Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-2-methylol-phenol

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PubChem ID

CID: 5152

SID: 14904552

Canonical SMILES	OCc1cc(ccc1O)C(O)CNCCCCCCOCCCCc1ccccc1 Show/Hide
Compound Formula	C25H37NO4

Compound Structure

Protein Name

Protein Info

Beta-2 adrenergic receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Adrenergic receptor

Uniprot ID

P07550

Gene Name

ADRB2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000612	BEAS-2B Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 0.5012 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	8
1	Activity = 0.07 nM	TI LI LO TS
2	EC50 = 0.07 nM	TI LI LO TS
3	EC50 = 0.2512 nM	TI LI LO TS
4	Kd = 1100 nM	TI LI LO TS
5	Ki = 0.18 nM	TI LI LO TS
6	Ki = 0.25 nM	TI LI LO TS
7	Ki = 0.39 nM	TI LI LO TS
8	Ki = 3.2 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	Ki = 1.5 nM	TI LI LO TS
2	Ki = 184 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 0.07943 nM	TI LI LO TS
2	EC50 = 0.1259 nM	TI LI LO TS
3	EC50 = 0.7943 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 0.04467 nM	TI LI LO TS
2	EC50 = 0.07762 nM	TI LI LO TS
3	EC50 = 0.1349 nM	TI LI LO TS
4	EC50 = 0.33 nM	TI LI LO TS
5	Ki = 2.4 nM	TI LI LO TS
CL000246	NCI-H292 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 0.7943 nM	TI LI LO TS

Biochemical Assays