-methyl-2-[4-[4-(2-methylimidazol-1-yl)phenyl]triazol-1-yl]acetamide Show/Hide	C21H18Cl2N6O	1
1	EC50 = 4995 nM Bioactivity Info	TI LI LO TS
CP0419293 Compound Info	N-(2,3-dichlorophenyl)-2-methyl-2-[4-[4-(2-methylimidazol-1-yl)phenyl]triazol-1-yl]propanamide Show/Hide	C22H20Cl2N6O	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0445954 Compound Info	2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide Show/Hide	C25H26N6O2	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0400990 Compound Info	N-[[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]methyl]naphthalen-1-amine Show/Hide	C24H22N6O	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0431887 Compound Info	N-[[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]methyl]naphthalene-1-carboxamide Show/Hide	C25H22N6O2	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0432998 Compound Info	1-[[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]methyl]-3-naphthalen-1-ylurea Show/Hide	C25H23N7O2	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0466144 Compound Info	N-(3-chlorophenyl)-10-(2-methylpyridin-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-amine Show/Hide	C22H18ClN5O	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0466143 Compound Info	10-(2-methylpyridin-4-yl)-N-[3-(trifluoromethoxy)phenyl]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-amine Show/Hide	C23H18F3N5O2	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0421592 Compound Info	10-pyridin-4-yl-N-[3-(trifluoromethyl)phenyl]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-amine Show/Hide	C22H16F3N5O	1
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
CP0568480 Compound Info	3-(3-chloro-2-fluorophenoxy)-10-(2-methylpyridin-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepine Show/Hide	C22H16ClFN4O2	1
1	IC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0558265 Compound Info	3-(3-chlorophenoxy)-10-(2-methylpyridin-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepine Show/Hide	C22H17ClN4O2	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0566008 Compound Info	10-pyridin-4-yl-N-[3-(trifluoromethoxy)phenyl]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-amine Show/Hide	C22H16F3N5O2	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0568481 Compound Info	10-(2-methylpyridin-4-yl)-N-[3-(trifluoromethyl)phenyl]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-amine Show/Hide	C23H18F3N5O	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0546099 Compound Info	10-(2-ethylpyridin-4-yl)-N-[3-(trifluoromethyl)phenyl]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepin-3-amine Show/Hide	C24H20F3N5O	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0421591 Compound Info	10-(2-methylpyridin-4-yl)-3-[3-(trifluoromethoxy)phenoxy]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepine Show/Hide	C23H17F3N4O3	1
1	IC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0421603 Compound Info	N-(3-cyanophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C22H18N4O2	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0421590 Compound Info	10-(2-methylpyridin-4-yl)-3-[2-(trifluoromethoxy)phenoxy]-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepine Show/Hide	C23H17F3N4O3	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0546098 Compound Info	3-(2-chlorophenoxy)-10-(2-methylpyridin-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepine Show/Hide	C22H17ClN4O2	1
1	IC50 = 102 nM Bioactivity Info	TI LI LO TS
CP0466150 Compound Info	N-(3-chlorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H18ClN3O2	1
1	IC50 = 108 nM Bioactivity Info	TI LI LO TS
CP0421594 Compound Info	N-(3-cyanophenyl)-7-imidazol-1-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C20H17N5O2	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0497286 Compound Info	N-(3-chloro-4-fluorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H17ClFN3O2	1
1	IC50 = 132 nM Bioactivity Info	TI LI LO TS
CP0421600 Compound Info	N-(3,4-dichlorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H17Cl2N3O2	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0421597 Compound Info	N-(3,4-dichlorophenyl)-7-pyridin-4-yl-1,2,3,5-tetrahydro-1,4-benzodiazepine-4-carboxamide Show/Hide	C21H18Cl2N4O	1
1	IC50 = 146 nM Bioactivity Info	TI LI LO TS
CP0560535 Compound Info	7-pyridin-4-yl-N-[3-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C22H18F3N3O2	1
1	IC50 = 158 nM Bioactivity Info	TI LI LO TS
CP0558267 Compound Info	N-(3-chloro-2-fluorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H17ClFN3O2	1
1	IC50 = 163 nM Bioactivity Info	TI LI LO TS
CP0546100 Compound Info	N-(3-methoxyphenyl)-7-(3-methoxypyridin-4-yl)-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C23H23N3O4	1
1	IC50 = 187 nM Bioactivity Info	TI LI LO TS
CP0560536 Compound Info	N-(3-fluorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H18FN3O2	1
1	IC50 = 224 nM Bioactivity Info	TI LI LO TS
CP0560537 Compound Info	N-(3-methoxyphenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C22H21N3O3	1
1	IC50 = 249 nM Bioactivity Info	TI LI LO TS
CP0490372 Compound Info	N-(3-phenylphenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C27H23N3O2	1
1	IC50 = 343 nM Bioactivity Info	TI LI LO TS
CP0572990 Compound Info	N-(3-methoxyphenyl)-7-(2-methylpyridin-4-yl)-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C23H23N3O3	1
1	IC50 = 374 nM Bioactivity Info	TI LI LO TS
CP0485432 Compound Info	N-(3-methoxyphenyl)-7-(3-methylpyridin-4-yl)-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C23H23N3O3	1
1	IC50 = 394 nM Bioactivity Info	TI LI LO TS
CP0500791 Compound Info	N-(2-methoxyphenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C22H21N3O3	1
1	IC50 = 517 nM Bioactivity Info	TI LI LO TS
CP0500788 Compound Info	3-[(3-chlorophenyl)methyl]-10-(2-methylpyridin-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-d][1,4]benzoxazepine Show/Hide	C23H19ClN4O	1
1	IC50 = 593 nM Bioactivity Info	TI LI LO TS
CP0568468 Compound Info	N-(2,3-dichlorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H17Cl2N3O2	1
1	IC50 = 708 nM Bioactivity Info	TI LI LO TS
CP0421604 Compound Info	N-phenyl-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H19N3O2	1
1	IC50 = 793 nM Bioactivity Info	TI LI LO TS
CP0500790 Compound Info	7-(2-aminopyridin-4-yl)-N-(3-cyanophenyl)-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C22H19N5O2	1
1	IC50 = 810 nM Bioactivity Info	TI LI LO TS
CP0421595 Compound Info	N-(3,4-dichlorophenyl)-8-pyridin-4-yl-1,3,4,5-tetrahydro-2-benzazepine-2-carboxamide Show/Hide	C22H19Cl2N3O	1
1	IC50 = 839 nM Bioactivity Info	TI LI LO TS
CP0466145 Compound Info	N-(3-methoxyphenyl)-7-quinolin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C26H23N3O3	1
1	IC50 = 962 nM Bioactivity Info	TI LI LO TS
CP0466148 Compound Info	N-(4-fluorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H18FN3O2	1
1	IC50 = 1220 nM Bioactivity Info	TI LI LO TS
CP0574306 Compound Info	N-(3-methoxyphenyl)-7-pyrimidin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H20N4O3	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0466149 Compound Info	1-(7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepin-4-yl)-2-[3-(trifluoromethyl)phenyl]ethanone Show/Hide	C23H19F3N2O2	1
1	IC50 = 1640 nM Bioactivity Info	TI LI LO TS
CP0421602 Compound Info	N-(3-phenoxyphenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C27H23N3O3	1
1	IC50 = 1720 nM Bioactivity Info	TI LI LO TS
CP0558266 Compound Info	N-(3,4-dichlorophenyl)-7-pyridin-4-yl-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C21H17Cl2N3O	1
1	IC50 = 1850 nM Bioactivity Info	TI LI LO TS
CP0466147 Compound Info	7-pyridin-4-yl-4-[[3-(trifluoromethyl)phenyl]methylsulfonyl]-3,5-dihydro-2H-1,4-benzoxazepine Show/Hide	C22H19F3N2O3S	1
1	IC50 = 2290 nM Bioactivity Info	TI LI LO TS
CP0549438 Compound Info	N-(3-methoxyphenyl)-7-(2-methoxypyridin-4-yl)-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C23H23N3O4	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0564323 Compound Info	N-(2-fluorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C21H18FN3O2	1
1	IC50 = 13100 nM Bioactivity Info	TI LI LO TS
CP0421598 Compound Info	N-(3,4-dichlorophenyl)-5-pyridin-4-yl-1,3-dihydroisoindole-2-carboxamide Show/Hide	C20H15Cl2N3O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0421599 Compound Info	N-(3,4-dichlorophenyl)-1-methyl-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Show/Hide	C22H20Cl2N4O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0421601 Compound Info	N-(3-methoxyphenyl)-N-methyl-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C23H23N3O3	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0466146 Compound Info	N-(3,4-dichlorophenyl)-7-pyridin-4-yl-3,4-dihydro-2H-quinoline-1-carboxamide Show/Hide	C21H17Cl2N3O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0466151 Compound Info	N-(4-methoxyphenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzoxazepine-4-carboxamide Show/Hide	C22H21N3O3	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0497287 Compound Info	1-butyl-N-(3,4-dichlorophenyl)-7-pyridin-4-yl-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide Show/Hide	C25H26Cl2N4O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0546101 Compound Info	N-(3,4-dichlorophenyl)-6-pyridin-4-yl-2,3-dihydroindole-1-carboxamide Show/Hide	C20H15Cl2N3O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han