Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01682 , Serine/threonine-protein kinase TBK1
Gene Name TBK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q9UHD2
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01682
 
Compound ID Compound Name Compound Formula
CP0236829
N-[3-[[2-(3-aminophenyl)-6-bromo-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamide
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C20H23BrN6O
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0134828
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C21H24BrN5O2
 2
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
2
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0273600
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]-N-methylcyclobutanecarboxamide
   Show/Hide
C22H26BrN5O2
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0084379
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamide
   Show/Hide
C22H26BrN5O2
 2
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
2
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0139219
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]-2,2-dimethylpropanamide
   Show/Hide
C21H26BrN5O2
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0139090
N-[3-[[6-bromo-2-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C27H35BrN6O2
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0170218
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]-2-methylpropanamide
   Show/Hide
C20H24BrN5O2
 1
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0139095
N-[3-[[6-bromo-2-(5-fluoro-2-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C21H23BrFN5O2
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0273412
1-(aminomethyl)-N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopropane-1-carboxamide
   Show/Hide
C21H25BrN6O2
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0176898
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopropanecarboxamide
   Show/Hide
C20H22BrN5O2
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0170223
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]thiophene-2-carboxamide
   Show/Hide
C21H20BrN5O2S
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0139221
N-[3-[[6-bromo-2-(4-fluoro-2-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C21H23BrFN5O2
 1
1
EC50 = 34 nM
   TI
   LI
   LO
   TS
CP0170207
N-[3-[[6-bromo-2-(2-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]-2-hydroxypropyl]cyclobutanecarboxamide
   Show/Hide
C21H24BrN5O3
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0139094
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]-3-hydroxycyclobutane-1-carboxamide
   Show/Hide
C21H24BrN5O3
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0170217
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]acetamide
   Show/Hide
C18H20BrN5O2
 1
1
EC50 = 73 nM
   TI
   LI
   LO
   TS
CP0236828
6-bromo-2-(4-methoxyphenyl)-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,5-b]pyridine
   Show/Hide
C19H21BrN4O2
 1
1
EC50 = 76 nM
   TI
   LI
   LO
   TS
CP0237722
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]benzamide
   Show/Hide
C23H22BrN5O2
 1
1
EC50 = 84 nM
   TI
   LI
   LO
   TS
CP0189282
N-[3-[[6-bromo-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]pyridine-3-carboxamide
   Show/Hide
C22H21BrN6O2
 1
1
EC50 = 87 nM
   TI
   LI
   LO
   TS
CP0170205
6-bromo-2-(4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine
   Show/Hide
C19H22BrN5O
 1
1
EC50 = 111 nM
   TI
   LI
   LO
   TS
CP0139091
7-[3-(cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C23H28N6O3
 1
1
EC50 = 139 nM
   TI
   LI
   LO
   TS
CP0139220
7-[3-(cyclobutanecarbonylamino)propylamino]-2-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-imidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C28H37N7O3
 1
1
EC50 = 1460 nM
   TI
   LI
   LO
   TS
CP0084380
2-[7-[3-(cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-1,3-thiazole-4-carboxamide
   Show/Hide
C26H29N7O3S
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0016675
N-(2,2-dimethylpropyl)-4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamide
   Show/Hide
C23H24N4O2S
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0016674
4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylpropyl)thiophene-2-carboxamide
   Show/Hide
C22H22N4O2S
 1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CP0016950
5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-methanesulfonylphenyl)methoxy]thiophene-2-carbonitrile
   Show/Hide
C22H19N3O5S2
 1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
CP0020231
4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(3-methylbutyl)thiophene-2-carboxamide
   Show/Hide
C23H24N4O2S
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0406417
4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylbutyl)thiophene-2-carboxamide
   Show/Hide
C23H24N4O2S
 1
1
IC50 = 89 nM
   TI
   LI
   LO
   TS
CP0247741
2-[7-[3-(cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylpropyl)-1,3-thiazole-4-carboxamide
   Show/Hide
C30H37N7O3S
 1
1
IC50 = 128 nM
   TI
   LI
   LO
   TS
CP0247754
N-(3-hydroxy-2,2-dimethylpropyl)-4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamide
   Show/Hide
C23H24N4O3S
 1
1
IC50 = 136 nM
   TI
   LI
   LO
   TS
CP0134827
N-[3-[[6-carbamothioyl-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-7-yl]amino]propyl]cyclopentanecarboxamide
   Show/Hide
C23H28N6O2S
 1
1
IC50 = 165 nM
   TI
   LI
   LO
   TS
CP0219524
N-(2-methoxyethyl)-4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamide
   Show/Hide
C21H20N4O3S
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0134826
4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxamide
   Show/Hide
C18H14N4O2S
 1
1
IC50 = 268 nM
   TI
   LI
   LO
   TS
CP0496361
N-[3-[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C18H23BrF3N7O
 1
1
IC50 = 321 nM
   TI
   LI
   LO
   TS
CP0496360
N-[3-[[5-bromo-4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C23H30BrN7O2
 1
1
IC50 = 338 nM
   TI
   LI
   LO
   TS
CP0169053
4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
   Show/Hide
C17H17BrF3N7O2S
 1
1
IC50 = 339 nM
   TI
   LI
   LO
   TS
CP0219523
4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-methylthiophene-2-carboxamide
   Show/Hide
C19H16N4O2S
 1
1
IC50 = 851 nM
   TI
   LI
   LO
   TS
CP0134834
1-[4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophen-2-yl]ethanone
   Show/Hide
C19H15N3O2S
 1
1
IC50 = 1780 nM
   TI
   LI
   LO
   TS
CP0273555
4-[[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
   Show/Hide
C25H30N6O3S
 1
1
IC50 = 2050 nM
   TI
   LI
   LO
   TS
CP0106201
2-[7-[3-(cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-1,3-thiazole-4-carboxylic acid
   Show/Hide
C26H28N6O4S
 1
1
IC50 = 2170 nM
   TI
   LI
   LO
   TS
CP0237749
BX-912
   Show/Hide
C20H23BrN8O
 1
1
IC50 = 2327 nM
   TI
   LI
   LO
   TS
CP0275666
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]-5-cyclopropylpyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C26H35N7O2
 1
1
IC50 = 2580 nM
   TI
   LI
   LO
   TS
CP0567307
N-[3-[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C21H28F3N7O
 1
1
IC50 = 2680 nM
   TI
   LI
   LO
   TS
CP0275673
N-[3-[[5-bromo-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C22H24BrN7O3S
 1
1
IC50 = 6170 nM
   TI
   LI
   LO
   TS
CP0551443
4-[[[5-cyclopropyl-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
   Show/Hide
C20H22F3N7O2S
 1
1
IC50 = 7456 nM
   TI
   LI
   LO
   TS
CP0260709
4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
   Show/Hide
C15H17F3N8
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275665
5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C20H24BrN7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275668
4-[[[5-bromo-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
   Show/Hide
C22H25BrN6O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275670
4-[[[2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
   Show/Hide
C22H26N6O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275671
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C23H29N7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275672
N-[3-[[4-[3-(cyclobutanecarbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C23H31N7O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0275674
5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
   Show/Hide
C18H21F3N8
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0344151
4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine
   Show/Hide
C20H25N7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0496362
5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine
   Show/Hide
C15H16BrF3N8
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0496364
4-[[[2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide
   Show/Hide
C17H18F3N7O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0543933
N-[3-[[5-cyclopropyl-4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C25H29N7O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0551444
N-[3-[[4-[(4-sulfamoylphenyl)methylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
   Show/Hide
C22H25N7O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0571203
N-[3-[[2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
   Show/Hide
C18H24F3N7O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0084381
5-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acid
   Show/Hide
C18H13N3O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0084382
5-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-3-carboxylic acid
   Show/Hide
C18H13N3O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0084383
4-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acid
   Show/Hide
C18H13N3O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0219496
5-[2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]furan-3-carboxylic acid
   Show/Hide
C18H13N3O4
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0156199
4-[7-[3-(cyclopentanecarbonylamino)propoxy]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acid
   Show/Hide
C27H28N4O5S
 1
1
IC50 > 3000 nM
   TI
   LI
   LO
   TS