Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

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PubChem ID

CID: 5994

SID: 14850243

Canonical SMILES	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C Show/Hide
Compound Formula	C21H30O2

Compound Structure

Protein Name

Protein Info

Progesterone receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 3

Uniprot ID

P06401

Gene Name

PGR

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	7
1	EC50 = 1.5 nM	TI LI LO TS
2	EC50 = 2.89 nM	TI LI LO TS
3	EC50 = 2.9 nM	TI LI LO TS
4	EC50 = 15.2 nM	TI LI LO TS
5	IC50 > 10000 nM	TI LI LO TS
6	IC50 < 10000 nM	TI LI LO TS
7	Ki = 3.8 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 2 nM	TI LI LO TS
CL000012	Sf21 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	Ki = 3.5 nM	TI LI LO TS
CL000078	T-47D Cell Line Info	Homo sapiens (Human)	6
1	EC50 = 0.1 nM	TI LI LO TS
2	EC50 = 0.9 nM	TI LI LO TS
3	EC50 = 0.92 nM	TI LI LO TS
4	EC50 = 1.8 nM	TI LI LO TS
5	EC50 = 2.2 nM	TI LI LO TS
6	IC50 = 3.5 nM	TI LI LO TS

Biochemical Assays