Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

Actos

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PubChem ID

CID: 4829

SID: 22395182

Canonical SMILES	CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 Show/Hide
Compound Formula	C19H20N2O3S

Compound Structure

Protein Name

Protein Info

Peroxisome proliferator-activated receptor gamma

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 1

Nuclear hormone receptor subfamily 1 group C

Nuclear hormone receptor subfamily 1 group C member 3

Uniprot ID

P37231

Gene Name

PPARG

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	EC50 = 140 nM	TI LI LO TS
2	EC50 = 390 nM	TI LI LO TS
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	EC50 = 390 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	5
1	EC50 = 200 nM	TI LI LO TS
2	EC50 = 300 nM	TI LI LO TS
3	EC50 = 320 nM	TI LI LO TS
4	EC50 = 380 nM	TI LI LO TS
5	EC50 = 1400 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	3
1	EC50 = 550 nM	TI LI LO TS
2	EC50 = 580 nM	TI LI LO TS
3	EC50 = 588.84 nM	TI LI LO TS
CL001002	GeneBLAzer UAS-bla HEK 293H Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 98 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	4
1	EC50 = 210 nM	TI LI LO TS
2	EC50 = 800 nM	TI LI LO TS
3	EC50 = 1100 nM	TI LI LO TS
4	IC50 = 22000 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 2053 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 570 nM	TI LI LO TS

Biochemical Assays