Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile
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 PubChem ID
CID: 9818903
SID: 14801907
Canonical SMILES
C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N
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Compound Formula C22H22N2O
Compound Structure
Protein Name
 Protein Info 
Histamine H3 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9Y5N1
Gene Name
HRH3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
Ki = 0.45 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Ki = 4 nM
   TI
   LI
   LO
   TS
2
Ki = 9.1 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.63 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  2
1
Kd = 12.88 nM
   TI
   LI
   LO
   TS
2
Ki = 0.45 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.4 nM
2 Ki = 0.45 nM
3 Ki = 1.35 nM
4 Ki = 2.4 nM