Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2',15'-dimethyl-5,5'-dioxo-(9'R)-spiro[tetrahydrofuran-2,14'-tetracyclo[8.7.0.02,7.011,15]heptadec-6'-ene]-9-yl ethanethioate

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PubChem ID

CID: 5833

SID: 22395181

Canonical SMILES	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]33CCC(=O)O3)[C@H]12 Show/Hide
Compound Formula	C24H32O4S

Compound Structure

Protein Name

Protein Info

Mineralocorticoid receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 2

Uniprot ID

P08235

Gene Name

NR3C2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	IC50 = 60 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	IC50 = 1.6 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 49 nM	TI LI LO TS
CL000148	Huh-7 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 13 nM	TI LI LO TS
CL000048	PC-3 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 76 nM	TI LI LO TS
CL000952	UAS-MR-bla HEK293 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 50.12 nM	TI LI LO TS

Biochemical Assays