General Information of the Compound
Compound ID
CP0495149
Compound Name
(2R,3R,4S,5R)-2-[6-[[(1R,2R)-2-(4-tert-butylphenoxy)cyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Structure
Formula
C25H33N5O5
Molecular Weight
483.569
Canonical SMILES
CC(C)(C)c1ccc(O[C@@H]2CCC[C@H]2Nc2ncnc3n(cnc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1
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InChI
InChI=1S/C25H33N5O5/c1-25(2,3)14-7-9-15(10-8-14)34-17-6-4-5-16(17)29-22-19-23(27-12-26-22)30(13-28-19)24-21(33)20(32)18(11-31)35-24/h7-10,12-13,16-18,20-21,24,31-33H,4-6,11H2,1-3H3,(H,26,27,29)/t16-,17-,18-,20-,21-,24-/m1/s1
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InChIKey
UUKIPCRYYDMZJF-LVNUPDNPSA-N
Physicochemical Property
logP
2.1473
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
134.78
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168269168
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 18.2 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  2
1
Kd = 363.08 nM
   TI
   LI
   LO
   TS
2
Ki = 446.68 nM
   TI
   LI
   LO
   TS
Protein ID: PT01717, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Kd = 676.08 nM
   TI
   LI
   LO
   TS
2
Ki = 199.53 nM
   TI
   LI
   LO
   TS