Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
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 PubChem ID
CID: 42611190
SID: 81046076
Canonical SMILES
OC(=O)c1cc(-c2ccc(cc2)C2CCNCC2)c2ccc(cc2c1)-c1ccc(cc1)C(F)(F)F
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Compound Formula C29H24F3NO2
Compound Structure
Protein Name
 Protein Info 
P2Y purinoceptor 14
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Nucleotide-like receptor (family A GPCR)
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Purine receptor
Uniprot ID
Q15391
Gene Name
P2RY14
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  7
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
2
IC50 = 7.96 nM
   TI
   LI
   LO
   TS
3
IC50 = 8 nM
   TI
   LI
   LO
   TS
4
IC50 = 9.75 nM
   TI
   LI
   LO
   TS
5
IC50 = 14.5 nM
   TI
   LI
   LO
   TS
6
IC50 = 19 nM
   TI
   LI
   LO
   TS
7
Ki = 0.43 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.98 nM
   TI
   LI
   LO
   TS
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.98 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 ~ 0.5 nM
2 Ki ~ 2.3 nM
3 Ki ~ 35 nM