General Information of the Protein
Protein ID
PT05020
Protein Name
Adenosine receptor A1
Gene Name
ADORA1
Sequence
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIEEDIPEEKADD
    Show/Hide
Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
>
Adenosine receptor
Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
    Show/Hide
Uniprot ID
Primary ID:
Q60612

Secondarily ID:
Q8BGU7
Q9WUF9
    Show/Hide
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0415983
 Compound Info 
3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
   Show/Hide
C18H22F3N3O4S
  1
1
IC50 > 6700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0362924
 Compound Info 
(2R,3R,4S,5R)-2-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
   Show/Hide
C17H23N5O4
  1
1
Ki = 0.14 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0534305
 Compound Info 
(2R,3R,4S,5S)-2-[6-[[(1R,4S)-2-bicyclo[2.2.1]heptanyl]amino]purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol
   Show/Hide
C17H22ClN5O3
  1
1
Ki = 0.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0077413
 Compound Info 
(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
   Show/Hide
C15H20ClN5O4
  1
1
Ki = 0.21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0049200
 Compound Info 
(2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
   Show/Hide
C15H21N5O4
  1
1
Ki = 0.22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0204638
 Compound Info 
(2R,3R,4S,5R)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
   Show/Hide
C19H27N5O4
  1
1
Ki = 0.37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0039348
 Compound Info 
(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
   Show/Hide
C12H16N6O4
  1
1
Ki = 0.45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169089
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-N-cyclopropyl-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamide
   Show/Hide
C22H27ClN6O3
  1
1
Ki = 0.45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169091
 Compound Info 
(1R,2R,3S,4R,5S)-4-[6-[di(cyclobutyl)methylamino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C21H29N5O3
  1
1
Ki = 0.53 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0139864
 Compound Info 
(2R,3R,4S,5R)-2-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
   Show/Hide
C19H26ClN5O4
  1
1
Ki = 0.65 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169090
 Compound Info 
(2S,3S,4R,5R)-2-(chloromethyl)-5-[6-[di(cyclobutyl)methylamino]purin-9-yl]oxolane-3,4-diol
   Show/Hide
C19H26ClN5O3
  1
1
Ki = 0.71 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0139869
 Compound Info 
(1S,2R,3S,4R,5S)-1-(chloromethyl)-4-[6-[di(cyclobutyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C21H28ClN5O2
  1
1
Ki = 1.05 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169097
 Compound Info 
(1R,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C19H24ClN5O3
  1
1
Ki = 1.05 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069838
 Compound Info 
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
   Show/Hide
C26H26N6O4
  1
1
Ki = 1.45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0440591
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-(2-hydroxyethyl)bicyclo[3.1.0]hexane-1-carboxamide
   Show/Hide
C21H27ClN6O4
  1
1
Ki = 1.56 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0266847
 Compound Info 
(1S,2R,3S,4R,5S)-4-[6-[[(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-2-chloropurin-9-yl]-1-(chloromethyl)bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C19H23Cl2N5O2
  1
1
Ki = 1.86 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0139868
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C21H28ClN5O3
  1
1
Ki = 2.47 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0354472
 Compound Info 
(2R,3R,4S,5S)-2-[6-[di(cyclobutyl)methylamino]purin-9-yl]-5-(ethylsulfanylmethyl)oxolane-3,4-diol
   Show/Hide
C21H31N5O3S
  1
1
Ki = 3.58 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169100
 Compound Info 
(1R,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C18H22ClN5O2
  1
1
Ki = 5.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169092
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-1-(chloromethyl)bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C21H27Cl2N5O2
  1
1
Ki = 11.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0204631
 Compound Info 
1-[(1S,2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]-1,2,4-triazole-3-carboxamide
   Show/Hide
C10H14N4O4
  1
1
Ki = 25.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0424466
 Compound Info 
8-[4-[4-[(3-bromophenyl)methyl]piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
   Show/Hide
C25H27BrN6O4S
  1
1
Ki = 107 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065233
 Compound Info 
4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
   Show/Hide
C14H14N4O5S
  1
1
Ki = 591 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420800
 Compound Info 
8-[4-[4-(4-chlorophenyl)piperazin-1-yl]sulfonylphenyl]-3-methyl-1-propyl-7H-purine-2,6-dione
   Show/Hide
C25H27ClN6O4S
  1
1
Ki = 1520 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0204629
 Compound Info 
(1S,2R,3S,4R,5S)-4-[2-chloro-6-[di(cyclobutyl)methylamino]purin-9-yl]-1-[(2-fluorophenyl)sulfanylmethyl]bicyclo[3.1.0]hexane-2,3-diol
   Show/Hide
C27H31ClFN5O2S
  1
1
Ki = 2490 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0169094
 Compound Info 
methyl 1-[(1S,2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-bicyclo[3.1.0]hexanyl]-1,2,4-triazole-3-carboxylate
   Show/Hide
C11H15N3O5
  1
1
Ki = 2990 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014362
 Compound Info 
Adenosine receptor agonist, 16
   Show/Hide
C8H12N4O5
  1
1
Ki = 4430 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420820
 Compound Info 
8-[4-[4-(3-fluorophenyl)piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
   Show/Hide
C24H25FN6O4S
  1
1
Ki > 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420803
 Compound Info 
8-[4-[4-(4-bromophenyl)piperazin-1-yl]sulfonylphenyl]-1-propyl-3,7-dihydropurine-2,6-dione
   Show/Hide
C24H25BrN6O4S
  1
1
Ki > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01717 Adenosine receptor A1 Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT00840 Adenosine receptor A1 Homo sapiens, Human
 Protein Info