General Information of the Compound
Compound ID
CP0156199
Compound Name
4-[7-[3-(cyclopentanecarbonylamino)propoxy]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]thiophene-2-carboxylic acid
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Structure
Formula
C27H28N4O5S
Molecular Weight
520.611
Canonical SMILES
COc1ccc(cc1)-c1nc2ncc(-c3csc(c3)C(O)=O)c(OCCCNC(=O)C3CCCC3)c2[nH]1
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InChI
InChI=1S/C27H28N4O5S/c1-35-19-9-7-16(8-10-19)24-30-22-23(36-12-4-11-28-26(32)17-5-2-3-6-17)20(14-29-25(22)31-24)18-13-21(27(33)34)37-15-18/h7-10,13-15,17H,2-6,11-12H2,1H3,(H,28,32)(H,33,34)(H,29,30,31)
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InChIKey
DGFPVDWEMXBLRG-UHFFFAOYSA-N
Physicochemical Property
logP
5.1355
Rotatable Bonds
10
Heavy Atom Count
37
Polar Areas
126.43
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 76325461
ChEMBL ID
CHEMBL3125724
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01682, Serine/threonine-protein kinase TBK1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 3000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 460 nM