Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea

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PubChem ID

CID: 24889392

SID: 51081888

Canonical SMILES	CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show/Hide
Compound Formula	C29H32N6O4S

Compound Structure

Protein Name

Protein Info

Receptor-type tyrosine-protein kinase FLT3

Protein Classification

Enzyme

Kinase

Protein Kinase

TK protein kinase group

Tyrosine protein kinase PDGFR family

Uniprot ID

P36888

Gene Name

FLT3

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000605	32D Cell Line Info	Mus musculus (Mouse)	4
1	GI50 = 16 nM	TI LI LO TS
2	GI50 = 27 nM	TI LI LO TS
3	GI50 = 150 nM	TI LI LO TS
4	GI50 = 220 nM	TI LI LO TS
CL000768	AML-1 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 2 nM	TI LI LO TS
CL000077	Ba/F3 Cell Line Info	Mus musculus (Mouse)	5
1	GI50 = 4.2 nM	TI LI LO TS
2	GI50 = 7 nM	TI LI LO TS
3	IC50 = 3.01 nM	TI LI LO TS
4	IC50 = 520 nM	TI LI LO TS
5	IC50 = 625 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	Kd = 1.6 nM	TI LI LO TS
CL000071	MOLM-13 Cell Line Info	Homo sapiens (Human)	1
1	GI50 = 4 nM	TI LI LO TS
CL000091	MV4-11 Cell Line Info	Homo sapiens (Human)	2
1	GI50 = 1 nM	TI LI LO TS
2	GI50 = 3 nM	TI LI LO TS
CL000120	RS4;11 Cell Line Info	Homo sapiens (Human)	3
1	GI50 = 2200 nM	TI LI LO TS
2	IC50 = 1.1 nM	TI LI LO TS
3	IC50 = 4.2 nM	TI LI LO TS
CL000012	Sf21 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	3
1	IC50 = 25.5 nM	TI LI LO TS
2	IC50 = 26.08 nM	TI LI LO TS
3	IC50 = 235.5 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	5
1	IC50 = 10 nM	TI LI LO TS
2	IC50 = 19.8 nM	TI LI LO TS
3	IC50 = 36 nM	TI LI LO TS
4	IC50 = 69 nM	TI LI LO TS
5	IC50 = 136 nM	TI LI LO TS

Biochemical Assays

1	IC50 < 0.51 nM
2	IC50 = 0.9 nM
3	IC50 = 2 nM
4	IC50 = 2.6 nM
5	IC50 = 4.1 nM
6	IC50 = 4.2 nM
7	IC50 = 4.8 nM
8	IC50 = 6.51 nM
9	IC50 = 7.4 nM
10	IC50 = 10 nM
11	IC50 = 12 nM
12	IC50 = 30 nM
13	IC50 = 39 nM
14	IC50 = 69 nM
15	IC50 = 93 nM
16	IC50 = 120 nM
17	IC50 = 137 nM
18	IC50 = 170 nM
19	IC50 = 258.2 nM
20	IC50 = 1330 nM
21	Kd = 1.3 nM
22	Kd = 1.6 nM
23	Kd = 2.2 nM
24	Kd = 3.7 nM
25	Kd = 4.1 nM
26	Kd = 5.1 nM
27	Kd = 7.1 nM
28	Kd = 8.8 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han