Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8546435, 3
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 PubChem ID
CID: 66788278
Canonical SMILES
COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)[C@@H](Cc2c[nH]c3ccccc23)NC(C)=O)cc1
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Compound Formula C38H36N8O3
Compound Structure
Protein Name
 Protein Info 
Growth hormone secretagogue receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
GRP-related receptor
Uniprot ID
Q92847
Gene Name
GHSR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CL000009 LLC-PK1
 Cell Line Info 
Sus scrofa (Pig)  1
1
Ki = 9 nM
   TI
   LI
   LO
   TS
CL000041 LTK-
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.6 nM