Brief Information of the Compound and Protein
Compound Name
4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide
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PubChem ID
CID: 135424953
SID: 17430900
Canonical SMILES
Nc1nonc1C(Nc1ccc(F)c(Cl)c1)=NO
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Compound Formula C9H7ClFN5O2
Compound Structure
Protein Name
Indoleamine 2,3-dioxygenase 1
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
P14902
Gene Name
IDO1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CL000979 LLTC Mus musculus (Mouse)  1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
CL000111 MDA-MB-231 Homo sapiens (Human)  1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CL000084 SK-OV-3 Homo sapiens (Human)  1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 53 nM
2 IC50 = 73 nM
3 IC50 = 91 nM
4 IC50 = 210 nM
5 Ki = 34000 nM