Brief Information of the Compound and Protein
Compound Name
1-[(2R,4R,5S)-4-[4-[(2,2-dioxo-1,2$l^6-benzoxathiin-6-yl)oxymethyl]triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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PubChem ID
CID: 166627603
Canonical SMILES
Cc1cn([C@H]2C[C@@H](n3cc(COc4ccc5c(c4)C=CS(=O)(=O)O5)nn3)[C@@H](CO)O2)c(=O)[nH]c1=O
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Compound Formula C21H21N5O8S
Compound Structure
Protein Name
Telomerase reverse transcriptase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
O14746
Gene Name
TERT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000163 COLO 205 Homo sapiens (Human)  1
1
IC50 = 19000 nM
   TI
   LI
   LO
   TS
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 48400 nM
   TI
   LI
   LO
   TS
CL000007 HT-29 Homo sapiens (Human)  1
1
IC50 = 65000 nM
   TI
   LI
   LO
   TS
CL000104 SW620 Homo sapiens (Human)  1
1
IC50 = 75400 nM
   TI
   LI
   LO
   TS