Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
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 PubChem ID
CID: 9803963
SID: 14760044
Canonical SMILES
Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F
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Compound Formula C21H18F3NO3S2
Compound Structure
Protein Name
 Protein Info 
Peroxisome proliferator-activated receptor gamma
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group C
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Nuclear hormone receptor subfamily 1 group C member 3
Uniprot ID
P37231
Gene Name
PPARG
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 4400 nM
   TI
   LI
   LO
   TS
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 912 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  4
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
2
EC50 = 8900 nM
   TI
   LI
   LO
   TS
3
EC50 > 1200 nM
   TI
   LI
   LO
   TS
4
EC50 > 1500 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 8600 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 800 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 850 nM
2 IC50 = 6309.57 nM