Brief Information of the Compound and Protein
Compound Name
 Compound Info 
BLU-945
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 PubChem ID
CID: 156538665
Canonical SMILES
CO[C@@H]1CCN(C[C@@H]1F)c1nccc(Nc2cc3c(ccc(N4C[C@H](CS(C)(=O)=O)[C@H]4C)c3cn2)C(C)C)n1
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Compound Formula C28H37FN6O3S
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 544 nM
   TI
   LI
   LO
   TS
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  2
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 40 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.1 nM
   TI
   LI
   LO
   TS
CL000379 PC-9
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  6
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
4
IC50 = 7.4 nM
   TI
   LI
   LO
   TS
5
IC50 = 25 nM
   TI
   LI
   LO
   TS
6
IC50 = 683 nM
   TI
   LI
   LO
   TS