N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]-6-[1-[[1-(trifluoromethyl)cyclopropyl]methyl]pyrazol-4-yl]pyridine-2-carboxamide

6-[1-(cyclopropylmethyl)pyrazol-4-yl]-N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]pyridine-2-carboxamide

N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-2-carboxamide

6-(1-cyclobutylpyrazol-4-yl)-N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]pyridine-2-carboxamide

N-[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-[2-[4-(2-hydroxypropan-2-yl)-2-azabicyclo[2.1.1]hexan-2-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-[2-[(2R,3S)-3-hydroxy-2-methylazetidin-1-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-[2-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-[2-(3-methoxyazetidin-1-yl)-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-[2-[(2R,3R)-3-hydroxy-2-methylpyrrolidin-1-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

(S)-2-methyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine

cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine

(R)-2-methyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine

6-(1-ethylpyrazol-4-yl)-N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]pyridine-2-carboxamide

N-[2-(3-hydroxyazetidin-1-yl)-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

US9493440, 3

N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-5-methylpyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

US9416126, D11

N-[6-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-methylpyrimidin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

4-(4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine

4-[[4-(2,2,2-trifluoroethylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]benzamide

5-isopropoxy-3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole

4-(4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)-1-methylpiperazin-2-one

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl)methanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-morpholin-4-ylmethanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone

(R)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(3-methylmorpholino)methanone

(S)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone

5-isopropoxy-3-(2-(4-(methylsulfonyl)piperazin-1-yl)pyridin-4-yl)-1H-indazole

(S)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(3-methylmorpholino)methanone

4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-N-(2-hydroxy-2-methylpropyl)-3-methoxybenzamide

[3-ethoxy-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

[3-(difluoromethoxy)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(4-methylpiperazin-1-yl)methanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-fluorophenyl]-(4-methylpiperazin-1-yl)methanone

(R)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone

3-(2-(4-(4H-1,2,4-triazol-4-yl)piperidin-1-yl)pyridin-4-yl)-5-isopropoxy-1H-indazole

[3-ethoxy-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-morpholin-4-ylmethanone

((2R,6S)-2,6-Dimethylmorpholino)(4-((4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)methanone

[3-chloro-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone

N-(1-cyclobutylpyrazol-4-yl)-2-(1-methylpyrazol-4-yl)-1,3-thiazole-4-carboxamide

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(4-fluoropiperidin-1-yl)methanone

3-(2-((3R,4R)-3,4-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-isopropoxy-1H-indazole

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-propan-2-yloxyphenyl]-(4-methylpiperazin-1-yl)methanone

[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-propan-2-yloxyphenyl]-morpholin-4-ylmethanone

N-(1-cyclobutylpyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide

N-(1-cyclobutylpyrazol-4-yl)-2-(1-methylpyrazol-4-yl)pyrimidine-4-carboxamide

N-(1-cyclobutylpyrazol-4-yl)-2-fluoro-3-(1-methylpyrazol-4-yl)benzamide

[3-(dimethylamino)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone