Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

CAS_29790-52-1

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PubChem ID

CID: 89594

SID: 14748051

Canonical SMILES	CN1CCC[C@H]1c1cccnc1 Show/Hide
Compound Formula	C10H14N2

Compound Structure

Protein Name

Protein Info

Neuronal acetylcholine receptor subunit alpha-7

Protein Classification

Ion channel

Ligand-gated ion channel

Nicotinic acetylcholine receptor

Nicotinic acetylcholine receptor alpha subunit

Uniprot ID

P36544

Gene Name

CHRNA7

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 3000 nM	TI LI LO TS
CL000033	GH3 Cell Line Info	Rattus norvegicus (Rat)	1
1	EC50 = 1584.89 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	Ki = 2110 nM	TI LI LO TS
2	Ki = 3000 nM	TI LI LO TS
CL000016	IMR-32 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 6300 nM	TI LI LO TS
CL000030	LCL Orang Asli K28 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 1610 nM	TI LI LO TS
CL000020	Neuro-2a Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 4710 nM	TI LI LO TS
CL000004	SH-SY5Y Cell Line Info	Homo sapiens (Human)	7
1	IC50 = 7600 nM	TI LI LO TS
2	IC50 = 21000 nM	TI LI LO TS
3	Kd = 1.06 nM	TI LI LO TS
4	Ki = 1000 nM	TI LI LO TS
5	Ki = 1023.29 nM	TI LI LO TS
6	Ki = 3800 nM	TI LI LO TS
7	Ki = 7200 nM	TI LI LO TS

Biochemical Assays