| Compound ID |
Compound Name |
Compound Formula |
|
CP0039348
|
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C12H16N6O4
|
5
|
| 1 |
EC50 = 0.12 nM
|
|
|
| 2 |
Kd = 234.42 nM
|
|
|
| 3 |
Ki = 1.04 nM
|
|
|
| 4 |
Ki = 204.17 nM
|
|
|
| 5 |
Ki = 245.47 nM
|
|
|
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CP0469503
|
N-[4-[6-amino-5-cyano-2-[[6-[3-[4-[2-(diethylamino)ethyl]piperazin-1-yl]-3-oxopropyl]pyridin-2-yl]methylsulfanyl]pyrimidin-4-yl]phenyl]acetamide
Show/Hide
|
C32H41N9O2S
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0204638
|
(2R,3R,4S,5R)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
C19H27N5O4
|
2
|
| 1 |
EC50 = 28 nM
|
|
|
| 2 |
IC50 = 0.14 nM
|
|
|
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CP0204631
|
1-[(1S,2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]-1,2,4-triazole-3-carboxamide
Show/Hide
|
C10H14N4O4
|
2
|
| 1 |
EC50 = 758 nM
|
|
|
| 2 |
IC50 = 87 nM
|
|
|
|
CP0572048
|
5-[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
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|
C15H12N6O2
|
1
|
| 1 |
IC50 = 25.9 nM
|
|
|
|
CP0543063
|
3-phenyl-7-(3,4,5-trimethoxyanilino)-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile
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|
C22H19N5O3
|
1
|
| 1 |
Kd = 1.738 nM
|
|
|
|
CP0544747
|
3-propan-2-yl-7-(3,4,5-trimethoxyanilino)-2H-pyrazolo[3,4-c]pyridine-5-carbonitrile
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|
C19H21N5O3
|
1
|
| 1 |
Kd = 13.8 nM
|
|
|
|
CP0488244
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(3-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24ClN5O5
|
2
|
| 1 |
Kd = 15.49 nM
|
|
|
| 2 |
Ki = 64.57 nM
|
|
|
|
CP0039042
|
N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide
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|
C21H14ClN5O2
|
2
|
| 1 |
Kd = 15.85 nM
|
|
|
| 2 |
Ki = 51.29 nM
|
|
|
|
CP0488422
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(3-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27ClN6O5
|
2
|
| 1 |
Kd = 17.78 nM
|
|
|
| 2 |
Ki = 37.15 nM
|
|
|
|
CP0488416
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(2-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27ClN6O5
|
2
|
| 1 |
Kd = 21.88 nM
|
|
|
| 2 |
Ki = 40.74 nM
|
|
|
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CP0495143
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-phenoxycyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C23H28N6O5
|
2
|
| 1 |
Kd = 23.44 nM
|
|
|
| 2 |
Ki = 50.12 nM
|
|
|
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CP0537770
|
3-phenyl-5-[(pyridin-3-ylmethylamino)methyl]-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C28H28N6O3
|
1
|
| 1 |
Kd = 28.84 nM
|
|
|
|
CP0488419
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(3-bromophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24BrN5O5
|
6
|
| 1 |
Kd = 33.88 nM
|
|
|
| 2 |
Ki = 8.128 nM
|
|
|
| 3 |
Ki = 28.18 nM
|
|
|
| 4 |
Ki = 63.1 nM
|
|
|
| 5 |
Ki = 100 nM
|
|
|
| 6 |
Ki = 426.58 nM
|
|
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CP0544745
|
5-(aminomethyl)-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
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|
C22H23N5O3
|
1
|
| 1 |
Kd = 40.74 nM
|
|
|
|
CP0895926
|
triethylamine hemi(5-(4-(2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)acetamido)butylcarbamoyl)-2-(6-amino-3-iminio-4,5-disulfonato-3H-xanthen-9-yl)benzoate)
Show/Hide
|
C58H71N13O13S2
|
2
|
| 1 |
Kd = 45.4 nM
|
|
|
| 2 |
Ki = 1680 nM
|
|
|
|
CP0488425
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(2-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24ClN5O5
|
2
|
| 1 |
Kd = 45.71 nM
|
|
|
| 2 |
Ki = 67.61 nM
|
|
|
|
CP0550419
|
N-benzyl-1-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-amine
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|
C19H17N5
|
2
|
| 1 |
Kd = 54.95 nM
|
|
|
| 2 |
Ki = 11.22 nM
|
|
|
|
CP0494931
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-(3-methoxyphenoxy)cyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C24H30N6O6
|
2
|
| 1 |
Kd = 58.88 nM
|
|
|
| 2 |
Ki = 54.95 nM
|
|
|
|
CP0544746
|
7-anilino-3-phenyl-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile
Show/Hide
|
C19H13N5
|
1
|
| 1 |
Kd = 61.66 nM
|
|
|
|
CP0550409
|
7-(3,4,5-trimethoxyanilino)-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile
Show/Hide
|
C16H15N5O3
|
1
|
| 1 |
Kd = 102.33 nM
|
|
|
|
CP0527804
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-phenoxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C21H25N5O5
|
2
|
| 1 |
Kd = 107.15 nM
|
|
|
| 2 |
Ki = 144.54 nM
|
|
|
|
CP0495148
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(2-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29ClN6O5
|
2
|
| 1 |
Kd = 114.82 nM
|
|
|
| 2 |
Ki = 234.42 nM
|
|
|
|
CP0488250
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(3-bromophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27BrN6O5
|
2
|
| 1 |
Kd = 123.03 nM
|
|
|
| 2 |
Ki = 89.13 nM
|
|
|
|
CP0488420
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-(3-methoxyphenoxy)cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C22H27N5O6
|
2
|
| 1 |
Kd = 125.89 nM
|
|
|
| 2 |
Ki = 245.47 nM
|
|
|
|
CP0543064
|
3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C21H20N4O3
|
1
|
| 1 |
Kd = 131.83 nM
|
|
|
|
CP0527802
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-[(3-methoxyphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C23H29N5O6
|
2
|
| 1 |
Kd = 169.82 nM
|
|
|
| 2 |
Ki = 213.8 nM
|
|
|
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CP0546622
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(2-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26ClN5O5
|
2
|
| 1 |
Kd = 181.97 nM
|
|
|
| 2 |
Ki = 275.42 nM
|
|
|
|
CP0495164
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(4-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C23H27ClN6O5
|
2
|
| 1 |
Kd = 194.98 nM
|
|
|
| 2 |
Ki = 138.04 nM
|
|
|
|
CP0537767
|
5-chloro-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C21H19ClN4O3
|
1
|
| 1 |
Kd = 199.53 nM
|
|
|
|
CP0488424
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(3-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29ClN6O5
|
2
|
| 1 |
Kd = 213.8 nM
|
|
|
| 2 |
Ki = 323.59 nM
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|
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CP0546210
|
5-[[(1-methylpiperidin-4-yl)methylamino]methyl]-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C29H36N6O3
|
1
|
| 1 |
Kd = 229.09 nM
|
|
|
|
CP0543596
|
5-chloro-3-propan-2-yl-N-(3,4,5-trimethoxyphenyl)-2H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C18H21ClN4O3
|
1
|
| 1 |
Kd = 281.84 nM
|
|
|
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CP0546191
|
2-anilino-N-(5-anilino-1H-pyrazolo[3,4-c]pyridin-3-yl)acetamide
Show/Hide
|
C20H18N6O
|
1
|
| 1 |
Kd = 281.84 nM
|
|
|
|
CP0001102
|
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C10H13N5O4
|
2
|
| 1 |
Kd = 295.12 nM
|
|
|
| 2 |
Ki = 812.83 nM
|
|
|
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CP0488415
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(3-chlorophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26ClN5O5
|
2
|
| 1 |
Kd = 331.13 nM
|
|
|
| 2 |
Ki = 707.95 nM
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CP0495149
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(4-tert-butylphenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C25H33N5O5
|
2
|
| 1 |
Kd = 363.08 nM
|
|
|
| 2 |
Ki = 446.68 nM
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|
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CP0551633
|
2-anilino-N-(5-anilino-1-methylpyrazolo[3,4-c]pyridin-3-yl)acetamide
Show/Hide
|
C21H20N6O
|
1
|
| 1 |
Kd = 398.11 nM
|
|
|
|
CP0546190
|
5-[(benzylamino)methyl]-3-phenyl-N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-amine
Show/Hide
|
C29H29N5O3
|
1
|
| 1 |
Kd = 426.58 nM
|
|
|
|
CP0381926
|
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-phenylmethoxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
|
C22H27N5O5
|
6
|
| 1 |
Kd = 501.19 nM
|
|
|
| 2 |
Ki = 117.49 nM
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|
|
| 3 |
Ki = 575.44 nM
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|
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| 4 |
Ki = 660.69 nM
|
|
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| 5 |
Ki = 977.24 nM
|
|
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| 6 |
Ki = 9332.54 nM
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CP0534813
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-(4-tert-butylphenoxy)cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C27H36N6O5
|
2
|
| 1 |
Kd = 588.84 nM
|
|
|
| 2 |
Ki = 446.68 nM
|
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|
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CP0488249
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(4-chlorophenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C21H24ClN5O5
|
2
|
| 1 |
Kd = 602.56 nM
|
|
|
| 2 |
Ki = 588.84 nM
|
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CP0488246
|
(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(4-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29BrN6O5
|
2
|
| 1 |
Kd = 741.31 nM
|
|
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| 2 |
Ki = 707.95 nM
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|
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CP0546208
|
N-(5-anilino-1-methylpyrazolo[3,4-c]pyridin-3-yl)benzamide
Show/Hide
|
C20H17N5O
|
1
|
| 1 |
Kd = 851.14 nM
|
|
|
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CP0495145
|
(2S,3S,4R,5R)-N-ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-[(3-methoxyphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Show/Hide
|
C25H32N6O6
|
2
|
| 1 |
Kd = 912.01 nM
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|
|
| 2 |
Ki = 407.38 nM
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CP0488421
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(4-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26BrN5O5
|
2
|
| 1 |
Kd = 954.99 nM
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|
| 2 |
Ki = 1148.15 nM
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CP0488423
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(2S,3S,4R,5R)-5-[6-[[(1R,2R)-2-[(3-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
|
C24H29BrN6O5
|
2
|
| 1 |
Kd = 1148.15 nM
|
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|
| 2 |
Ki = 288.4 nM
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CP0488245
|
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(3-bromophenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
|
C22H26BrN5O5
|
6
|
| 1 |
Kd = 1445.44 nM
|
|
|
| 2 |
Ki = 416.87 nM
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|
| 3 |
Ki = 588.84 nM
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| 4 |
Ki = 691.83 nM
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| 5 |
Ki = 3311.31 nM
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| 6 |
Ki = 8709.64 nM
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CP0470939
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8-(2-Thioxo-7(3-p-chlorophenyl.)-2-(2-furyl)thiazolo[4,3-e]1, 2 4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8ClN5OS2
|
1
|
| 1 |
Ki = 0.03 nM
|
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|
|
CP0507723
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8-(2-Thioxo-7(3-ethyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C12H9N5OS2
|
1
|
| 1 |
Ki = 0.096 nM
|
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CP0431968
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-butyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C15H14BrN3S2
|
1
|
| 1 |
Ki = 0.1 nM
|
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|
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CP0373116
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8-(2-Thioxo-7(3-m-chlorophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8ClN5OS2
|
1
|
| 1 |
Ki = 0.19 nM
|
|
|
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CP0495120
|
8-cyclopentyl-2-(3-hydroxyphenyl)-1-propyl-7H-purin-6-one
Show/Hide
|
C19H22N4O2
|
2
|
| 1 |
Ki = 0.2 nM
|
|
|
| 2 |
Ki = 1 nM
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CP0443841
|
4-[(E)-(4-bromophenyl)methylideneamino]-3-(2-phenylethyl)-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
|
C19H14BrN3S2
|
1
|
| 1 |
Ki = 0.25 nM
|
|
|
|
CP0114093
|
8-cyclopentyl-2-(2-methylpyridin-3-yl)oxy-1-propyl-7H-purin-6-one
Show/Hide
|
C19H23N5O2
|
2
|
| 1 |
Ki = 0.28 nM
|
|
|
| 2 |
Ki = 6.6 nM
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CP0504229
|
8-(2-Thioxo-7(3-o-iodophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H8IN5OS2
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0058033
|
1,3-dipropyl-8-cyclopentylxanthine
Show/Hide
|
C16H24N4O2
|
2
|
| 1 |
Ki = 0.5888 nM
|
|
|
| 2 |
Ki = 1.6 nM
|
|
|
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CP0376070
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(3-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 1.24 nM
|
|
|
|
CP0451808
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(4-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 1.52 nM
|
|
|
|
CP0435534
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-phenylprop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H26N6O5
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1
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| 1 |
Ki = 1.63 nM
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CP0495169
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2-(5-chloropyridin-3-yl)oxy-8-cyclopentyl-1-propyl-7H-purin-6-one
Show/Hide
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C18H20ClN5O2
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2
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| 1 |
Ki = 2.2 nM
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| 2 |
Ki = 12 nM
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CP0495165
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8-cyclopentyl-2-(3-methoxyphenoxy)-1-propyl-7H-purin-6-one
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C20H24N4O3
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2
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| 1 |
Ki = 2.3 nM
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| 2 |
Ki = 12.5 nM
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CP0443842
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4-[(E)-(4-chlorophenyl)methylideneamino]-3-propyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
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C14H12ClN3S2
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1
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| 1 |
Ki = 2.32 nM
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CP0502809
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8-(2-Thioxo-7(3-m-iodophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
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C16H8IN5OS2
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1
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| 1 |
Ki = 2.62 nM
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CP0453295
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R)-3-hydroxyoct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C22H32N6O5
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1
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| 1 |
Ki = 2.8 nM
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CP0381502
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((S)-3-hydroxyoct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C22H32N6O5
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1
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| 1 |
Ki = 3.12 nM
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CP0504231
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8-(2-Thioxo-7(3-p fluorophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
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C16H8FN5OS2
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1
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| 1 |
Ki = 3.21 nM
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CP0424936
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(2-nitrophenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H25N7O7
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1
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| 1 |
Ki = 3.47 nM
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CP0492761
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2-(2-chloropyridin-3-yl)oxy-8-cyclopentyl-1-propyl-7H-purin-6-one
Show/Hide
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C18H20ClN5O2
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1
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| 1 |
Ki = 3.6 nM
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CP0069173
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2-Furan-2-yl-7-[3-(4-methoxy-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
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C20H19N7O2
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1
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| 1 |
Ki = 3.8 nM
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CP0018686
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(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide
Show/Hide
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C18H19IN6O4
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1
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| 1 |
Ki = 3.98 nM
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CP0432711
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R)-3-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C18H24N6O5
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1
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| 1 |
Ki = 4.24 nM
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CP0436562
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(2-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C24H28N6O6
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1
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| 1 |
Ki = 4.27 nM
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CP0044275
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9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine
Show/Hide
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C13H8ClN5O
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1
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| 1 |
Ki = 4.5 nM
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CP0017043
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(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Show/Hide
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C18H18ClIN6O4
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1
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| 1 |
Ki = 5.26 nM
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CP0495119
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8-cyclopentyl-2-(1H-indol-7-yloxy)-1-propyl-7H-purin-6-one
Show/Hide
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C21H23N5O2
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2
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| 1 |
Ki = 5.5 nM
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| 2 |
Ki = 5.6 nM
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CP0376071
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(2S,3S,4R,5R)-5-(2-((R,S)-3-cyclohexyl-3-hydroxyprop-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H32N6O5
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1
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| 1 |
Ki = 5.59 nM
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CP0513657
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8-cyclopentyl-1-propyl-2-[3-(trifluoromethyl)phenoxy]-7H-purin-6-one
Show/Hide
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C20H21F3N4O2
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2
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| 1 |
Ki = 5.9 nM
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| 2 |
Ki = 19 nM
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CP0432710
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(R,S)-methyl 3-(3-(6-(ethylamino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1-hydroxyprop-2-ynyl)benzoate
Show/Hide
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C25H28N6O7
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1
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| 1 |
Ki = 6.11 nM
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CP0526834
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8-(2-Thioxo-7(3-p-iodophenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
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C16H8IN5OS2
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1
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| 1 |
Ki = 6.13 nM
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CP0381594
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(2S,3S,4R,5R)-5-(2-((R,S)-3-cyclopentyl-3-hydroxyprop-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C22H30N6O5
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1
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| 1 |
Ki = 6.81 nM
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CP0104008
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N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C21H28N6O4
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2
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| 1 |
Ki = 6.82 nM
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| 2 |
Ki = 17.2 nM
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CP0506356
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(pyrrolidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C20H23N7O
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1
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| 1 |
Ki = 7.2 nM
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CP0376072
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((S)-3-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C18H24N6O5
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1
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| 1 |
Ki = 7.98 nM
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CP0059564
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N-[2-(furan-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]acetamide
Show/Hide
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C13H11N5O2
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1
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| 1 |
Ki = 9.2 nM
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CP0242073
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8-cyclopentyl-2-(3-hydroxycyclopentyl)oxy-1-propyl-7H-purin-6-one
Show/Hide
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C18H26N4O3
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2
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| 1 |
Ki = 9.6 nM
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| 2 |
Ki = 57 nM
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CP0498519
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N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C17H22N4O3
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1
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| 1 |
Ki = 10.5 nM
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CP0475925
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8-cyclopentyl-2-(3-hydroxyphenoxy)-1-propyl-7H-purin-6-one
Show/Hide
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C19H22N4O3
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1
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| 1 |
Ki = 10.5 nM
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CP0376069
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(3-nitrophenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H25N7O7
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1
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| 1 |
Ki = 11.3 nM
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CP0464062
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8-cyclopentyl-1-propyl-2-[3-(trifluoromethyl)phenyl]-7H-purin-6-one
Show/Hide
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C20H21F3N4O
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1
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| 1 |
Ki = 12 nM
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CP0480969
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8-cyclopentyl-2-(oxan-4-yloxy)-1-propyl-7H-purin-6-one
Show/Hide
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C18H26N4O3
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2
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| 1 |
Ki = 12 nM
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| 2 |
Ki = 20 nM
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CP0201120
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8-cyclopentyl-2-(3,4-difluorophenoxy)-1-propyl-7H-purin-6-one
Show/Hide
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C19H20F2N4O2
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2
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| 1 |
Ki = 13 nM
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| 2 |
Ki = 23 nM
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CP0464061
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8-cyclopentyl-2-cyclopentyloxy-1-propyl-7H-purin-6-one
Show/Hide
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C18H26N4O2
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2
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| 1 |
Ki = 13 nM
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| 2 |
Ki = 14 nM
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CP0246514
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8-cyclopentyl-2-(3-methoxyphenyl)-1-propyl-7H-purin-6-one
Show/Hide
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C20H24N4O2
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2
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| 1 |
Ki = 15 nM
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| 2 |
Ki = 16 nM
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CP0381503
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(3-phenylprop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H26N6O4
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1
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| 1 |
Ki = 15.5 nM
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CP0508529
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3-butyl-4-[(E)-(4-fluorophenyl)methylideneamino]-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
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C15H14FN3S2
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1
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| 1 |
Ki = 16.7 nM
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CP0109688
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2-(4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy)-N-(4-fluorophenyl)acetamide
Show/Hide
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C25H26FN5O4
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1
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| 1 |
Ki = 17.9 nM
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CP0417737
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8-(2-Thioxo-7(3-allyl)-2-(2-furyl)thiazole[4,3-e]1,2,4-triazolo[1, 5-c]pyrimidine
Show/Hide
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C13H9N5OS2
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1
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| 1 |
Ki = 19.01 nM
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CP0406452
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4-[(E)-(4-chlorophenyl)methylideneamino]-3-ethyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
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C13H10ClN3S2
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1
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| 1 |
Ki = 19.82 nM
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CP0408090
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(4-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C18H24N6O5
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1
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| 1 |
Ki = 19.9 nM
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CP0376073
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-iodo-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C14H19IN6O4
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1
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| 1 |
Ki = 20.6 nM
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CP0373930
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N-[6-(3,5-dimethoxyphenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C19H21N5O3
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1
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| 1 |
Ki = 22 nM
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CP0495170
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8-cyclopentyl-1-propyl-2-[[4-(trifluoromethyl)phenyl]methylamino]-7H-purin-6-one
Show/Hide
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C21H24F3N5O
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1
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| 1 |
Ki = 23 nM
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CP0464059
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8-cyclopentyl-2-[(4-methylphenyl)methylamino]-1-propyl-7H-purin-6-one
Show/Hide
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C21H27N5O
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1
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| 1 |
Ki = 27 nM
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CP0454172
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2-dimethylamino-N-(2-furan-2-yl-6-pyrazol-1-yl-pyrimidin-4-yl)-acetamide
Show/Hide
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C15H16N6O2
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1
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| 1 |
Ki = 28 nM
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CP0386238
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(piperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C21H25N7O
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1
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| 1 |
Ki = 31 nM
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CP0399741
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(3-methoxyazetidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C20H23N7O2
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1
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| 1 |
Ki = 34 nM
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CP0453292
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(1-hydroxycyclopentyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C21H28N6O5
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1
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| 1 |
Ki = 34.4 nM
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CP0457319
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8-cyclopentyl-2-(1H-indol-5-yloxy)-1-propyl-7H-purin-6-one
Show/Hide
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C21H23N5O2
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1
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| 1 |
Ki = 36 nM
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CP0132091
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2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-phenylacetamide
Show/Hide
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C25H27N5O4
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1
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| 1 |
Ki = 40.1 nM
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CP0394429
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4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
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C20H27N3O4S
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2
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| 1 |
Ki = 41.8 nM
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| 2 |
Ki = 90 nM
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CP0503048
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(1-hydroxycyclohexyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C22H30N6O5
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1
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| 1 |
Ki = 44.2 nM
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CP0495886
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8-(2-Thioxo-7(3-phenyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
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C16H9N5OS2
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1
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| 1 |
Ki = 47.96 nM
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CP0273477
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N-(4-chlorophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C25H26ClN5O4
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1
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| 1 |
Ki = 49.7 nM
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CP0526193
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8-cyclopentyl-2-[(3R)-oxolan-3-yl]oxy-1-propyl-7H-purin-6-one
Show/Hide
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C17H24N4O3
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1
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| 1 |
Ki = 50 nM
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CP0442091
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-4-hydroxypent-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C19H26N6O5
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1
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| 1 |
Ki = 51.6 nM
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CP0154687
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N-benzyl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C26H29N5O4
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1
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| 1 |
Ki = 54.7 nM
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CP0439413
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-{6-[(2-methoxyethyl)(methyl)amino]pyridin-2-yl}pyrimidin-4-yl]acetamide
Show/Hide
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C20H25N7O2
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1
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| 1 |
Ki = 55 nM
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CP0510576
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2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine
Show/Hide
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C11H9N5O
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1
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| 1 |
Ki = 56 nM
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CP0453330
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2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-nitro-phenyl)-acetamide (0.43CH3OH)
Show/Hide
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C25H26N6O6
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1
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| 1 |
Ki = 57 nM
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CP0464064
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8-cyclopentyl-2-(oxolan-3-yloxy)-1-propyl-7H-purin-6-one
Show/Hide
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C17H24N4O3
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1
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| 1 |
Ki = 59 nM
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CP0034930
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2-[3-[(dimethylamino)methyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C25H28N6O3
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1
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| 1 |
Ki = 60 nM
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CP0397722
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2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-trifluoromethyl-phenyl)-acetamide
Show/Hide
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C26H26F3N5O4
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1
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| 1 |
Ki = 61.2 nM
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CP0496592
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N-[2-(furan-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]-2-morpholin-4-ylacetamide
Show/Hide
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C17H18N6O3
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1
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| 1 |
Ki = 63 nM
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CP0445403
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]propanamide
Show/Hide
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C18H26N6O2
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1
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| 1 |
Ki = 64 nM
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CP0474617
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(pyridin-2-yloxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C21H25N7O2
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1
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| 1 |
Ki = 64 nM
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CP0489914
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
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C18H19N5O2
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1
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| 1 |
Ki = 65 nM
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CP0376044
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(5-phenylpent-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C25H30N6O4
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1
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| 1 |
Ki = 65.3 nM
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CP0063439
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-[[ethyl(methyl)amino]methyl]phenoxy]acetamide
Show/Hide
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C26H30N6O3
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1
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| 1 |
Ki = 68 nM
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CP0360098
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-(ethylaminomethyl)phenoxy]acetamide
Show/Hide
|
C25H28N6O3
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1
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| 1 |
Ki = 68 nM
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CP0445402
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N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-pyridin-2-ylpyrimidin-4-yl]acetamide
Show/Hide
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C17H21N5O2
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1
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| 1 |
Ki = 69 nM
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CP0408163
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(2S,3S,4R,5R)-5-(2-(dec-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C24H36N6O4
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1
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| 1 |
Ki = 69.6 nM
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CP0375126
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]propanamide
Show/Hide
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C18H20N6O2
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1
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| 1 |
Ki = 70 nM
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CP0394856
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-[(dimethylamino)methyl]piperidin-1-yl]acetamide
Show/Hide
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C24H33N7O2
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1
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| 1 |
Ki = 71 nM
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CP0081968
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2-(3-(aminomethyl)phenoxy)-N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C23H24N6O3
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1
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| 1 |
Ki = 73 nM
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CP0161793
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N-(4-bromophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C25H26BrN5O4
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1
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| 1 |
Ki = 73.5 nM
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CP0492759
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8-cyclopentyl-2-(1H-indol-4-yloxy)-1-propyl-7H-purin-6-one
Show/Hide
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C21H23N5O2
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1
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| 1 |
Ki = 74 nM
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CP0528169
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2-[3-[2-(dimethylamino)ethyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C26H30N6O3
|
1
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| 1 |
Ki = 78 nM
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CP0549783
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N-[4-(3-fluoro-5-methylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
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C21H15FN4OS
|
1
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| 1 |
Ki = 78.7 nM
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CP0466764
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(dimethylamino)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C18H21N7O
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1
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| 1 |
Ki = 81 nM
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CP0168564
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxypiperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C22H27N7O2
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1
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| 1 |
Ki = 85 nM
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CP0492767
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8-cyclopentyl-2-[(3S)-oxolan-3-yl]oxy-1-propyl-7H-purin-6-one
Show/Hide
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C17H24N4O3
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1
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| 1 |
Ki = 85 nM
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CP0385401
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5-[4-[(4-bromophenyl)methyl]piperazin-1-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Show/Hide
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C19H19BrN8O
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1
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| 1 |
Ki = 86.7 nM
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CP0509954
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2-(3-cyanophenoxy)-N-(2-(pyridin-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C21H14N6O2S
|
1
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| 1 |
Ki = 87 nM
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CP0432709
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(hex-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C20H28N6O4
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1
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| 1 |
Ki = 87 nM
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CP0474620
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]-3-methylbutanamide
Show/Hide
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C20H30N6O2
|
1
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| 1 |
Ki = 92 nM
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CP0384021
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4,6-dimethylpyrimidin-2-yl)oxyacetamide
Show/Hide
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C22H23N7O3
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1
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| 1 |
Ki = 95 nM
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CP0392930
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2-[4-[(dimethylamino)methyl]-2-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C26H30N6O4
|
1
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| 1 |
Ki = 100 nM
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CP0484715
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4-[(E)-(4-fluorophenyl)methylideneamino]-3-propyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
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C14H12FN3S2
|
1
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| 1 |
Ki = 101.8 nM
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CP0856049
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N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylamide
Show/Hide
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C26H28N6O5
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1
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| 1 |
Ki = 105 nM
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CP0397979
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8-[1-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H28F3N7O3
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1
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| 1 |
Ki = 108 nM
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CP0441884
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(6-hydroxyhex-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C20H28N6O5
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1
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| 1 |
Ki = 109 nM
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CP0386239
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[5-(2-methoxyethoxy)pyridin-3-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C19H22N6O3
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1
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| 1 |
Ki = 110 nM
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CP0497739
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2-fluoro-3-methoxyphenyl)pyrimidin-4-yl]acetamide
Show/Hide
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C18H18FN5O2
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1
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| 1 |
Ki = 110 nM
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CP0453415
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-fluoro-5-(pyrrolidin-1-ylmethyl)phenoxy]acetamide
Show/Hide
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C27H29FN6O3
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1
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| 1 |
Ki = 120 nM
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CP0509952
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2-[4-[(dimethylamino)methyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C25H28N6O3
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1
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| 1 |
Ki = 120 nM
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CP0127357
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H26N8O
|
1
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| 1 |
Ki = 120 nM
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CP0526187
|
2-[(3-chlorophenyl)methylamino]-8-cyclopentyl-1-propyl-7H-purin-6-one
Show/Hide
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C20H24ClN5O
|
1
|
| 1 |
Ki = 120 nM
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CP0474618
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N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-pyridin-2-ylpyrimidin-4-yl]acetamide
Show/Hide
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C17H21N5O2
|
1
|
| 1 |
Ki = 125 nM
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CP0310128
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(morpholin-4-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C20H23N7O2
|
1
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| 1 |
Ki = 130 nM
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CP0381593
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(R,S)-3-(3-(6-(ethylamino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1-hydroxyprop-2-ynyl)benzoic acid
Show/Hide
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C24H26N6O7
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1
|
| 1 |
Ki = 131 nM
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CP0040261
|
BW-A1433
Show/Hide
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C20H22N4O4
|
1
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| 1 |
Ki = 140 nM
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CP0371800
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2-[3-[(dimethylamino)methyl]-5-fluorophenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H27FN6O3
|
1
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| 1 |
Ki = 140 nM
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CP0522050
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8-(2-Thioxo-7(3-butyl)-2-(2-furyl),thiazolo,[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
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C14H13N5OS2
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1
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| 1 |
Ki = 147.9 nM
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CP0397632
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2-[4-(1,3-dibutyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetic acid
Show/Hide
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C21H26N4O5
|
1
|
| 1 |
Ki = 149 nM
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CP0516508
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2-[4-[(dimethylamino)methyl]-3-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C26H30N6O4
|
1
|
| 1 |
Ki = 150 nM
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CP0435231
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N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C15H19N5O2S
|
1
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| 1 |
Ki = 150 nM
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CP0308003
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N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C27H29N5O5
|
1
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| 1 |
Ki = 157 nM
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CP0395301
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4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzamide
Show/Hide
|
C26H28N6O5
|
1
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| 1 |
Ki = 161 nM
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CP0404077
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4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzoic acid (0.60CH2CL2)
Show/Hide
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C26H27N5O6
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1
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| 1 |
Ki = 161 nM
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CP0040740
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C17H24N6O2
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1
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| 1 |
Ki = 162 nM
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CP0259712
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N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
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C22H18N4OS
|
1
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| 1 |
Ki = 162 nM
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CP0057629
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2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetic acid
Show/Hide
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C19H22N4O5
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1
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| 1 |
Ki = 175 nM
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CP0408091
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(oct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H32N6O4
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1
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| 1 |
Ki = 176 nM
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CP0406633
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8-[1-[2-oxo-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H31F3N8O3
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1
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| 1 |
Ki = 177 nM
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CP0496626
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2-(3-fluorophenoxy)-N-(2-(pyridin-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C20H14FN5O2S
|
1
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| 1 |
Ki = 180 nM
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CP0475062
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4-[(E)-(4-bromophenyl)methylideneamino]-3-phenyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
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C17H10BrN3S2
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1
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| 1 |
Ki = 186 nM
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CP0418019
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(1R,2R,3S,4R,5S)-4-[2-[2-(2-fluorophenyl)ethynyl]-6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
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C28H26FN5O4
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1
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| 1 |
Ki = 186 nM
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CP0272424
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C17H18N6O2
|
1
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| 1 |
Ki = 190 nM
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CP0373932
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-hydroxypyridin-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C16H16N6O2
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1
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| 1 |
Ki = 195 nM
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CP0344410
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2-[2-[(dimethylamino)methyl]-4-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O4
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1
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| 1 |
Ki = 200 nM
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CP0445404
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N-[6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-2-thiophen-2-ylpyrimidin-4-yl]acetamide
Show/Hide
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C16H20N4O2S
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1
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| 1 |
Ki = 203 nM
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CP0470988
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(1R,2R,3S,4R,5S)-4-[6-[2-(3,4-dimethoxyphenyl)ethylamino]-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
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C29H29N5O4
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1
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| 1 |
Ki = 208 nM
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CP0372840
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-3-(dimethylamino)propanamide
Show/Hide
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C19H24N6O2
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1
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| 1 |
Ki = 210 nM
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CP0474621
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N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C17H22N4O3
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1
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| 1 |
Ki = 215 nM
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CP0405015
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N-[2-(furan-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C18H20N6O2S
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2
|
| 1 |
Ki = 218 nM
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| 2 |
Ki = 220 nM
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CP0372841
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]acetamide
Show/Hide
|
C23H31N7O2
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1
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| 1 |
Ki = 220 nM
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CP0373934
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[5-(morpholin-4-yl)pyridin-3-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C20H23N7O2
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1
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| 1 |
Ki = 220 nM
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CP0431083
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5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine
Show/Hide
|
C19H19ClN8O
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1
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| 1 |
Ki = 220 nM
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CP0491373
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(3-propylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C18H26N6O
|
1
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| 1 |
Ki = 222 nM
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CP0443759
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4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzoic acid methyl ester
Show/Hide
|
C27H29N5O6
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1
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| 1 |
Ki = 225 nM
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CP0504228
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8-(2-Thioxo-7(3-propyl)-2-(2-furyl)thiazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine
Show/Hide
|
C13H11N5OS2
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1
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| 1 |
Ki = 228.4 nM
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CP0448990
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N-(3-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C27H29N5O5
|
1
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| 1 |
Ki = 234 nM
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CP0372835
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
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C22H29N7O2
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1
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| 1 |
Ki = 262 nM
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CP0037365
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N-[2-(furan-2-yl)-6-pyrazol-1-ylpyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C18H21N7O2
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2
|
| 1 |
Ki = 266 nM
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| 2 |
Ki = 270 nM
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CP0371798
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2-[2-[(dimethylamino)methyl]phenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C25H28N6O3
|
1
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| 1 |
Ki = 270 nM
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CP0422346
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2-[2-[(dimethylamino)methyl]-4-methylphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
|
C26H30N6O3
|
1
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| 1 |
Ki = 270 nM
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CP0433200
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-(ethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
|
C22H29N7O2
|
1
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| 1 |
Ki = 270 nM
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CP0459773
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(2S,3S,4R,5R)-5-(2-(2-cyclohexenylethynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H28N6O4
|
1
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| 1 |
Ki = 280 nM
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CP0493500
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(1,4-oxazepan-4-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
|
C21H25N7O2
|
1
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| 1 |
Ki = 280 nM
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CP0439354
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-phenylpyrimidin-4-yl]acetamide
Show/Hide
|
C17H17N5O
|
1
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| 1 |
Ki = 290 nM
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CP0057624
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-(4-iodophenyl)acetamide
Show/Hide
|
C25H26IN5O4
|
1
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| 1 |
Ki = 293 nM
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CP0474613
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C17H24N6O2
|
1
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| 1 |
Ki = 320 nM
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CP0437852
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N-[6-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
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C20H22N6O
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1
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| 1 |
Ki = 323 nM
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CP0375019
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N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-thiophen-2-ylpyrimidin-4-yl]acetamide
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C16H20N4O2S
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1
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| 1 |
Ki = 325 nM
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CP0397463
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N-(2-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
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C27H29N5O5
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1
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| 1 |
Ki = 335 nM
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CP0378476
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8-[1-[[2-oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
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C26H28F3N7O4
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1
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| 1 |
Ki = 340 nM
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CP0529960
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(1R,2R,3S,4R,5S)-4-[2-[2-(3,4-difluorophenyl)ethynyl]-6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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C28H25F2N5O4
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1
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| 1 |
Ki = 341 nM
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CP0395760
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tert-butyl N-[3-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]propyl]carbamate
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C16H22N8O3
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1
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| 1 |
Ki = 344 nM
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CP0378491
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3-ethyl-8-[1-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C24H26FN7O3
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1
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| 1 |
Ki = 346 nM
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CP0394855
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(pyrrolidin-1-yl)acetamide
Show/Hide
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C20H24N6O2
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1
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| 1 |
Ki = 347 nM
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CP0474622
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R,4S)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C18H26N6O3
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1
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| 1 |
Ki = 352 nM
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CP0374544
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N-[6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
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C15H19N5O2S
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1
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| 1 |
Ki = 354 nM
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CP0551693
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(2S,3S,4R,5R)-5-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
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C20H21FN6O4S
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1
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| 1 |
Ki = 369 nM
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CP0427855
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-(ethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
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C22H29N7O2
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1
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| 1 |
Ki = 370 nM
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CP0479710
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8-cyclopentyl-1-propyl-2-[3-(trifluoromethyl)anilino]-7H-purin-6-one
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C20H22F3N5O
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1
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| 1 |
Ki = 370 nM
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CP0427857
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-{4-[(dimethylamino)methyl]piperidin-1-yl}acetamide
Show/Hide
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C24H33N7O2
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1
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| 1 |
Ki = 380 nM
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CP0433199
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2-(4-methylpiperazin-1-yl)-N-[6-(pyridin-2-yl)-2-(thiophen-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C20H22N6OS
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1
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| 1 |
Ki = 389 nM
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CP0403153
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N-[6-(5-methyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
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C20H25N7O2
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1
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| 1 |
Ki = 390 nM
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CP0069838
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(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
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C26H26N6O4
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1
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| 1 |
Ki = 403 nM
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CP0443843
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4-[(E)-(4-chlorophenyl)methylideneamino]-3-phenyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
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C17H10ClN3S2
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1
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| 1 |
Ki = 412.7 nM
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CP0560739
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(2S,3S,4R,5R)-5-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Show/Hide
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C18H17FN6O4S
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1
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| 1 |
Ki = 432 nM
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CP0386240
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N-[6-(6-aminopyridin-2-yl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]acetamide
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C16H17N7O
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1
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| 1 |
Ki = 440 nM
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CP0373931
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-hydroxypiperidin-1-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
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C21H25N7O2
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1
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| 1 |
Ki = 470 nM
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CP0422356
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-fluoro-5-(morpholin-4-ylmethyl)phenoxy]acetamide
Show/Hide
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C27H29FN6O4
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1
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| 1 |
Ki = 480 nM
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CP0372834
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(morpholin-4-yl)acetamide
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C20H24N6O3
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1
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| 1 |
Ki = 500 nM
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CP0083160
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2-(4-fluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
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C21H23FN4O4S
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1
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| 1 |
Ki = 500 nM
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CP0392931
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-(2-morpholin-4-ylethyl)phenoxy]acetamide
Show/Hide
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C28H32N6O4
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1
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| 1 |
Ki = 540 nM
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CP0403158
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-acetylpiperazin-1-yl)acetamide
Show/Hide
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C22H27N7O3
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1
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| 1 |
Ki = 540 nM
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CP0436314
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]acetamide
Show/Hide
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C23H31N7O2
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1
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| 1 |
Ki = 550 nM
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CP0408095
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(4-methoxyphenyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H26N6O5
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1
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| 1 |
Ki = 558 nM
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CP0439356
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[2-(morpholin-4-yl)pyridin-4-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C20H23N7O2
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1
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| 1 |
Ki = 580 nM
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CP0054097
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2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
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C18H15N7O
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1
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| 1 |
Ki = 594.1 nM
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CP0392932
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[3-(morpholin-4-ylmethyl)phenoxy]acetamide
Show/Hide
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C27H30N6O4
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1
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| 1 |
Ki = 600 nM
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CP0431967
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4-[(E)-(4-bromophenyl)methylideneamino]-3-propyl-2-sulfanylidene-1,3-thiazole-5-carbonitrile
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C14H12BrN3S2
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1
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| 1 |
Ki = 606.7 nM
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CP0474623
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C18H26N6O3
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1
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| 1 |
Ki = 620 nM
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CP0462580
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ethyl N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]carbamate
Show/Hide
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C18H20N6O3
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1
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| 1 |
Ki = 620 nM
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CP0372836
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(1,4-oxazepan-4-yl)acetamide
Show/Hide
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C21H26N6O3
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1
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| 1 |
Ki = 630 nM
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CP0422562
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-3-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]propanamide
Show/Hide
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C23H31N7O2
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1
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| 1 |
Ki = 630 nM
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CP0466161
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8-cyclopentyl-2-(6-methylpyridin-3-yl)oxy-1-propyl-7H-purin-6-one
Show/Hide
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C19H23N5O2
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1
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| 1 |
Ki = 630 nM
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CP0470973
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(1R,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
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C26H24ClN5O4S
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1
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| 1 |
Ki = 649 nM
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CP0384020
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2-(2-fluorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C20H15FN4O3S
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1
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| 1 |
Ki = 650 nM
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CP0427802
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5-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Show/Hide
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C19H19FN8O
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1
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| 1 |
Ki = 655 nM
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CP0432813
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3-ethyl-8-[1-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C25H26F3N7O3
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1
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| 1 |
Ki = 670 nM
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CP0403028
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N,N-dibenzyl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C33H35N5O4
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1
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| 1 |
Ki = 690 nM
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CP0378475
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3-ethyl-8-[1-[[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C25H29N7O4
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1
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| 1 |
Ki = 711 nM
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CP0381591
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(2S,3S,4R,5R)-5-(2-(2-(1-aminocyclohexyl)ethynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C22H31N7O4
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1
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| 1 |
Ki = 716 nM
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CP0433180
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N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C19H22N6O2S
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1
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| 1 |
Ki = 720 nM
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CP0276174
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(2,6-dimethylpyridin-4-yl)oxyacetamide
Show/Hide
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C23H24N6O3
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1
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| 1 |
Ki = 740 nM
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CP0873015
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2-(2-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethoxy)ethoxy)ethanaminium 2,2,2-trifluoroacetate
Show/Hide
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C16H21F3N8O5
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1
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| 1 |
Ki = 769 nM
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CP0462579
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methyl N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]carbamate
Show/Hide
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C17H18N6O3
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1
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| 1 |
Ki = 780 nM
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CP0501881
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(pyridin-4-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C16H16N6O
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1
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| 1 |
Ki = 820 nM
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CP0169910
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JMC511730 Compound 1
Show/Hide
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C21H27N7O2
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1
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| 1 |
Ki = 850 nM
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CP0403152
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2-(4-methylpiperazin-1-yl)-N-[6-(1H-pyrazol-1-yl)-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C17H20N8OS
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1
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| 1 |
Ki = 850 nM
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CP0505123
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N-[2-(5-methylfuran-2-yl)-6-(1H-pyrazol-1-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C19H23N7O2
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1
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| 1 |
Ki = 850 nM
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CP0521309
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4-[(E)-(4-fluorophenyl)methylideneamino]-3-(2-phenylethyl)-2-sulfanylidene-1,3-thiazole-5-carbonitrile
Show/Hide
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C19H14FN3S2
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1
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| 1 |
Ki = 889.2 nM
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CP0394857
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3R)-3-[(dimethylamino)methyl]piperidin-1-yl]acetamide
Show/Hide
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C24H33N7O2
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1
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| 1 |
Ki = 890 nM
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CP0494653
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(2-oxopyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C15H18N6O2
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1
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| 1 |
Ki = 913 nM
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CP0405086
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2-(4-methylpiperazin-1-yl)-N-[6-(1H-pyrazol-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C19H22N8O
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1
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| 1 |
Ki = 930 nM
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CP0433201
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]acetamide
Show/Hide
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C22H29N7O2
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1
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| 1 |
Ki = 940 nM
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CP0467978
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(5-methoxypyridin-3-yl)pyrimidin-4-yl]-2-(morpholin-4-yl)acetamide
Show/Hide
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C21H25N7O3
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1
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| 1 |
Ki = 940 nM
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CP0491371
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methyl N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]carbamate
Show/Hide
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C17H24N6O3
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1
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| 1 |
Ki = 960 nM
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CP0431136
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tert-butyl N-[5-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]pentyl]carbamate
Show/Hide
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C18H26N8O3
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1
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| 1 |
Ki = 963 nM
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CP0388115
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5-(4-Benzyl-piperazin-1-yl)-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine
Show/Hide
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C19H20N8O
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1
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| 1 |
Ki = 978 nM
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CP0392155
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1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-(4-chlorophenyl)ethanone
Show/Hide
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C20H19ClN8O2
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1
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| 1 |
Ki = 991 nM
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CP0395526
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1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-(4-bromophenyl)ethanone
Show/Hide
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C20H19BrN8O2
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1
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| 1 |
Ki = 1010 nM
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CP0372833
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(1-methylpiperidin-4-yl)acetamide
Show/Hide
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C22H28N6O2
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1
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| 1 |
Ki = 1020 nM
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CP0474615
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(2-methylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C16H22N6O
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1
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| 1 |
Ki = 1037 nM
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CP0438935
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N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-phenoxyacetamide
Show/Hide
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C20H16N4O3S
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1
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| 1 |
Ki = 1100 nM
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CP0330093
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2-(3,4-difluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
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C22H23F2N3O4S
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1
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| 1 |
Ki = 1100 nM
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CP0076892
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(2S,3S,4R,5R)-5-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Show/Hide
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C20H21ClN6O4S
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1
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| 1 |
Ki = 1160 nM
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CP0277159
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[2-(2-morpholin-4-ylethyl)phenoxy]acetamide
Show/Hide
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C28H32N6O4
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1
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| 1 |
Ki = 1200 nM
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CP0315512
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4-(diethylamino)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
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C24H36N4O3S
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1
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| 1 |
Ki = 1200 nM
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CP0372839
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methoxypiperidin-1-yl)acetamide
Show/Hide
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C22H28N6O3
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1
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| 1 |
Ki = 1210 nM
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CP0576784
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4-[[(1R,2R)-2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]cyclopentyl]oxymethyl]benzamide
Show/Hide
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C23H28N6O6
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1
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| 1 |
Ki = 1258.93 nM
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CP0494651
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1-[2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxymethylpyrrolidin-1-yl)pyrimidin-4-yl]-3-isopropylurea
Show/Hide
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C19H29N7O2
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1
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| 1 |
Ki = 1283 nM
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CP0471995
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2-(4-fluorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C20H15FN4O3S
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1
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| 1 |
Ki = 1300 nM
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CP0866827
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2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(3-aminopropyl)acetamide
Show/Hide
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C24H27N9O3
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1
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| 1 |
Ki = 1300 nM
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CP0873223
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(4-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)methyl)cyclohexyl)methanaminium 2,2,2-trifluoroacetate
Show/Hide
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C18H23F3N8O3
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1
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| 1 |
Ki = 1350 nM
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CP0496627
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2-[2-[(dimethylamino)methyl]-6-methoxyphenoxy]-N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C26H30N6O4
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1
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| 1 |
Ki = 1400 nM
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CP0395527
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2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Show/Hide
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C8H7N7O
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1
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| 1 |
Ki = 1410 nM
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CP0537614
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4-[[(1R,2R)-2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]cyclopentyl]oxymethyl]benzonitrile
Show/Hide
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C23H26N6O5
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1
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| 1 |
Ki = 1412.54 nM
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CP0532493
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N-[4-(3-bromo-5-methylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
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C21H15BrN4OS
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1
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| 1 |
Ki = 1450 nM
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CP0509956
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2-(3-chlorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C20H15ClN4O3S
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1
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| 1 |
Ki = 1500 nM
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CP0395525
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5-[4-(3-Chloro-benzyl)-piperazin-1-yl]-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine
Show/Hide
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C19H19ClN8O
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1
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| 1 |
Ki = 1510 nM
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CP0502363
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C16H22N6O2
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1
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| 1 |
Ki = 1533 nM
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CP0533723
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methyl (E)-3-[3-methyl-5-[2-(pyridine-3-carbonylamino)-5-pyridin-4-yl-1,3-thiazol-4-yl]phenyl]prop-2-enoate
Show/Hide
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C25H20N4O3S
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1
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| 1 |
Ki = 1570 nM
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CP0385399
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tert-butyl N-[2-[2-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethoxy]ethoxy]ethyl]carbamate
Show/Hide
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C19H28N8O5
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1
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| 1 |
Ki = 1580 nM
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CP0491372
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(methoxymethyl)-5-methylpyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C18H26N6O2
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1
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| 1 |
Ki = 1640 nM
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CP0448382
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2-[4-[2,6-dioxo-1,3-bis(prop-2-enyl)-7H-purin-8-yl]phenoxy]acetic acid
Show/Hide
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C19H18N4O5
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1
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| 1 |
Ki = 1660 nM
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CP0532744
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ethyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
Show/Hide
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C21H20FN5O4S
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1
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| 1 |
Ki = 1670 nM
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CP0570799
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1R,2R)-2-[(4-propan-2-ylphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
Show/Hide
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C25H33N5O5
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1
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| 1 |
Ki = 1698.24 nM
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CP0386237
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C19H24N8OS
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1
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| 1 |
Ki = 1700 nM
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CP0427854
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(furan-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C20H25N7O2
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2
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| 1 |
Ki = 1700 nM
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| 2 |
Ki = 1730 nM
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CP0234129
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A2A
Show/Hide
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C19H26N4O4S
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1
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| 1 |
Ki = 1700 nM
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CP0237282
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5-amino-3-[2-[4-[3-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-8-(1,3-thiazol-2-yl)-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
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C25H29FN10O3S
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1
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| 1 |
Ki = 1700 nM
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CP0545842
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5-amino-8-(furan-2-yl)-3-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
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C26H31N9O4
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1
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| 1 |
Ki = 1700 nM
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CP0388101
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N-[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]benzamide
Show/Hide
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C15H11N7O2
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1
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| 1 |
Ki = 1800 nM
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CP0412622
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-ethylpiperazin-1-yl)acetamide
Show/Hide
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C22H29N7O2
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1
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| 1 |
Ki = 1880 nM
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CP0866817
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2-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(5-aminopentyl)acetamide
Show/Hide
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C26H31N9O3
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1
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| 1 |
Ki = 1910 nM
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CP0427799
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2-(furan-2-yl)-5-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Show/Hide
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C12H13N7O
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1
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| 1 |
Ki = 1940 nM
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CP0095644
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C19H24N8OS
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1
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| 1 |
Ki = 2000 nM
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CP0323463
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2-(4-fluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
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C22H24FN3O4S
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2
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| 1 |
Ki = 2000 nM
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| 2 |
Ki = 5000 nM
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CP0509955
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N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyrimidin-4-yl]-2-(4-methylphenoxy)acetamide
Show/Hide
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C21H18N4O3S
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1
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| 1 |
Ki = 2100 nM
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CP0427858
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(4-methyl-1,4-diazepan-1-yl)acetamide
Show/Hide
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C22H29N7O2
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1
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| 1 |
Ki = 2100 nM
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CP0439355
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(pyridin-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C16H16N6O
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1
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| 1 |
Ki = 2100 nM
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CP0438934
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2-(3-fluorophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C20H15FN4O3S
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1
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| 1 |
Ki = 2200 nM
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CP0438037
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(1R,2R,3S,4R,5S)-4-[6-[2-(3-fluorophenyl)ethylamino]-2-[2-(5-fluorothiophen-2-yl)ethynyl]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
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C25H21F2N5O2S
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1
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| 1 |
Ki = 2290 nM
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CP0471160
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-[(3S)-3-(propan-2-yloxy)pyrrolidin-1-yl]acetamide
Show/Hide
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C23H30N6O3
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1
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| 1 |
Ki = 2300 nM
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CP0905099
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2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(4-aminobutyl)acetamide
Show/Hide
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C25H29N9O3
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1
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| 1 |
Ki = 2390 nM
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CP0375018
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2-(3,5-Dimethylpyrazol-1-yl)-6-((R)-2-methoxymethylpyrrolidin-1-yl)pyrimidin-4-ylamine
Show/Hide
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C15H22N6O
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1
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| 1 |
Ki = 2473 nM
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CP0403160
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2-[(3S)-3-(diethylamino)pyrrolidin-1-yl]-N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C24H33N7O2
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1
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| 1 |
Ki = 2600 nM
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CP0570800
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(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-[(4-tert-butylphenyl)methoxy]cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
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C26H35N5O5
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1
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| 1 |
Ki = 2630.27 nM
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CP0529956
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(1R,2R,3S,4R,5S)-4-[6-[2-(3-fluorophenyl)ethylamino]-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
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C27H24FN5O2
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1
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| 1 |
Ki = 2680 nM
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CP0190420
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4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1,4-dimethylcyclohexane-1-carboxamide
Show/Hide
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C21H29N3O4S
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1
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| 1 |
Ki = 2900 nM
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CP0375020
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(R)-1-[6-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]pyrrolidine-2-carboxylic Acid Methyl Ester
Show/Hide
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C17H22N6O3
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1
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| 1 |
Ki = 2934 nM
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CP0880294
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5-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)pentan-1-aminium 2,2,2-trifluoroacetate
Show/Hide
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C15H19F3N8O3
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1
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| 1 |
Ki = 2950 nM
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CP0377525
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N-(3,4-dimethyl-2,5-dioxopyrrol-1-yl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C25H28N6O6
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1
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| 1 |
Ki = 3030 nM
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CP0462143
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7-amino-2-(furan-2-yl)-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-one
Show/Hide
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C8H6N6O2
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1
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| 1 |
Ki = 3110 nM
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CP0474619
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-piperidin-1-ylpyrimidin-4-yl]acetamide
Show/Hide
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C16H22N6O
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1
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| 1 |
Ki = 3364.3 nM
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CP0388116
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1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-phenylethanone
Show/Hide
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C20H20N8O2
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1
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| 1 |
Ki = 3510 nM
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CP0395523
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tert-butyl N-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]carbamate
Show/Hide
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C15H20N8O3
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1
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| 1 |
Ki = 3730 nM
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CP0393643
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tert-butyl N-[[4-[[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]methyl]cyclohexyl]methyl]carbamate
Show/Hide
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C21H30N8O3
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1
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| 1 |
Ki = 3890 nM
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CP0532745
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(1S,2R,3S,4R,5S)-4-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Show/Hide
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C22H23FN6O3S
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1
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| 1 |
Ki = 3980 nM
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CP0494654
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[2-(ethoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C18H26N6O2
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1
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| 1 |
Ki = 4186 nM
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CP0851744
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4-((4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenoxy)methyl)benzenesulfonic acid, ammonia salt
Show/Hide
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C26H26N8O5S
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1
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| 1 |
Ki = 4190 nM
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CP0433198
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N-[2,6-bis(1H-pyrazol-1-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C17H21N9O
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1
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| 1 |
Ki = 4200 nM
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CP0432814
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8-[3-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H27F3N6O5
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1
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| 1 |
Ki = 4200 nM
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CP0509953
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2-(3-cyanophenoxy)-N-(2-(5-methylfuran-2-yl)-6-(thiazol-2-yl)pyrimidin-4-yl)acetamide
Show/Hide
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C21H15N5O3S
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1
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| 1 |
Ki = 4300 nM
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CP0372885
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N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
Show/Hide
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C21H26N8O
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1
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| 1 |
Ki = 4400 nM
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CP0374549
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N-[6-(diethylamino)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C15H22N6O
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1
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| 1 |
Ki = 4466 nM
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CP0445405
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C17H24N6O2
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1
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| 1 |
Ki = 4468 nM
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CP0495168
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8-cyclopentyl-2-(3-fluoroanilino)-1-propyl-7H-purin-6-one
Show/Hide
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C19H22FN5O
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1
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| 1 |
Ki = 4500 nM
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CP0529515
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[4-(morpholin-4-yl)pyridin-2-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C20H23N7O2
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1
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| 1 |
Ki = 4600 nM
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CP0388777
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(2-methoxyethyl)piperidin-1-yl]pyrimidin-4-yl]acetamide
Show/Hide
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C19H28N6O2
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1
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| 1 |
Ki = 4695 nM
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CP0894597
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3-[4-(1,3-Bis-cyclohexylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylic acid
Show/Hide
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C28H34N4O4
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1
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| 1 |
Ki = 4890 nM
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CP0474624
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-pyrrolidin-1-ylpyrimidin-4-yl]acetamide
Show/Hide
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C15H20N6O
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1
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| 1 |
Ki = 4954 nM
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CP0408010
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4-[4-[2-[5-amino-8-(furan-2-yl)-1-methyl-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]piperazin-1-yl]benzonitrile
Show/Hide
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C24H24N10O2
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1
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| 1 |
Ki = 5000 nM
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CP0392209
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tert-butyl 4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazine-1-carboxylate
Show/Hide
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C17H22N8O3
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1
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| 1 |
Ki = 5400 nM
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CP0903161
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2-(4-(3-(5-Amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7yl)propyl)phenoxy)-N-(6-aminohexyl)acetamide
Show/Hide
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C27H33N9O3
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1
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| 1 |
Ki = 6500 nM
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CP0575929
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N-benzyl-1-methyl-3-propan-2-ylpyrazolo[3,4-d]pyridazin-7-amine
Show/Hide
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C16H19N5
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1
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| 1 |
Ki = 6760.83 nM
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CP0395529
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1-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-diphenylethanone
Show/Hide
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C26H24N8O2
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1
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| 1 |
Ki = 7470 nM
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CP0494655
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-morpholin-4-ylpyrimidin-4-yl]acetamide
Show/Hide
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C15H20N6O2
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1
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| 1 |
Ki = 8124 nM
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CP0543930
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N-[4-(3-iodo-5-methylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
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C21H15IN4OS
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1
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| 1 |
Ki = 8770 nM
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CP0422355
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N-[6-(3,5-dimethylpyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl]-2-(3-fluorophenoxy)acetamide
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C22H20FN5O3
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1
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| 1 |
Ki = 9700 nM
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CP0433197
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(1,3-oxazol-5-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
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C19H24N8O2
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1
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| 1 |
Ki > 10000 nM
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CP0516551
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N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-methyl-1,3-oxazol-5-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide
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C20H26N8O2
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1
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| 1 |
Ki > 10000 nM
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CP0498521
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]acetamide
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C16H23N7O
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1
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| 1 |
Ki > 10000 nM
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CP0545475
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4-(1-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-yl)morpholine
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C16H17N5O
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1
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| 1 |
Ki > 10000 nM
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CP0546925
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N-benzyl-2-methyl-3-propan-2-ylpyrazolo[3,4-d]pyridazin-7-amine
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C16H19N5
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1
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| 1 |
Ki > 10000 nM
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CP0546942
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4-(2-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-yl)morpholine
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C16H17N5O
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1
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| 1 |
Ki > 10000 nM
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CP0569089
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N-benzyl-2-methyl-3-phenylpyrazolo[3,4-d]pyridazin-7-amine
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C19H17N5
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1
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| 1 |
Ki > 10000 nM
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CP0374550
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N-[2-(3,5-dimethylpyrazol-1-yl)-6-[(2S)-2-(pyridin-2-yloxymethyl)pyrrolidin-1-yl]pyrimidin-4-yl]acetamide
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C21H25N7O2
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1
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| 1 |
Ki = 12100 nM
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CP0397513
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3-butyl-4-[(E)-(4-chlorophenyl)methylideneamino]-2-sulfanylidene-1,3-thiazole-5-carbonitrile
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C15H14ClN3S2
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1
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| 1 |
Ki = 24630 nM
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CP0516509
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2-(3-cyanophenoxy)-N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2-yl)pyrimidin-4-yl)acetamide
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C23H20N6O3
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1
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| 1 |
Ki = 25000 nM
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CP0406628
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8-[6-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]pyridin-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
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C28H29F3N6O4
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1
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| 1 |
Ki > 800 nM
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CP0464063
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4-[(8-cyclopentyl-6-oxo-1-propyl-7H-purin-2-yl)oxy]benzamide
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C20H23N5O3
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1
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| 1 |
Ki > 1000 nM
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CP0466156
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3-(8-cyclopentyl-6-oxo-1-propyl-7H-purin-2-yl)benzamide
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C20H23N5O2
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1
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| 1 |
Ki > 1000 nM
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CP0478619
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2-[3-[(8-cyclopentyl-6-oxo-1-propyl-7H-purin-2-yl)oxy]phenyl]acetic acid
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C21H24N4O4
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1
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| 1 |
Ki > 1000 nM
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CP0480968
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8-cyclopentyl-2-(1-methylpyrrolidin-3-yl)oxy-1-propyl-7H-purin-6-one
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C18H27N5O2
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1
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| 1 |
Ki > 1000 nM
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CP0492756
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8-cyclopentyl-2-(4-fluoroanilino)-1-propyl-7H-purin-6-one
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C19H22FN5O
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1
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| 1 |
Ki > 1000 nM
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CP0492757
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8-cyclopentyl-2-(4-methylpyridin-2-yl)oxy-1-propyl-7H-purin-6-one
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C19H23N5O2
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1
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| 1 |
Ki > 1000 nM
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CP0495166
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4-[(8-cyclopentyl-6-oxo-1-propyl-7H-purin-2-yl)oxy]benzenesulfonamide
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C19H23N5O4S
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1
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| 1 |
Ki > 1000 nM
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CP0495167
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2-anilino-8-cyclopentyl-1-propyl-7H-purin-6-one
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C19H23N5O
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1
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| 1 |
Ki > 1000 nM
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