Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)

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PubChem ID

CID: 3559

SID: 14902191

Canonical SMILES	OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show/Hide
Compound Formula	C21H23ClFNO2

Compound Structure

Protein Name

Protein Info

D(3) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P35462

Gene Name

DRD3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	14
1	Ki = 1.585 nM	TI LI LO TS
2	Ki = 2 nM	TI LI LO TS
3	Ki = 2.2 nM	TI LI LO TS
4	Ki = 2.3 nM	TI LI LO TS
5	Ki = 2.6 nM	TI LI LO TS
6	Ki = 2.7 nM	TI LI LO TS
7	Ki = 6.3 nM	TI LI LO TS
8	Ki = 6.4 nM	TI LI LO TS
9	Ki = 6.8 nM	TI LI LO TS
10	Ki = 7.5 nM	TI LI LO TS
11	Ki = 7.943 nM	TI LI LO TS
12	Ki = 8.318 nM	TI LI LO TS
13	Ki = 16 nM	TI LI LO TS
14	Ki = 25 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	IC50 = 0.25 nM	TI LI LO TS
2	Ki = 0.96 nM	TI LI LO TS
3	Ki = 2.2 nM	TI LI LO TS
4	Ki = 6.4 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	3
1	IC50 = 3.467 nM	TI LI LO TS
2	Ki = 1.122 nM	TI LI LO TS
3	Ki = 16.04 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	Ki = 2 nM	TI LI LO TS
2	Ki = 12.7 nM	TI LI LO TS
3	Ki = 29 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	2
1	Ki = 0.9 nM	TI LI LO TS
2	Ki = 18 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.06 nM	TI LI LO TS

Biochemical Assays