General Information of the Compound
Compound ID
CP0553103
Compound Name
3-hydroxy-4-[(5-oxo-4-phenyl-1,4-dihydroimidazol-2-yl)amino]benzonitrile
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Formula
C16H12N4O2
Molecular Weight
292.298
Canonical SMILES
Oc1cc(ccc1NC1=NC(=O)C(N1)c1ccccc1)C#N
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InChI
InChI=1S/C16H12N4O2/c17-9-10-6-7-12(13(21)8-10)18-16-19-14(15(22)20-16)11-4-2-1-3-5-11/h1-8,14,21H,(H2,18,19,20,22)
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InChIKey
ULOZITGKQPTPQD-UHFFFAOYSA-N
Physicochemical Property
logP
1.90288
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
97.51
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4777637
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01304, C-X-C chemokine receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01013, C-X-C chemokine receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 23600 nM
   TI
   LI
   LO
   TS