Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride

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PubChem ID

CID: 6005

SID: 14823961

Canonical SMILES	CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 Show/Hide
Compound Formula	C17H17NO2

Compound Structure

Protein Name

Protein Info

D(2) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P14416

Gene Name

DRD2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 4 nM	TI LI LO TS
2	Ki = 26 nM	TI LI LO TS
3	Ki = 32 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	3
1	EC50 = 12.7 nM	TI LI LO TS
2	IC50 = 4.2 nM	TI LI LO TS
3	Ki > 217 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	Kd = 24 nM	TI LI LO TS
CL000386	Flp-In-CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 = 1.7 nM	TI LI LO TS
2	IC50 = 117 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	10
1	EC50 = 1.8 nM	TI LI LO TS
2	EC50 = 4 nM	TI LI LO TS
3	EC50 = 5.8 nM	TI LI LO TS
4	Ki = 0.62 nM	TI LI LO TS
5	Ki = 3.6 nM	TI LI LO TS
6	Ki = 42 nM	TI LI LO TS
7	Ki = 50 nM	TI LI LO TS
8	Ki = 53 nM	TI LI LO TS
9	Ki = 98 nM	TI LI LO TS
10	Ki = 244 nM	TI LI LO TS
CL000041	LTK- Cell Line Info	Mus musculus (Mouse)	1
1	Ki = 41.9 nM	TI LI LO TS
CL000035	NIH 3T3 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 575.44 nM	TI LI LO TS

Biochemical Assays