Protein Information

General Information of the Protein

Protein ID	PT01717
Protein Name	Adenosine receptor A1
Gene Name	ADORA1
Sequence	MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Nucleotide-like receptor (family A GPCR) > Adenosine receptor
Function	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Show/Hide
Uniprot ID	P25099
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0362924 Compound Info	(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H23N5O4	1
1	Ki = 0.34 nM Bioactivity Info	TI LI LO TS
CP0039632 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopropyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C13H16N6O4	1
1	Ki = 6.4 nM Bioactivity Info	TI LI LO TS
CP0378926 Compound Info	(1S,2R,3S,4R,5S)-4-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Show/Hide	C18H23ClN6O3	1
1	Ki = 17.4 nM Bioactivity Info	TI LI LO TS
CP0211418 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclobutyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C14H18N6O4	1
1	Ki = 43 nM Bioactivity Info	TI LI LO TS
CP0039348 Compound Info	(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C12H16N6O4	1
1	Ki = 63 nM Bioactivity Info	TI LI LO TS
CP0217091 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C11H14N6O4	1
1	Ki = 84 nM Bioactivity Info	TI LI LO TS
CP0118650 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-(3-iodobenzylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrothiophene-2-carboxamide Show/Hide	C18H18ClIN6O3S	1
1	Ki = 140 nM Bioactivity Info	TI LI LO TS
CP0316519 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrothiophene-2-carboxamide Show/Hide	C12H15ClN6O3S	1
1	Ki = 198 nM Bioactivity Info	TI LI LO TS
CP0435131 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-(2-chloroethyl)-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C12H15ClN6O4	1
1	Ki = 248 nM Bioactivity Info	TI LI LO TS
CP0378001 Compound Info	(2-chloropurin-9-yl)-3,4-dihydroxytetrahydrothiphene-2-carboxylic acid methyl amide Show/Hide	C11H13ClN6O3S	1
1	Ki = 294 nM Bioactivity Info	TI LI LO TS
CP0039042 Compound Info	N-[9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide Show/Hide	C21H14ClN5O2	1
1	Ki = 305 nM Bioactivity Info	TI LI LO TS
CP0379088 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-cyclopentyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C15H20N6O4	1
1	Ki = 770 nM Bioactivity Info	TI LI LO TS
CP0017043 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H18ClIN6O4	1
1	Ki = 820 nM Bioactivity Info	TI LI LO TS
CP0198142 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-(2,2,2-trifluoroethyl)oxolane-2-carboxamide Show/Hide	C12H13F3N6O4	1
1	Ki = 1190 nM Bioactivity Info	TI LI LO TS
CP0198141 Compound Info	(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-propyloxolane-2-carboxamide Show/Hide	C13H18N6O4	1
1	Ki = 1240 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000386 , Flp-In-CHO

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0039348 Compound Info	(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide Show/Hide	C12H16N6O4	5
1	IC50 = 10 nM
2	IC50 = 52000 nM
3	IC50 = 90000 nM
4	Ki = 6.3 nM
5	Ki = 10.3 nM
CP0362924 Compound Info	(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C17H23N5O4	1
1	Ki = 0.34 nM
CP0058033 Compound Info	1,3-dipropyl-8-cyclopentylxanthine Show/Hide	C16H24N4O2	7
1	Ki = 0.46 nM
2	Ki = 0.5 nM
3	Ki = 0.6166 nM
4	Ki = 0.77 nM
5	Ki = 0.9 nM
6	Ki = 1.2 nM
7	Ki = 1.46 nM
CP0077413 Compound Info	(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C15H20ClN5O4	1
1	Ki = 0.6 nM
CP0330238 Compound Info	(2R,3R,4S,5R)-2-[6-(9H-fluoren-9-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C24H23N5O4	1
1	Ki = 5.2 nM
CP0146806 Compound Info	(2R,3R,4S,5R)-2-[6-(2,2-Diphenyl-ethylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol Show/Hide	C24H25N5O4	1
1	Ki = 6.8 nM
CP0001102 Compound Info	(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Show/Hide	C10H13N5O4	1
1	Ki = 10 nM
CP0083663 Compound Info	8-(2-Hydroxy-4-methoxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione Show/Hide	C18H22N4O4	1
1	Ki = 11 nM
CP0150055 Compound Info	8-Cyclopentyl-1-propyl-3,7-dihydro-purine-2,6-dione Show/Hide	C13H18N4O2	1
1	Ki = 14 nM
CP0255221 Compound Info	8-(2,4-Dihydroxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione Show/Hide	C17H20N4O4	1
1	Ki = 15 nM
CP0069838 Compound Info	(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester Show/Hide	C26H26N6O4	1
1	Ki = 16.8 nM
CP0277937 Compound Info	8-(2,3-Dihydroxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione Show/Hide	C17H20N4O4	1
1	Ki = 33 nM
CP0018686 Compound Info	(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide Show/Hide	C18H19IN6O4	1
1	Ki = 54 nM
CP0301653 Compound Info	8-(2,5-Dihydroxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione Show/Hide	C17H20N4O4	1
1	Ki = 360 nM
CP0017043 Compound Info	(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide Show/Hide	C18H18ClIN6O4	1
1	Ki = 820 nM
CP0042654 Compound Info	1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione Show/Hide	C7H8N4O2	2
1	Ki = 8500 nM
2	Ki = 14000 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT05020	Adenosine receptor A1	Mus musculus, Mouse	Protein Info

50% Identity

Protein ID	Protein Name	Protein Organism
PT00840	Adenosine receptor A1	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han