Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
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 PubChem ID
CID: 208908
SID: 14911387
Canonical SMILES
CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
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Compound Formula C29H26ClFN4O4S
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
2
IC50 = 52 nM
   TI
   LI
   LO
   TS
3
IC50 = 2685 nM
   TI
   LI
   LO
   TS
CL000217 CAL-27
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 < 32 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 27.1 nM
   TI
   LI
   LO
   TS
CL000220 KB
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 62 nM
   TI
   LI
   LO
   TS
CL000215 MiaPaCa(BCRP)
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 433 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 14781 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  3
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
2
IC50 = 224.89 nM
   TI
   LI
   LO
   TS
3
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  3
1
IC50 = 0.06 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
3
IC50 = 24 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.9 nM
2 IC50 = 3 nM
3 IC50 = 5.5 nM
4 IC50 = 7.9 nM
5 IC50 = 8 nM
6 IC50 = 8.9 nM
7 IC50 = 9 nM
8 IC50 = 10 nM
9 IC50 = 10.2 nM
10 IC50 = 10.8 nM
11 IC50 = 11 nM
12 IC50 = 11.2 nM
13 IC50 = 12 nM
14 IC50 = 13.42 nM
15 IC50 = 15 nM
16 IC50 = 17 nM
17 IC50 = 22 nM
18 IC50 = 27.06 nM
19 IC50 = 46 nM
20 IC50 = 52 nM
21 IC50 = 52.2 nM
22 IC50 = 280 nM
23 IC50 = 61060 nM
24 IC50 > 4000 nM
25 Kd = 0.92 nM
26 Kd = 1.2 nM
27 Kd = 2.1 nM
28 Kd = 2.2 nM
29 Kd = 2.4 nM
30 Kd = 2.8 nM
31 Kd = 3.5 nM
32 Kd = 3.9 nM
33 Kd = 4.2 nM
34 Kd = 5.5 nM
35 Kd = 8.6 nM
36 Kd = 860 nM
37 Kd > 10000 nM
38 Ki = 3 nM