Brief Information of the Compound and Protein
Compound Name
 Compound Info 
methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate
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 PubChem ID
CID: 443872
SID: 12015198
Canonical SMILES
COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]23O[C@@H]2C[C@@]2(C)[C@@H](CC[C@@]22CCC(=O)O2)[C@H]13
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Compound Formula C24H30O6
Compound Structure
Protein Name
 Protein Info 
Mineralocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 2
Uniprot ID
P08235
Gene Name
NR3C2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CL000213 EA.hy 926
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
2
IC50 = 63.1 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CL000148 Huh-7
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 122 nM
   TI
   LI
   LO
   TS
2
IC50 = 135 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CL000952 UAS-MR-bla HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 122 nM
2 IC50 = 240 nM
3 IC50 = 244 nM
4 Ki = 125.89 nM