| Compound ID |
Compound Name |
Compound Formula |
|
CP0429355
|
5-[(2,3-difluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
|
C15H14F2N4O2S2
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
Kd = 1.259 nM
|
|
|
|
CP0444372
|
5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
|
C15H14ClFN4O2S2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0560130
|
2-[(2,3-difluorophenyl)methylsulfanyl]-4-[[(2R)-1-hydroxypropan-2-yl]amino]-8H-pteridin-7-one
Show/Hide
|
C16H15F2N5O2S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0467717
|
methyl 2-[(2,3-difluorophenyl)methylsulfanyl]-4-[[(2R)-1-hydroxypropan-2-yl]amino]-7-oxo-8H-pteridine-6-carboxylate
Show/Hide
|
C18H17F2N5O4S
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0511668
|
5-[(2-fluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
|
C15H15FN4O2S2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0388858
|
N-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide
Show/Hide
|
C17H21ClFN5O3S2
|
2
|
| 1 |
IC50 = 2.512 nM
|
|
|
| 2 |
Kd = 10 nM
|
|
|
|
CP0457799
|
(2R)-2-[[2-amino-5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C15H15ClFN5OS2
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 3.981 nM
|
|
|
|
CP0404926
|
(2R)-2-[[2-amino-5-[(2,3-difluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C15H15F2N5OS2
|
3
|
| 1 |
IC50 = 3.981 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
| 3 |
Kd = 12.59 nM
|
|
|
|
CP0527807
|
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]morpholine-4-sulfonamide
Show/Hide
|
C18H23F2N5O4S2
|
2
|
| 1 |
IC50 = 3.981 nM
|
|
|
| 2 |
Kd = 10 nM
|
|
|
|
CP0561043
|
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]azetidine-1-sulfonamide
Show/Hide
|
C17H21F2N5O3S2
|
2
|
| 1 |
IC50 = 3.981 nM
|
|
|
| 2 |
Kd = 1.995 nM
|
|
|
|
CP0462409
|
5-benzylsulfanyl-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
|
C15H16N4O2S2
|
2
|
| 1 |
IC50 = 4.5 nM
|
|
|
| 2 |
IC50 = 5 nM
|
|
|
|
CP0457801
|
5-(furan-2-ylmethylsulfanyl)-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
|
C13H14N4O3S2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0471423
|
N-[5-[(2,3-difluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-[1,3]thiazolo[4,5-d]pyrimidin-2-yl]methanesulfonamide
Show/Hide
|
C16H17F2N5O3S3
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0429357
|
N-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]morpholine-4-sulfonamide
Show/Hide
|
C18H23ClFN5O4S2
|
2
|
| 1 |
IC50 = 5.012 nM
|
|
|
| 2 |
Kd = 15.85 nM
|
|
|
|
CP0543163
|
2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-4-(dimethylsulfamoylamino)-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidine
Show/Hide
|
C16H21ClFN5O3S2
|
1
|
| 1 |
IC50 = 5.012 nM
|
|
|
|
CP0558702
|
2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-phenyl-1,4-dihydroimidazol-5-one
Show/Hide
|
C18H18ClN3O4S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0524198
|
(2R)-2-[[7-amino-2-[(2,3-difluorophenyl)methylsulfanyl]pteridin-4-yl]amino]propan-1-ol
Show/Hide
|
C16H16F2N6OS
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0913063
|
(2R)-2-[[5-[(2,3-difluorophenyl)methylsulfanyl]-2-(methylamino)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C16H17F2N5OS2
|
1
|
| 1 |
IC50 = 7.943 nM
|
|
|
|
CP0386796
|
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]piperidine-1-sulfonamide
Show/Hide
|
C19H25F2N5O3S2
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
Kd = 15.85 nM
|
|
|
|
CP0387145
|
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]pyrrolidine-1-sulfonamide
Show/Hide
|
C18H23F2N5O3S2
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
Kd = 12.59 nM
|
|
|
|
CP0515774
|
N-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]piperazine-1-sulfonamide
Show/Hide
|
C18H24ClFN6O3S2
|
2
|
| 1 |
IC50 = 7.943 nM
|
|
|
| 2 |
Kd > 316.23 nM
|
|
|
|
CP0469244
|
2-[4-chloro-2-hydroxy-3-(2-methoxyethylsulfonyl)anilino]-4-phenyl-1,4-dihydroimidazol-5-one
Show/Hide
|
C18H18ClN3O5S
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0460146
|
(R)-2-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-ol
Show/Hide
|
C16H17F2N5OS2
|
2
|
| 1 |
IC50 = 9.5 nM
|
|
|
| 2 |
IC50 = 25.12 nM
|
|
|
|
CP0573232
|
N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]-1,1,1-trifluoromethanesulfonamide
Show/Hide
|
C15H17F3N4O3S2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0052095
|
(R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)benzamide
Show/Hide
|
C21H23N3O5
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0264842
|
(4R)-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-cyclohexyl-1,4-dihydroimidazol-5-one
Show/Hide
|
C18H24ClN3O4S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0484306
|
(2R)-2-[[2-amino-5-[(2-fluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C15H16FN5OS2
|
2
|
| 1 |
IC50 = 12.59 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0913062
|
(2R)-2-[[2-amino-5-[(3-chlorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C15H16ClN5OS2
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0380176
|
N-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]-1-methylimidazole-4-sulfonamide
Show/Hide
|
C18H20ClFN6O3S2
|
2
|
| 1 |
IC50 = 12.59 nM
|
|
|
| 2 |
Kd = 199.53 nM
|
|
|
|
CP0410715
|
N-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]methanesulfonamide
Show/Hide
|
C15H18ClFN4O3S2
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0501287
|
(2R)-2-[[8-amino-2-[(2,3-difluorophenyl)methylsulfanyl]-7H-purin-6-yl]amino]propan-1-ol
Show/Hide
|
C15H16F2N6OS
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0525678
|
(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]propan-1-ol
Show/Hide
|
C15H17N5OS2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0179941
|
1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-(2,3-dichlorophenyl)urea
Show/Hide
|
C13H10Cl3N3O4S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0502622
|
2-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)-2-methylpropan-1-ol
Show/Hide
|
C16H17F2N5OS2
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 = 25.12 nM
|
|
|
|
CP0517171
|
tert-butyl N-[3-[6-chloro-2-hydroxy-3-[(5-oxo-4-phenyl-1,4-dihydroimidazol-2-yl)amino]phenyl]sulfonylpropyl]carbamate
Show/Hide
|
C23H27ClN4O6S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0910625
|
(R)-2-(5-(3-fluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol
Show/Hide
|
C15H16FN5OS2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0910918
|
(2R,3R)-2-[[2-amino-5-[(2,3-difluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]butane-1,3-diol
Show/Hide
|
C16H17F2N5O2S2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0935612
|
(R)-2-(5-(2,3-dichlorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol
Show/Hide
|
C15H15Cl2N5OS2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0511665
|
2-[(2,3-difluorophenyl)methylsulfanyl]-4-[[(2R)-1-hydroxypropan-2-yl]amino]-7-oxo-8H-pyrido[2,3-d]pyrimidine-6-carbonitrile
Show/Hide
|
C18H15F2N5O2S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0946914
|
(2R)-2-[[2-(cyclopropylamino)-5-[(2,3-difluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C18H19F2N5OS2
|
1
|
| 1 |
IC50 = 19.95 nM
|
|
|
|
CP0551868
|
US9090596, 38
Show/Hide
|
C25H29N3O6
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0398736
|
N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]-4-cyanobenzenesulfonamide
Show/Hide
|
C21H21N5O3S2
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0403037
|
US9090596, 48
Show/Hide
|
C24H24F3N3O6
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0402122
|
5-(2-chlorophenyl)-2-[(3-chlorophenyl)methyl]-1H-1,2,4-triazole-3-thione
Show/Hide
|
C15H11Cl2N3S
|
1
|
| 1 |
IC50 < 28 nM
|
|
|
|
CP0469247
|
(4R)-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-propyl-1,4-dihydroimidazol-5-one
Show/Hide
|
C15H20ClN3O4S
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0402813
|
US9090596, 53
Show/Hide
|
C25H29ClN4O7S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0384781
|
US9090596, 22
Show/Hide
|
C22H24ClN3O7S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0524199
|
(2R)-2-[[2-amino-5-(furan-2-ylmethylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
|
C13H15N5O2S2
|
2
|
| 1 |
IC50 = 31.62 nM
|
|
|
| 2 |
IC50 = 35 nM
|
|
|
|
CP0858963
|
(R)-2-(5-(2-chlorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol
Show/Hide
|
C15H16ClN5OS2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0910665
|
2-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)propane-1,3-diol
Show/Hide
|
C15H15F2N5O2S2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0946913
|
(R)-2-(5-(2,3-difluorobenzylthio)-2-(isopropylamino)thiazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol
Show/Hide
|
C18H21F2N5OS2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0388857
|
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]-1-methylimidazole-4-sulfonamide
Show/Hide
|
C18H20F2N6O3S2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0529493
|
N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]methanesulfonamide
Show/Hide
|
C15H18F2N4O3S2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0543162
|
N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]-4-chlorobenzenesulfonamide
Show/Hide
|
C20H21ClN4O3S2
|
1
|
| 1 |
IC50 = 31.62 nM
|
|
|
|
CP0552831
|
1-(3-fluoro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
|
C17H15FN2O4S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0409783
|
US9090596, 8
Show/Hide
|
C27H29N3O8
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0517170
|
4-butyl-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-1,4-dihydroimidazol-5-one
Show/Hide
|
C16H22ClN3O4S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0545743
|
1-(2-chloro-3-fluorophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
|
C16H14ClFN2O4S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0462416
|
2-[(2,3-difluorophenyl)methylsulfanyl]-4-[[(2R)-1-hydroxypropan-2-yl]amino]-5,8-dihydropteridine-6,7-dione
Show/Hide
|
C16H15F2N5O3S
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0552829
|
1-(2-bromophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
|
C16H13BrN2O4S
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0445525
|
2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)-2-methylpropan-1-ol
Show/Hide
|
C22H23N5O2S2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0388856
|
N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]-1-phenylmethanesulfonamide
Show/Hide
|
C21H24N4O3S2
|
1
|
| 1 |
IC50 = 50.12 nM
|
|
|
|
CP0568283
|
2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-(2-chlorophenyl)-1,4-dihydroimidazol-5-one
Show/Hide
|
C18H17Cl2N3O4S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0457800
|
7-[[(2R)-1-hydroxypropan-2-yl]amino]-5-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
|
C13H15N5O2S3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0401337
|
US9090596, 9
Show/Hide
|
C27H29N3O8
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0845259
|
(S)-2-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol
Show/Hide
|
C15H15F2N5OS2
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0387144
|
2-benzylsulfanyl-4-(dimethylsulfamoylamino)-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidine
Show/Hide
|
C16H23N5O3S2
|
1
|
| 1 |
IC50 = 63.1 nM
|
|
|
|
CP0577268
|
1-(2-chlorophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
|
C16H13ClN2O4S
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
|
CP0567534
|
2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-propyl-1,4-dihydroimidazol-5-one
Show/Hide
|
C15H20ClN3O4S
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
|
CP0385156
|
US9090596, 50
Show/Hide
|
C23H25N3O6
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0469311
|
US9090596, 51
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C24H27N3O6
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1
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| 1 |
IC50 = 72 nM
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CP0578869
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3-(2-bromoanilino)-4-[(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
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C19H13BrN2O5S
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1
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| 1 |
IC50 = 78 nM
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CP0935613
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2-[[2-amino-5-[(2,3-difluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methylpropane-1,3-diol
Show/Hide
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C16H17F2N5O2S2
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1
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| 1 |
IC50 = 79.43 nM
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CP0380174
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N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]benzenesulfonamide
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C20H22N4O3S2
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1
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| 1 |
IC50 = 79.43 nM
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CP0429356
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N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]methanesulfonamide
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C15H20N4O3S2
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1
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| 1 |
IC50 = 79.43 nM
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CP0384013
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2-(3-Chloro-benzyl)-5-(2,4-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
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C15H10Cl3N3S
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1
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| 1 |
IC50 = 92 nM
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CP0549271
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1-(3-fluoro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
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C17H17FN2O4S
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1
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| 1 |
IC50 = 95 nM
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CP0422501
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US9090596, 25
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C21H23N3O6S
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1
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| 1 |
IC50 = 96 nM
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CP0555767
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(4R)-4-benzyl-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-1,4-dihydroimidazol-5-one
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C19H20ClN3O4S
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1
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| 1 |
IC50 = 98 nM
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CP0855665
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2-(2-amino-5-(furan-2-ylmethylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)-2-methylpropan-1-ol
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C14H17N5O2S2
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1
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| 1 |
IC50 = 100 nM
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CP0910626
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(2R)-2-[[5-[(2,3-difluorophenyl)methylsulfanyl]-2-(propan-2-ylamino)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]butan-1-ol
Show/Hide
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C19H23F2N5OS2
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1
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| 1 |
IC50 = 100 nM
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CP0910664
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2-[[2-(cyclopropylamino)-5-[(2,3-difluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propane-1,3-diol
Show/Hide
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C18H19F2N5O2S2
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1
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| 1 |
IC50 = 100 nM
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CP0416409
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US9090596, 12
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C24H26N2O6
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1
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| 1 |
IC50 = 100 nM
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CP0440529
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US9090596, 7
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C30H35N3O8
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1
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| 1 |
IC50 = 100 nM
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CP0395058
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US9090596, 34
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C22H23N3O5S
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1
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| 1 |
IC50 = 106 nM
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CP0538927
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US9090596, 3
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C24H27N3O6
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1
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| 1 |
IC50 = 106 nM
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CP0489275
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(2R)-2-[[2-amino-5-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]propan-1-ol
Show/Hide
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C13H16N6OS3
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2
|
| 1 |
IC50 = 120 nM
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| 2 |
IC50 = 125.89 nM
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CP0462822
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(R)-2-(2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-ol
Show/Hide
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C16H19N5OS2
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2
|
| 1 |
IC50 = 120 nM
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| 2 |
Ki = 160 nM
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CP0495303
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1-(2,3-dichlorophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
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C16H12Cl2N2O4S
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1
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| 1 |
IC50 = 130 nM
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CP0525672
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(2R)-2-[[2-[(2,3-difluorophenyl)methylsulfanyl]-6-methylpteridin-4-yl]amino]propan-1-ol
Show/Hide
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C17H17F2N5OS
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1
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| 1 |
IC50 = 140 nM
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CP0469246
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2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-ethyl-1,4-dihydroimidazol-5-one
Show/Hide
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C14H18ClN3O4S
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1
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| 1 |
IC50 = 140 nM
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CP0552832
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1-(2-bromophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
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C16H15BrN2O4S
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1
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| 1 |
IC50 = 140 nM
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CP0512538
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US9090596, 35
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C23H25N3O5S
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1
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| 1 |
IC50 = 146 nM
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CP0573566
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3-(2-bromoanilino)-4-[(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
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C19H15BrN2O5S
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1
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| 1 |
IC50 = 150 nM
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CP0410716
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N-[2-[(2,3-dichlorophenyl)methylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]methanesulfonamide
Show/Hide
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C15H18Cl2N4O3S2
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1
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| 1 |
IC50 = 158.49 nM
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CP0419725
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N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]propane-1-sulfonamide
Show/Hide
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C17H24N4O3S2
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1
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| 1 |
IC50 = 158.49 nM
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CP0461258
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5-(2,4-Dichloro-phenyl)-2-(3-phenoxy-benzyl)-2H-[1,2,4]triazole-3-thiol
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C21H15Cl2N3OS
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1
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| 1 |
IC50 = 170 nM
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CP0576799
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1-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)-3-(4-methylphenyl)urea
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C17H16N2O4S
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1
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| 1 |
IC50 = 190 nM
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CP0462850
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US9090596, 36
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C22H23N3O6
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1
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| 1 |
IC50 = 198 nM
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CP0574693
|
3-(2-chloroanilino)-4-[(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
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C19H13ClN2O5S
|
1
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| 1 |
IC50 = 200 nM
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CP0578048
|
1-(2,3-dichlorophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
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C16H14Cl2N2O4S
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1
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| 1 |
IC50 = 210 nM
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CP0578870
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1-(2-chlorophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
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C16H15ClN2O4S
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1
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| 1 |
IC50 = 210 nM
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CP0467716
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(2R)-2-[[6-[(2,3-difluorophenyl)methylsulfanyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]propan-1-ol
Show/Hide
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C15H15F2N5OS
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1
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| 1 |
IC50 = 220 nM
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CP0429663
|
US9090596, 27
Show/Hide
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C24H27N3O6
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1
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| 1 |
IC50 = 244 nM
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CP0472449
|
US9090596, 21
Show/Hide
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C22H25N3O7S
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1
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| 1 |
IC50 = 257 nM
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CP0385811
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US9090596, 14
Show/Hide
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C25H27N3O6
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1
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| 1 |
IC50 = 262 nM
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CP0469242
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2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-methyl-1,4-dihydroimidazol-5-one
Show/Hide
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C13H16ClN3O4S
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1
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| 1 |
IC50 = 269 nM
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CP0512241
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5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ol
Show/Hide
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C12H8F2N4OS2
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1
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| 1 |
IC50 = 270 nM
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CP0472418
|
US9090596, 2
Show/Hide
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C23H24FN3O6
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1
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| 1 |
IC50 = 272 nM
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CP0404928
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(2R)-2-[[2-[(2,3-difluorophenyl)methylsulfanyl]-7-methylpteridin-4-yl]amino]propan-1-ol
Show/Hide
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C17H17F2N5OS
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1
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| 1 |
IC50 = 280 nM
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CP0511667
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(2R)-2-[[2-[(2,3-difluorophenyl)methylsulfanyl]pteridin-4-yl]amino]propan-1-ol
Show/Hide
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C16H15F2N5OS
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1
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| 1 |
IC50 = 280 nM
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CP0438143
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2-(4-Chloro-benzyl)-5-(2,4-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H10Cl3N3S
|
1
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| 1 |
IC50 = 300 nM
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CP0534480
|
2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-(3-chlorophenyl)-1,4-dihydroimidazol-5-one
Show/Hide
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C18H17Cl2N3O4S
|
1
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| 1 |
IC50 = 305 nM
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CP0553101
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2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-(2-methylpropyl)-1,4-dihydroimidazol-5-one
Show/Hide
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C16H22ClN3O4S
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1
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| 1 |
IC50 = 305 nM
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CP0384794
|
US9090596, 42
Show/Hide
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C21H19N3O5
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1
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| 1 |
IC50 = 311 nM
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CP0552828
|
1-(2-fluorophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
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C16H13FN2O4S
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1
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| 1 |
IC50 = 320 nM
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CP0486558
|
US9090596, 20
Show/Hide
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C19H19N3O5
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1
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| 1 |
IC50 = 335 nM
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CP0401286
|
US9090596, 5
Show/Hide
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C25H27N3O7
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1
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| 1 |
IC50 = 341 nM
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CP0429170
|
US9090596, 30
Show/Hide
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C25H25N3O7
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1
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| 1 |
IC50 = 349 nM
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CP0486371
|
2-Benzyl-5-(2,3-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H11Cl2N3S
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1
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| 1 |
IC50 = 350 nM
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CP0554768
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2-Benzyl-5-(2-bromo-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H12BrN3S
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1
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| 1 |
IC50 = 350 nM
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CP0527996
|
2-[(2,3-difluorophenyl)methylsulfanyl]-4-[[(2R)-1-hydroxypropan-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
Show/Hide
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C17H16F2N4O2S
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1
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| 1 |
IC50 = 350 nM
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CP0442262
|
(R)-2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-ol
Show/Hide
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C22H23N5O2S2
|
1
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| 1 |
IC50 = 350 nM
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CP0573567
|
3-(3-fluoro-2-methylanilino)-4-[(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
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C20H15FN2O5S
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1
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| 1 |
IC50 = 370 nM
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CP0380479
|
US9090596, 52
Show/Hide
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C23H24ClN3O6
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1
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| 1 |
IC50 = 373 nM
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CP0413773
|
US9090596, 19
Show/Hide
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C20H21N3O5
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1
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| 1 |
IC50 = 394 nM
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CP0947423
|
(R)-2-(5-(2,3-difluorobenzylthio)-2-(diethylamino)thiazolo[4,5-d]pyrimidin-7-ylamino)propan-1-ol
Show/Hide
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C19H23F2N5OS2
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1
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| 1 |
IC50 = 398.11 nM
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CP0488599
|
N-[2-benzylsulfanyl-6-[[(2R)-1-hydroxybutan-2-yl]amino]pyrimidin-4-yl]methanesulfonamide
Show/Hide
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C16H22N4O3S2
|
1
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| 1 |
IC50 = 398.11 nM
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CP0498554
|
2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidine-4-carboxylic acid
Show/Hide
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C15H17N3O3S
|
1
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| 1 |
IC50 = 398.11 nM
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CP0577881
|
1-(2,3-dichlorophenyl)-3-(8-hydroxy-1,1,4-trioxo-2,3-dihydrothiochromen-7-yl)urea
Show/Hide
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C16H12Cl2N2O5S
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1
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| 1 |
IC50 = 400 nM
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CP0509121
|
2-Benzyl-5-(2,4-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H11Cl2N3S
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1
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| 1 |
IC50 = 410 nM
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CP0578868
|
1-(3-fluoro-2-methylphenyl)-3-(8-hydroxy-1,1,4-trioxo-2,3-dihydrothiochromen-7-yl)urea
Show/Hide
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C17H15FN2O5S
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1
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| 1 |
IC50 = 420 nM
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CP0546563
|
US9090596, 29
Show/Hide
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C25H27N3O6
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1
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| 1 |
IC50 = 433 nM
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CP0456914
|
2-Benzyl-5-(2-chloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H12ClN3S
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1
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| 1 |
IC50 = 450 nM
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CP0507727
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5-(2,4-Dichloro-phenyl)-2-phenethyl-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C16H13Cl2N3S
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1
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| 1 |
IC50 = 450 nM
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CP0567535
|
(4R)-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-methyl-1,4-dihydroimidazol-5-one
Show/Hide
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C13H16ClN3O4S
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1
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| 1 |
IC50 = 470 nM
|
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CP0409892
|
US9090596, 28
Show/Hide
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C25H27N3O6
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1
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| 1 |
IC50 = 475 nM
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CP0518024
|
5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ol
Show/Hide
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C18H14N4O2S2
|
1
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| 1 |
IC50 = 480 nM
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CP0406693
|
US9090596, 40
Show/Hide
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C19H18ClN3O5
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1
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| 1 |
IC50 = 502 nM
|
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CP0541410
|
US9090596, 11
Show/Hide
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C22H24N2O6
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1
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| 1 |
IC50 = 549 nM
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CP0538397
|
US9090596, 15
Show/Hide
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C25H27N3O7
|
1
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| 1 |
IC50 = 626 nM
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CP0433265
|
(2R)-2-[[2-[(2,3-difluorophenyl)methylsulfanyl]-8-methyl-7H-purin-6-yl]amino]propan-1-ol
Show/Hide
|
C16H17F2N5OS
|
1
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| 1 |
IC50 = 630 nM
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CP0573231
|
N-[2-[2-(2,3-difluorophenoxy)ethylsulfanyl]-6-[[(2R)-1-hydroxypropan-2-yl]amino]pyrimidin-4-yl]methanesulfonamide
Show/Hide
|
C16H20F2N4O4S2
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1
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| 1 |
IC50 = 630.96 nM
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CP0495471
|
2-Benzyl-5-(2,5-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H11Cl2N3S
|
1
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| 1 |
IC50 = 670 nM
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CP0532937
|
3-(2-chloro-3-fluoroanilino)-4-[(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
|
C19H12ClFN2O5S
|
1
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| 1 |
IC50 = 700 nM
|
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CP0458993
|
US9090596, 31
Show/Hide
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C25H27N3O6
|
1
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| 1 |
IC50 = 716 nM
|
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CP0506370
|
5-(2,4-Dichloro-phenyl)-2-(3-methyl-benzyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C16H13Cl2N3S
|
1
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| 1 |
IC50 = 730 nM
|
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CP0385678
|
US9090596, 49
Show/Hide
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C23H25N3O6
|
1
|
| 1 |
IC50 = 733 nM
|
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CP0398407
|
2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]-N-methylsulfonylpyrimidine-4-carboxamide
Show/Hide
|
C16H20N4O4S2
|
1
|
| 1 |
IC50 = 794.33 nM
|
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CP0436575
|
2-Benzyl-5-(3,4-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H11Cl2N3S
|
1
|
| 1 |
IC50 = 800 nM
|
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CP0487403
|
2-Benzyl-5-(4-chloro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C15H12ClN3S
|
1
|
| 1 |
IC50 = 830 nM
|
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CP0404927
|
(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[5,4-d]pyrimidin-7-yl)amino]propan-1-ol
Show/Hide
|
C15H17N5OS2
|
1
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| 1 |
IC50 = 850 nM
|
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|
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CP0429914
|
2-Benzyl-5-(2-fluoro-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
|
C15H12FN3S
|
1
|
| 1 |
IC50 = 890 nM
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CP0562203
|
2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-(4-chlorophenyl)-1,4-dihydroimidazol-5-one
Show/Hide
|
C18H17Cl2N3O4S
|
1
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| 1 |
IC50 = 915 nM
|
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CP0415904
|
US9090596, 33
Show/Hide
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C27H29N3O8
|
1
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| 1 |
IC50 = 962 nM
|
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CP0520142
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2-Benzyl-5-(3-chloro-phenyl)-2H-[1,2,4]triazole-3-thiol
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C15H12ClN3S
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1
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| 1 |
IC50 = 1000 nM
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CP0916140
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2-(2-amino-5-((2-methylthiazol-4-yl)methylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)-2-methylpropan-1-ol
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C14H18N6OS3
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1
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| 1 |
IC50 = 1000 nM
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CP0574694
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1-(2-fluorophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
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C16H15FN2O4S
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1
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| 1 |
IC50 = 1020 nM
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CP0459950
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US9090596, 39
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C20H21N3O6
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1
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| 1 |
IC50 = 1035 nM
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CP0577266
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3-(2-chloroanilino)-4-[(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
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C19H15ClN2O5S
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1
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| 1 |
IC50 = 1050 nM
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CP0420004
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US9090596, 6
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C25H27N3O7
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1
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| 1 |
IC50 = 1088 nM
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CP0442571
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2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-ol
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C12H10N4OS2
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1
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| 1 |
IC50 = 1300 nM
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CP0577273
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1-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)-3-(4-methylphenyl)urea
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C17H18N2O4S
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1
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| 1 |
IC50 = 1320 nM
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CP0578047
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3-(3-fluoro-2-methylanilino)-4-[(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
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C20H17FN2O5S
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1
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| 1 |
IC50 = 1360 nM
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CP0466889
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2-Benzyl-5-o-tolyl-2H-[1,2,4]triazole-3-thiol
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C16H15N3S
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1
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| 1 |
IC50 = 1400 nM
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CP0542043
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2-Benzyl-5-(2-methoxy-phenyl)-2H-[1,2,4]triazole-3-thiol
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C16H15N3OS
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1
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| 1 |
IC50 = 1400 nM
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CP0562388
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(S)-2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-ol
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C22H23N5O2S2
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1
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| 1 |
IC50 = 1400 nM
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CP0578049
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1-(4-bromophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
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C16H13BrN2O4S
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1
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| 1 |
IC50 = 1480 nM
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CP0881594
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2-(5-(2,3-difluorobenzylthio)-2-(diethylamino)thiazolo[4,5-d]pyrimidin-7-ylamino)propane-1,3-diol
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C19H23F2N5O2S2
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1
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| 1 |
IC50 = 1584.89 nM
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CP0495301
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1-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)-3-[2-(trifluoromethyl)phenyl]urea
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C17H13F3N2O4S
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1
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| 1 |
IC50 = 1600 nM
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CP0543940
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1-(3-chloro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
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C17H15ClN2O4S
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1
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| 1 |
IC50 = 1640 nM
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CP0523830
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2-Benzyl-5-thiophen-2-yl-2H-[1,2,4]triazole-3-thiol
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C13H11N3S2
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1
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| 1 |
IC50 = 2000 nM
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CP0530996
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2-Benzyl-5-(3,5-dichloro-phenyl)-2H-[1,2,4]triazole-3-thiol
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C15H11Cl2N3S
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1
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| 1 |
IC50 = 2000 nM
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CP0558703
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2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-(4-fluorophenyl)-1,4-dihydroimidazol-5-one
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C18H17ClFN3O4S
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1
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| 1 |
IC50 = 2190 nM
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CP0374701
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2-Benzyl-5-(4-methoxy-phenyl)-2H-[1,2,4]triazole-3-thiol
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C16H15N3OS
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1
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| 1 |
IC50 = 2300 nM
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CP0502518
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2-Benzyl-5-phenyl-2H-[1,2,4]triazole-3-thiol
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C15H13N3S
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1
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| 1 |
IC50 = 2400 nM
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CP0576797
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1-(3-chloro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
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C17H17ClN2O4S
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1
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| 1 |
IC50 = 2430 nM
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CP0454309
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2-benzylsulfanyl-6-[[(2R)-1-hydroxypropan-2-yl]amino]-7,9-dihydropurin-8-one
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C15H17N5O2S
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1
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| 1 |
IC50 = 2500 nM
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CP0577271
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3-(2,3-dichloroanilino)-4-[(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
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C19H12Cl2N2O5S
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1
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| 1 |
IC50 = 2500 nM
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CP0539045
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2-Benzyl-5-(4-trifluoromethyl-phenyl)-2H-[1,2,4]triazole-3-thiol
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C16H12F3N3S
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1
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| 1 |
IC50 = 2800 nM
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CP0469248
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(4S)-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-propyl-1,4-dihydroimidazol-5-one
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C15H20ClN3O4S
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1
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| 1 |
IC50 = 2800 nM
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CP0553102
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(4S)-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-methyl-1,4-dihydroimidazol-5-one
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C13H16ClN3O4S
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1
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| 1 |
IC50 = 3100 nM
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CP0419724
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N-[2-benzylsulfanyl-6-(2-hydroxyethylamino)pyrimidin-4-yl]methanesulfonamide
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C14H18N4O3S2
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1
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| 1 |
IC50 = 3162.28 nM
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CP0576798
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3-(2-chloro-3-fluoroanilino)-4-[(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
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C19H14ClFN2O5S
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1
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| 1 |
IC50 = 3450 nM
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CP0494924
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4-(1-Benzyl-5-mercapto-1H-[1,2,4]triazol-3-yl)-benzonitrile
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C16H12N4S
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1
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| 1 |
IC50 = 3500 nM
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CP0555276
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2-Benzyl-5-(3-trifluoromethyl-phenyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C16H12F3N3S
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1
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| 1 |
IC50 = 3500 nM
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CP0518023
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(S)-2-(2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)butan-1-ol
Show/Hide
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C16H19N5OS2
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1
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| 1 |
IC50 = 3900 nM
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CP0517172
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(4S)-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-4-cyclohexyl-1,4-dihydroimidazol-5-one
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C18H24ClN3O4S
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1
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| 1 |
IC50 = 4000 nM
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CP0497203
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2-Benzyl-5-furan-2-yl-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C13H11N3OS
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1
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| 1 |
IC50 = 4200 nM
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CP0506391
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5-(2,4-Dichloro-phenyl)-2-(3-methoxy-benzyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C16H13Cl2N3OS
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1
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| 1 |
IC50 = 4200 nM
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CP0438202
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3-(5-Mercapto-3-phenyl-[1,2,4]triazol-1-ylmethyl)-phenol
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C15H13N3OS
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1
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| 1 |
IC50 = 4400 nM
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CP0573568
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1-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)-3-[2-(trifluoromethyl)phenyl]urea
Show/Hide
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C17H15F3N2O4S
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1
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| 1 |
IC50 = 4510 nM
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CP0577270
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1-(2,4-dichlorophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
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C16H12Cl2N2O4S
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1
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| 1 |
IC50 = 5920 nM
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CP0442570
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2-(2-amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)ethanol
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C12H19N5OS2
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1
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| 1 |
IC50 = 7000 nM
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CP0464947
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2-Benzyl-5-pyridin-4-yl-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C14H12N4S
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1
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| 1 |
IC50 = 7700 nM
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CP0488598
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N-[2-benzylsulfanyl-6-[[(2S)-2-hydroxypropyl]amino]pyrimidin-4-yl]methanesulfonamide
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C15H20N4O3S2
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1
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| 1 |
IC50 = 7943.28 nM
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CP0573333
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3-(2,3-dichloroanilino)-4-[(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)amino]cyclobut-3-ene-1,2-dione
Show/Hide
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C19H14Cl2N2O5S
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1
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| 1 |
IC50 = 9990 nM
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CP0511344
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5-(2,4-Dichloro-phenyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazole-3-thiol
Show/Hide
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C16H13Cl2N3OS
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1
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| 1 |
IC50 = 10000 nM
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CP0464707
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2-amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol
Show/Hide
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C10H14N4OS2
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1
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| 1 |
IC50 = 10000 nM
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CP0512242
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5-(benzylthio)thiazolo[4,5-d]pyrimidine-2,7-diamine
Show/Hide
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C12H11N5S2
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1
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| 1 |
IC50 = 10000 nM
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CP0559338
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5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol
Show/Hide
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C10H13N3OS2
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1
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| 1 |
IC50 = 10000 nM
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CP0795225
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1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylaminocarbonyl)oxime
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C19H16N2O2S
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1
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| 1 |
IC50 > 10000 nM
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CP0380175
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2-benzylsulfanyl-4-[[(2R)-1-hydroxypropan-2-yl]amino]-6-(sulfamoylamino)pyrimidine
Show/Hide
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C14H19N5O3S2
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1
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| 1 |
IC50 > 10000 nM
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CP0542326
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1-(2,4-dichlorophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
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C16H14Cl2N2O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0577934
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1-(4-bromophenyl)-3-(8-hydroxy-1,1-dioxo-3,4-dihydro-2H-thiochromen-7-yl)urea
Show/Hide
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C16H15BrN2O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0469243
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3-chloro-6-[(5-phenyl-1H-1,2,4-triazol-3-yl)amino]-2-propan-2-ylsulfonylphenol
Show/Hide
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C17H17ClN4O3S
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1
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| 1 |
IC50 = 15000 nM
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CP0576800
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1-(2-chloro-3-fluorophenyl)-3-(8-hydroxy-1,1-dioxo-2H-thiochromen-7-yl)urea
Show/Hide
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C16H12ClFN2O4S
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1
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| 1 |
IC50 = 19000 nM
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CP0553103
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3-hydroxy-4-[(5-oxo-4-phenyl-1,4-dihydroimidazol-2-yl)amino]benzonitrile
Show/Hide
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C16H12N4O2
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1
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| 1 |
IC50 = 23600 nM
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CP0553136
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(4S)-4-benzyl-2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-1,4-dihydroimidazol-5-one
Show/Hide
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C19H20ClN3O4S
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1
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| 1 |
IC50 = 25000 nM
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CP0555768
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2-(4-chloro-2-hydroxy-3-propan-2-ylsulfonylanilino)-1,4-dihydroimidazol-5-one
Show/Hide
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C12H14ClN3O4S
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1
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| 1 |
IC50 = 29700 nM
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CP0469245
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2-hydroxy-N,N-dimethyl-3-[(5-oxo-4-phenyl-1,4-dihydroimidazol-2-yl)amino]benzamide
Show/Hide
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C18H18N4O3
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1
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| 1 |
IC50 > 100000 nM
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CP0531943
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2-(2-hydroxy-4-nitroanilino)-4-phenyl-1,4-dihydroimidazol-5-one
Show/Hide
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C15H12N4O4
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1
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| 1 |
IC50 > 100000 nM
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CP0946915
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(1-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-2-yl)methanol
Show/Hide
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C17H17F2N5OS2
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1
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| 1 |
IC50 < 1000 nM
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CP0511343
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2-benzyl-5-pyridin-3-yl-1H-1,2,4-triazole-3-thione
Show/Hide
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C14H12N4S
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1
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| 1 |
IC50 < 4600 nM
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CP0443172
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5-[(2,3-difluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C18H20F2N4O2S2
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1
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| 1 |
Ki = 4.1 nM
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CP0465327
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5-benzylsulfanyl-7-[[(2R)-1-hydroxybutan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C16H18N4O2S2
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1
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| 1 |
Ki = 21 nM
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CP0423464
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(2R)-2-[[2-amino-5-(pyridin-2-ylmethylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Show/Hide
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C17H22N6OS2
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1
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| 1 |
Ki = 64 nM
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CP0423474
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(2R)-2-[[2-amino-5-[(2,3-difluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Show/Hide
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C18H21F2N5OS2
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1
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| 1 |
Ki = 79 nM
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CP0435855
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5-benzylsulfanyl-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C18H22N4O2S2
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1
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| 1 |
Ki = 79 nM
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CP0507101
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5-benzylsulfonyl-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C18H22N4O4S2
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1
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| 1 |
Ki = 100 nM
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CP0507103
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(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-3-methylbutan-1-ol
Show/Hide
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C17H21N5OS2
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1
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| 1 |
Ki = 150 nM
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CP0462406
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(2R)-2-[[2-amino-5-[(3-bromophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Show/Hide
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C18H22BrN5OS2
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1
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| 1 |
Ki = 190 nM
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CP0423472
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7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-5-[(1S)-1-phenylethyl]sulfanyl-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C19H24N4O2S2
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1
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| 1 |
Ki = 210 nM
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CP0382419
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5-[(1S)-1-(4-chloropyridin-3-yl)ethyl]sulfanyl-7-[[(2R)-1-hydroxypentan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C17H20ClN5O2S2
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1
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| 1 |
Ki = 220 nM
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CP0382873
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(2R)-2-[[2-amino-5-[(2-fluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Show/Hide
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C18H22FN5OS2
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1
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| 1 |
Ki = 220 nM
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CP0462404
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4-[[2-amino-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanylmethyl]benzonitrile
Show/Hide
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C19H22N6OS2
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1
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| 1 |
Ki = 258 nM
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CP0423462
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(2R)-2-[[2-amino-5-(2-phenylethylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Show/Hide
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C19H25N5OS2
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1
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| 1 |
Ki = 349 nM
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CP0382876
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(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-3,3-dimethylbutan-1-ol
Show/Hide
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C18H23N5OS2
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1
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| 1 |
Ki = 370 nM
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CP0473397
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5-benzylsulfinyl-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C18H22N4O3S2
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1
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| 1 |
Ki = 460 nM
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CP0382414
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5-[(1S)-1-(4-chloropyridin-2-yl)ethyl]sulfanyl-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Show/Hide
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C18H22ClN5O2S2
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1
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| 1 |
Ki = 489 nM
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CP0455313
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(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]pentan-1-ol
Show/Hide
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C17H21N5OS2
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1
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| 1 |
Ki = 510 nM
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CP0449546
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(2R)-2-[[2-amino-5-(3-phenylpropylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
Show/Hide
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C20H27N5OS2
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1
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| 1 |
Ki = 523 nM
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CP0423057
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(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol
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C18H23N5OS2
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1
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| 1 |
Ki = 530 nM
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CP0488530
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(2R)-2-[[2-amino-5-[(4-bromo-2-fluorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C18H21BrFN5OS2
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1
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| 1 |
Ki = 567 nM
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CP0423469
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7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-5-phenylmethoxy-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
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C18H22N4O3S
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1
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| 1 |
Ki = 580 nM
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CP0462408
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(2R)-2-[[2-amino-5-[(2-methoxyphenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H25N5O2S2
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1
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| 1 |
Ki = 590 nM
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CP0462411
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3-[(1S)-1-[[7-[[(2R)-1-hydroxypentan-2-yl]amino]-2-oxo-3H-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]ethyl]benzonitrile
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C19H21N5O2S2
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1
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| 1 |
Ki = 920 nM
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CP0462410
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(2R)-2-[[2-amino-5-[(1S)-1-(4-chloropyridin-2-yl)ethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C18H23ClN6OS2
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1
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| 1 |
Ki = 1129 nM
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CP0382421
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7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-5-[(1R)-1-phenylethyl]sulfanyl-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
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C19H24N4O2S2
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1
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| 1 |
Ki = 1360 nM
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CP0382416
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(2R)-2-[[2-amino-5-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H24FN5OS2
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1
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| 1 |
Ki = 1400 nM
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CP0473399
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(2R)-2-[[2-amino-5-[(2-methylphenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H25N5OS2
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1
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| 1 |
Ki = 1500 nM
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CP0423467
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(2R)-2-[[2-amino-5-[(4-bromophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C18H22BrN5OS2
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1
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| 1 |
Ki = 1600 nM
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CP0382874
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(2R)-2-[[2-amino-5-[(2-bromophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C18H22BrN5OS2
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1
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| 1 |
Ki = 1750 nM
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CP0449542
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(2R)-2-[[2-amino-5-[(2-chlorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C18H22ClN5OS2
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1
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| 1 |
Ki = 1790 nM
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CP0382418
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methyl (2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentanoate
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C19H23N5O2S2
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1
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| 1 |
Ki = 1940 nM
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CP0462405
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3-[[2-amino-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanylmethyl]benzonitrile
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C19H22N6OS2
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1
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| 1 |
Ki = 1980 nM
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CP0507104
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(2R)-2-[[2-amino-5-[(1R)-1-phenylethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H25N5OS2
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1
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| 1 |
Ki = 2100 nM
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CP0443171
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(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentanamide
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C18H22N6OS2
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1
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| 1 |
Ki = 2400 nM
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CP0423471
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(2R)-2-[[2-amino-5-[(1S)-1-(2-bromophenyl)ethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H24BrN5OS2
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1
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| 1 |
Ki = 2600 nM
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CP0059888
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(2R)-2-[[2-amino-5-[(1S)-1-phenylethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H25N5OS2
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1
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| 1 |
Ki = 2800 nM
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CP0382417
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2-[[2-amino-7-[[(2R)-1-hydroxy-4-methylpentan-2-yl]amino]-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanylmethyl]benzonitrile
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C19H22N6OS2
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1
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| 1 |
Ki = 4100 nM
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CP0435531
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methyl (2R)-2-[[2-amino-5-[(2-chlorophenyl)methylsulfanyl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentanoate
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C19H22ClN5O2S2
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1
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| 1 |
Ki = 4200 nM
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CP0382422
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(2R)-2-[[2-amino-5-(pyridin-3-ylmethylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C17H22N6OS2
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1
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| 1 |
Ki = 5400 nM
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CP0435577
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(2R)-2-[(2-amino-5-benzylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentanoic acid
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C18H21N5O2S2
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1
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| 1 |
Ki = 5900 nM
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CP0382420
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(2R)-2-[[2-amino-5-[(1R)-1-(2-bromophenyl)ethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C19H24BrN5OS2
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1
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| 1 |
Ki = 6000 nM
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CP0423473
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(2R)-2-[[2-amino-5-(pyridin-4-ylmethylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C17H22N6OS2
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1
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| 1 |
Ki = 9000 nM
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CP0507102
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3-[(1S)-1-[[2-amino-7-[[(2R)-1-hydroxypentan-2-yl]amino]-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]ethyl]benzonitrile
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C19H22N6OS2
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1
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| 1 |
Ki = 13000 nM
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CP0382415
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(2R)-2-[[2-amino-5-[(1S)-1-(3-methylsulfonylphenyl)ethyl]sulfanyl-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methylpentan-1-ol
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C20H27N5O3S3
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1
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| 1 |
Ki > 100000 nM
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