General Information of the Compound
Compound ID
CP0247741
Compound Name
2-[7-[3-(cyclopentanecarbonylamino)propylamino]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridin-6-yl]-N-(2-methylpropyl)-1,3-thiazole-4-carboxamide
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Structure
Formula
C30H37N7O3S
Molecular Weight
575.739
Canonical SMILES
COc1ccc(cc1)-c1nc2ncc(-c3nc(cs3)C(=O)NCC(C)C)c(NCCCNC(=O)C3CCCC3)c2[nH]1
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InChI
InChI=1S/C30H37N7O3S/c1-18(2)15-34-29(39)23-17-41-30(35-23)22-16-33-27-25(36-26(37-27)19-9-11-21(40-3)12-10-19)24(22)31-13-6-14-32-28(38)20-7-4-5-8-20/h9-12,16-18,20H,4-8,13-15H2,1-3H3,(H,32,38)(H,34,39)(H2,31,33,36,37)
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InChIKey
YSDVXKUGVXDCHH-UHFFFAOYSA-N
Physicochemical Property
logP
5.2512
Rotatable Bonds
12
Heavy Atom Count
41
Polar Areas
133.92
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 76336290
ChEMBL ID
CHEMBL3125720
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01682, Serine/threonine-protein kinase TBK1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 128 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 388 nM