Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxylic acid ((1S,2S,4R)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide

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PubChem ID

CID: 3081355

SID: 14785424

Canonical SMILES	Cc1ccc(Cn2nc(cc2-c2ccc(Cl)c(C)c2)C(=O)N[C@H]2[C@@]3(C)CC[C@H](C3)C2(C)C)cc1 Show/Hide
Compound Formula	C29H34ClN3O

Compound Structure

Protein Name

Protein Info

Cannabinoid receptor 2

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Cannabinoid receptor

Uniprot ID

P34972

Gene Name

CNR2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 0.6 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 26690 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	12
1	EC50 = 23.31 nM	TI LI LO TS
2	IC50 = 19.95 nM	TI LI LO TS
3	IC50 = 760 nM	TI LI LO TS
4	IC50 = 7160 nM	TI LI LO TS
5	Ki = 1.8 nM	TI LI LO TS
6	Ki = 1.82 nM	TI LI LO TS
7	Ki = 4.35 nM	TI LI LO TS
8	Ki = 5.6 nM	TI LI LO TS
9	Ki = 19.7 nM	TI LI LO TS
10	Ki = 51 nM	TI LI LO TS
11	Ki = 117 nM	TI LI LO TS
12	Ki = 1820 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 96.2 nM	TI LI LO TS
2	Ki = 0.31 nM	TI LI LO TS
CL000883	HTLA Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 41 nM	TI LI LO TS
2	EC50 = 1360 nM	TI LI LO TS
CL000043	U2OS Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 1174.9 nM	TI LI LO TS

Biochemical Assays

1	Ki = 2.23 nM