Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01102 , Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name CACNA1C
Organism Homo sapiens, Human
Protein Classification Ion channel
Uniprot ID Q13936
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01102
 
Compound ID Compound Name Compound Formula
CP0223810
Dynacirc
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C19H21N3O5
 1
1
IC50 = 2.2 nM
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CP0424490
CAS_119442
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C28H40N2O5
 1
1
IC50 = 17 nM
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CP0015320
BAY-E-9736
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C21H26N2O7
 1
1
IC50 = 110 nM
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CP0425135
[(1S,8S,9S)-9-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-9-tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl] cyclopropanecarboxylate
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C29H35N3O2
 1
1
IC50 = 140 nM
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CP0539423
[(1S,2R,4R)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-phenylmethoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C37H46FN3O3
 1
1
IC50 = 156 nM
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CP0459982
[(1S,2S,4R)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-4-butyl-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate
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C33H46FN3O3
 1
1
IC50 = 173 nM
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CP0013607
2-methoxyacetic acid [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methyl-amino]ethyl]-6-fluoro-1-isopropyl-tetralin-2-yl] ester;hydrate;hydrochloride
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C29H38FN3O3
 1
1
IC50 = 202 nM
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CP0463072
[(1S,2R,4S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-phenylmethoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C37H46FN3O3
 1
1
IC50 = 225 nM
   TI
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CP0055461
CHEBI:7550
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C26H29N3O6
 1
1
IC50 = 250 nM
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CP0573758
[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C30H40FN3O2
 1
1
IC50 = 347 nM
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CP0463071
[(1R,8R,12R)-12-[2-[3-(4-methoxy-1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-12-tricyclo[6.3.2.02,7]trideca-2,4,6-trienyl] 2-methylpropanoate
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C31H41N3O3
 1
1
IC50 = 387 nM
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CP0428656
[(1S,2R,4S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-methoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C31H42FN3O3
 1
1
IC50 = 403 nM
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CP0553937
[(1R,8R,9R)-9-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-9-tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl] 2-methylpropanoate
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C29H37N3O2
 1
1
IC50 = 424 nM
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CP0404137
[(1S,2R,4S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-hydroxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C30H40FN3O3
 1
1
IC50 = 426 nM
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CP0425136
[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4,4-dimethyl-1-propan-2-yl-1,3-dihydronaphthalen-2-yl] 2-methoxyacetate
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C31H42FN3O3
 1
1
IC50 = 434 nM
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CP0425133
[(1R,8R,12R)-12-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-12-tricyclo[6.3.2.02,7]trideca-2,4,6-trienyl] 2-methylpropanoate
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C30H39N3O2
 1
1
IC50 = 455 nM
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CP0404138
[(1S,2R,4R)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-hydroxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C30H40FN3O3
 1
1
IC50 = 504 nM
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CP0392225
[(1S,2R,4R)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-4-methoxy-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methylpropanoate
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C31H42FN3O3
 1
1
IC50 = 588 nM
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CP0030899
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
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C22H17ClN2
 1
1
IC50 = 590 nM
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CP0428655
[(1S,8S,9S)-9-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-9-tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl] 2-methoxyacetate
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C28H35N3O3
 1
1
IC50 = 748 nM
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CP0541307
N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-ethyl-4-(2,2,2-trifluoroethoxy)phenyl]acetamide
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C22H20F3N5O2
 1
1
IC50 = 1100 nM
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CP0033565
(+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
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C32H41NO2
 1
1
IC50 = 1320 nM
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CP0035893
(Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine
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C21H26N2S2
 1
1
IC50 = 1320 nM
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CP0382464
5-(4-bromophenyl)-N-cyclohexyl-3-(4-fluorophenyl)-3,4-dihydropyrazole-2-carboxamide
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C22H23BrFN3O
 1
1
IC50 = 1340 nM
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CP0278751
BEPRIDIL HYDROCHLORIDE
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C24H34N2O
 1
1
IC50 = 1400 nM
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CP0366788
N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(trifluoromethoxy)phenyl]acetamide
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C20H16F3N5O2
 1
1
IC50 = 1480 nM
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CP0459416
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-(2-phenylethyl)-3,4-dihydropyrazole-2-carboxamide
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C24H21BrFN3O
 1
1
IC50 = 1880 nM
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CP0376861
N-(4-fluorophenyl)-5-(2-hydroxyethyl)-3,5-diphenyl-4H-pyrazole-1-carboxamide
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C24H22FN3O2
 1
1
IC50 = 1940 nM
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CP0227177
N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(3,3,3-trifluoropropoxy)phenyl]acetamide
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C22H20F3N5O2
 1
1
IC50 = 2080 nM
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CP0567829
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-pyridin-2-yl-3,4-dihydropyrazole-2-carboxamide
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C21H16BrFN4O
 1
1
IC50 = 2180 nM
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CP0399522
5-[2-(dimethylamino)ethyl]-N-(4-fluorophenyl)-5-(4-methylphenyl)-3-phenyl-4H-pyrazole-1-carboxamide
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C27H29FN4O
 1
1
IC50 = 2200 nM
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CP0399517
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-propan-2-yl-3,4-dihydropyrazole-2-carboxamide
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C19H19BrFN3O
 1
1
IC50 = 2360 nM
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CP0085643
Act-709478
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C22H18F3N5O
 1
1
IC50 = 2410 nM
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CP0412178
2-(4-tert-butylphenyl)-N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]acetamide
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C22H23N5O
 1
1
IC50 = 2420 nM
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CP0399518
N,5-bis(4-fluorophenyl)-5-(hydroxymethyl)-3-phenyl-4H-pyrazole-1-carboxamide
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C23H19F2N3O2
 1
1
IC50 = 2650 nM
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CP0425128
3-(1H-benzimidazol-2-yl)-N-[2-[(1S,8S,9S)-9-methoxy-9-tricyclo[6.2.2.02,7]dodeca-2,4,6-trienyl]ethyl]-N-methylpropan-1-amine
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C26H33N3O
 1
1
IC50 = 2670 nM
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CP0482178
N-(1-benzylpyrazol-3-yl)-2-(3-chlorophenyl)acetamide
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C18H16ClN3O
 1
1
IC50 = 2800 nM
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CP0380491
3-(4-fluorophenyl)-5-phenyl-N-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamide
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C21H17FN4O
 1
1
IC50 = 3090 nM
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CP0255833
N-[1-[(5-cyanopyridin-2-yl)methyl]pyrazol-3-yl]-2-[3-methyl-4-(2,2,2-trifluoroethoxy)phenyl]acetamide
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C21H18F3N5O2
 1
1
IC50 = 3310 nM
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CP0542453
N-(4-fluorophenyl)-5-(4-methylphenyl)-5-[2-(4-methylpiperazin-1-yl)ethyl]-3-phenyl-4H-pyrazole-1-carboxamide
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C30H34FN5O
 1
1
IC50 = 3600 nM
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CP0463866
N-(4-fluorophenyl)-3-methyl-5-phenyl-3,4-dihydropyrazole-2-carboxamide
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C17H16FN3O
 1
1
IC50 = 3900 nM
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CP0399520
(5R)-N-(4-bromophenyl)-5-(2-hydroxyethyl)-5-(4-methoxyphenyl)-3-pyridin-3-yl-4H-pyrazole-1-carboxamide
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C24H23BrN4O3
 1
1
IC50 = 4800 nM
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CP0459417
(3S)-N,3-bis(4-fluorophenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamide
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C21H16F2N4O
 1
1
IC50 = 5400 nM
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CP0435082
methyl 5-[3-(1H-benzimidazol-2-yl)propyl-methylamino]-2-(4-bromophenyl)-5-oxo-2-propan-2-ylpentanoate
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C26H32BrN3O3
 1
1
IC50 = 5420 nM
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CP0408272
(5R)-N-(4-chlorophenyl)-5-(2-hydroxyethyl)-3-(4-methoxyphenyl)-5-pyridin-3-yl-4H-pyrazole-1-carboxamide
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C24H23ClN4O3
 1
1
IC50 = 5700 nM
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CP0458312
methyl 2-(4-bromophenyl)-5-[4-(2-methoxyphenyl)piperazin-1-yl]-5-oxo-2-propan-2-ylpentanoate
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C26H33BrN2O4
 1
1
IC50 = 5900 nM
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CP0459412
N-(4-fluorophenyl)-5-(4-methylphenyl)-5-(2-morpholin-4-ylethyl)-3-phenyl-4H-pyrazole-1-carboxamide
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C29H31FN4O2
 1
1
IC50 = 5900 nM
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CP0554826
N-(4-fluorophenyl)-5-(2-hydroxyethyl)-5-[4-(2-methoxyethoxy)phenyl]-3-phenyl-4H-pyrazole-1-carboxamide
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C27H28FN3O4
 1
1
IC50 = 6300 nM
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CP0059960
N,3-bis(4-fluorophenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamide
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C21H16F2N4O
 1
1
IC50 = 6400 nM
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CP0477388
N-[1-[(3,4-difluorophenyl)methyl]pyrazol-3-yl]-2-[4-(dimethylamino)phenyl]acetamide
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C20H20F2N4O
 1
1
IC50 = 7100 nM
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CP0398337
(3R)-N,3-bis(4-fluorophenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamide
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C21H16F2N4O
 1
1
IC50 = 7800 nM
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CP0574410
1-(2,6-diethylphenyl)-3-(N'-ethylcarbamimidoyl)urea
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C14H22N4O
 1
1
IC50 = 8350 nM
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CP0566172
N-(4-fluorophenyl)-5-(2-hydroxyethyl)-5-(4-methylphenyl)-3-pyridin-4-yl-4H-pyrazole-1-carboxamide
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C24H23FN4O2
 1
1
IC50 = 8600 nM
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CP0376862
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-phenyl-3,4-dihydropyrazole-2-carboxamide
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C22H17BrFN3O
 1
1
IC50 > 10000 nM
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CP0380490
5-(4-bromophenyl)-N-(4-ethylphenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazole-2-carboxamide
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C24H21BrFN3O
 1
1
IC50 > 10000 nM
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CP0382465
N,3-bis(4-fluorophenyl)-5-(1-oxidopyridin-1-ium-4-yl)-3,4-dihydropyrazole-2-carboxamide
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C21H16F2N4O2
 1
1
IC50 > 10000 nM
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CP0398336
5-(4-bromophenyl)-3-(4-fluorophenyl)-N-(4-methoxyphenyl)-3,4-dihydropyrazole-2-carboxamide
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C23H19BrFN3O2
 1
1
IC50 > 10000 nM
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CP0399519
5-[4-[2-(dimethylamino)ethoxy]phenyl]-N-(4-fluorophenyl)-5-(2-hydroxyethyl)-3-phenyl-4H-pyrazole-1-carboxamide
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C28H31FN4O3
 1
1
IC50 > 10000 nM
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CP0399521
N-(4-fluorophenyl)-5-(methoxymethyl)-5-(4-methylphenyl)-3-phenyl-4H-pyrazole-1-carboxamide
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C25H24FN3O2
 1
1
IC50 > 10000 nM
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CP0410029
N-(4-bromophenyl)-5-(2-hydroxyethyl)-5-(4-methoxyphenyl)-3-pyridin-3-yl-4H-pyrazole-1-carboxamide
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C24H23BrN4O3
 1
1
IC50 > 10000 nM
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CP0459413
5-(4-bromophenyl)-N-(3-fluorophenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazole-2-carboxamide
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C22H16BrF2N3O
 1
1
IC50 > 10000 nM
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CP0459414
[5-(4-bromophenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]-phenylmethanone
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C22H16BrFN2O
 1
1
IC50 > 10000 nM
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CP0459418
N-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)-5-phenyl-3,4-dihydropyrazole-2-carboxamide
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C23H20FN3O3S
 1
1
IC50 > 10000 nM
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CP0469496
N,3-bis(4-fluorophenyl)-5-phenyl-3,4-dihydropyrazole-2-carboxamide
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C22H17F2N3O
 1
1
IC50 > 10000 nM
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CP0469497
N,3-bis(4-fluorophenyl)-5-methyl-3,4-dihydropyrazole-2-carboxamide
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C17H15F2N3O
 1
1
IC50 > 10000 nM
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CP0520712
N-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)-5-pyridin-4-yl-3,4-dihydropyrazole-2-carboxamide
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C22H19FN4O3S
 1
1
IC50 > 10000 nM
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CP0554828
5-(4-bromophenyl)-N,3-bis(4-fluorophenyl)-3,4-dihydropyrazole-2-carboxamide
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C22H16BrF2N3O
 1
1
IC50 > 10000 nM
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CP0555467
N-(4-fluorophenyl)-5-(2-hydroxyethyl)-5-(4-methylsulfonylphenyl)-3-phenyl-4H-pyrazole-1-carboxamide
   Show/Hide
C25H24FN3O4S
 1
1
IC50 > 10000 nM
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CP0555472
5-(4-bromophenyl)-N-(2-fluorophenyl)-3-(4-fluorophenyl)-3,4-dihydropyrazole-2-carboxamide
   Show/Hide
C22H16BrF2N3O
 1
1
IC50 > 10000 nM
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CP0567831
5-(4-bromophenyl)-N,3-bis(4-fluorophenyl)-3,4-dihydropyrazole-2-carbothioamide
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C22H16BrF2N3S
 1
1
IC50 > 10000 nM
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CP0032823
3-chloro-4-[(3R,4S)-4-(4-chlorophenyl)sulfonyl-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl]sulfonylbenzonitrile
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C18H16Cl2N2O6S2
 1
1
IC50 > 10000 nM
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CP0006743
4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
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C16H19NO3S
 1
1
IC50 > 15848.93 nM
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CP0010657
CAS_99200-09-6
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C22H25F2NO4
 1
1
IC50 = 15848.93 nM
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CP0034615
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
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C20H24N2O2
 1
1
IC50 = 19820 nM
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CP0041613
Anapriline
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C16H21NO2
 1
1
IC50 = 21000 nM
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CP0542508
N-benzyl-3,5-diethyl-4-[(N'-ethylcarbamimidoyl)carbamoylamino]benzamide
   Show/Hide
C22H29N5O2
 1
1
IC50 = 22500 nM
   TI
   LI
   LO
   TS
CP0001111
(2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol
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C19H26N6O
 1
1
IC50 = 23400 nM
   TI
   LI
   LO
   TS
CP0007317
(+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol
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C22H31NO
 1
1
IC50 = 25118.86 nM
   TI
   LI
   LO
   TS
CP0008168
CAS_136434-34-9
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C18H19NOS
 1
1
IC50 = 25118.86 nM
   TI
   LI
   LO
   TS
CP0569879
Lidamidine
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C11H16N4O
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0569881
3,5-diethyl-4-[(N'-ethylcarbamimidoyl)carbamoylamino]-N-propan-2-ylbenzamide
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C18H29N5O2
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0569882
1-[2,6-diethyl-4-(ethylsulfamoyl)phenyl]-3-(N'-ethylcarbamimidoyl)urea
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C16H27N5O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0574560
1-[4-(benzenesulfonamido)-2,6-diethylphenyl]-3-(N'-ethylcarbamimidoyl)urea
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C20H27N5O3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0084730
Oliceridine
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C22H30N2O2S
 1
1
IC50 = 36000 nM
   TI
   LI
   LO
   TS
CP0077731
(+)-cis-Diltiazem
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C22H26N2O4S
 1
1
IC50 = 44000 nM
   TI
   LI
   LO
   TS
CP0006292
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
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C18H24O2
 1
1
IC50 = 50000 nM
   TI
   LI
   LO
   TS
CP0395472
2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]-N-(thiophen-2-ylmethyl)ethanamine
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C21H28N2OS
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0425132
[(1S,8S,9S)-9-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-3,6-diazatricyclo[6.2.2.02,7]dodeca-2,4,6-trien-9-yl] 2-methylpropanoate
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C27H35N5O2
 1
1
IC50 > 4600 nM
   TI
   LI
   LO
   TS